Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase PTC7 homolog

Gene

Pptc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Manganese 1By similarity1
Metal bindingi84Manganese 2By similarity1
Metal bindingi85Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi229Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog (EC:3.1.3.16)
Alternative name(s):
T-cell activation protein phosphatase 2C
Short name:
TA-PP2C
Gene namesi
Name:Pptc7
Synonyms:Tapp2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2444593 Pptc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287461 – 310Protein phosphatase PTC7 homologAdd BLAST310

Proteomic databases

EPDiQ6NVE9
PaxDbiQ6NVE9
PeptideAtlasiQ6NVE9
PRIDEiQ6NVE9

PTM databases

iPTMnetiQ6NVE9
PhosphoSitePlusiQ6NVE9

Expressioni

Gene expression databases

BgeeiENSMUSG00000038582
GenevisibleiQ6NVE9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051838

Structurei

3D structure databases

ProteinModelPortaliQ6NVE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 305PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 93Gly-richAdd BLAST77

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG1379 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00390000011937
HOGENOMiHOG000239282
HOVERGENiHBG060636
InParanoidiQ6NVE9
KOiK17508
OMAiSIYWTGR
OrthoDBiEOG091G0G5G
PhylomeDBiQ6NVE9
TreeFamiTF315105

Family and domain databases

Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PfamiView protein in Pfam
PF07228 SpoIIE, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NVE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGGGGSSGDY GLVTAGCGFG
60 70 80 90 100
KDFRKGLLKK GACYGDDACF VARHRSADVL GVADGVGGWR DYGVDPSQFS
110 120 130 140 150
GTLMRTCERL VKEGRFVPSN PVGILTTSYC ELLQNKVPLL GSSTACIVVL
160 170 180 190 200
DRSSHRLHTA NLGDSGFLVV RGGEVVHRSD EQQHYFNTPF QLSIAPPEAE
210 220 230 240 250
GVVLSDSPDA ADSTSFDVQL GDIILTATDG LFDNMPDYMI LQELKKLKNS
260 270 280 290 300
NYESIQRTAR SIAEQAHELA YDPNYMSPFA QFACDNGLNV RGGKPDDITV
310
LLSIVAEYTD
Length:310
Mass (Da):33,048
Last modified:July 5, 2004 - v1
Checksum:i36F226F82515DB7B
GO
Isoform 2 (identifier: Q6NVE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:207
Mass (Da):22,770
Checksum:iF6E2255F88FDA842
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0327721 – 103Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078914 mRNA Translation: BAC37456.1
AK135118 mRNA Translation: BAE22428.1
AK162261 mRNA Translation: BAE36822.1
BC068149 mRNA Translation: AAH68149.1
CCDSiCCDS39255.1 [Q6NVE9-1]
RefSeqiNP_796216.2, NM_177242.4 [Q6NVE9-1]
UniGeneiMm.489670

Genome annotation databases

EnsembliENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582 [Q6NVE9-1]
ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582 [Q6NVE9-2]
GeneIDi320717
KEGGimmu:320717
UCSCiuc008zky.1 mouse [Q6NVE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPTC7_MOUSE
AccessioniPrimary (citable) accession number: Q6NVE9
Secondary accession number(s): Q3TS53, Q8BVC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health