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Q6NUQ1 (RINT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RAD50-interacting protein 1
Alternative name(s):
RAD50 interactor 1
Short name=HsRINT-1
Short name=RINT-1
Gene names
Name:RINT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length792 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control. Ref.1 Ref.6 Ref.7

Subunit structure

Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form. Ref.1 Ref.5 Ref.6 Ref.7

Subcellular location

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein Ref.5 Ref.6.

Developmental stage

Expressed throughout the cell cycle. Ref.1

Miscellaneous

According to Ref.1, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.

Sequence similarities

Belongs to the RINT1 family.

Contains 1 RINT1/TIP20 domain.

Sequence caution

The sequence AAG42101.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAQ96849.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAQ96850.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAB13910.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 792792RAD50-interacting protein 1
PRO_0000097349

Regions

Domain220 – 792573RINT1/TIP20
Coiled coil103 – 12422 Potential

Natural variations

Natural variant401S → C.
Corresponds to variant rs11556986 [ dbSNP | Ensembl ].
VAR_051322
Natural variant6681F → S.
Corresponds to variant rs35971380 [ dbSNP | Ensembl ].
VAR_034418
Natural variant7591P → L.
Corresponds to variant rs34310648 [ dbSNP | Ensembl ].
VAR_034419

Experimental info

Sequence conflict7581L → P Ref.4
Sequence conflict759 – 7602PA → ST in AAG42101. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6NUQ1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6671066FCC5E74D6

FASTA79290,632
        10         20         30         40         50         60 
MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG DLPSYVSAFI 

        70         80         90        100        110        120 
EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP KRIRSALKNA EESKQFLNQF 

       130        140        150        160        170        180 
LEQETHLFSA INSHLLTAQP WMDDLGTMIS QIEEIERHLA YLKWISQIEE LSDNIQQYLM 

       190        200        210        220        230        240 
TNNVPEAAST LVSMAELDIK LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH 

       250        260        270        280        290        300 
WPFIAPPQSQ TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP 

       310        320        330        340        350        360 
SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF LDEKIQPILD 

       370        380        390        400        410        420 
KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH LVDEVLLFER ELHSVHGYPG 

       430        440        450        460        470        480 
TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDITDV DEMKVPDCAE 

       490        500        510        520        530        540 
TFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL 

       550        560        570        580        590        600 
NAVNYISTVL ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE 

       610        620        630        640        650        660 
RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDHLL 

       670        680        690        700        710        720 
QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC 

       730        740        750        760        770        780 
KRPENYFKHI KEACIVLNLN VGSALLLKDV LQSASGQLPA TAALNEVGIY KLAQQDVEIL 

       790 
LNLRTNWPNT GK 

« Hide

References

« Hide 'large scale' references
[1]"RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control."
Xiao J., Liu C.-C., Chen P.-L., Lee W.-H.
J. Biol. Chem. 276:6105-6111(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, INTERACTION WITH RAD50.
Tissue: B-cell.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 367-792.
Tissue: Embryo.
[5]"Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH SEC22B; STX18; USE1L AND ZW10.
[6]"Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BNIP1.
[7]"The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1."
Kong L.-J., Meloni A.R., Nevins J.R.
Mol. Cell 22:63-71(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RBL2.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF317622 mRNA. Translation: AAG42101.1. Different initiation.
AC073073 Genomic DNA. Translation: AAQ96849.1. Sequence problems.
AC073073 Genomic DNA. Translation: AAQ96850.1. Sequence problems.
BC007120 mRNA. Translation: AAH07120.2.
BC068483 mRNA. Translation: AAH68483.1.
AK021847 mRNA. Translation: BAB13910.1. Different initiation.
CCDSCCDS34726.1.
RefSeqNP_068749.3. NM_021930.4.
UniGeneHs.531388.

3D structure databases

ProteinModelPortalQ6NUQ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121942. 10 interactions.
DIPDIP-36477N.
IntActQ6NUQ1. 8 interactions.
MINTMINT-1393029.
STRING9606.ENSP00000257700.

PTM databases

PhosphoSiteQ6NUQ1.

Polymorphism databases

DMDM71152944.

Proteomic databases

MaxQBQ6NUQ1.
PaxDbQ6NUQ1.
PRIDEQ6NUQ1.

Protocols and materials databases

DNASU60561.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257700; ENSP00000257700; ENSG00000135249.
GeneID60561.
KEGGhsa:60561.
UCSCuc003vda.1. human.

Organism-specific databases

CTD60561.
GeneCardsGC07P105172.
H-InvDBHIX0033650.
HGNCHGNC:21876. RINT1.
HPAHPA019875.
HPA031646.
MIM610089. gene.
neXtProtNX_Q6NUQ1.
PharmGKBPA143485595.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG244420.
HOGENOMHOG000118368.
HOVERGENHBG057727.
InParanoidQ6NUQ1.
OMAQESSCSH.
OrthoDBEOG70GMFF.
PhylomeDBQ6NUQ1.
TreeFamTF324274.

Gene expression databases

ArrayExpressQ6NUQ1.
BgeeQ6NUQ1.
CleanExHS_RINT1.
GenevestigatorQ6NUQ1.

Family and domain databases

InterProIPR007528. RINT1_TIP1.
[Graphical view]
PfamPF04437. RINT1_TIP1. 1 hit.
[Graphical view]
PROSITEPS51386. RINT1_TIP20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRINT1.
GenomeRNAi60561.
NextBio65449.
PROQ6NUQ1.
SOURCESearch...

Entry information

Entry nameRINT1_HUMAN
AccessionPrimary (citable) accession number: Q6NUQ1
Secondary accession number(s): Q75MG9 expand/collapse secondary AC list , Q75MH0, Q96IW8, Q9H229, Q9HAD9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM