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Protein

UDP-glucuronosyltransferase 3A1

Gene

UGT3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: MGI
  2. UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. flavonoid biosynthetic process Source: GO_Central
  3. flavonoid glucuronidation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:UGT3A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26625. UGT3A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 483461ExtracellularSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. UDP-N-acetylglucosamine transferase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670642.

Polymorphism and mutation databases

BioMutaiUGT3A1.
DMDMi74749002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 523501UDP-glucuronosyltransferase 3A1PRO_0000299150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NUS8.
PRIDEiQ6NUS8.

PTM databases

PhosphoSiteiQ6NUS8.

Expressioni

Gene expression databases

BgeeiQ6NUS8.
CleanExiHS_UGT3A1.
ExpressionAtlasiQ6NUS8. baseline and differential.
GenevestigatoriQ6NUS8.

Organism-specific databases

HPAiHPA056290.

Interactioni

Protein-protein interaction databases

BioGridi126370. 1 interaction.
STRINGi9606.ENSP00000274278.

Structurei

3D structure databases

ProteinModelPortaliQ6NUS8.
SMRiQ6NUS8. Positions 277-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ6NUS8.
OMAiNFIANFG.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ6NUS8.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG
60 70 80 90 100
HNVTMLHQSG KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA
110 120 130 140 150
LDGRKESEAL VKLMEIFGTQ CSYLLSRKDI MDSLKNENYD LVFVEAFDFC
160 170 180 190 200
SFLIAEKLVK PFVAILPTTF GSLDFGLPSP LSYVPVFPSL LTDHMDFWGR
210 220 230 240 250
VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL LLKAELWFVN
260 270 280 290 300
SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF
310 320 330 340 350
GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD
360 370 380 390 400
WLPQSDLLAH PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR
410 420 430 440 450
VVAKNYGVSI RLNQVTADTL TLTMKQVIED KRYKSAVVAA SVILHSQPLS
460 470 480 490 500
PAQRLVGWID HILQTGGATH LKPYAFQQPW HEQYLIDVFV FLLGLTLGTM
510 520
WLCGKLLGVV ARWLRGARKV KKT
Length:523
Mass (Da):59,151
Last modified:July 5, 2004 - v1
Checksum:i602AE3D75CE986BD
GO
Isoform 2 (identifier: Q6NUS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     282-306: DLDNFIANFGDAGFVLVAFGSMLNT → NGQPALFTTPSLFSSGVYPEPLRWL
     307-523: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:252
Mass (Da):29,186
Checksum:i956BB9F9718B8982
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391Y → C in BAB71358 (PubMed:14702039).Curated
Sequence conflicti378 – 3781A → T in BAB71358 (PubMed:14702039).Curated
Sequence conflicti475 – 4751A → V in BAB71358 (PubMed:14702039).Curated
Isoform 2 (identifier: Q6NUS8-2)
Sequence conflicti251 – 2511W → R in AAH35012 (PubMed:15372022).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211C → G.
Corresponds to variant rs3756669 [ dbSNP | Ensembl ].
VAR_034791

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_044985Add
BLAST
Alternative sequencei282 – 30625DLDNF…SMLNT → NGQPALFTTPSLFSSGVYPE PLRWL in isoform 2. 1 PublicationVSP_044986Add
BLAST
Alternative sequencei307 – 523217Missing in isoform 2. 1 PublicationVSP_044987Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057066 mRNA. Translation: BAB71358.1.
AK091977 mRNA. No translation available.
AC016612 Genomic DNA. No translation available.
AC112204 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55928.1.
BC035012 mRNA. Translation: AAH35012.1.
BC068446 mRNA. Translation: AAH68446.1.
CCDSiCCDS3913.1. [Q6NUS8-1]
CCDS54841.1. [Q6NUS8-2]
RefSeqiNP_001165344.1. NM_001171873.1. [Q6NUS8-2]
NP_689617.3. NM_152404.3. [Q6NUS8-1]
UniGeneiHs.254699.

Genome annotation databases

EnsembliENST00000274278; ENSP00000274278; ENSG00000145626. [Q6NUS8-1]
ENST00000333811; ENSP00000328033; ENSG00000145626. [Q6NUS8-2]
GeneIDi133688.
KEGGihsa:133688.
UCSCiuc003jjv.2. human. [Q6NUS8-1]
uc003jjy.2. human.

Polymorphism and mutation databases

BioMutaiUGT3A1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057066 mRNA. Translation: BAB71358.1.
AK091977 mRNA. No translation available.
AC016612 Genomic DNA. No translation available.
AC112204 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55928.1.
BC035012 mRNA. Translation: AAH35012.1.
BC068446 mRNA. Translation: AAH68446.1.
CCDSiCCDS3913.1. [Q6NUS8-1]
CCDS54841.1. [Q6NUS8-2]
RefSeqiNP_001165344.1. NM_001171873.1. [Q6NUS8-2]
NP_689617.3. NM_152404.3. [Q6NUS8-1]
UniGeneiHs.254699.

3D structure databases

ProteinModelPortaliQ6NUS8.
SMRiQ6NUS8. Positions 277-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126370. 1 interaction.
STRINGi9606.ENSP00000274278.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiQ6NUS8.

Polymorphism and mutation databases

BioMutaiUGT3A1.
DMDMi74749002.

Proteomic databases

PaxDbiQ6NUS8.
PRIDEiQ6NUS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274278; ENSP00000274278; ENSG00000145626. [Q6NUS8-1]
ENST00000333811; ENSP00000328033; ENSG00000145626. [Q6NUS8-2]
GeneIDi133688.
KEGGihsa:133688.
UCSCiuc003jjv.2. human. [Q6NUS8-1]
uc003jjy.2. human.

Organism-specific databases

CTDi133688.
GeneCardsiGC05M035951.
HGNCiHGNC:26625. UGT3A1.
HPAiHPA056290.
neXtProtiNX_Q6NUS8.
PharmGKBiPA142670642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ6NUS8.
OMAiNFIANFG.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ6NUS8.
TreeFamiTF315472.

Miscellaneous databases

GenomeRNAii133688.
NextBioi83266.
PROiQ6NUS8.

Gene expression databases

BgeeiQ6NUS8.
CleanExiHS_UGT3A1.
ExpressionAtlasiQ6NUS8. baseline and differential.
GenevestigatoriQ6NUS8.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Small intestine.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiUD3A1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUS8
Secondary accession number(s): G5E961
, Q8IYS9, Q8NAW4, Q96DM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.