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Protein

WD repeat-containing protein 44

Gene

Wdr44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 44
Alternative name(s):
Rabphilin-11
Gene namesi
Name:Wdr44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1919654. Wdr44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 915914WD repeat-containing protein 44PRO_0000262770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei11 – 111PhosphotyrosineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei221 – 2211PhosphothreonineCombined sources
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei273 – 2731PhosphothreonineBy similarity
Modified residuei344 – 3441PhosphoserineCombined sources
Modified residuei351 – 3511PhosphothreonineBy similarity
Modified residuei403 – 4031PhosphothreonineCombined sources
Modified residuei405 – 4051PhosphoserineCombined sources
Modified residuei472 – 4721PhosphoserineCombined sources
Modified residuei473 – 4731PhosphoserineCombined sources
Modified residuei474 – 4741PhosphoserineCombined sources
Modified residuei481 – 4811PhosphotyrosineCombined sources
Modified residuei563 – 5631PhosphoserineCombined sources
Modified residuei567 – 5671PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NVE8.
MaxQBiQ6NVE8.
PaxDbiQ6NVE8.
PRIDEiQ6NVE8.

PTM databases

iPTMnetiQ6NVE8.
PhosphoSiteiQ6NVE8.

Expressioni

Gene expression databases

BgeeiQ6NVE8.
CleanExiMM_WDR44.
ExpressionAtlasiQ6NVE8. baseline and differential.
GenevisibleiQ6NVE8. MM.

Interactioni

Subunit structurei

Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins (By similarity).By similarity

Protein-protein interaction databases

BioGridi215359. 1 interaction.
STRINGi10090.ENSMUSP00000044616.

Structurei

3D structure databases

ProteinModelPortaliQ6NVE8.
SMRiQ6NVE8. Positions 458-866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati511 – 55040WD 1Add
BLAST
Repeati607 – 64539WD 2Add
BLAST
Repeati647 – 68741WD 3Add
BLAST
Repeati692 – 73140WD 4Add
BLAST
Repeati742 – 78140WD 5Add
BLAST
Repeati786 – 82540WD 6Add
BLAST
Repeati840 – 88041WD 7Add
BLAST
Repeati882 – 91534WD 8Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 173172Binding activityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili114 – 13926Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi213 – 25947Pro-richAdd
BLAST

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0283. Eukaryota.
ENOG410XQPJ. LUCA.
GeneTreeiENSGT00530000063479.
HOGENOMiHOG000267152.
HOVERGENiHBG080376.
InParanoidiQ6NVE8.
OMAiKTDHTEV.
OrthoDBiEOG7W6WK0.
PhylomeDBiQ6NVE8.
TreeFamiTF329226.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NVE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASESDTEEF YDAPEDVHLG TGYPVGSPGK VGLLSFKEAE NTANQAGNES
60 70 80 90 100
PVQELRQDVS KKIIESIIEE SQKVLQLEDD SLDSKGKGLS DEATAGPSVA
110 120 130 140 150
GTEFSNIPGL LAIEHELQQD SEKAESQNVA EESELETQKC FPSDETCEKS
160 170 180 190 200
EKTVDETDNL TEVSSGEQLD ASGLEAETLN KEALEVKEGD VLDPASLDTL
210 220 230 240 250
STTDFAAVEE VAPAKPPRHL TPEPDIVAST KKPVPARPPP PTNFPPPRPP
260 270 280 290 300
PPSRPAPPPR KKKSELEFEA LKTPDLDVPK ENITSDSLLT TNMASENTVR
310 320 330 340 350
DSLPSLDLAS ATSGDKIVTA QENGKAPDVQ TVAGEVMGPQ RPRSNSGREL
360 370 380 390 400
TDEEILASVM IKNLDTGEEI PLSLAEEKLP TGINPLTLHI MRRTKEYVSN
410 420 430 440 450
DATQSDDEEK LQSQQTDTDG GRLKQKTTQL KKFLGKSVKR AKHLAEEYGE
460 470 480 490 500
RAINKVKSVR DEVFHTDQDD PSSSDDEGMP YTRPVKFKAA HGFKGPYDFD
510 520 530 540 550
QIKVVQDLSG EHMGAVWTMK FSHCGRLLAS AGQDNIVRIW ALKNAFDYFN
560 570 580 590 600
NMRMKYNTEG RVSPSPSQES LSSSKSDTDM GVCSGTDEDP DDKNAPFRQR
610 620 630 640 650
PFCKYKGHTA DLLDLSWSKN YFLLSSSMDK TVRLWHISRR ECLCCFQHID
660 670 680 690 700
FVTAIAFHPR DDRYFLSGSL DGKLRLWNIP DKKVALWNEV DGQTKLITAA
710 720 730 740 750
NFCQNGKYAV IGTYDGRCIF YDTEHLKYHT QIHVRSTRGR NKVGRKITGI
760 770 780 790 800
EPLPGENKIL VTSNDSRIRL YDLRDLSLSM KYKGYVNSSS QIKASFSHDF
810 820 830 840 850
TYLVSGSEDK YVYIWSTYHD LSKFTSVRRD RNDFWEGIKA HNAVVTSAIF
860 870 880 890 900
APNPSLMLSL DVQSEKLEGI DKYEDAEVLD STSTGIVKTD NTEVLLSADF
910
TGAIKVFINK RKTVS
Length:915
Mass (Da):101,555
Last modified:July 5, 2004 - v1
Checksum:iB5FDF8A4C87295DC
GO
Isoform 2 (identifier: Q6NVE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.

