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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

Cyp11a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.UniRule annotation

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Pathwayi: C21-steroid hormone metabolism

This protein is involved in the pathway C21-steroid hormone metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway C21-steroid hormone metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, SteroidogenesisUniRule annotation, Sterol metabolism
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrialUniRule annotation (EC:1.14.15.6UniRule annotation)
Alternative name(s):
Cholesterol desmolaseUniRule annotation
Gene namesi
Name:Cyp11a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88582 Cyp11a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NV84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
HOVERGENiHBG051098

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NV84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAKGLSLRS VLVKGCQPFL SPTWQGPVLS TGKGAGTSTS SPRSFNEIPS
60 70 80 90 100
PGDNGWLNLY HFWRESGTQK IHYHQMQSFQ KYGPIYREKL GTLESVYIVD
110 120 130 140 150
PKDASILFSC EGPNPERFLV PPWVAYHQYY QRPIGVLFKS SDAWKKDRIV
160 170 180 190 200
LNQEVMAPGA IKNFVPLLEG VAQDFIKVLH RRIKQQNSGN FSGVISDDLF
210 220 230 240 250
RFSFESISSV IFGERMGMLE EIVDPEAQRF INAVYQMFHT SVPMLNLPPD
260 270 280 290 300
FFRLLRTKTW KDHAAAWDVI FNKADEYTQN FYWDLRQKRD FSQYPGVLYS
310 320 330 340 350
LLGGNKLPFK NIQANITEML AGGVDTTSMT LQWNLYEMAH NLKVQEMLRA
360 370 380 390 400
EVLAARRQAQ GDMAKMVQLV SLLKASIKET LRLHPISVTL QRYTVNDLVL
410 420 430 440 450
RNYKIPAKTL VQVASFAMGR DPGFFPNPNK FDPTRWLEKS QNTTHFRYLG
460 470 480 490 500
FGWGVRQCLG RRIAELEMTI LLINLLENFR IEVQNLRDVG TKFSLILMPE
510 520
NPILFNFQPL KQDLGPAVTR KDNTVN
Length:526
Mass (Da):60,305
Last modified:July 5, 2004 - v1
Checksum:iE5006A16F3512B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068264 mRNA Translation: AAH68264.1
UniGeneiMm.302865

Similar proteinsi

Entry informationi

Entry nameiQ6NV84_MOUSE
AccessioniPrimary (citable) accession number: Q6NV84
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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