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Q6NVD0

- FREM2_MOUSE

UniProt

Q6NVD0 - FREM2_MOUSE

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Protein

FRAS1-related extracellular matrix protein 2

Gene

Frem2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell communication Source: InterPro
  2. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  3. inner ear development Source: MGI
  4. morphogenesis of an epithelium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 2
Alternative name(s):
ECM3 homolog
NV domain-containing protein 1
Gene namesi
Name:Frem2
Synonyms:Nv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2444465. Frem2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 31053066ExtracellularSequence AnalysisAdd
BLAST
Transmembranei3106 – 312621HelicalSequence AnalysisAdd
BLAST
Topological domaini3127 – 316034CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basement membrane Source: BHF-UCL
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display cryptophthalmos, syndactyly and renal defects. Frem2 corresponds to the X-ray irradiated-induced allele 'myelencephalic blebs' (my).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 31603121FRAS1-related extracellular matrix protein 2PRO_0000010125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1233 – 12331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1358 – 13581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1573 – 15731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1730 – 17301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6NVD0.
PaxDbiQ6NVD0.
PRIDEiQ6NVD0.

PTM databases

PhosphoSiteiQ6NVD0.

Expressioni

Tissue specificityi

First expressed from E10 in the mesodermal core of the branchial arches, developing lens, otic vesicle and limb apical ectodermal ridge. Later, it is expressed in the vibrissae and vibrissae pad, eyelids ear and pelage follicles and, at low levels, in the epidermis. Also expressed in caudal somites and, in later embryos, in facial, limb and intercostal muscles. In contrast to Frem1, it is not expressed in the developing mammary glands or in the caecum. Restricted to the epithelia in a pattern complementary to that of Frem1 (which is generally expressed in the dermis and mesenchyme). In the developing kidney, it is expressed At in the mesonephric and metanephric epithelia at E11.5, with a highest expression at the tips of the developing ureteric buds. At E12.5 and E13.5, it is still expressed throughout the epithelial components of the kidney, including epithelia fated to form nephrons, which are induced by the ureter tips to differentiate from the mesenchymal condensations that surround them.1 Publication

Gene expression databases

BgeeiQ6NVD0.
CleanExiMM_FREM2.
GenevestigatoriQ6NVD0.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997463.

Structurei

3D structure databases

ProteinModelPortaliQ6NVD0.
SMRiQ6NVD0. Positions 1759-2392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati291 – 412122CSPG 1Add
BLAST
Repeati413 – 534122CSPG 2Add
BLAST
Repeati535 – 670136CSPG 3Add
BLAST
Repeati671 – 800130CSPG 4Add
BLAST
Repeati801 – 910110CSPG 5Add
BLAST
Repeati911 – 1041131CSPG 6Add
BLAST
Repeati1042 – 1160119CSPG 7Add
BLAST
Repeati1161 – 1273113CSPG 8Add
BLAST
Repeati1274 – 1389116CSPG 9Add
BLAST
Repeati1390 – 1503114CSPG 10Add
BLAST
Repeati1504 – 1622119CSPG 11Add
BLAST
Repeati1623 – 1747125CSPG 12Add
BLAST
Domaini1748 – 1847100Calx-beta 1Add
BLAST
Domaini1860 – 1971112Calx-beta 2Add
BLAST
Domaini1986 – 2092107Calx-beta 3Add
BLAST
Domaini2107 – 2209103Calx-beta 4Add
BLAST
Domaini2227 – 2331105Calx-beta 5Add
BLAST

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

Sequence similaritiesi

Belongs to the FRAS1 family.Curated
Contains 5 Calx-beta domains.Curated
Contains 12 CSPG (NG2) repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000007464.
HOVERGENiHBG081537.
InParanoidiQ6NVD0.
OMAiEDSKFLD.
OrthoDBiEOG751NDJ.
PhylomeDBiQ6NVD0.
TreeFamiTF316876.

