UniProtKB - Q6NVE9 (PPTC7_MOUSE)
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Protein
Protein phosphatase PTC7 homolog
Gene
Pptc7
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 84 | Manganese 1By similarity | 1 | |
Metal bindingi | 84 | Manganese 2By similarity | 1 | |
Metal bindingi | 85 | Manganese 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 229 | Manganese 2By similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- phosphoprotein phosphatase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Ligand | Magnesium, Manganese, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase PTC7 homolog (EC:3.1.3.16)Alternative name(s): T-cell activation protein phosphatase 2C Short name: TA-PP2C |
Gene namesi | Name:Pptc7 Synonyms:Tapp2c |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444593. Pptc7. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328746 | 1 – 310 | Protein phosphatase PTC7 homologAdd BLAST | 310 |
Proteomic databases
EPDi | Q6NVE9. |
PaxDbi | Q6NVE9. |
PeptideAtlasi | Q6NVE9. |
PRIDEi | Q6NVE9. |
PTM databases
iPTMneti | Q6NVE9. |
PhosphoSitePlusi | Q6NVE9. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 305 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 267 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 93 | Gly-richAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the PP2C family.Curated
Phylogenomic databases
eggNOGi | KOG1379. Eukaryota. COG0631. LUCA. |
GeneTreei | ENSGT00390000011937. |
HOGENOMi | HOG000239282. |
HOVERGENi | HBG060636. |
InParanoidi | Q6NVE9. |
KOi | K17508. |
OMAi | SIYWTGR. |
OrthoDBi | EOG091G0G5G. |
PhylomeDBi | Q6NVE9. |
TreeFami | TF315105. |
Family and domain databases
Gene3Di | 3.60.40.10. 1 hit. |
InterProi | View protein in InterPro IPR036457. PPM-type_dom_sf. IPR001932. PPM-type_phosphatase_dom. |
Pfami | View protein in Pfam PF07228. SpoIIE. 1 hit. |
SMARTi | View protein in SMART SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. |
SUPFAMi | SSF81606. SSF81606. 1 hit. |
PROSITEi | View protein in PROSITE PS51746. PPM_2. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6NVE9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGGGGSSGDY GLVTAGCGFG
60 70 80 90 100
KDFRKGLLKK GACYGDDACF VARHRSADVL GVADGVGGWR DYGVDPSQFS
110 120 130 140 150
GTLMRTCERL VKEGRFVPSN PVGILTTSYC ELLQNKVPLL GSSTACIVVL
160 170 180 190 200
DRSSHRLHTA NLGDSGFLVV RGGEVVHRSD EQQHYFNTPF QLSIAPPEAE
210 220 230 240 250
GVVLSDSPDA ADSTSFDVQL GDIILTATDG LFDNMPDYMI LQELKKLKNS
260 270 280 290 300
NYESIQRTAR SIAEQAHELA YDPNYMSPFA QFACDNGLNV RGGKPDDITV
310
LLSIVAEYTD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032772 | 1 – 103 | Missing in isoform 2. 1 PublicationAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK078914 mRNA. Translation: BAC37456.1. AK135118 mRNA. Translation: BAE22428.1. AK162261 mRNA. Translation: BAE36822.1. BC068149 mRNA. Translation: AAH68149.1. |
CCDSi | CCDS39255.1. [Q6NVE9-1] |
RefSeqi | NP_796216.2. NM_177242.4. [Q6NVE9-1] |
UniGenei | Mm.489670. |
Genome annotation databases
Ensembli | ENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582. [Q6NVE9-1] ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582. [Q6NVE9-2] |
GeneIDi | 320717. |
KEGGi | mmu:320717. |
UCSCi | uc008zky.1. mouse. [Q6NVE9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | PPTC7_MOUSE | |
Accessioni | Q6NVE9Primary (citable) accession number: Q6NVE9 Secondary accession number(s): Q3TS53, Q8BVC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | March 28, 2018 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |