Q6NVD0 (FREM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FRAS1-related extracellular matrix protein 2

Alternative name(s):
ECM3 homolog
NV domain-containing protein 1

Gene names

Name:	Frem2
Synonyms:	Nv1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion. Ref.1
Subcellular location	Cell membrane; Single-pass type I membrane protein; Extracellular side Potential.
Tissue specificity	First expressed from E10 in the mesodermal core of the branchial arches, developing lens, otic vesicle and limb apical ectodermal ridge. Later, it is expressed in the vibrissae and vibrissae pad, eyelids ear and pelage follicles and, at low levels, in the epidermis. Also expressed in caudal somites and, in later embryos, in facial, limb and intercostal muscles. In contrast to Frem1, it is not expressed in the developing mammary glands or in the caecum. Restricted to the epithelia in a pattern complementary to that of Frem1 (which is generally expressed in the dermis and mesenchyme). In the developing kidney, it is expressed At in the mesonephric and metanephric epithelia at E11.5, with a highest expression at the tips of the developing ureteric buds. At E12.5 and E13.5, it is still expressed throughout the epithelial components of the kidney, including epithelia fated to form nephrons, which are induced by the ureter tips to differentiate from the mesenchymal condensations that surround them. Ref.1
Domain	The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding By similarity.
Disruption phenotype	Mice display cryptophthalmos, syndactyly and renal defects. Frem2 corresponds to the X-ray irradiated-induced allele 'myelencephalic blebs' (my). Ref.1
Sequence similarities	Belongs to the FRAS1 family. Contains 5 Calx-beta domains. Contains 12 CSPG (NG2) repeats.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro homophilic cell adhesion Inferred from electronic annotation. Source: InterPro inner ear development Inferred from direct assay PubMed 21795542. Source: MGI morphogenesis of an epithelium Inferred from mutant phenotype Ref.1. Source: MGI
Cellular_component	basement membrane Inferred from direct assay PubMed 16880404PubMed 17596926. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NVD0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NVD0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2287: Missing.
     2288-2297: SGEDYHPVSE → MVGPGNFRKR

