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Q6NVD0

- FREM2_MOUSE

UniProt

Q6NVD0 - FREM2_MOUSE

Protein

FRAS1-related extracellular matrix protein 2

Gene

Frem2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cell communication Source: InterPro
    2. homophilic cell adhesion Source: InterPro
    3. inner ear development Source: MGI
    4. morphogenesis of an epithelium Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FRAS1-related extracellular matrix protein 2
    Alternative name(s):
    ECM3 homolog
    NV domain-containing protein 1
    Gene namesi
    Name:Frem2
    Synonyms:Nv1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2444465. Frem2.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice display cryptophthalmos, syndactyly and renal defects. Frem2 corresponds to the X-ray irradiated-induced allele 'myelencephalic blebs' (my).1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 31603121FRAS1-related extracellular matrix protein 2PRO_0000010125Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1233 – 12331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1358 – 13581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1573 – 15731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1730 – 17301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6NVD0.
    PaxDbiQ6NVD0.
    PRIDEiQ6NVD0.

    PTM databases

    PhosphoSiteiQ6NVD0.

    Expressioni

    Tissue specificityi

    First expressed from E10 in the mesodermal core of the branchial arches, developing lens, otic vesicle and limb apical ectodermal ridge. Later, it is expressed in the vibrissae and vibrissae pad, eyelids ear and pelage follicles and, at low levels, in the epidermis. Also expressed in caudal somites and, in later embryos, in facial, limb and intercostal muscles. In contrast to Frem1, it is not expressed in the developing mammary glands or in the caecum. Restricted to the epithelia in a pattern complementary to that of Frem1 (which is generally expressed in the dermis and mesenchyme). In the developing kidney, it is expressed At in the mesonephric and metanephric epithelia at E11.5, with a highest expression at the tips of the developing ureteric buds. At E12.5 and E13.5, it is still expressed throughout the epithelial components of the kidney, including epithelia fated to form nephrons, which are induced by the ureter tips to differentiate from the mesenchymal condensations that surround them.1 Publication

    Gene expression databases

    BgeeiQ6NVD0.
    CleanExiMM_FREM2.
    GenevestigatoriQ6NVD0.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NVD0.
    SMRiQ6NVD0. Positions 1759-2392.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini40 – 31053066ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini3127 – 316034CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3106 – 312621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati291 – 412122CSPG 1Add
    BLAST
    Repeati413 – 534122CSPG 2Add
    BLAST
    Repeati535 – 670136CSPG 3Add
    BLAST
    Repeati671 – 800130CSPG 4Add
    BLAST
    Repeati801 – 910110CSPG 5Add
    BLAST
    Repeati911 – 1041131CSPG 6Add
    BLAST
    Repeati1042 – 1160119CSPG 7Add
    BLAST
    Repeati1161 – 1273113CSPG 8Add
    BLAST
    Repeati1274 – 1389116CSPG 9Add
    BLAST
    Repeati1390 – 1503114CSPG 10Add
    BLAST
    Repeati1504 – 1622119CSPG 11Add
    BLAST
    Repeati1623 – 1747125CSPG 12Add
    BLAST
    Domaini1748 – 1847100Calx-beta 1Add
    BLAST
    Domaini1860 – 1971112Calx-beta 2Add
    BLAST
    Domaini1986 – 2092107Calx-beta 3Add
    BLAST
    Domaini2107 – 2209103Calx-beta 4Add
    BLAST
    Domaini2227 – 2331105Calx-beta 5Add
    BLAST

    Domaini

    The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

    Sequence similaritiesi

    Belongs to the FRAS1 family.Curated
    Contains 5 Calx-beta domains.Curated
    Contains 12 CSPG (NG2) repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00550000074429.
    HOGENOMiHOG000007464.
    HOVERGENiHBG081537.
    InParanoidiQ6NVD0.
    OMAiEDSKFLD.
    OrthoDBiEOG751NDJ.
    PhylomeDBiQ6NVD0.
    TreeFamiTF316876.