Family and domain databases

InterProiIPR002126. Cadherin.
IPR003644. Calx_beta.
[Graphical view]
PfamiPF03160. Calx-beta. 5 hits.
[Graphical view]
SMARTiSM00112. CA. 1 hit.
SM00237. Calx_beta. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NVD0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRARRTAK FSSFQPILAQ SPRLLLLLLL LSLVSYVSTQ AAGPGAALQS
60 70 80 90 100
LGLSGTSGVP TEEAIVVANR GLRVPFGREV WLDPLRDLVL QVQPGDRCTV
110 120 130 140 150
TVLDNDALAQ RPGHLSPKRF ACDYGPGEVR YSHLGARSPS RDRVRLQLRY
160 170 180 190 200
DAPGGAIVLP LALEVEVVFT QLEIVTRNLP LVVEELLGTS NALDDRSLEF
210 220 230 240 250
AYQPETEECR VGILSGLSAL PRYGELLHYP QVQGGAGDRG TSKTLLMDCK
260 270 280 290 300
AFQELGVRYR HTAPSRSPNR DWLPMVVELH SRGAPEGSPA LKREHFQVLV
310 320 330 340 350
RIRGGAENTA PKPSFVAMMM MEVDQFVLTA LTPDMLAAED AESDPDLLIF
360 370 380 390 400
NLTSAFQPGQ GYLVSTDDRS LPLSSFTQRD LRLLKIAYQP PSEDSDQERL
410 420 430 440 450
FELELEIVDP EGAASDPFAF MVVVKPMNTL APVVTRNTGL ILYEGQYRPL
460 470 480 490 500
TGPIGSGPQN LVISDEDDLE AVRLEVVAGL RHGHLVILGS PSSDSAPKTF
510 520 530 540 550
TVAELAAGQV VYQHDDKDGS LSDNLVLRMS DGGGRHQVQF LFPITLVPVD
560 570 580 590 600
DQPPVLNANT GLTVAEGETV PIPPLTLSAT DIDSDDSQLV FVLLPPFSSL
610 620 630 640 650
GHLLLRQRHV PQEEQGLWQK QGSFYERTVT EWRQQDITEG KLFYRHSGPH
660 670 680 690 700
SPGPVMDQFM FRVQDNHDPP NQSGIQRFVI RIHPVDRLPP ELGSGCPLRM
710 720 730 740 750
VVQESQLTPL RKRWLHYTDL DTDDRELQYT VTQPPTDTDE NHSPAPLGTL
760 770 780 790 800
VFTDNPSVVV SHFTQAQVNH HKIAYRPPGQ ELGVAARVAQ FQFQVEDRAG
810 820 830 840 850
NVAPGTFTLY LQPVDNQPPE IVNTGFTVEE KGHHILRETE LHVSDVDTDV
860 870 880 890 900
THISFTLTQA PKHGHMQISG RPLHVGGQFH LEDIKHGRIS YWNSGDESLT
910 920 930 940 950
DSCSLEVSDR HHVVPITLRV NVRPGDREGP MSVLPAGTLE SYLDVLENGA
960 970 980 990 1000
TEVTANIIKG AYQGTDDLML TFLLEGPPSY GEILVNGAPA EQFTQRDILE
1010 1020 1030 1040 1050
GSVVYAHTSG EIGLLPKADS FNLSLSAMSQ EWRIGSSIVQ GVTVWVTILP
1060 1070 1080 1090 1100
VDSQAPEISL GEQFVVLEGD KSVISLTHLS AEDMDSLKDD LLCTIVIQPT
1110 1120 1130 1140 1150
SGYVENISPA PGSEKSRAGV AISAFTLKDL RQGHINYVQS VHRGVEPVED
1160 1170 1180 1190 1200
RFIFRCSDGI NFSERQIFPI VIIPTNDEQP EMFMREFMVM EGMSLVVNRL
1210 1220 1230 1240 1250
ILNAADADIP RDDLTFTITR FPTHGHVMNQ LINGTVLVES FTLDQIIESS
1260 1270 1280 1290 1300
SIIYEHDDSE TQEDSFVIKL TDGKHSVEKM VLIVVIPVDD ETPRMTINNG
1310 1320 1330 1340 1350
LEIEIGETKV INNKVLMATD LDSDDKSLVY IIRYGPGHGL LQRQKPLGAF
1360 1370 1380 1390 1400
ENITLGMNFT QDEVDRNLIQ YVHFGQEGIR DLIKFDVTDG TNALIDRYFY
1410 1420 1430 1440 1450
VTIGSVDIVF PDVVSKGVSL KEGGKVTLTT DLLSTSDLNS PDENLVFTIT
1460 1470 1480 1490 1500
RAPMRGHLEC TDRRGLSITS FTQLQLAGNK IYYIHTAEDE VKMDSFEFQV
1510 1520 1530 1540 1550
TDGRNPVFRT FRISISDVDN KKPVVTIHNL VVSESESKLI TPFELTVEDR
1560 1570 1580 1590 1600
DTPDRLLKFI VTQVPVHGHL LFNNTRSVMV FTKQDLNENL ISYKHDGTES
