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Protein
Submitted name:

Integrin alpha 4

Gene

Itga4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha 4Imported
Gene namesi
Name:Itga4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96603. Itga4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei976 – 1000HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33UniRule annotationAdd BLAST33
ChainiPRO_500142610334 – 1032UniRule annotationAdd BLAST999

Structurei

3D structure databases

ProteinModelPortaliQ6NV53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 100FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati110 – 177FG-GAPPROSITE-ProRule annotationAdd BLAST68
Repeati186 – 237FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati239 – 291FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati292 – 351FG-GAPPROSITE-ProRule annotationAdd BLAST60
Repeati355 – 412FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati416 – 478FG-GAPPROSITE-ProRule annotationAdd BLAST63
Domaini463 – 856Integrin_alpha2InterPro annotationAdd BLAST394

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPB2. Eukaryota.
ENOG410XTAR. LUCA.
HOGENOMiHOG000088626.
HOVERGENiHBG004538.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom_sf.
PfamiView protein in Pfam
PF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 6 hits.
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NV53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEARCRPR SRGIALREAV MLLLYFGVPT GHSYNLDPEN ALLYQGPSGT
60 70 80 90 100
LFGYSVVLHS HGSKRWLIVG APTASWLSNA SVVNPGAIYR CGIRKNPNQT
110 120 130 140 150
CEQLQLGSPS GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN
160 170 180 190 200
IFYMKSDNKL PTGICYVMPS DLRTELSKRM APCYKDYTRK FGENFASCQA
210 220 230 240 250
GISSFYTQDL IVMGAPGSSY WTGTVFVYNI TTNQYKAFVD RQNQVKFGSY
260 270 280 290 300
LGYSVGAGHF RSPHTTEVVG GAPQHEQIGK AYIFSIDENE LNIVYEMKGK
310 320 330 340 350
KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGMGAV
360 370 380 390 400
MVEMERVLVG SDKYAARFGE SIANLGDIDN DGFEDIAIGA PQEDDLRGAV
410 420 430 440 450
YIYNGRVDGI SSTYSQRIEG QQISKSLRMF GQSISGQIDA DNNGYVDVAI
460 470 480 490 500
GAFHSDSAVL LRTRPVVIVE ASLSHPESVN RTKFDCTENG LPSVCMHLTL
510 520 530 540 550
CFSYKGKEVP GYIVLFYNVS LDVHRKAESP SRFYFFSNGT SDVITGSIRV
560 570 580 590 600
SSSGEKCRTH QAFMRKDVRD ILTPIHVEAT YHLGHHVITK RNTEEFPPLQ
610 620 630 640 650
PILQQKKEKD VIRKMINFAR FCAYENCSAD LQVSAKVGFL KPYENKTYLA
660 670 680 690 700
VGSMKTIMLN VSLFNAGDDA YETTLNVQLP TGLYFIKILD LEEKQINCEV
710 720 730 740 750
TESSGIVKLA CSLGYIYVDR LSRIDISFLL DVSSLSRAHE DLSISVHASC
760 770 780 790 800
ENEGELDQVR DNRVTLTIPL RYEVMLTVHG LVNPTSFVYG SSEENEPETC
810 820 830 840 850
MAEKLNLTFH VINTGISMAP NVSVKIMVPN SFLPQDDKLF NVLDVQTTTG
860 870 880 890 900
QCHFKHYGRE CTFAQQKGIA GTLTDIVKFL SKTDKRLLYC MKADQHCLDF
910 920 930 940 950
LCNFGKMESG KEASVHIQLE GRPSILEMDE TSSLKFEIKA TAFPEPHPKV
960 970 980 990 1000
IELNKDENVA HVFLEGLHHQ RPKRHFTIII ITISLLLGLI VLLLISCVMW
1010 1020 1030
KAGFFKRQYK SILQEENRRD SWSYVNSKSN DD
Length:1,032
Mass (Da):115,109
Last modified:July 5, 2004 - v1
Checksum:i2D0AB34521461F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068313 mRNA. Translation: AAH68313.1.
UniGeneiMm.31903.

Similar proteinsi

Entry informationi

Entry nameiQ6NV53_MOUSE
AccessioniPrimary (citable) accession number: Q6NV53
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 31, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)