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Protein

Procollagen galactosyltransferase 2

Gene

Colgalt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues on collagen.By similarity

Catalytic activityi

UDP-alpha-D-galactose + [procollagen]-(2S,5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-1650814. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen galactosyltransferase 2 (EC:2.4.1.50By similarity)
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 2
Glycosyltransferase 25 family member 2
Hydroxylysine galactosyltransferase 2
Gene namesi
Name:Colgalt2
Synonyms:Glt25d2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138232. Colgalt2.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000030954227 – 625Procollagen galactosyltransferase 2Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi579N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NVG7.
PRIDEiQ6NVG7.

PTM databases

PhosphoSitePlusiQ6NVG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032649.
CleanExiMM_GLT25D2.
ExpressionAtlasiQ6NVG7. baseline and differential.
GenevisibleiQ6NVG7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037532.

Structurei

3D structure databases

ProteinModelPortaliQ6NVG7.
SMRiQ6NVG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi622 – 625Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4179. Eukaryota.
ENOG410XQQN. LUCA.
GeneTreeiENSGT00550000074427.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiQ6NVG7.
KOiK11703.
OMAiMQVQQPE.
OrthoDBiEOG091G0SKW.
PhylomeDBiQ6NVG7.
TreeFamiTF313826.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NVG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARLATVAC ALFLLSSALL RLGCRARFAA EPDSDEDGEE TVAFPESPPQ
60 70 80 90 100
KPTVFVVVLA RNAAHTLPYF LGCLERLDYP KSRMAIWAAT DHNVDNTTEI
110 120 130 140 150
LREWLKSVQR LYHYVEWRPM NEPESYPDEI GPKHWPNSRF SHVMKLRQAA
160 170 180 190 200
LRTAREKWSD YILFIDVDNF LTNPQTLNLM IVENKTIVAP MLESRGLYSN
210 220 230 240 250
FWCGITPQGF YKRTPDYLQI REWKRMGCFP VPMVHSTFLI DLRKEASDKL
260 270 280 290 300
AFYPPHQDYT WTFDDIIVFA FSSRQAGIQM YLCNKEHYGY LPIPLKPHQT
310 320 330 340 350
LQEDVENLIH VQIEAMIDHP PMEPSQFVSV VPKYPDKMGF DEIFMINLKR
360 370 380 390 400
RKDRRDRMLR TLYEQEIEVK IVEAVDGKAL NTSQLKAWNI EMLPGYRDPY
410 420 430 440 450
SSRPLTRGEI GCFLSHFSVW KEVIDRELEK TLVIEDDVRF EHQFKRKLMK
460 470 480 490 500
LMEDIDKAQL DWELIYIGRK RMQVKEPEKA VPNVVNLVEA DYSYWTLGYA
510 520 530 540 550
ISLEGAQKLV GADPFGKMLP VDEFLPIMYN KHPVAEYKEY YESRDLKAFS
560 570 580 590 600
AEPLLIYPTH YTGQPGYLSD TETSTIWDNE TVATDWDRTH SWKSRKQGHI
610 620
RSTAKNTEAL PPPTSLDTVP SRDEL
Length:625
Mass (Da):72,788
Last modified:November 13, 2007 - v2
Checksum:iCEEAB275790C1F3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti398D → G in BAC35169 (PubMed:16141072).Curated1
Sequence conflicti616L → V in AAH68118 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052838 mRNA. Translation: BAC35169.1.
BC068118 mRNA. Translation: AAH68118.1.
CCDSiCCDS15364.1.
RefSeqiNP_808424.3. NM_177756.4.
UniGeneiMm.23782.

Genome annotation databases

EnsembliENSMUST00000044311; ENSMUSP00000037532; ENSMUSG00000032649.
GeneIDi269132.
KEGGimmu:269132.
UCSCiuc007czg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052838 mRNA. Translation: BAC35169.1.
BC068118 mRNA. Translation: AAH68118.1.
CCDSiCCDS15364.1.
RefSeqiNP_808424.3. NM_177756.4.
UniGeneiMm.23782.

3D structure databases

ProteinModelPortaliQ6NVG7.
SMRiQ6NVG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037532.

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

PTM databases

PhosphoSitePlusiQ6NVG7.

Proteomic databases

PaxDbiQ6NVG7.
PRIDEiQ6NVG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044311; ENSMUSP00000037532; ENSMUSG00000032649.
GeneIDi269132.
KEGGimmu:269132.
UCSCiuc007czg.2. mouse.

Organism-specific databases

CTDi23127.
MGIiMGI:2138232. Colgalt2.

Phylogenomic databases

eggNOGiKOG4179. Eukaryota.
ENOG410XQQN. LUCA.
GeneTreeiENSGT00550000074427.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiQ6NVG7.
KOiK11703.
OMAiMQVQQPE.
OrthoDBiEOG091G0SKW.
PhylomeDBiQ6NVG7.
TreeFamiTF313826.

Enzyme and pathway databases

ReactomeiR-MMU-1650814. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

PROiQ6NVG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032649.
CleanExiMM_GLT25D2.
ExpressionAtlasiQ6NVG7. baseline and differential.
GenevisibleiQ6NVG7. MM.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGT252_MOUSE
AccessioniPrimary (citable) accession number: Q6NVG7
Secondary accession number(s): Q8BWD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.