Pptc7

Functionⁱ

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Cofactorⁱ

Mg²⁺Curated, Mn²⁺Curated

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	84	Manganese 1By similarity	1
Metal bindingⁱ	84	Manganese 2By similarity	1
Metal bindingⁱ	85	Manganese 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	229	Manganese 2By similarity	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
phosphoprotein phosphatase activity Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Ligand	Magnesium, Manganese, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase PTC7 homolog (EC:3.1.3.16) Alternative name(s): T-cell activation protein phosphatase 2C Short name: TA-PP2C
Gene namesⁱ	Name:Pptc7 Synonyms:Tapp2c
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2444593. Pptc7.

Subcellular locationⁱ

GO - Cellular componentⁱ

mitochondrion
Source: MGI
Inferred from direct assayⁱ
- 18614015

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000328746	1 – 310	Protein phosphatase PTC7 homologAdd BLAST		310

Proteomic databases

EPDⁱ	Q6NVE9.
PaxDbⁱ	Q6NVE9.
PeptideAtlas More...PeptideAtlasⁱ	Q6NVE9.
PRIDEⁱ	Q6NVE9.

PTM databases

iPTMnetⁱ	Q6NVE9.
PhosphoSitePlusⁱ	Q6NVE9.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000038582.
Genevisibleⁱ	Q6NVE9. MM.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000051838.

STRINGⁱ

10090.ENSMUSP00000051838.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6NVE9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 305	PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST		267

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	17 – 93	Gly-richAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1379. Eukaryota. COG0631. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011937.
HOGENOMⁱ	HOG000239282.
HOVERGENⁱ	HBG060636.
InParanoidⁱ	Q6NVE9.
KEGG Orthology (KO) More...KOⁱ	K17508.
OMAⁱ	NLGDSWC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G5G.
PhylomeDBⁱ	Q6NVE9.
TreeFamⁱ	TF315105.

Family and domain databases

Gene3Dⁱ	3.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001932. PPM-type_phosphatase_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07228. SpoIIE. 1 hit.
SMARTⁱ	View protein in SMART SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit.
SUPFAMⁱ	SSF81606. SSF81606. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51746. PPM_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6NVE9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGGGGSSGDY GLVTAGCGFG 
        60         70         80         90        100
KDFRKGLLKK GACYGDDACF VARHRSADVL GVADGVGGWR DYGVDPSQFS 
       110        120        130        140        150
GTLMRTCERL VKEGRFVPSN PVGILTTSYC ELLQNKVPLL GSSTACIVVL 
       160        170        180        190        200
DRSSHRLHTA NLGDSGFLVV RGGEVVHRSD EQQHYFNTPF QLSIAPPEAE 
       210        220        230        240        250
GVVLSDSPDA ADSTSFDVQL GDIILTATDG LFDNMPDYMI LQELKKLKNS 
       260        270        280        290        300
NYESIQRTAR SIAEQAHELA YDPNYMSPFA QFACDNGLNV RGGKPDDITV 
       310
LLSIVAEYTD

Length:310

Mass (Da):33,048

Last modified:July 5, 2004 - v1

Checksum:ⁱ36F226F82515DB7B

GO

Isoform 2 (identifier: Q6NVE9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-103: Missing.

« Hide

        10         20         30         40         50
MRTCERLVKE GRFVPSNPVG ILTTSYCELL QNKVPLLGSS TACIVVLDRS 
        60         70         80         90        100
SHRLHTANLG DSGFLVVRGG EVVHRSDEQQ HYFNTPFQLS IAPPEAEGVV 
       110        120        130        140        150
LSDSPDAADS TSFDVQLGDI ILTATDGLFD NMPDYMILQE LKKLKNSNYE 
       160        170        180        190        200
SIQRTARSIA EQAHELAYDP NYMSPFAQFA CDNGLNVRGG KPDDITVLLS 

IVAEYTD

Show »

Length:207

Mass (Da):22,770

Checksum:ⁱF6E2255F88FDA842

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_032772	1 – 103	Missing in isoform 2. 1 PublicationAdd BLAST		103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK078914 mRNA. Translation: BAC37456.1. AK135118 mRNA. Translation: BAE22428.1. AK162261 mRNA. Translation: BAE36822.1. BC068149 mRNA. Translation: AAH68149.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39255.1. [Q6NVE9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_796216.2. NM_177242.4. [Q6NVE9-1]
UniGeneⁱ	Mm.489670.

Genome annotation databases

Ensemblⁱ	ENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582. [Q6NVE9-1] ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582. [Q6NVE9-2]
GeneIDⁱ	320717.
KEGGⁱ	mmu:320717.
UCSC genome browser More...UCSCⁱ	uc008zky.1. mouse. [Q6NVE9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK078914 mRNA. Translation: BAC37456.1. AK135118 mRNA. Translation: BAE22428.1. AK162261 mRNA. Translation: BAE36822.1. BC068149 mRNA. Translation: AAH68149.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39255.1. [Q6NVE9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_796216.2. NM_177242.4. [Q6NVE9-1]
UniGeneⁱ	Mm.489670.

3D structure databases

ProteinModelPortalⁱ	Q6NVE9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000051838.

STRINGⁱ

10090.ENSMUSP00000051838.

PTM databases

iPTMnetⁱ	Q6NVE9.
PhosphoSitePlusⁱ	Q6NVE9.

Proteomic databases

EPDⁱ	Q6NVE9.
PaxDbⁱ	Q6NVE9.
PeptideAtlas More...PeptideAtlasⁱ	Q6NVE9.
PRIDEⁱ	Q6NVE9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582. [Q6NVE9-1] ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582. [Q6NVE9-2]
GeneIDⁱ	320717.
KEGGⁱ	mmu:320717.
UCSC genome browser More...UCSCⁱ	uc008zky.1. mouse. [Q6NVE9-1]

Organism-specific databases

CTDⁱ	160760.
MGIⁱ	MGI:2444593. Pptc7.

Phylogenomic databases

eggNOGⁱ	KOG1379. Eukaryota. COG0631. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011937.
HOGENOMⁱ	HOG000239282.
HOVERGENⁱ	HBG060636.
InParanoidⁱ	Q6NVE9.
KEGG Orthology (KO) More...KOⁱ	K17508.
OMAⁱ	NLGDSWC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G5G.
PhylomeDBⁱ	Q6NVE9.
TreeFamⁱ	TF315105.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6NVE9.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038582.
Genevisibleⁱ	Q6NVE9. MM.

Family and domain databases

Gene3Dⁱ	3.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001932. PPM-type_phosphatase_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07228. SpoIIE. 1 hit.
SMARTⁱ	View protein in SMART SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit.
SUPFAMⁱ	SSF81606. SSF81606. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51746. PPM_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPTC7_MOUSE
Accessionⁱ	Q6NVE9Primary (citable) accession number: Q6NVE9 Secondary accession number(s): Q3TS53, Q8BVC7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	July 5, 2004
	Last modified:	June 7, 2017
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6NVE9 (PPTC7_MOUSE)

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Protein phosphatase PTC7 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