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Q6NUS8

- UD3A1_HUMAN

UniProt

Q6NUS8 - UD3A1_HUMAN

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Protein
UDP-glucuronosyltransferase 3A1
Gene
UGT3A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. UDP-glycosyltransferase activity Source: MGI
  2. glucuronosyltransferase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:UGT3A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:26625. UGT3A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 483461Extracellular Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 52319Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. UDP-N-acetylglucosamine transferase complex Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 523501UDP-glucuronosyltransferase 3A1
PRO_0000299150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NUS8.
PRIDEiQ6NUS8.

PTM databases

PhosphoSiteiQ6NUS8.

Expressioni

Gene expression databases

ArrayExpressiQ6NUS8.
BgeeiQ6NUS8.
CleanExiHS_UGT3A1.
GenevestigatoriQ6NUS8.

Organism-specific databases

HPAiHPA056290.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274278.

Structurei

3D structure databases

ProteinModelPortaliQ6NUS8.
SMRiQ6NUS8. Positions 277-441.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ6NUS8.
OMAiNFIANFG.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ6NUS8.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NUS8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG    50
HNVTMLHQSG KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA 100
LDGRKESEAL VKLMEIFGTQ CSYLLSRKDI MDSLKNENYD LVFVEAFDFC 150
SFLIAEKLVK PFVAILPTTF GSLDFGLPSP LSYVPVFPSL LTDHMDFWGR 200
VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL LLKAELWFVN 250
SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF 300
GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD 350
WLPQSDLLAH PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR 400
VVAKNYGVSI RLNQVTADTL TLTMKQVIED KRYKSAVVAA SVILHSQPLS 450
PAQRLVGWID HILQTGGATH LKPYAFQQPW HEQYLIDVFV FLLGLTLGTM 500
WLCGKLLGVV ARWLRGARKV KKT 523
Length:523
Mass (Da):59,151
Last modified:July 5, 2004 - v1
Checksum:i602AE3D75CE986BD
GO
Isoform 2 (identifier: Q6NUS8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     282-306: DLDNFIANFGDAGFVLVAFGSMLNT → NGQPALFTTPSLFSSGVYPEPLRWL
     307-523: Missing.

Note: No experimental confirmation available.

Show »
Length:252
Mass (Da):29,186
Checksum:i956BB9F9718B8982
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211C → G.
Corresponds to variant rs3756669 [ dbSNP | Ensembl ].
VAR_034791

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2.
VSP_044985Add
BLAST
Alternative sequencei282 – 30625DLDNF…SMLNT → NGQPALFTTPSLFSSGVYPE PLRWL in isoform 2.
VSP_044986Add
BLAST
Alternative sequencei307 – 523217Missing in isoform 2.
VSP_044987Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391Y → C in BAB71358. 1 Publication
Sequence conflicti378 – 3781A → T in BAB71358. 1 Publication
Sequence conflicti475 – 4751A → V in BAB71358. 1 Publication
Isoform 2 (identifier: Q6NUS8-2)
Sequence conflicti251 – 2511W → R in AAH35012. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057066 mRNA. Translation: BAB71358.1.
AK091977 mRNA. No translation available.
AC016612 Genomic DNA. No translation available.
AC112204 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55928.1.
BC035012 mRNA. Translation: AAH35012.1.
BC068446 mRNA. Translation: AAH68446.1.
CCDSiCCDS3913.1. [Q6NUS8-1]
CCDS54841.1. [Q6NUS8-2]
RefSeqiNP_001165344.1. NM_001171873.1. [Q6NUS8-2]
NP_689617.3. NM_152404.3. [Q6NUS8-1]
UniGeneiHs.254699.

Genome annotation databases

EnsembliENST00000274278; ENSP00000274278; ENSG00000145626. [Q6NUS8-1]
ENST00000333811; ENSP00000328033; ENSG00000145626. [Q6NUS8-2]
GeneIDi133688.
KEGGihsa:133688.
UCSCiuc003jjv.2. human. [Q6NUS8-1]
uc003jjy.2. human.

Polymorphism databases

DMDMi74749002.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057066 mRNA. Translation: BAB71358.1 .
AK091977 mRNA. No translation available.
AC016612 Genomic DNA. No translation available.
AC112204 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55928.1 .
BC035012 mRNA. Translation: AAH35012.1 .
BC068446 mRNA. Translation: AAH68446.1 .
CCDSi CCDS3913.1. [Q6NUS8-1 ]
CCDS54841.1. [Q6NUS8-2 ]
RefSeqi NP_001165344.1. NM_001171873.1. [Q6NUS8-2 ]
NP_689617.3. NM_152404.3. [Q6NUS8-1 ]
UniGenei Hs.254699.

3D structure databases

ProteinModelPortali Q6NUS8.
SMRi Q6NUS8. Positions 277-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000274278.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q6NUS8.

Polymorphism databases

DMDMi 74749002.

Proteomic databases

PaxDbi Q6NUS8.
PRIDEi Q6NUS8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274278 ; ENSP00000274278 ; ENSG00000145626 . [Q6NUS8-1 ]
ENST00000333811 ; ENSP00000328033 ; ENSG00000145626 . [Q6NUS8-2 ]
GeneIDi 133688.
KEGGi hsa:133688.
UCSCi uc003jjv.2. human. [Q6NUS8-1 ]
uc003jjy.2. human.

Organism-specific databases

CTDi 133688.
GeneCardsi GC05M035951.
HGNCi HGNC:26625. UGT3A1.
HPAi HPA056290.
neXtProti NX_Q6NUS8.
PharmGKBi PA142670642.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG106370.
InParanoidi Q6NUS8.
OMAi NFIANFG.
OrthoDBi EOG7GBFWS.
PhylomeDBi Q6NUS8.
TreeFami TF315472.

Miscellaneous databases

GenomeRNAii 133688.
NextBioi 83266.
PROi Q6NUS8.

Gene expression databases

ArrayExpressi Q6NUS8.
Bgeei Q6NUS8.
CleanExi HS_UGT3A1.
Genevestigatori Q6NUS8.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Small intestine.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiUD3A1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUS8
Secondary accession number(s): G5E961
, Q8IYS9, Q8NAW4, Q96DM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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