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Protein

Small ubiquitin-related modifier 3-like

Gene

sumo3l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • definitive hemopoiesis Source: ZFIN
  • protein sumoylation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-3065679. SUMO is proteolytically processed.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3232118. SUMOylation of transcription factors.
R-DRE-4615885. SUMOylation of DNA replication proteins.
R-DRE-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3-like
Alternative name(s):
SUMO-3-A
Gene namesi
Name:sumo3l
Synonyms:sumo3, sumo3a
ORF Names:zgc:65847, zgc:85643
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-040426-2133. sumo3a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Small ubiquitin-related modifier 3-likePRO_0000267630Add
BLAST
Propeptidei93 – 942By similarityPRO_0000267631

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki92 – 92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6NV25.
PRIDEiQ6NV25.

Expressioni

Gene expression databases

BgeeiENSDARG00000028119.

Interactioni

Subunit structurei

Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000035513.

Structurei

3D structure databases

ProteinModelPortaliQ6NV25.
SMRiQ6NV25. Positions 1-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6NV25.
KOiK12160.
OMAiRTENNDH.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ6NV25.
TreeFamiTF315116.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NV25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90
GLSIRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGSC
Length:94
Mass (Da):10,683
Last modified:July 5, 2004 - v1
Checksum:iC78B9D3AB033A43F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068341 mRNA. Translation: AAH68341.1.
BC058303 mRNA. Translation: AAH58303.1.
RefSeqiNP_998289.1. NM_213124.2.
UniGeneiDr.1291.

Genome annotation databases

EnsembliENSDART00000035905; ENSDARP00000035513; ENSDARG00000028119.
GeneIDi406398.
KEGGidre:406398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068341 mRNA. Translation: AAH68341.1.
BC058303 mRNA. Translation: AAH58303.1.
RefSeqiNP_998289.1. NM_213124.2.
UniGeneiDr.1291.

3D structure databases

ProteinModelPortaliQ6NV25.
SMRiQ6NV25. Positions 1-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000035513.

Proteomic databases

PaxDbiQ6NV25.
PRIDEiQ6NV25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000035905; ENSDARP00000035513; ENSDARG00000028119.
GeneIDi406398.
KEGGidre:406398.

Organism-specific databases

CTDi406398.
ZFINiZDB-GENE-040426-2133. sumo3a.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6NV25.
KOiK12160.
OMAiRTENNDH.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ6NV25.
TreeFamiTF315116.

Enzyme and pathway databases

ReactomeiR-DRE-3065679. SUMO is proteolytically processed.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3232118. SUMOylation of transcription factors.
R-DRE-4615885. SUMOylation of DNA replication proteins.
R-DRE-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

PROiQ6NV25.

Gene expression databases

BgeeiENSDARG00000028119.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMO3L_DANRE
AccessioniPrimary (citable) accession number: Q6NV25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.