Note: No experimental confirmation available.
Show »
Length:437
Mass (Da):49,775
Checksum:iB1674DA4CD67F780
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti629 – 6291D → E in BAE24167 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 478478Missing in isoform 2. 1 PublicationVSP_021811Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088885 mRNA. Translation: BAC40631.2.
AK139877 mRNA. Translation: BAE24167.1.
BC068151 mRNA. Translation: AAH68151.1.
BC049191 mRNA. Translation: AAH49191.1.
CCDSiCCDS40892.1. [Q6NVE8-1]
RefSeqiNP_001292604.1. NM_001305675.1. [Q6NVE8-1]
NP_780389.2. NM_175180.3. [Q6NVE8-1]
XP_006527763.1. XM_006527700.2. [Q6NVE8-1]
UniGeneiMm.423.

Genome annotation databases

EnsembliENSMUST00000035766; ENSMUSP00000044616; ENSMUSG00000036769. [Q6NVE8-1]
ENSMUST00000101670; ENSMUSP00000099193; ENSMUSG00000036769. [Q6NVE8-1]
GeneIDi72404.
KEGGimmu:72404.
UCSCiuc009suw.2. mouse. [Q6NVE8-1]
uc009suy.1. mouse. [Q6NVE8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088885 mRNA. Translation: BAC40631.2.
AK139877 mRNA. Translation: BAE24167.1.
BC068151 mRNA. Translation: AAH68151.1.
BC049191 mRNA. Translation: AAH49191.1.
CCDSiCCDS40892.1. [Q6NVE8-1]
RefSeqiNP_001292604.1. NM_001305675.1. [Q6NVE8-1]
NP_780389.2. NM_175180.3. [Q6NVE8-1]
XP_006527763.1. XM_006527700.2. [Q6NVE8-1]
UniGeneiMm.423.

3D structure databases

ProteinModelPortaliQ6NVE8.
SMRiQ6NVE8. Positions 458-866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215359. 1 interaction.
STRINGi10090.ENSMUSP00000044616.

PTM databases

iPTMnetiQ6NVE8.
PhosphoSiteiQ6NVE8.

Proteomic databases

EPDiQ6NVE8.
MaxQBiQ6NVE8.
PaxDbiQ6NVE8.
PRIDEiQ6NVE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035766; ENSMUSP00000044616; ENSMUSG00000036769. [Q6NVE8-1]
ENSMUST00000101670; ENSMUSP00000099193; ENSMUSG00000036769. [Q6NVE8-1]
GeneIDi72404.
KEGGimmu:72404.
UCSCiuc009suw.2. mouse. [Q6NVE8-1]
uc009suy.1. mouse. [Q6NVE8-2]

Organism-specific databases

CTDi54521.
MGIiMGI:1919654. Wdr44.

Phylogenomic databases

eggNOGiKOG0283. Eukaryota.
ENOG410XQPJ. LUCA.
GeneTreeiENSGT00530000063479.
HOGENOMiHOG000267152.
HOVERGENiHBG080376.
InParanoidiQ6NVE8.
OMAiKTDHTEV.
OrthoDBiEOG7W6WK0.
PhylomeDBiQ6NVE8.
TreeFamiTF329226.

Miscellaneous databases

NextBioi336206.
PROiQ6NVE8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NVE8.
CleanExiMM_WDR44.
ExpressionAtlasiQ6NVE8. baseline and differential.
GenevisibleiQ6NVE8. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-259 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Egg and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Colon.
  3. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-405; SER-472; SER-473 AND SER-474, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; THR-221; SER-344; THR-403; SER-405; SER-472; SER-473; SER-474; TYR-481; SER-563 AND SER-567, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiWDR44_MOUSE
AccessioniPrimary (citable) accession number: Q6NVE8
Secondary accession number(s): Q3UT13, Q8BTS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.