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6NVD0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2851: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 39	39	Potential
	Chain	40 – 3160	3121	FRAS1-related extracellular matrix protein 2		PRO_0000010125
Regions
	Topological domain	40 – 3105	3066	Extracellular Potential
	Transmembrane	3106 – 3126	21	Helical; Potential
	Topological domain	3127 – 3160	34	Cytoplasmic Potential
	Repeat	291 – 412	122	CSPG 1
	Repeat	413 – 534	122	CSPG 2
	Repeat	535 – 670	136	CSPG 3
	Repeat	671 – 800	130	CSPG 4
	Repeat	801 – 910	110	CSPG 5
	Repeat	911 – 1041	131	CSPG 6
	Repeat	1042 – 1160	119	CSPG 7
	Repeat	1161 – 1273	113	CSPG 8
	Repeat	1274 – 1389	116	CSPG 9
	Repeat	1390 – 1503	114	CSPG 10
	Repeat	1504 – 1622	119	CSPG 11
	Repeat	1623 – 1747	125	CSPG 12
	Domain	1748 – 1847	100	Calx-beta 1
	Domain	1860 – 1971	112	Calx-beta 2
	Domain	1986 – 2092	107	Calx-beta 3
	Domain	2107 – 2209	103	Calx-beta 4
	Domain	2227 – 2331	105	Calx-beta 5
Amino acid modifications
	Glycosylation	351	1	N-linked (GlcNAc...) Potential
	Glycosylation	1233	1	N-linked (GlcNAc...) Potential
	Glycosylation	1358	1	N-linked (GlcNAc...) Potential
	Glycosylation	1573	1	N-linked (GlcNAc...) Potential
	Glycosylation	1730	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 2851	2851	Missing in isoform 3.		VSP_015037
	Alternative sequence	1 – 2287	2287	Missing in isoform 2.		VSP_015038
	Alternative sequence	2288 – 2297	10	SGEDYHPVSE → MVGPGNFRKR in isoform 2.		VSP_015039
Experimental info
	Sequence conflict	2437	1	S → N in BAC27425. Ref.2
	Sequence conflict	2851	1	H → N in BAC27425. Ref.2
	Sequence conflict	3031	1	P → H in AAH46388. Ref.3
	Sequence conflict	3040	1	S → G in AAH46388. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 579F20BD79957E06	FASTA	3,160	350,640
	10 20 30 40 50 60 MASRARRTAK FSSFQPILAQ SPRLLLLLLL LSLVSYVSTQ AAGPGAALQS LGLSGTSGVP 70 80 90 100 110 120 TEEAIVVANR GLRVPFGREV WLDPLRDLVL QVQPGDRCTV TVLDNDALAQ RPGHLSPKRF 130 140 150 160 170 180 ACDYGPGEVR YSHLGARSPS RDRVRLQLRY DAPGGAIVLP LALEVEVVFT QLEIVTRNLP 190 200 210 220 230 240 LVVEELLGTS NALDDRSLEF AYQPETEECR VGILSGLSAL PRYGELLHYP QVQGGAGDRG 250 260 270 280 290 300 TSKTLLMDCK AFQELGVRYR HTAPSRSPNR DWLPMVVELH SRGAPEGSPA LKREHFQVLV 310 320 330 340 350 360 RIRGGAENTA PKPSFVAMMM MEVDQFVLTA LTPDMLAAED AESDPDLLIF NLTSAFQPGQ 370 380 390 400 410 420 GYLVSTDDRS LPLSSFTQRD LRLLKIAYQP PSEDSDQERL FELELEIVDP EGAASDPFAF 430 440 450 460 470 480 MVVVKPMNTL APVVTRNTGL ILYEGQYRPL TGPIGSGPQN LVISDEDDLE AVRLEVVAGL 490 500 510 520 530 540 RHGHLVILGS PSSDSAPKTF TVAELAAGQV VYQHDDKDGS LSDNLVLRMS DGGGRHQVQF 550 560 570 580 590 600 LFPITLVPVD DQPPVLNANT GLTVAEGETV PIPPLTLSAT DIDSDDSQLV FVLLPPFSSL 610 620 630 640 650 660 GHLLLRQRHV