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Protein

Small ubiquitin-related modifier 3-like

Gene

sumo3l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • definitive hemopoiesis Source: ZFIN
  • protein sumoylation Source: GO_Central

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-3065679. SUMO is proteolytically processed.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3232118. SUMOylation of transcription factors.
R-DRE-4551638. SUMOylation of chromatin organization proteins.
R-DRE-4615885. SUMOylation of DNA replication proteins.
R-DRE-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3-like
Alternative name(s):
SUMO-3-A
Gene namesi
Name:sumo3l
Synonyms:sumo3, sumo3a
ORF Names:zgc:65847, zgc:85643
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-040426-2133. sumo3a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676301 – 92Small ubiquitin-related modifier 3-likeAdd BLAST92
PropeptideiPRO_000026763193 – 94By similarity2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6NV25.
PRIDEiQ6NV25.

Expressioni

Gene expression databases

BgeeiENSDARG00000028119.

Interactioni

Subunit structurei

Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000035513.

Structurei

3D structure databases

ProteinModelPortaliQ6NV25.
SMRiQ6NV25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 92Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6NV25.
KOiK12160.
OMAiAYCERAS.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ6NV25.
TreeFamiTF315116.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiView protein in InterPro
IPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF11976. Rad60-SLD. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NV25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90
GLSIRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGSC
Length:94
Mass (Da):10,683
Last modified:July 5, 2004 - v1
Checksum:iC78B9D3AB033A43F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068341 mRNA. Translation: AAH68341.1.
BC058303 mRNA. Translation: AAH58303.1.
RefSeqiNP_998289.1. NM_213124.2.
UniGeneiDr.1291.

Genome annotation databases

EnsembliENSDART00000035905; ENSDARP00000035513; ENSDARG00000028119.
GeneIDi406398.
KEGGidre:406398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068341 mRNA. Translation: AAH68341.1.
BC058303 mRNA. Translation: AAH58303.1.
RefSeqiNP_998289.1. NM_213124.2.
UniGeneiDr.1291.

3D structure databases

ProteinModelPortaliQ6NV25.
SMRiQ6NV25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000035513.

Proteomic databases

PaxDbiQ6NV25.
PRIDEiQ6NV25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000035905; ENSDARP00000035513; ENSDARG00000028119.
GeneIDi406398.
KEGGidre:406398.

Organism-specific databases

CTDi406398.
ZFINiZDB-GENE-040426-2133. sumo3a.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6NV25.
KOiK12160.
OMAiAYCERAS.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ6NV25.
TreeFamiTF315116.

Enzyme and pathway databases

ReactomeiR-DRE-3065679. SUMO is proteolytically processed.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3232118. SUMOylation of transcription factors.
R-DRE-4551638. SUMOylation of chromatin organization proteins.
R-DRE-4615885. SUMOylation of DNA replication proteins.
R-DRE-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

PROiPR:Q6NV25.

Gene expression databases

BgeeiENSDARG00000028119.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiView protein in InterPro
IPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF11976. Rad60-SLD. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMO3L_DANRE
AccessioniPrimary (citable) accession number: Q6NV25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.