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Protein

Probable G-protein coupled receptor 153

Gene

GPR153

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 153
Alternative name(s):
G-protein coupled receptor PGR1
Gene namesi
Name:GPR153
Synonyms:PGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23618. GPR153.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111ExtracellularSequence analysisAdd
BLAST
Transmembranei12 – 3221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini33 – 419CytoplasmicSequence analysis
Transmembranei42 – 6221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini63 – 8422ExtracellularSequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini106 – 12621CytoplasmicSequence analysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini148 – 17528ExtracellularSequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini197 – 24347CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 27612ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 609312CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929175.

Polymorphism and mutation databases

BioMutaiGPR153.
DMDMi81170632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Probable G-protein coupled receptor 153PRO_0000069637Add
BLAST

Proteomic databases

PaxDbiQ6NV75.
PRIDEiQ6NV75.

PTM databases

PhosphoSiteiQ6NV75.

Expressioni

Gene expression databases

BgeeiQ6NV75.
CleanExiHS_GPR153.
ExpressionAtlasiQ6NV75. baseline and differential.
GenevisibleiQ6NV75. HS.

Organism-specific databases

HPAiHPA007159.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367125.

Structurei

3D structure databases

ProteinModelPortaliQ6NV75.
SMRiQ6NV75. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi479 – 55274Pro-richAdd
BLAST
Compositional biasi579 – 5824Poly-Gly

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ6NV75.
KOiK08437.
OMAiFECEPQA.
OrthoDBiEOG7RV9FS.
PhylomeDBiQ6NV75.
TreeFamiTF330832.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022335. GPR153.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01992. GPR153.
PR01991. GPR153GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NV75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA
60 70 80 90 100
ATHMLNVAVP IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS
110 120 130 140 150
VTSLSYHRMW MVCWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH
160 170 180 190 200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGVIC TAIALFQTLA
210 220 230 240 250
VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL QTTGLVTTIV
260 270 280 290 300
FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC
310 320 330 340 350
DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG
360 370 380 390 400
DFVALDRMAK YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA
410 420 430 440 450
DVWAAVPLPA FLPRWGSGED LAALAHLVLP AGPERRRASL LAFAEDAPPS
460 470 480 490 500
RARRRSAESL LSLRPSALDS GPRGARDSPP GSPRRRPGPG PRSASASLLP
510 520 530 540 550
DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP PSSAQRSPGP
560 570 580 590 600
RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL

HSDSLGSAS
Length:609
Mass (Da):65,361
Last modified:November 8, 2005 - v2
Checksum:i7FEFA536BEB5ADE2
GO

Sequence cautioni

The sequence CAI19434.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 2091R → H.2 Publications
Corresponds to variant rs12735670 [ dbSNP | Ensembl ].
VAR_023741

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA. Translation: CAI19434.1. Sequence problems.
BC068275 mRNA. Translation: AAH68275.1.
AY255529 mRNA. Translation: AAO85041.1.
CR627473 mRNA. Translation: CAH10674.1.
CCDSiCCDS64.1.
RefSeqiNP_997253.2. NM_207370.2.
XP_011539736.1. XM_011541434.1.
UniGeneiHs.531581.

Genome annotation databases

EnsembliENST00000377893; ENSP00000367125; ENSG00000158292.
GeneIDi387509.
KEGGihsa:387509.
UCSCiuc001amp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA. Translation: CAI19434.1. Sequence problems.
BC068275 mRNA. Translation: AAH68275.1.
AY255529 mRNA. Translation: AAO85041.1.
CR627473 mRNA. Translation: CAH10674.1.
CCDSiCCDS64.1.
RefSeqiNP_997253.2. NM_207370.2.
XP_011539736.1. XM_011541434.1.
UniGeneiHs.531581.

3D structure databases

ProteinModelPortaliQ6NV75.
SMRiQ6NV75. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367125.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6NV75.

Polymorphism and mutation databases

BioMutaiGPR153.
DMDMi81170632.

Proteomic databases

PaxDbiQ6NV75.
PRIDEiQ6NV75.

Protocols and materials databases

DNASUi387509.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377893; ENSP00000367125; ENSG00000158292.
GeneIDi387509.
KEGGihsa:387509.
UCSCiuc001amp.2. human.

Organism-specific databases

CTDi387509.
GeneCardsiGPR153.
HGNCiHGNC:23618. GPR153.
HPAiHPA007159.
neXtProtiNX_Q6NV75.
PharmGKBiPA134929175.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ6NV75.
KOiK08437.
OMAiFECEPQA.
OrthoDBiEOG7RV9FS.
PhylomeDBiQ6NV75.
TreeFamiTF330832.

Miscellaneous databases

GeneWikiiGPR153.
GenomeRNAii387509.
NextBioi101364.
PROiQ6NV75.

Gene expression databases

BgeeiQ6NV75.
CleanExiHS_GPR153.
ExpressionAtlasiQ6NV75. baseline and differential.
GenevisibleiQ6NV75. HS.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022335. GPR153.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01992. GPR153.
PR01991. GPR153GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-209.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-326, VARIANT HIS-209.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-609.
    Tissue: Melanoma.

Entry informationi

Entry nameiGP153_HUMAN
AccessioniPrimary (citable) accession number: Q6NV75
Secondary accession number(s): Q5TGR5, Q6AHW8, Q86SP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.