PQEEQGLWQK QGSFYERTVT EWRQQDITEG KLFYRHSGPH SPGPVMDQFM 670 680 690 700 710 720 FRVQDNHDPP NQSGIQRFVI RIHPVDRLPP ELGSGCPLRM VVQESQLTPL RKRWLHYTDL 730 740 750 760 770 780 DTDDRELQYT VTQPPTDTDE NHSPAPLGTL VFTDNPSVVV SHFTQAQVNH HKIAYRPPGQ 790 800 810 820 830 840 ELGVAARVAQ FQFQVEDRAG NVAPGTFTLY LQPVDNQPPE IVNTGFTVEE KGHHILRETE 850 860 870 880 890 900 LHVSDVDTDV THISFTLTQA PKHGHMQISG RPLHVGGQFH LEDIKHGRIS YWNSGDESLT 910 920 930 940 950 960 DSCSLEVSDR HHVVPITLRV NVRPGDREGP MSVLPAGTLE SYLDVLENGA TEVTANIIKG 970 980 990 1000 1010 1020 AYQGTDDLML TFLLEGPPSY GEILVNGAPA EQFTQRDILE GSVVYAHTSG EIGLLPKADS 1030 1040 1050 1060 1070 1080 FNLSLSAMSQ EWRIGSSIVQ GVTVWVTILP VDSQAPEISL GEQFVVLEGD KSVISLTHLS 1090 1100 1110 1120 1130 1140 AEDMDSLKDD LLCTIVIQPT SGYVENISPA PGSEKSRAGV AISAFTLKDL RQGHINYVQS 1150 1160 1170 1180 1190 1200 VHRGVEPVED RFIFRCSDGI NFSERQIFPI VIIPTNDEQP EMFMREFMVM EGMSLVVNRL 1210 1220 1230 1240 1250 1260 ILNAADADIP RDDLTFTITR FPTHGHVMNQ LINGTVLVES FTLDQIIESS SIIYEHDDSE 1270 1280 1290 1300 1310 1320 TQEDSFVIKL TDGKHSVEKM VLIVVIPVDD ETPRMTINNG LEIEIGETKV INNKVLMATD 1330 1340 1350 1360 1370 1380 LDSDDKSLVY IIRYGPGHGL LQRQKPLGAF ENITLGMNFT QDEVDRNLIQ YVHFGQEGIR 1390 1400 1410 1420 1430 1440 DLIKFDVTDG TNALIDRYFY VTIGSVDIVF PDVVSKGVSL KEGGKVTLTT DLLSTSDLNS 1450 1460 1470 1480 1490 1500 PDENLVFTIT RAPMRGHLEC TDRRGLSITS FTQLQLAGNK IYYIHTAEDE VKMDSFEFQV 1510 1520 1530 1540 1550 1560 TDGRNPVFRT FRISISDVDN KKPVVTIHNL VVSESESKLI TPFELTVEDR DTPDRLLKFI 1570 1580 1590 1600 1610 1620 VTQVPVHGHL LFNNTRSVMV FTKQDLNENL ISYKHDGTES TEDSFSFTVT DGTHSDFYVF 1630 1640 1650 1660 1670 1680 PDTVFETRRP QVMKIQVLPV DNSVPQIVVN KGASTLRTLA TGHLGFMITS KILKVEDRDS 1690 1700 1710 1720 1730 1740 LHFSLRFIVT EAPQHGYLLN LGQGNHSVTQ FTQADIDDMK ICYVLRERAN ATSDMFHFIV 1750 1760 1770 1780 1790 1800 EDDGGNRLTN QHFRLNWAWI SFEKEYYLIN EDSKFLDIVL TRRGYLGETS FISIGTRDGT 1810 1820 1830 1840 1850 1860 AEKDRDFKGK AQKQVQFNPG QTRASWRVRI LSDGEHEHSE TFQVVLSEPV LAILEFPTVT 1870 1880 1890 1900 1910 1920 TVEIIDPGDE STVFIPQSEY SVEEDVGELF IPIRRSGDIS RELMVICYTQ QGTATSTVRT 1930 1940 1950 1960 1970 1980 SVLSYSDYIS RPEDHSSVIR FDKDEREKMC RILVIDDSLY EEEETFQVLL SMPMGGRIGD 1990 2000 2010 2020 2030 2040 KFPGANVTIL TDRDDEPAFY FGDTQYSVDE SAGYVELQVW RTGTDLSKPS SVTVRSRKTE 2050 2060 2070 2080 2090 2100 SLSADAGTDY VGISRNLDFA PGVNMQTVRV VILDDLGRPI LEGIEKFELV LRMPMNAALG 2110 2120 2130 2140 2150 2160 EPSKATVSIN DSASDLPKMQ FKERVYTCNE NDGRVVAMIY RSGDIQHRSS VRCYTRQGSA 2170 2180 2190 2200 2210 2220 QVMMDFEERP NTDVSTVTFL PGEMEKPCVL ELMDDAVYED VEELRLVLGT PQGSSAFGAA 2230 2240 2250 2260 2270 2280 VGEQNETLIK IQDEADKAVI KFGETKFSVT EPSRPGESVV VKIPVIRQGD TSKVSIVRVH 2290 2300 2310 2320 2330 2340 TKDGSATSGE DYHPVSEEIE FKEGETQHTV EIEVIFDGVR EMREAFTVHL KPDENMVAET 2350 2360 2370 2380 