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Q6NUS8

- UD3A1_HUMAN

UniProt

Q6NUS8 - UD3A1_HUMAN

Protein

UDP-glucuronosyltransferase 3A1

Gene

UGT3A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: MGI
    2. UDP-glycosyltransferase activity Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
    Short name:
    UDPGT 3A1
    Gene namesi
    Name:UGT3A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:26625. UGT3A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. UDP-N-acetylglucosamine transferase complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 523501UDP-glucuronosyltransferase 3A1PRO_0000299150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6NUS8.
    PRIDEiQ6NUS8.

    PTM databases

    PhosphoSiteiQ6NUS8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NUS8.
    BgeeiQ6NUS8.
    CleanExiHS_UGT3A1.
    GenevestigatoriQ6NUS8.

    Organism-specific databases

    HPAiHPA056290.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000274278.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NUS8.
    SMRiQ6NUS8. Positions 277-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 483461ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG106370.
    InParanoidiQ6NUS8.
    OMAiNFIANFG.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiQ6NUS8.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NUS8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG    50
    HNVTMLHQSG KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA 100
    LDGRKESEAL VKLMEIFGTQ CSYLLSRKDI MDSLKNENYD LVFVEAFDFC 150
    SFLIAEKLVK PFVAILPTTF GSLDFGLPSP LSYVPVFPSL LTDHMDFWGR 200
    VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL LLKAELWFVN 250
    SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF 300
    GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD 350
    WLPQSDLLAH PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR 400
    VVAKNYGVSI RLNQVTADTL TLTMKQVIED KRYKSAVVAA SVILHSQPLS 450
    PAQRLVGWID HILQTGGATH LKPYAFQQPW HEQYLIDVFV FLLGLTLGTM 500
    WLCGKLLGVV ARWLRGARKV KKT 523
    Length:523
    Mass (Da):59,151
    Last modified:July 5, 2004 - v1
    Checksum:i602AE3D75CE986BD
    GO
    Isoform 2 (identifier: Q6NUS8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-54: Missing.
         282-306: DLDNFIANFGDAGFVLVAFGSMLNT → NGQPALFTTPSLFSSGVYPEPLRWL
         307-523: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:252
    Mass (Da):29,186
    Checksum:i956BB9F9718B8982
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391Y → C in BAB71358. (PubMed:14702039)Curated
    Sequence conflicti378 – 3781A → T in BAB71358. (PubMed:14702039)Curated
    Sequence conflicti475 – 4751A → V in BAB71358. (PubMed:14702039)Curated
    Isoform 2 (identifier: Q6NUS8-2)
    Sequence conflicti251 – 2511W → R in AAH35012. (PubMed:15372022)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211C → G.
    Corresponds to variant rs3756669 [ dbSNP | Ensembl ].
    VAR_034791

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_044985Add
    BLAST
    Alternative sequencei282 – 30625DLDNF…SMLNT → NGQPALFTTPSLFSSGVYPE PLRWL in isoform 2. 1 PublicationVSP_044986Add
    BLAST
    Alternative sequencei307 – 523217Missing in isoform 2. 1 PublicationVSP_044987Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057066 mRNA. Translation: BAB71358.1.
    AK091977 mRNA. No translation available.
    AC016612 Genomic DNA. No translation available.
    AC112204 Genomic DNA. No translation available.
    CH471119 Genomic DNA. Translation: EAW55928.1.
    BC035012 mRNA. Translation: AAH35012.1.
    BC068446 mRNA. Translation: AAH68446.1.
    CCDSiCCDS3913.1. [Q6NUS8-1]
    CCDS54841.1. [Q6NUS8-2]
    RefSeqiNP_001165344.1. NM_001171873.1. [Q6NUS8-2]
    NP_689617.3. NM_152404.3. [Q6NUS8-1]
    UniGeneiHs.254699.

    Genome annotation databases

    EnsembliENST00000274278; ENSP00000274278; ENSG00000145626. [Q6NUS8-1]
    ENST00000333811; ENSP00000328033; ENSG00000145626. [Q6NUS8-2]
    GeneIDi133688.
    KEGGihsa:133688.
    UCSCiuc003jjv.2. human. [Q6NUS8-1]
    uc003jjy.2. human.

    Polymorphism databases

    DMDMi74749002.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057066 mRNA. Translation: BAB71358.1 .
    AK091977 mRNA. No translation available.
    AC016612 Genomic DNA. No translation available.
    AC112204 Genomic DNA. No translation available.
    CH471119 Genomic DNA. Translation: EAW55928.1 .
    BC035012 mRNA. Translation: AAH35012.1 .
    BC068446 mRNA. Translation: AAH68446.1 .
    CCDSi CCDS3913.1. [Q6NUS8-1 ]
    CCDS54841.1. [Q6NUS8-2 ]
    RefSeqi NP_001165344.1. NM_001171873.1. [Q6NUS8-2 ]
    NP_689617.3. NM_152404.3. [Q6NUS8-1 ]
    UniGenei Hs.254699.

    3D structure databases

    ProteinModelPortali Q6NUS8.
    SMRi Q6NUS8. Positions 277-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000274278.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q6NUS8.

    Polymorphism databases

    DMDMi 74749002.

    Proteomic databases

    PaxDbi Q6NUS8.
    PRIDEi Q6NUS8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274278 ; ENSP00000274278 ; ENSG00000145626 . [Q6NUS8-1 ]
    ENST00000333811 ; ENSP00000328033 ; ENSG00000145626 . [Q6NUS8-2 ]
    GeneIDi 133688.
    KEGGi hsa:133688.
    UCSCi uc003jjv.2. human. [Q6NUS8-1 ]
    uc003jjy.2. human.

    Organism-specific databases

    CTDi 133688.
    GeneCardsi GC05M035951.
    HGNCi HGNC:26625. UGT3A1.
    HPAi HPA056290.
    neXtProti NX_Q6NUS8.
    PharmGKBi PA142670642.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG106370.
    InParanoidi Q6NUS8.
    OMAi NFIANFG.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi Q6NUS8.
    TreeFami TF315472.

    Miscellaneous databases

    GenomeRNAii 133688.
    NextBioi 83266.
    PROi Q6NUS8.

    Gene expression databases

    ArrayExpressi Q6NUS8.
    Bgeei Q6NUS8.
    CleanExi HS_UGT3A1.
    Genevestigatori Q6NUS8.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney and Small intestine.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiUD3A1_HUMAN
    AccessioniPrimary (citable) accession number: Q6NUS8
    Secondary accession number(s): G5E961
    , Q8IYS9, Q8NAW4, Q96DM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3