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Protein

UDP-glucuronosyltransferase 3A1

Gene

UGT3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: MGI
  • UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS07266-MONOMER.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:UGT3A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26625. UGT3A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 483ExtracellularSequence analysisAdd BLAST461
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 523CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • UDP-N-acetylglucosamine transferase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi133688.
OpenTargetsiENSG00000145626.
PharmGKBiPA142670642.

Polymorphism and mutation databases

BioMutaiUGT3A1.
DMDMi74749002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029915023 – 523UDP-glucuronosyltransferase 3A1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6NUS8.
PaxDbiQ6NUS8.
PeptideAtlasiQ6NUS8.
PRIDEiQ6NUS8.

PTM databases

iPTMnetiQ6NUS8.
PhosphoSitePlusiQ6NUS8.

Expressioni

Gene expression databases

BgeeiENSG00000145626.
CleanExiHS_UGT3A1.
ExpressionAtlasiQ6NUS8. baseline and differential.
GenevisibleiQ6NUS8. HS.

Organism-specific databases

HPAiHPA056290.

Interactioni

Protein-protein interaction databases

BioGridi126370. 1 interactor.
STRINGi9606.ENSP00000274278.

Structurei

3D structure databases

ProteinModelPortaliQ6NUS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ6NUS8.
OMAiNFIANFG.
OrthoDBiEOG091G06JC.
PhylomeDBiQ6NUS8.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG
60 70 80 90 100
HNVTMLHQSG KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA
110 120 130 140 150
LDGRKESEAL VKLMEIFGTQ CSYLLSRKDI MDSLKNENYD LVFVEAFDFC
160 170 180 190 200
SFLIAEKLVK PFVAILPTTF GSLDFGLPSP LSYVPVFPSL LTDHMDFWGR
210 220 230 240 250
VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL LLKAELWFVN
260 270 280 290 300
SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF
310 320 330 340 350
GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD
360 370 380 390 400
WLPQSDLLAH PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR
410 420 430 440 450
VVAKNYGVSI RLNQVTADTL TLTMKQVIED KRYKSAVVAA SVILHSQPLS
460 470 480 490 500
PAQRLVGWID HILQTGGATH LKPYAFQQPW HEQYLIDVFV FLLGLTLGTM
510 520
WLCGKLLGVV ARWLRGARKV KKT
Length:523
Mass (Da):59,151
Last modified:July 5, 2004 - v1
Checksum:i602AE3D75CE986BD
GO
Isoform 2 (identifier: Q6NUS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     282-306: DLDNFIANFGDAGFVLVAFGSMLNT → NGQPALFTTPSLFSSGVYPEPLRWL
     307-523: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:252
Mass (Da):29,186
Checksum:i956BB9F9718B8982
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139Y → C in BAB71358 (PubMed:14702039).Curated1
Sequence conflicti378A → T in BAB71358 (PubMed:14702039).Curated1
Sequence conflicti475A → V in BAB71358 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q6NUS8-2)
Sequence conflicti251W → R in AAH35012 (PubMed:15372022).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034791121C → G.Corresponds to variant rs3756669dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449851 – 54Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_044986282 – 306DLDNF…SMLNT → NGQPALFTTPSLFSSGVYPE PLRWL in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_044987307 – 523Missing in isoform 2. 1 PublicationAdd BLAST217

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057066 mRNA. Translation: BAB71358.1.
AK091977 mRNA. No translation available.
AC016612 Genomic DNA. No translation available.
AC112204 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55928.1.
BC035012 mRNA. Translation: AAH35012.1.
BC068446 mRNA. Translation: AAH68446.1.
CCDSiCCDS3913.1. [Q6NUS8-1]
CCDS54841.1. [Q6NUS8-2]
RefSeqiNP_001165344.1. NM_001171873.1. [Q6NUS8-2]
NP_689617.3. NM_152404.3. [Q6NUS8-1]
UniGeneiHs.254699.

Genome annotation databases

EnsembliENST00000274278; ENSP00000274278; ENSG00000145626. [Q6NUS8-1]
ENST00000333811; ENSP00000328033; ENSG00000145626. [Q6NUS8-2]
ENST00000625798; ENSP00000487376; ENSG00000145626. [Q6NUS8-2]
GeneIDi133688.
KEGGihsa:133688.
UCSCiuc003jjv.3. human. [Q6NUS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057066 mRNA. Translation: BAB71358.1.
AK091977 mRNA. No translation available.
AC016612 Genomic DNA. No translation available.
AC112204 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55928.1.
BC035012 mRNA. Translation: AAH35012.1.
BC068446 mRNA. Translation: AAH68446.1.
CCDSiCCDS3913.1. [Q6NUS8-1]
CCDS54841.1. [Q6NUS8-2]
RefSeqiNP_001165344.1. NM_001171873.1. [Q6NUS8-2]
NP_689617.3. NM_152404.3. [Q6NUS8-1]
UniGeneiHs.254699.

3D structure databases

ProteinModelPortaliQ6NUS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126370. 1 interactor.
STRINGi9606.ENSP00000274278.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ6NUS8.
PhosphoSitePlusiQ6NUS8.

Polymorphism and mutation databases

BioMutaiUGT3A1.
DMDMi74749002.

Proteomic databases

EPDiQ6NUS8.
PaxDbiQ6NUS8.
PeptideAtlasiQ6NUS8.
PRIDEiQ6NUS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274278; ENSP00000274278; ENSG00000145626. [Q6NUS8-1]
ENST00000333811; ENSP00000328033; ENSG00000145626. [Q6NUS8-2]
ENST00000625798; ENSP00000487376; ENSG00000145626. [Q6NUS8-2]
GeneIDi133688.
KEGGihsa:133688.
UCSCiuc003jjv.3. human. [Q6NUS8-1]

Organism-specific databases

CTDi133688.
DisGeNETi133688.
GeneCardsiUGT3A1.
HGNCiHGNC:26625. UGT3A1.
HPAiHPA056290.
MIMi616383. gene.
neXtProtiNX_Q6NUS8.
OpenTargetsiENSG00000145626.
PharmGKBiPA142670642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ6NUS8.
OMAiNFIANFG.
OrthoDBiEOG091G06JC.
PhylomeDBiQ6NUS8.
TreeFamiTF315472.

Enzyme and pathway databases

BioCyciZFISH:HS07266-MONOMER.

Miscellaneous databases

GenomeRNAii133688.
PROiQ6NUS8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145626.
CleanExiHS_UGT3A1.
ExpressionAtlasiQ6NUS8. baseline and differential.
GenevisibleiQ6NUS8. HS.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD3A1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUS8
Secondary accession number(s): G5E961
, Q8IYS9, Q8NAW4, Q96DM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.