2390 2400 QATKAIVYIE EIHSMADVTF PSVPHIVSLL IYDDPSKGRE DTGPVSGYPV VCITACNPKY 2410 2420 2430 2440 2450 2460 PDYEKTGSIC ASENINDTLT RYRWLISAPA GPDGVTSPMR EVDFDTFFTS SKMITLDSIY 2470 2480 2490 2500 2510 2520 FQPGSRVQCA ARAVNTNGNE GLELMSPIVT IGREEGLCQP RVPGVVGAEP FSAKLRYTGP 2530 2540 2550 2560 2570 2580 EDPDFANLIK LTVTMPHIDG MLPAISTREL SNFELTLSPD GTRVGNHKCS NLLDYNEVKT 2590 2600 2610 2620 2630 2640 HHGFLTNATK NPEVIGETYP YQYSVPVRGS STLRFYRNLN LEACLWEFVS YYDMTELLAD 2650 2660 2670 2680 2690 2700 CGGTIGTDGQ VLNLVQSYVT LRVPLYVSYV FHSPVGVGGW QHFDLKSELR LTFVYDTAIL 2710 2720 2730 2740 2750 2760 WNHGIGSPPE AELQGSLYPT SMRIGEEGRL AVNFKTEAQF HGLFVLSHPA SFTSSLIVSA 2770 2780 2790 2800 2810 2820 DHPGLTFSLR LIRSEPTYNQ PVQQWSFVSD FAVRDYSGTY TVKLVPCTTP SNQEYRLPVT 2830 2840 2850 2860 2870 2880 CNPREPVTFD LDIRFQQVSD PVATEFSLNT HMYLLSKKNL WLSDGSMGFG QESDVAFAEG 2890 2900 2910 2920 2930 2940 DVIYGRVMVD PVQNLGDSFY CSIEKVFLCT GDDGYVPKYS PANAEYGCLA DSPSLLHRFK 2950 2960 2970 2980 2990 3000 IVDKAQPETQ ATSFGDVLFN AKLAVDDPEA VLLVNQPGSD GFKVDSTPLF QVALGREWYI 3010 3020 3030 3040 3050 3060 HTIYTVKSKD NTHRGIGKRS LEYQYHSVVH PGPPQATTKS WKKRAVRSTP SLAGEIGAEN 3070 3080 3090 3100 3110 3120 NRGTNIQHIS LNRRGKRQVP HGRIPPDGIL PWELNSPSSE VSLVTVLGGL TVGLLTVCLA 3130 3140 3150 3160 VAAAVMCRNR STKGKDTPKG SGSTEPMMSP QSHYNDSSEV
	Isoform 2 [UniParc]. Checksum: 198D3BE068E6C0DB	FASTA	873	96,504
	10 20 30 40 50 60 MVGPGNFRKR EIEFKEGETQ HTVEIEVIFD GVREMREAFT VHLKPDENMV AETQATKAIV 70 80 90 100 110 120 YIEEIHSMAD VTFPSVPHIV SLLIYDDPSK GREDTGPVSG YPVVCITACN PKYPDYEKTG 130 140 150 160 170 180 SICASENIND TLTRYRWLIS APAGPDGVTS PMREVDFDTF FTSSKMITLD SIYFQPGSRV 190 200 210 220 230 240 QCAARAVNTN GNEGLELMSP IVTIGREEGL CQPRVPGVVG AEPFSAKLRY TGPEDPDFAN 250 260 270 280 290 300 LIKLTVTMPH IDGMLPAIST RELSNFELTL SPDGTRVGNH KCSNLLDYNE VKTHHGFLTN 310 320 330 340 350 360 ATKNPEVIGE TYPYQYSVPV RGSSTLRFYR NLNLEACLWE FVSYYDMTEL LADCGGTIGT 370 380 390 400 410 420 DGQVLNLVQS YVTLRVPLYV SYVFHSPVGV GGWQHFDLKS ELRLTFVYDT AILWNHGIGS 430 440 450 460 470 480 PPEAELQGSL YPTSMRIGEE GRLAVNFKTE AQFHGLFVLS HPASFTSSLI VSADHPGLTF 490 500 510 520 530 540 SLRLIRSEPT YNQPVQQWSF VSDFAVRDYS GTYTVKLVPC TTPSNQEYRL PVTCNPREPV 550 560 570 580 590 600 TFDLDIRFQQ VSDPVATEFS LNTHMYLLSK KNLWLSDGSM GFGQESDVAF AEGDVIYGRV 610 620 630 640 650 660 MVDPVQNLGD SFYCSIEKVF LCTGDDGYVP KYSPANAEYG CLADSPSLLH RFKIVDKAQP 670 680 690 700 710 720 ETQATSFGDV LFNAKLAVDD PEAVLLVNQP GSDGFKVDST PLFQVALGRE WYIHTIYTVK 730 740 750 760 770 780 SKDNTHRGIG KRSLEYQYHS VVHPGPPQAT TKSWKKRAVR STPSLAGEIG AENNRGTNIQ 790 800 810 820 830 840 HISLNRRGKR QVPHGRIPPD GILPWELNSP SSEVSLVTVL GGLTVGLLTV CLAVAAAVMC 850 860 870 RNRSTKGKDT PKGSGSTEPM MSPQSHYNDS SEV
	Isoform 3 [UniParc]. Checksum: B0E805BEB9A456F1	FASTA	309	33,633