1610 1620 1630 1640 1650
TEDSFSFTVT DGTHSDFYVF PDTVFETRRP QVMKIQVLPV DNSVPQIVVN
1660 1670 1680 1690 1700
KGASTLRTLA TGHLGFMITS KILKVEDRDS LHFSLRFIVT EAPQHGYLLN
1710 1720 1730 1740 1750
LGQGNHSVTQ FTQADIDDMK ICYVLRERAN ATSDMFHFIV EDDGGNRLTN
1760 1770 1780 1790 1800
QHFRLNWAWI SFEKEYYLIN EDSKFLDIVL TRRGYLGETS FISIGTRDGT
1810 1820 1830 1840 1850
AEKDRDFKGK AQKQVQFNPG QTRASWRVRI LSDGEHEHSE TFQVVLSEPV
1860 1870 1880 1890 1900
LAILEFPTVT TVEIIDPGDE STVFIPQSEY SVEEDVGELF IPIRRSGDIS
1910 1920 1930 1940 1950
RELMVICYTQ QGTATSTVRT SVLSYSDYIS RPEDHSSVIR FDKDEREKMC
1960 1970 1980 1990 2000
RILVIDDSLY EEEETFQVLL SMPMGGRIGD KFPGANVTIL TDRDDEPAFY
2010 2020 2030 2040 2050
FGDTQYSVDE SAGYVELQVW RTGTDLSKPS SVTVRSRKTE SLSADAGTDY
2060 2070 2080 2090 2100
VGISRNLDFA PGVNMQTVRV VILDDLGRPI LEGIEKFELV LRMPMNAALG
2110 2120 2130 2140 2150
EPSKATVSIN DSASDLPKMQ FKERVYTCNE NDGRVVAMIY RSGDIQHRSS
2160 2170 2180 2190 2200
VRCYTRQGSA QVMMDFEERP NTDVSTVTFL PGEMEKPCVL ELMDDAVYED
2210 2220 2230 2240 2250
VEELRLVLGT PQGSSAFGAA VGEQNETLIK IQDEADKAVI KFGETKFSVT
2260 2270 2280 2290 2300
EPSRPGESVV VKIPVIRQGD TSKVSIVRVH TKDGSATSGE DYHPVSEEIE
2310 2320 2330 2340 2350
FKEGETQHTV EIEVIFDGVR EMREAFTVHL KPDENMVAET QATKAIVYIE
2360 2370 2380 2390 2400
EIHSMADVTF PSVPHIVSLL IYDDPSKGRE DTGPVSGYPV VCITACNPKY
2410 2420 2430 2440 2450
PDYEKTGSIC ASENINDTLT RYRWLISAPA GPDGVTSPMR EVDFDTFFTS
2460 2470 2480 2490 2500
SKMITLDSIY FQPGSRVQCA ARAVNTNGNE GLELMSPIVT IGREEGLCQP
2510 2520 2530 2540 2550
RVPGVVGAEP FSAKLRYTGP EDPDFANLIK LTVTMPHIDG MLPAISTREL
2560 2570 2580 2590 2600
SNFELTLSPD GTRVGNHKCS NLLDYNEVKT HHGFLTNATK NPEVIGETYP
2610 2620 2630 2640 2650
YQYSVPVRGS STLRFYRNLN LEACLWEFVS YYDMTELLAD CGGTIGTDGQ
2660 2670 2680 2690 2700
VLNLVQSYVT LRVPLYVSYV FHSPVGVGGW QHFDLKSELR LTFVYDTAIL
2710 2720 2730 2740 2750
WNHGIGSPPE AELQGSLYPT SMRIGEEGRL AVNFKTEAQF HGLFVLSHPA
2760 2770 2780 2790 2800
SFTSSLIVSA DHPGLTFSLR LIRSEPTYNQ PVQQWSFVSD FAVRDYSGTY
2810 2820 2830 2840 2850
TVKLVPCTTP SNQEYRLPVT CNPREPVTFD LDIRFQQVSD PVATEFSLNT
2860 2870 2880 2890 2900
HMYLLSKKNL WLSDGSMGFG QESDVAFAEG DVIYGRVMVD PVQNLGDSFY
2910 2920 2930 2940 2950
CSIEKVFLCT GDDGYVPKYS PANAEYGCLA DSPSLLHRFK IVDKAQPETQ
2960 2970 2980 2990 3000
ATSFGDVLFN AKLAVDDPEA VLLVNQPGSD GFKVDSTPLF QVALGREWYI
3010 3020 3030 3040 3050
HTIYTVKSKD NTHRGIGKRS LEYQYHSVVH PGPPQATTKS WKKRAVRSTP
3060 3070 3080 3090 3100
SLAGEIGAEN NRGTNIQHIS LNRRGKRQVP HGRIPPDGIL PWELNSPSSE
3110 3120 3130 3140 3150
VSLVTVLGGL TVGLLTVCLA VAAAVMCRNR STKGKDTPKG SGSTEPMMSP
3160
QSHYNDSSEV
Length:3,160
Mass (Da):350,640
Last modified:August 16, 2005 - v2
Checksum:i579F20BD79957E06
GO
Isoform 2 (identifier: Q6NVD0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2287: Missing.
     2288-2297: SGEDYHPVSE → MVGPGNFRKR