    Family and domain databases

    InterProiIPR002126. Cadherin.
    IPR003644. Calx_beta.
    [Graphical view]
    PfamiPF03160. Calx-beta. 5 hits.
    [Graphical view]
    SMARTiSM00112. CA. 1 hit.
    SM00237. Calx_beta. 5 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NVD0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRARRTAK FSSFQPILAQ SPRLLLLLLL LSLVSYVSTQ AAGPGAALQS     50
    LGLSGTSGVP TEEAIVVANR GLRVPFGREV WLDPLRDLVL QVQPGDRCTV 100
    TVLDNDALAQ RPGHLSPKRF ACDYGPGEVR YSHLGARSPS RDRVRLQLRY 150
    DAPGGAIVLP LALEVEVVFT QLEIVTRNLP LVVEELLGTS NALDDRSLEF 200
    AYQPETEECR VGILSGLSAL PRYGELLHYP QVQGGAGDRG TSKTLLMDCK 250
    AFQELGVRYR HTAPSRSPNR DWLPMVVELH SRGAPEGSPA LKREHFQVLV 300
    RIRGGAENTA PKPSFVAMMM MEVDQFVLTA LTPDMLAAED AESDPDLLIF 350
    NLTSAFQPGQ GYLVSTDDRS LPLSSFTQRD LRLLKIAYQP PSEDSDQERL 400
    FELELEIVDP EGAASDPFAF MVVVKPMNTL APVVTRNTGL ILYEGQYRPL 450
    TGPIGSGPQN LVISDEDDLE AVRLEVVAGL RHGHLVILGS PSSDSAPKTF 500
    TVAELAAGQV VYQHDDKDGS LSDNLVLRMS DGGGRHQVQF LFPITLVPVD 550
    DQPPVLNANT GLTVAEGETV PIPPLTLSAT DIDSDDSQLV FVLLPPFSSL 600
    GHLLLRQRHV PQEEQGLWQK QGSFYERTVT EWRQQDITEG KLFYRHSGPH 650
    SPGPVMDQFM FRVQDNHDPP NQSGIQRFVI RIHPVDRLPP ELGSGCPLRM 700
    VVQESQLTPL RKRWLHYTDL DTDDRELQYT VTQPPTDTDE NHSPAPLGTL 750
    VFTDNPSVVV SHFTQAQVNH HKIAYRPPGQ ELGVAARVAQ FQFQVEDRAG 800
    NVAPGTFTLY LQPVDNQPPE IVNTGFTVEE KGHHILRETE LHVSDVDTDV 850
    THISFTLTQA PKHGHMQISG RPLHVGGQFH LEDIKHGRIS YWNSGDESLT 900
    DSCSLEVSDR HHVVPITLRV NVRPGDREGP MSVLPAGTLE SYLDVLENGA 950
    TEVTANIIKG AYQGTDDLML TFLLEGPPSY GEILVNGAPA EQFTQRDILE 1000
    GSVVYAHTSG EIGLLPKADS FNLSLSAMSQ EWRIGSSIVQ GVTVWVTILP 1050
    VDSQAPEISL GEQFVVLEGD KSVISLTHLS AEDMDSLKDD LLCTIVIQPT 1100
    SGYVENISPA PGSEKSRAGV AISAFTLKDL RQGHINYVQS VHRGVEPVED 1150
    RFIFRCSDGI NFSERQIFPI VIIPTNDEQP EMFMREFMVM EGMSLVVNRL 1200
    ILNAADADIP RDDLTFTITR FPTHGHVMNQ LINGTVLVES FTLDQIIESS 1250
    SIIYEHDDSE TQEDSFVIKL TDGKHSVEKM VLIVVIPVDD ETPRMTINNG 1300
    LEIEIGETKV INNKVLMATD LDSDDKSLVY IIRYGPGHGL LQRQKPLGAF 1350
    ENITLGMNFT QDEVDRNLIQ YVHFGQEGIR DLIKFDVTDG TNALIDRYFY 1400
    VTIGSVDIVF PDVVSKGVSL KEGGKVTLTT DLLSTSDLNS PDENLVFTIT 1450
    RAPMRGHLEC TDRRGLSITS FTQLQLAGNK IYYIHTAEDE VKMDSFEFQV 1500
    TDGRNPVFRT FRISISDVDN KKPVVTIHNL VVSESESKLI TPFELTVEDR 1550
