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Q6NVE9

- PPTC7_MOUSE

UniProt

Q6NVE9 - PPTC7_MOUSE

Protein

Protein phosphatase PTC7 homolog

Gene

Pptc7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium or manganese.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Manganese 1By similarity
    Metal bindingi84 – 841Manganese 2By similarity
    Metal bindingi85 – 851Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi229 – 2291Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PTC7 homolog (EC:3.1.3.16)
    Alternative name(s):
    T-cell activation protein phosphatase 2C
    Short name:
    TA-PP2C
    Gene namesi
    Name:Pptc7
    Synonyms:Tapp2c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2444593. Pptc7.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Protein phosphatase PTC7 homologPRO_0000328746Add
    BLAST

    Proteomic databases

    MaxQBiQ6NVE9.
    PaxDbiQ6NVE9.
    PRIDEiQ6NVE9.

    PTM databases

    PhosphoSiteiQ6NVE9.

    Expressioni

    Gene expression databases

    BgeeiQ6NVE9.
    GenevestigatoriQ6NVE9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000051838.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NVE9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 303260PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 9377Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00390000011937.
    HOGENOMiHOG000239282.
    HOVERGENiHBG060636.
    InParanoidiQ6NVE9.
    KOiK17508.
    OMAiMKAREHG.
    OrthoDBiEOG7DRJ3F.
    PhylomeDBiQ6NVE9.
    TreeFamiTF315105.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    [Graphical view]
    PfamiPF07228. SpoIIE. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NVE9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGGGGSSGDY GLVTAGCGFG    50
    KDFRKGLLKK GACYGDDACF VARHRSADVL GVADGVGGWR DYGVDPSQFS 100
    GTLMRTCERL VKEGRFVPSN PVGILTTSYC ELLQNKVPLL GSSTACIVVL 150
    DRSSHRLHTA NLGDSGFLVV RGGEVVHRSD EQQHYFNTPF QLSIAPPEAE 200
    GVVLSDSPDA ADSTSFDVQL GDIILTATDG LFDNMPDYMI LQELKKLKNS 250
    NYESIQRTAR SIAEQAHELA YDPNYMSPFA QFACDNGLNV RGGKPDDITV 300
    LLSIVAEYTD 310
    Length:310
    Mass (Da):33,048
    Last modified:July 5, 2004 - v1
    Checksum:i36F226F82515DB7B
    GO
    Isoform 2 (identifier: Q6NVE9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-103: Missing.

    Show »
    Length:207
    Mass (Da):22,770
    Checksum:iF6E2255F88FDA842
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 103103Missing in isoform 2. 1 PublicationVSP_032772Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078914 mRNA. Translation: BAC37456.1.
    AK135118 mRNA. Translation: BAE22428.1.
    AK162261 mRNA. Translation: BAE36822.1.
    BC068149 mRNA. Translation: AAH68149.1.
    CCDSiCCDS39255.1. [Q6NVE9-1]
    RefSeqiNP_796216.2. NM_177242.4. [Q6NVE9-1]
    UniGeneiMm.489670.

    Genome annotation databases

    EnsembliENSMUST00000053426; ENSMUSP00000051838; ENSMUSG00000038582. [Q6NVE9-1]
    ENSMUST00000119015; ENSMUSP00000113194; ENSMUSG00000038582. [Q6NVE9-2]
    GeneIDi320717.
    KEGGimmu:320717.
    UCSCiuc008zky.1. mouse. [Q6NVE9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078914 mRNA. Translation: BAC37456.1 .
    AK135118 mRNA. Translation: BAE22428.1 .
    AK162261 mRNA. Translation: BAE36822.1 .
    BC068149 mRNA. Translation: AAH68149.1 .
    CCDSi CCDS39255.1. [Q6NVE9-1 ]
    RefSeqi NP_796216.2. NM_177242.4. [Q6NVE9-1 ]
    UniGenei Mm.489670.

    3D structure databases

    ProteinModelPortali Q6NVE9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000051838.

    PTM databases

    PhosphoSitei Q6NVE9.

    Proteomic databases

    MaxQBi Q6NVE9.
    PaxDbi Q6NVE9.
    PRIDEi Q6NVE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053426 ; ENSMUSP00000051838 ; ENSMUSG00000038582 . [Q6NVE9-1 ]
    ENSMUST00000119015 ; ENSMUSP00000113194 ; ENSMUSG00000038582 . [Q6NVE9-2 ]
    GeneIDi 320717.
    KEGGi mmu:320717.
    UCSCi uc008zky.1. mouse. [Q6NVE9-1 ]

    Organism-specific databases

    CTDi 160760.
    MGIi MGI:2444593. Pptc7.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00390000011937.
    HOGENOMi HOG000239282.
    HOVERGENi HBG060636.
    InParanoidi Q6NVE9.
    KOi K17508.
    OMAi MKAREHG.
    OrthoDBi EOG7DRJ3F.
    PhylomeDBi Q6NVE9.
    TreeFami TF315105.

    Miscellaneous databases

    NextBioi 397293.
    PROi Q6NVE9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NVE9.
    Genevestigatori Q6NVE9.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    [Graphical view ]
    Pfami PF07228. SpoIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Cecum, Egg and Olfactory bulb.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPPTC7_MOUSE
    AccessioniPrimary (citable) accession number: Q6NVE9
    Secondary accession number(s): Q3TS53, Q8BVC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3