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Q6NUS6

- TECT3_HUMAN

UniProt

Q6NUS6 - TECT3_HUMAN

Protein

Tectonic-3

Gene

TCTN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition By similarity. May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.By similarity2 Publications

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cilium morphogenesis Source: UniProtKB
    3. smoothened signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tectonic-3
    Gene namesi
    Name:TCTN3
    Synonyms:C10orf61, TECT3
    ORF Names:PSEC0041, UNQ1881/PRO4324
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24519. TCTN3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Orofaciodigital syndrome 4 (OFD4) [MIM:258860]: A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD4 patients have tongue nodules, multiple frenulae, broad flat nose, hypertelorism, and short rib polydactyly with tibial dysplasia (Majewski syndrome). The presence of severe tibial aplasia differentiates OFD4 from OFD1. Additional features of cystic dysplastic kidneys and brain malformation, including occipital encephalocele, are observed in severely affected patients.
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Joubert syndrome 18 (JBTS18) [MIM:614815]: A form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS18 patients have vermis agenesis and the molar tooth sign as well as severe kyphoscoliosis. Other features include intrauterine growth retardation, oral anomalies, micrognathism, polydactyly and camptodactyly, joint laxity, horseshoe kidney, and ventricular septal defect.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. TCTN3-mutated fibroblasts from JBTS18 patients fail to respond to Shh agonists suggesting that at least some of the defects in affected individuals may be secondary to reduced Shh signaling (PubMed:22883145).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti314 – 3141G → R in JBTS18. 1 Publication
    VAR_068823

    Keywords - Diseasei

    Ciliopathy, Disease mutation, Joubert syndrome

    Organism-specific databases

    MIMi258860. phenotype.
    614815. phenotype.
    Orphaneti2754. Joubert syndrome with orofaciodigital defect.
    2753. Orofaciodigital syndrome type 4.
    PharmGKBiPA162405513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 607585Tectonic-3PRO_0000229921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6NUS6.
    PaxDbiQ6NUS6.
    PRIDEiQ6NUS6.

    PTM databases

    PhosphoSiteiQ6NUS6.

    Expressioni

    Gene expression databases

    BgeeiQ6NUS6.
    CleanExiHS_TCTN3.
    GenevestigatoriQ6NUS6.

    Organism-specific databases

    HPAiHPA026987.

    Interactioni

    Subunit structurei

    Part of the tectonic-like complex (also named B9 complex).By similarity

    Protein-protein interaction databases

    BioGridi117565. 1 interaction.
    MINTiMINT-4722379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NUS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 581559ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini603 – 6075CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei582 – 60221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi90 – 10920Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the tectonic family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG87342.
    HOGENOMiHOG000070061.
    HOVERGENiHBG094032.
    InParanoidiQ6NUS6.
    OrthoDBiEOG7S4X62.
    PhylomeDBiQ6NUS6.
    TreeFamiTF329169.

    Family and domain databases

    InterProiIPR011677. DUF1619.
    [Graphical view]
    PfamiPF07773. DUF1619. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NUS6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRTPQLALLQ VFFLVFPDGV RPQPSSSPSG AVPTSLELQR GTDGGTLQSP    50
    SEATATRPAV PGLPTVVPTL VTPSAPGNRT VDLFPVLPIC VCDLTPGACD 100
    INCCCDRDCY LLHPRTVFSF CLPGSVRSSS WVCVDNSVIF RSNSPFPSRV 150
    FMDSNGIRQF CVHVNNSNLN YFQKLQKVNA TNFQALAAEF GGESFTSTFQ 200
    TQSPPSFYRA GDPILTYFPK WSVISLLRQP AGVGAGGLCA ESNPAGFLES 250
    KSTTCTRFFK NLASSCTLDS ALNAASYYNF TVLKVPRSMT DPQNMEFQVP 300
    VILTSQANAP LLAGNTCQNV VSQVTYEIET NGTFGIQKVS VSLGQTNLTV 350
    EPGASLQQHF ILRFRAFQQS TAASLTSPRS GNPGYIVGKP LLALTDDISY 400
    SMTLLQSQGN GSCSVKRHEV QFGVNAISGC KLRLKKADCS HLQQEIYQTL 450
    HGRPRPEYVA IFGNADPAQK GGWTRILNRH CSISAINCTS CCLIPVSLEI 500
    QVLWAYVGLL SNPQAHVSGV RFLYQCQSIQ DSQQVTEVSL TTLVNFVDIT 550
    QKPQPPRGQP KMDWKWPFDF FPFKVAFSRG VFSQKCSVSP ILILCLLLLG 600
    VLNLETM 607
    Length:607
    Mass (Da):66,157
    Last modified:April 4, 2006 - v2
    Checksum:i41CE275DEDF358E6
    GO
    Isoform 2 (identifier: Q6NUS6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         402-443: MTLLQSQGNG...LKKADCSHLQ → VSFLELGGLL...FVHYNEVLIY
         444-607: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:443
    Mass (Da):47,985
    Checksum:i12499DB14EB8C0D2
    GO
    Isoform 3 (identifier: Q6NUS6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: Missing.
         297-323: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:429
    Mass (Da):47,284
    Checksum:iBA9CF7DC7490F6C3
    GO
    Isoform 4 (identifier: Q6NUS6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-211: AG → VS
         212-607: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:211
    Mass (Da):22,846
    Checksum:iBFFB9036766D2867
    GO
    Isoform 5 (identifier: Q6NUS6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         167-246: SNLNYFQKLQ...GLCAESNPAG → C
         297-365: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:459
    Mass (Da):50,258
    Checksum:i3BCD657AE2F53BDB
    GO