    DTPDRLLKFI VTQVPVHGHL LFNNTRSVMV FTKQDLNENL ISYKHDGTES 1600
    TEDSFSFTVT DGTHSDFYVF PDTVFETRRP QVMKIQVLPV DNSVPQIVVN 1650
    KGASTLRTLA TGHLGFMITS KILKVEDRDS LHFSLRFIVT EAPQHGYLLN 1700
    LGQGNHSVTQ FTQADIDDMK ICYVLRERAN ATSDMFHFIV EDDGGNRLTN 1750
    QHFRLNWAWI SFEKEYYLIN EDSKFLDIVL TRRGYLGETS FISIGTRDGT 1800
    AEKDRDFKGK AQKQVQFNPG QTRASWRVRI LSDGEHEHSE TFQVVLSEPV 1850
    LAILEFPTVT TVEIIDPGDE STVFIPQSEY SVEEDVGELF IPIRRSGDIS 1900
    RELMVICYTQ QGTATSTVRT SVLSYSDYIS RPEDHSSVIR FDKDEREKMC 1950
    RILVIDDSLY EEEETFQVLL SMPMGGRIGD KFPGANVTIL TDRDDEPAFY 2000
    FGDTQYSVDE SAGYVELQVW RTGTDLSKPS SVTVRSRKTE SLSADAGTDY 2050
    VGISRNLDFA PGVNMQTVRV VILDDLGRPI LEGIEKFELV LRMPMNAALG 2100
    EPSKATVSIN DSASDLPKMQ FKERVYTCNE NDGRVVAMIY RSGDIQHRSS 2150
    VRCYTRQGSA QVMMDFEERP NTDVSTVTFL PGEMEKPCVL ELMDDAVYED 2200
    VEELRLVLGT PQGSSAFGAA VGEQNETLIK IQDEADKAVI KFGETKFSVT 2250
    EPSRPGESVV VKIPVIRQGD TSKVSIVRVH TKDGSATSGE DYHPVSEEIE 2300
    FKEGETQHTV EIEVIFDGVR EMREAFTVHL KPDENMVAET QATKAIVYIE 2350
    EIHSMADVTF PSVPHIVSLL IYDDPSKGRE DTGPVSGYPV VCITACNPKY 2400
    PDYEKTGSIC ASENINDTLT RYRWLISAPA GPDGVTSPMR EVDFDTFFTS 2450
    SKMITLDSIY FQPGSRVQCA ARAVNTNGNE GLELMSPIVT IGREEGLCQP 2500
    RVPGVVGAEP FSAKLRYTGP EDPDFANLIK LTVTMPHIDG MLPAISTREL 2550
    SNFELTLSPD GTRVGNHKCS NLLDYNEVKT HHGFLTNATK NPEVIGETYP 2600
    YQYSVPVRGS STLRFYRNLN LEACLWEFVS YYDMTELLAD CGGTIGTDGQ 2650
    VLNLVQSYVT LRVPLYVSYV FHSPVGVGGW QHFDLKSELR LTFVYDTAIL 2700
    WNHGIGSPPE AELQGSLYPT SMRIGEEGRL AVNFKTEAQF HGLFVLSHPA 2750
    SFTSSLIVSA DHPGLTFSLR LIRSEPTYNQ PVQQWSFVSD FAVRDYSGTY 2800
    TVKLVPCTTP SNQEYRLPVT CNPREPVTFD LDIRFQQVSD PVATEFSLNT 2850
    HMYLLSKKNL WLSDGSMGFG QESDVAFAEG DVIYGRVMVD PVQNLGDSFY 2900
    CSIEKVFLCT GDDGYVPKYS PANAEYGCLA DSPSLLHRFK IVDKAQPETQ 2950
    ATSFGDVLFN AKLAVDDPEA VLLVNQPGSD GFKVDSTPLF QVALGREWYI 3000
    HTIYTVKSKD NTHRGIGKRS LEYQYHSVVH PGPPQATTKS WKKRAVRSTP 3050
    SLAGEIGAEN NRGTNIQHIS LNRRGKRQVP HGRIPPDGIL PWELNSPSSE 3100
    VSLVTVLGGL TVGLLTVCLA VAAAVMCRNR STKGKDTPKG SGSTEPMMSP 3150
    QSHYNDSSEV 3160
    Length:3,160
    Mass (Da):350,640
    Last modified:August 16, 2005 - v2
    Checksum:i579F20BD79957E06
    GO
    Isoform 2 (identifier: Q6NVD0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2287: Missing.
         2288-2297: SGEDYHPVSE → MVGPGNFRKR

