Reviewed, UniProtKB/Swiss-Prot Q6NUS8 (UD3A1_HUMAN)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 3A1
      Short name=UDPGT 3A1
    EC=2.4.1.17

Gene names

Name:

UGT3A1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 523	501	UDP-glucuronosyltransferase 3A1		PRO_0000299150
Regions
	Topological domain	23 – 483	461	Extracellular Potential
	Transmembrane	484 – 504	21	Potential
	Topological domain	505 – 523	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	121	1	C → G: dbSNP rs3756669.		VAR_034791
Experimental info
	Sequence conflict	139	1	Y → C in BAB71358. Ref.1
	Sequence conflict	378	1	A → T in BAB71358. Ref.1
	Sequence conflict	475	1	A → V in BAB71358. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6NUS8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 602AE3D75CE986BD	FASTA	523	59,151
	10 20 30 40 50 60 MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG HNVTMLHQSG 70 80 90 100 110 120 KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA LDGRKESEAL VKLMEIFGTQ 130 140 150 160 170 180 CSYLLSRKDI MDSLKNENYD LVFVEAFDFC SFLIAEKLVK PFVAILPTTF GSLDFGLPSP 190 200 210 220 230 240 LSYVPVFPSL LTDHMDFWGR VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL 250 260 270 280 290 300 LLKAELWFVN SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF 310 320 330 340 350 360 GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD WLPQSDLLAH 370 380 390 400 410 420 PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR VVAKNYGVSI RLNQVTADTL 430 440 450 460 470 480 TLTMKQVIED KRYKSAVVAA SVILHSQPLS PAQRLVGWID HILQTGGATH LKPYAFQQPW 490 500 510 520 HEQYLIDVFV FLLGLTLGTM WLCGKLLGVV ARWLRGARKV KKT

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Small intestine.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK057066 mRNA. Translation: BAB71358.1. AK091977 mRNA. No translation available. BC068446 mRNA. Translation: AAH68446.1.
IPI	IPI00060990.
RefSeq	NP_689617.2.
UniGene	Hs.254699
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	Q6NUS8.
Genome annotation databases
Ensembl	ENSG00000145626. Homo sapiens. [Contig view]
GeneID	133688.
KEGG	hsa:133688.
Organism-specific databases
GeneCards	GC05M035989.
HGNC	HGNC:26625. UGT3A1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q6NUS8.
HOVERGEN	Q6NUS8.
OMA	Q6NUS8. IRHGVPM.
Enzyme and pathway databases
BRENDA	2.4.1.17. 247.
Gene expression databases
ArrayExpress	Q6NUS8.
Bgee	Q6NUS8.
CleanEx	HS_UGT3A1.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	83266.

Entry information

Entry name

UD3A1_HUMAN

Accession

Primary (citable) accession number: Q6NUS8
Secondary accession number(s): Q8NAW4, Q96DM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	July 5, 2004
Last modified:	July 7, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)