    Sequence cautioni

    The sequence BAC11567.1 differs from that shown. Reason: Frameshift at position 238.
    The sequence AAH68449.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence ABB90564.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAC87634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI16768.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301G → E in BAC11567. (PubMed:14702039)Curated
    Sequence conflicti492 – 4921C → R in BAC11567. (PubMed:14702039)Curated
    Sequence conflicti516 – 5161H → Q in CAB43242. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti314 – 3141G → R in JBTS18. 1 Publication
    VAR_068823

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 151151Missing in isoform 3. 1 PublicationVSP_017791Add
    BLAST
    Alternative sequencei167 – 24680SNLNY…SNPAG → C in isoform 5. 1 PublicationVSP_043266Add
    BLAST
    Alternative sequencei210 – 2112AG → VS in isoform 4. 1 PublicationVSP_017792
    Alternative sequencei212 – 607396Missing in isoform 4. 1 PublicationVSP_017793Add
    BLAST
    Alternative sequencei297 – 36569Missing in isoform 5. 1 PublicationVSP_043267Add
    BLAST
    Alternative sequencei297 – 32327Missing in isoform 3. 1 PublicationVSP_017794Add
    BLAST
    Alternative sequencei402 – 44342MTLLQ…CSHLQ → VSFLELGGLLQPNEKSCKGF QTYVRLAKGEEFFVHYNEVL IY in isoform 2. 1 PublicationVSP_017795Add
    BLAST
    Alternative sequencei444 – 607164Missing in isoform 2. 1 PublicationVSP_017796Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ278872 mRNA. Translation: ABB90564.1. Different initiation.
    AK075357 mRNA. Translation: BAC11567.1. Frameshift.
    AY359022 mRNA. Translation: AAQ89381.1.
    AK098295 mRNA. Translation: BAC05278.1.
    AK128834 mRNA. Translation: BAC87634.1. Different initiation.
    AK299141 mRNA. Translation: BAG61193.1.
    AL050022 mRNA. Translation: CAB43242.2.
    AL356632 Genomic DNA. Translation: CAI16768.2. Different initiation.
    AL356632 Genomic DNA. Translation: CAQ07589.1.
    BC009494 mRNA. Translation: AAH09494.2.
    BC061582 mRNA. Translation: AAH61582.1.
    BC068449 mRNA. Translation: AAH68449.2. Different initiation.
    CCDSiCCDS31258.2. [Q6NUS6-1]
    CCDS44461.1. [Q6NUS6-5]
    PIRiT08708.
    RefSeqiNP_001137445.1. NM_001143973.1. [Q6NUS6-5]
    NP_056446.4. NM_015631.5. [Q6NUS6-1]
    UniGeneiHs.438991.

    Genome annotation databases

    EnsembliENST00000265993; ENSP00000265993; ENSG00000119977.
    ENST00000371209; ENSP00000360253; ENSG00000119977. [Q6NUS6-2]
    ENST00000371217; ENSP00000360261; ENSG00000119977. [Q6NUS6-1]
    ENST00000430368; ENSP00000387567; ENSG00000119977. [Q6NUS6-5]
    GeneIDi26123.
    KEGGihsa:26123.
    UCSCiuc001klb.4. human. [Q6NUS6-1]
    uc001kld.3. human. [Q6NUS6-2]
    uc009xux.1. human. [Q6NUS6-3]
    uc010qoi.2. human. [Q6NUS6-5]

