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Q6NVG7

- GT252_MOUSE

UniProt

Q6NVG7 - GT252_MOUSE

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Protein

Procollagen galactosyltransferase 2

Gene

Colgalt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues on collagen.By similarity

Catalytic activityi

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

GO - Molecular functioni

  1. procollagen galactosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen galactosyltransferase 2 (EC:2.4.1.50)
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 2
Glycosyltransferase 25 family member 2
Hydroxylysine galactosyltransferase 2
Gene namesi
Name:Colgalt2
Synonyms:Glt25d2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2138232. Colgalt2.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 625599Procollagen galactosyltransferase 2PRO_0000309542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6NVG7.

PTM databases

PhosphoSiteiQ6NVG7.

Expressioni

Gene expression databases

BgeeiQ6NVG7.
CleanExiMM_GLT25D2.
ExpressionAtlasiQ6NVG7. baseline and differential.
GenevestigatoriQ6NVG7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037532.

Structurei

3D structure databases

ProteinModelPortaliQ6NVG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi622 – 6254Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
GeneTreeiENSGT00550000074427.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiQ6NVG7.
KOiK11703.
OMAiQIREWKR.
OrthoDBiEOG7060RC.
PhylomeDBiQ6NVG7.
TreeFamiTF313826.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NVG7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARLATVAC ALFLLSSALL RLGCRARFAA EPDSDEDGEE TVAFPESPPQ
60 70 80 90 100
KPTVFVVVLA RNAAHTLPYF LGCLERLDYP KSRMAIWAAT DHNVDNTTEI
110 120 130 140 150
LREWLKSVQR LYHYVEWRPM NEPESYPDEI GPKHWPNSRF SHVMKLRQAA
160 170 180 190 200
LRTAREKWSD YILFIDVDNF LTNPQTLNLM IVENKTIVAP MLESRGLYSN
210 220 230 240 250
FWCGITPQGF YKRTPDYLQI REWKRMGCFP VPMVHSTFLI DLRKEASDKL
260 270 280 290 300
AFYPPHQDYT WTFDDIIVFA FSSRQAGIQM YLCNKEHYGY LPIPLKPHQT
310 320 330 340 350
LQEDVENLIH VQIEAMIDHP PMEPSQFVSV VPKYPDKMGF DEIFMINLKR
360 370 380 390 400
RKDRRDRMLR TLYEQEIEVK IVEAVDGKAL NTSQLKAWNI EMLPGYRDPY
410 420 430 440 450
SSRPLTRGEI GCFLSHFSVW KEVIDRELEK TLVIEDDVRF EHQFKRKLMK
460 470 480 490 500
LMEDIDKAQL DWELIYIGRK RMQVKEPEKA VPNVVNLVEA DYSYWTLGYA
510 520 530 540 550
ISLEGAQKLV GADPFGKMLP VDEFLPIMYN KHPVAEYKEY YESRDLKAFS
560 570 580 590 600
AEPLLIYPTH YTGQPGYLSD TETSTIWDNE TVATDWDRTH SWKSRKQGHI
610 620
RSTAKNTEAL PPPTSLDTVP SRDEL
Length:625
Mass (Da):72,788
Last modified:November 13, 2007 - v2
Checksum:iCEEAB275790C1F3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti398 – 3981D → G in BAC35169. (PubMed:16141072)Curated
Sequence conflicti616 – 6161L → V in AAH68118. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052838 mRNA. Translation: BAC35169.1.
BC068118 mRNA. Translation: AAH68118.1.
CCDSiCCDS15364.1.
RefSeqiNP_808424.3. NM_177756.4.
UniGeneiMm.23782.

Genome annotation databases

EnsembliENSMUST00000044311; ENSMUSP00000037532; ENSMUSG00000032649.
GeneIDi269132.
KEGGimmu:269132.
UCSCiuc007czg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052838 mRNA. Translation: BAC35169.1 .
BC068118 mRNA. Translation: AAH68118.1 .
CCDSi CCDS15364.1.
RefSeqi NP_808424.3. NM_177756.4.
UniGenei Mm.23782.

3D structure databases

ProteinModelPortali Q6NVG7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000037532.

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

PTM databases

PhosphoSitei Q6NVG7.

Proteomic databases

PRIDEi Q6NVG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044311 ; ENSMUSP00000037532 ; ENSMUSG00000032649 .
GeneIDi 269132.
KEGGi mmu:269132.
UCSCi uc007czg.2. mouse.

Organism-specific databases

CTDi 23127.
MGIi MGI:2138232. Colgalt2.

Phylogenomic databases

eggNOGi COG3306.
GeneTreei ENSGT00550000074427.
HOGENOMi HOG000007198.
HOVERGENi HBG058097.
InParanoidi Q6NVG7.
KOi K11703.
OMAi QIREWKR.
OrthoDBi EOG7060RC.
PhylomeDBi Q6NVG7.
TreeFami TF313826.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi 392706.
PROi Q6NVG7.
SOURCEi Search...

Gene expression databases

Bgeei Q6NVG7.
CleanExi MM_GLT25D2.
ExpressionAtlasi Q6NVG7. baseline and differential.
Genevestigatori Q6NVG7.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGT252_MOUSE
AccessioniPrimary (citable) accession number: Q6NVG7
Secondary accession number(s): Q8BWD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3