    Note: No experimental confirmation available.

    Show »
    Length:873
    Mass (Da):96,504
    Checksum:i198D3BE068E6C0DB
    GO
    Isoform 3 (identifier: Q6NVD0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2851: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:309
    Mass (Da):33,633
    Checksum:iB0E805BEB9A456F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2437 – 24371S → N in BAC27425. (PubMed:16141072)Curated
    Sequence conflicti2851 – 28511H → N in BAC27425. (PubMed:16141072)Curated
    Sequence conflicti3031 – 30311P → H in AAH46388. (PubMed:15489334)Curated
    Sequence conflicti3040 – 30401S → G in AAH46388. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 28512851Missing in isoform 3. 1 PublicationVSP_015037Add
    BLAST
    Alternative sequencei1 – 22872287Missing in isoform 2. 1 PublicationVSP_015038Add
    BLAST
    Alternative sequencei2288 – 229710SGEDYHPVSE → MVGPGNFRKR in isoform 2. 1 PublicationVSP_015039

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ833643 mRNA. Translation: CAH55760.1.
    AK031494 mRNA. Translation: BAC27425.1.
    AK082256 mRNA. Translation: BAC38448.1.
    BC046388 mRNA. Translation: AAH46388.1.
    BC068185 mRNA. Translation: AAH68185.1.
    AB160988 mRNA. Translation: BAD89016.1.
    CCDSiCCDS17348.1. [Q6NVD0-1]
    RefSeqiNP_766450.2. NM_172862.3. [Q6NVD0-1]
    UniGeneiMm.38378.

    Genome annotation databases

    EnsembliENSMUST00000091137; ENSMUSP00000088670; ENSMUSG00000037016. [Q6NVD0-1]
    GeneIDi242022.
    KEGGimmu:242022.
    UCSCiuc008pex.1. mouse. [Q6NVD0-3]
    uc008pey.1. mouse. [Q6NVD0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ833643 mRNA. Translation: CAH55760.1 .
    AK031494 mRNA. Translation: BAC27425.1 .
    AK082256 mRNA. Translation: BAC38448.1 .
    BC046388 mRNA. Translation: AAH46388.1 .
    BC068185 mRNA. Translation: AAH68185.1 .
    AB160988 mRNA. Translation: BAD89016.1 .
    CCDSi CCDS17348.1. [Q6NVD0-1 ]
    RefSeqi NP_766450.2. NM_172862.3. [Q6NVD0-1 ]
    UniGenei Mm.38378.

    3D structure databases

    ProteinModelPortali Q6NVD0.
    SMRi Q6NVD0. Positions 1759-2392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997463.

    PTM databases

    PhosphoSitei Q6NVD0.

    Proteomic databases

    MaxQBi Q6NVD0.
    PaxDbi Q6NVD0.
    PRIDEi Q6NVD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000091137 ; ENSMUSP00000088670 ; ENSMUSG00000037016 . [Q6NVD0-1 ]
    GeneIDi 242022.
    KEGGi mmu:242022.
    UCSCi uc008pex.1. mouse. [Q6NVD0-3 ]
    uc008pey.1. mouse. [Q6NVD0-1 ]

    Organism-specific databases

    CTDi 341640.
    MGIi MGI:2444465. Frem2.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00550000074429.
    HOGENOMi HOG000007464.
    HOVERGENi HBG081537.
    InParanoidi Q6NVD0.
    OMAi EDSKFLD.
    OrthoDBi EOG751NDJ.
    PhylomeDBi Q6NVD0.
    TreeFami TF316876.

    Miscellaneous databases

    NextBioi 385204.
    PROi Q6NVD0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NVD0.
    CleanExi MM_FREM2.
    Genevestigatori Q6NVD0.

    Family and domain databases

    InterProi IPR002126. Cadherin.
    IPR003644. Calx_beta.
    [Graphical view ]
    Pfami PF03160. Calx-beta. 5 hits.
    [Graphical view ]
    SMARTi SM00112. CA. 1 hit.
    SM00237. Calx_beta. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2277-3160.
      Strain: C57BL/6 and Czech II.
      Tissue: Head and Mammary tumor.
    4. "QBRICK, a novel cell-adhesive protein expressed in the basement membrane of the developing hair follicle."
      Kiyozumi D., Osada A., Sugimoto N., Weber C.N., Ono Y., Imai T., Okada A., Sekiguchi K.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-291.

    Entry informationi

    Entry nameiFREM2_MOUSE
    AccessioniPrimary (citable) accession number: Q6NVD0
    Secondary accession number(s): Q4W2Q5
    , Q5H8C0, Q811G9, Q8C4G5, Q8CD46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3