    Polymorphism databases

    DMDMi91208025.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ278872 mRNA. Translation: ABB90564.1 . Different initiation.
    AK075357 mRNA. Translation: BAC11567.1 . Frameshift.
    AY359022 mRNA. Translation: AAQ89381.1 .
    AK098295 mRNA. Translation: BAC05278.1 .
    AK128834 mRNA. Translation: BAC87634.1 . Different initiation.
    AK299141 mRNA. Translation: BAG61193.1 .
    AL050022 mRNA. Translation: CAB43242.2 .
    AL356632 Genomic DNA. Translation: CAI16768.2 . Different initiation.
    AL356632 Genomic DNA. Translation: CAQ07589.1 .
    BC009494 mRNA. Translation: AAH09494.2 .
    BC061582 mRNA. Translation: AAH61582.1 .
    BC068449 mRNA. Translation: AAH68449.2 . Different initiation.
    CCDSi CCDS31258.2. [Q6NUS6-1 ]
    CCDS44461.1. [Q6NUS6-5 ]
    PIRi T08708.
    RefSeqi NP_001137445.1. NM_001143973.1. [Q6NUS6-5 ]
    NP_056446.4. NM_015631.5. [Q6NUS6-1 ]
    UniGenei Hs.438991.

    3D structure databases

    ProteinModelPortali Q6NUS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117565. 1 interaction.
    MINTi MINT-4722379.

    PTM databases

    PhosphoSitei Q6NUS6.

    Polymorphism databases

    DMDMi 91208025.

    Proteomic databases

    MaxQBi Q6NUS6.
    PaxDbi Q6NUS6.
    PRIDEi Q6NUS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265993 ; ENSP00000265993 ; ENSG00000119977 .
    ENST00000371209 ; ENSP00000360253 ; ENSG00000119977 . [Q6NUS6-2 ]
    ENST00000371217 ; ENSP00000360261 ; ENSG00000119977 . [Q6NUS6-1 ]
    ENST00000430368 ; ENSP00000387567 ; ENSG00000119977 . [Q6NUS6-5 ]
    GeneIDi 26123.
    KEGGi hsa:26123.
    UCSCi uc001klb.4. human. [Q6NUS6-1 ]
    uc001kld.3. human. [Q6NUS6-2 ]
    uc009xux.1. human. [Q6NUS6-3 ]
    uc010qoi.2. human. [Q6NUS6-5 ]

    Organism-specific databases

    CTDi 26123.
    GeneCardsi GC10M097414.
    GeneReviewsi TCTN3.
    HGNCi HGNC:24519. TCTN3.
    HPAi HPA026987.
    MIMi 258860. phenotype.
    613847. gene.
    614815. phenotype.
    neXtProti NX_Q6NUS6.
    Orphaneti 2754. Joubert syndrome with orofaciodigital defect.
    2753. Orofaciodigital syndrome type 4.
    PharmGKBi PA162405513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87342.
    HOGENOMi HOG000070061.
    HOVERGENi HBG094032.
    InParanoidi Q6NUS6.
    OrthoDBi EOG7S4X62.
    PhylomeDBi Q6NUS6.
    TreeFami TF329169.

    Miscellaneous databases

    GenomeRNAii 26123.
    NextBioi 48139.
    PROi Q6NUS6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NUS6.
    CleanExi HS_TCTN3.
    Genevestigatori Q6NUS6.

    Family and domain databases

    InterProi IPR011677. DUF1619.
    [Graphical view ]
    Pfami PF07773. DUF1619. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition."
      Reiter J.F., Skarnes W.C.
      Genes Dev. 20:22-27(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
      Tissue: Teratocarcinoma, Testis and Uterus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-607 (ISOFORM 2).
      Tissue: Lung, Testis and Uterus.
    7. "Identification of novel regulators of apoptosis using a high-throughput cell-based screen."
      Park K.M., Kang E., Jeon Y.-J., Kim N., Kim N.-S., Yoo H.-S., Yeom Y.I., Kim S.J.
      Mol. Cells 23:170-174(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. Cited for: FUNCTION, INVOLVEMENT IN OFDS4, VARIANT JBTS18 ARG-314.

    Entry informationi

    Entry nameiTECT3_HUMAN
    AccessioniPrimary (citable) accession number: Q6NUS6
    Secondary accession number(s): A6NIC8
    , B0QZ90, B4DR81, Q6P7P3, Q6UW27, Q6ZQQ0, Q8N7K1, Q8NBQ0, Q96GF7, Q9Y3U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3