	10 20 30 40 50 60 MYLLSKKNLW LSDGSMGFGQ ESDVAFAEGD VIYGRVMVDP VQNLGDSFYC SIEKVFLCTG 70 80 90 100 110 120 DDGYVPKYSP ANAEYGCLAD SPSLLHRFKI VDKAQPETQA TSFGDVLFNA KLAVDDPEAV 130 140 150 160 170 180 LLVNQPGSDG FKVDSTPLFQ VALGREWYIH TIYTVKSKDN THRGIGKRSL EYQYHSVVHP 190 200 210 220 230 240 GPPQATTKSW KKRAVRSTPS LAGEIGAENN RGTNIQHISL NRRGKRQVPH GRIPPDGILP 250 260 270 280 290 300 WELNSPSSEV SLVTVLGGLT VGLLTVCLAV AAAVMCRNRS TKGKDTPKGS GSTEPMMSPQ SHYNDSSEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs." Jadeja S., Smyth I., Pitera J.E., Taylor M.S., van Haelst M., Bentley E., McGregor L., Hopkins J., Chalepakis G., Philip N., Perez Aytes A., Watt F.M., Darling S.M., Jackson I., Woolf A.S., Scambler P.J. Nat. Genet. 37:520-525(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6J. Tissue: Cerebellum and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2277-3160. Strain: C57BL/6 and Czech II. Tissue: Head and Mammary tumor.
[4]	"QBRICK, a novel cell-adhesive protein expressed in the basement membrane of the developing hair follicle." Kiyozumi D., Osada A., Sugimoto N., Weber C.N., Ono Y., Imai T., Okada A., Sekiguchi K. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-291.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ833643 mRNA. Translation: CAH55760.1. AK031494 mRNA. Translation: BAC27425.1. AK082256 mRNA. Translation: BAC38448.1. BC046388 mRNA. Translation: AAH46388.1. BC068185 mRNA. Translation: AAH68185.1. AB160988 mRNA. Translation: BAD89016.1.
IPI	IPI00469279. IPI00553703. IPI00648770.
RefSeq	NP_766450.2. NM_172862.3.
UniGene	Mm.38378.
3D structure databases
ProteinModelPortal	Q6NVD0.
SMR	Q6NVD0. Positions 1760-2378.
ModBase	Search...
PTM databases
PhosphoSite	Q6NVD0.
Proteomic databases
PaxDb	Q6NVD0.
PRIDE	Q6NVD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000091137; ENSMUSP00000088670; ENSMUSG00000037016.
GeneID	242022.
KEGG	mmu:242022.
UCSC	uc008pex.1. mouse. uc008pey.1. mouse.
Organism-specific databases
CTD	341640.
MGI	MGI:2444465. Frem2.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00550000074429.
HOGENOM	HOG000007464.
HOVERGEN	HBG081537.
InParanoid	Q6NVD0.
OMA	EDSKFLD.
OrthoDB	EOG4WDD9T.
Gene expression databases
Bgee	Q6NVD0.
CleanEx	MM_FREM2.
Genevestigator	Q6NVD0.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR003644. Calx_beta. [Graphical view]
Pfam	PF03160. Calx-beta. 5 hits. [Graphical view]
SMART	SM00112. CA. 1 hit. SM00237. Calx_beta. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	385204.
SOURCE	Search...

Entry information

Entry name

FREM2_MOUSE

Accession

Primary (citable) accession number: Q6NVD0
Secondary accession number(s): Q4W2Q5 , Q5H8C0, Q811G9, Q8C4G5, Q8CD46

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program