Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase PTC7 homolog

Gene

Pptc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Manganese 1By similarity
Metal bindingi84 – 841Manganese 2By similarity
Metal bindingi85 – 851Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi229 – 2291Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog (EC:3.1.3.16)
Alternative name(s):
T-cell activation protein phosphatase 2C
Short name:
TA-PP2C
Gene namesi
Name:Pptc7
Synonyms:Tapp2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2444593. Pptc7.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Protein phosphatase PTC7 homologPRO_0000328746Add
BLAST

Proteomic databases

MaxQBiQ6NVE9.
PaxDbiQ6NVE9.
PRIDEiQ6NVE9.

PTM databases

PhosphoSiteiQ6NVE9.

Expressioni

Gene expression databases

BgeeiQ6NVE9.
GenevestigatoriQ6NVE9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051838.

Structurei

3D structure databases

ProteinModelPortaliQ6NVE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 303260PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 9377Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000239282.
HOVERGENiHBG060636.
InParanoidiQ6NVE9.
KOiK17508.
OMAiWDNLSEQ.
OrthoDBiEOG7DRJ3F.
PhylomeDBiQ6NVE9.
TreeFamiTF315105.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NVE9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGGGGSSGDY GLVTAGCGFG
60 70 80 90 100
KDFRKGLLKK GACYGDDACF VARHRSADVL GVADGVGGWR DYGVDPSQFS
110 120 130 140 150
GTLMRTCERL VKEGRFVPSN PVGILTTSYC ELLQNKVPLL GSSTACIVVL
160 170 180 190 200
DRSSHRLHTA NLGDSGFLVV RGGEVVHRSD EQQHYFNTPF QLSIAPPEAE
210 220 230 240 250
GVVLSDSPDA ADSTSFDVQL GDIILTATDG LFDNMPDYMI LQELKKLKNS
260 270 280 290 300
NYESIQRTAR SIAEQAHELA YDPNYMSPFA QFACDNGLNV RGGKPDDITV
310
LLSIVAEYTD
Length:310
Mass (Da):33,048
Last modified:July 5, 2004 - v1
Checksum:i36F226F82515DB7B
GO
Isoform 2 (identifier: Q6NVE9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:207
Mass (Da):22,770
Checksum:iF6E2255F88FDA842
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103Missing in isoform 2. 1 PublicationVSP_032772Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078914 mRNA. Translation: BAC37456.1.
AK135118 mRNA. Translation: BAE22428.1.
AK162261 mRNA. Translation: BAE36822.1.
BC068149 mRNA. Translation: AAH68149.1.
CCDSiCCDS39255.1. [Q6NVE9-1]
RefSeqiNP_796216.2. NM_177242.4. [Q6NVE9-1]
UniGeneiMm.489670.

Genome annotation databases

EnsembliENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582. [Q6NVE9-1]
ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582. [Q6NVE9-2]
GeneIDi320717.
KEGGimmu:320717.
UCSCiuc008zky.1. mouse. [Q6NVE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078914 mRNA. Translation: BAC37456.1.
AK135118 mRNA. Translation: BAE22428.1.
AK162261 mRNA. Translation: BAE36822.1.
BC068149 mRNA. Translation: AAH68149.1.
CCDSiCCDS39255.1. [Q6NVE9-1]
RefSeqiNP_796216.2. NM_177242.4. [Q6NVE9-1]
UniGeneiMm.489670.

3D structure databases

ProteinModelPortaliQ6NVE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051838.

PTM databases

PhosphoSiteiQ6NVE9.

Proteomic databases

MaxQBiQ6NVE9.
PaxDbiQ6NVE9.
PRIDEiQ6NVE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582. [Q6NVE9-1]
ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582. [Q6NVE9-2]
GeneIDi320717.
KEGGimmu:320717.
UCSCiuc008zky.1. mouse. [Q6NVE9-1]

Organism-specific databases

CTDi160760.
MGIiMGI:2444593. Pptc7.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000239282.
HOVERGENiHBG060636.
InParanoidiQ6NVE9.
KOiK17508.
OMAiWDNLSEQ.
OrthoDBiEOG7DRJ3F.
PhylomeDBiQ6NVE9.
TreeFamiTF315105.

Miscellaneous databases

NextBioi397293.
PROiQ6NVE9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NVE9.
GenevestigatoriQ6NVE9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cecum, Egg and Olfactory bulb.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPPTC7_MOUSE
AccessioniPrimary (citable) accession number: Q6NVE9
Secondary accession number(s): Q3TS53, Q8BVC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.