Note: No experimental confirmation available.

Show »
Length:873
Mass (Da):96,504
Checksum:i198D3BE068E6C0DB
GO
Isoform 3 (identifier: Q6NVD0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2851: Missing.

Note: No experimental confirmation available.

Show »
Length:309
Mass (Da):33,633
Checksum:iB0E805BEB9A456F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2437 – 24371S → N in BAC27425. (PubMed:16141072)Curated
Sequence conflicti2851 – 28511H → N in BAC27425. (PubMed:16141072)Curated
Sequence conflicti3031 – 30311P → H in AAH46388. (PubMed:15489334)Curated
Sequence conflicti3040 – 30401S → G in AAH46388. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 28512851Missing in isoform 3. 1 PublicationVSP_015037Add
BLAST
Alternative sequencei1 – 22872287Missing in isoform 2. 1 PublicationVSP_015038Add
BLAST
Alternative sequencei2288 – 229710SGEDYHPVSE → MVGPGNFRKR in isoform 2. 1 PublicationVSP_015039

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ833643 mRNA. Translation: CAH55760.1.
AK031494 mRNA. Translation: BAC27425.1.
AK082256 mRNA. Translation: BAC38448.1.
BC046388 mRNA. Translation: AAH46388.1.
BC068185 mRNA. Translation: AAH68185.1.
AB160988 mRNA. Translation: BAD89016.1.
CCDSiCCDS17348.1. [Q6NVD0-1]
RefSeqiNP_766450.2. NM_172862.3. [Q6NVD0-1]
UniGeneiMm.38378.

Genome annotation databases

EnsembliENSMUST00000091137; ENSMUSP00000088670; ENSMUSG00000037016. [Q6NVD0-1]
GeneIDi242022.
KEGGimmu:242022.
UCSCiuc008pex.1. mouse. [Q6NVD0-3]
uc008pey.1. mouse. [Q6NVD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ833643 mRNA. Translation: CAH55760.1 .
AK031494 mRNA. Translation: BAC27425.1 .
AK082256 mRNA. Translation: BAC38448.1 .
BC046388 mRNA. Translation: AAH46388.1 .
BC068185 mRNA. Translation: AAH68185.1 .
AB160988 mRNA. Translation: BAD89016.1 .
CCDSi CCDS17348.1. [Q6NVD0-1 ]
RefSeqi NP_766450.2. NM_172862.3. [Q6NVD0-1 ]
UniGenei Mm.38378.

3D structure databases

ProteinModelPortali Q6NVD0.
SMRi Q6NVD0. Positions 1759-2392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997463.

PTM databases

PhosphoSitei Q6NVD0.

Proteomic databases

MaxQBi Q6NVD0.
PaxDbi Q6NVD0.
PRIDEi Q6NVD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091137 ; ENSMUSP00000088670 ; ENSMUSG00000037016 . [Q6NVD0-1 ]
GeneIDi 242022.
KEGGi mmu:242022.
UCSCi uc008pex.1. mouse. [Q6NVD0-3 ]
uc008pey.1. mouse. [Q6NVD0-1 ]

Organism-specific databases

CTDi 341640.
MGIi MGI:2444465. Frem2.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074429.
HOGENOMi HOG000007464.
HOVERGENi HBG081537.
InParanoidi Q6NVD0.
OMAi EDSKFLD.
OrthoDBi EOG751NDJ.
PhylomeDBi Q6NVD0.
TreeFami TF316876.

Miscellaneous databases

NextBioi 385204.
PROi Q6NVD0.
SOURCEi Search...

Gene expression databases

Bgeei Q6NVD0.
CleanExi MM_FREM2.
Genevestigatori Q6NVD0.

Family and domain databases

InterProi IPR002126. Cadherin.
IPR003644. Calx_beta.
[Graphical view ]
Pfami PF03160. Calx-beta. 5 hits.
[Graphical view ]
SMARTi SM00112. CA. 1 hit.
SM00237. Calx_beta. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2277-3160.
    Strain: C57BL/6 and Czech II.
    Tissue: Head and Mammary tumor.
  4. "QBRICK, a novel cell-adhesive protein expressed in the basement membrane of the developing hair follicle."
    Kiyozumi D., Osada A., Sugimoto N., Weber C.N., Ono Y., Imai T., Okada A., Sekiguchi K.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-291.

Entry informationi

Entry nameiFREM2_MOUSE
AccessioniPrimary (citable) accession number: Q6NVD0
Secondary accession number(s): Q4W2Q5
, Q5H8C0, Q811G9, Q8C4G5, Q8CD46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3