Q6NUQ1 (RINT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RAD50-interacting protein 1

Alternative name(s):
RAD50 interactor 1
Short name=HsRINT-1
Short name=RINT-1

Gene names

Name:

RINT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	792 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control. Ref.1 Ref.6 Ref.7
Subunit structure	Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form. Ref.1 Ref.5 Ref.6 Ref.7
Subcellular location	Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein Ref.5 Ref.6.
Developmental stage	Expressed throughout the cell cycle. Ref.1
Miscellaneous	According to Ref.1, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.
Sequence similarities	Belongs to the RINT1 family. Contains 1 RINT1/TIP20 domain.
Sequence caution	The sequence AAG42101.1 differs from that shown. Reason: Erroneous initiation. The sequence AAQ96849.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAQ96850.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB13910.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle ER-Golgi transport Protein transport Transport
Cellular component	Cytoplasm Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	G2 DNA damage checkpoint Inferred from mutant phenotype Ref.1. Source: HGNC protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum Inferred from direct assay Ref.5. Source: HGNC endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 792	792	RAD50-interacting protein 1		PRO_0000097349
Regions
	Domain	220 – 792	573	RINT1/TIP20
	Coiled coil	103 – 124	22	Potential
Natural variations
	Natural variant	40	1	S → C. Corresponds to variant rs11556986 [ dbSNP | Ensembl ].		VAR_051322
	Natural variant	668	1	F → S. Corresponds to variant rs35971380 [ dbSNP | Ensembl ].		VAR_034418
	Natural variant	759	1	P → L. Corresponds to variant rs34310648 [ dbSNP | Ensembl ].		VAR_034419
Experimental info
	Sequence conflict	758	1	L → P Ref.4
	Sequence conflict	759 – 760	2	PA → ST in AAG42101. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6NUQ1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6671066FCC5E74D6	FASTA	792	90,632
	10 20 30 40 50 60 MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG DLPSYVSAFI 70 80 90 100 110 120 EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP KRIRSALKNA EESKQFLNQF 130 140 150 160 170 180 LEQETHLFSA INSHLLTAQP WMDDLGTMIS QIEEIERHLA YLKWISQIEE LSDNIQQYLM 190 200 210 220 230 240 TNNVPEAAST LVSMAELDIK LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH 250 260 270 280 290 300 WPFIAPPQSQ TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP 310 320 330 340 350 360 SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF LDEKIQPILD 370 380 390 400 410 420 KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH LVDEVLLFER ELHSVHGYPG 430 440 450 460 470 480 TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDITDV DEMKVPDCAE 490 500 510 520 530 540 TFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL 550 560 570 580 590 600 NAVNYISTVL ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE 610 620 630 640 650 660 RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDHLL 670 680 690 700 710 720 QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC 730 740 750 760 770 780 KRPENYFKHI KEACIVLNLN VGSALLLKDV LQSASGQLPA TAALNEVGIY KLAQQDVEIL 790 LNLRTNWPNT GK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control." Xiao J., Liu C.-C., Chen P.-L., Lee W.-H. J. Biol. Chem. 276:6105-6111(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, INTERACTION WITH RAD50. Tissue: B-cell.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 367-792. Tissue: Embryo.
[5]	"Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi." Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M. EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH SEC22B; STX18; USE1L AND ZW10.
[6]	"Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion." Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M. EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BNIP1.
[7]	"The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1." Kong L.-J., Meloni A.R., Nevins J.R. Mol. Cell 22:63-71(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RBL2.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317622 mRNA. Translation: AAG42101.1. Different initiation. AC073073 Genomic DNA. Translation: AAQ96849.1. Sequence problems. AC073073 Genomic DNA. Translation: AAQ96850.1. Sequence problems. BC007120 mRNA. Translation: AAH07120.2. BC068483 mRNA. Translation: AAH68483.1. AK021847 mRNA. Translation: BAB13910.1. Different initiation.
IPI	IPI00072224.
RefSeq	NP_068749.3. NM_021930.4.
UniGene	Hs.531388.
3D structure databases
ProteinModelPortal	Q6NUQ1.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-36477N.
IntAct	Q6NUQ1. 7 interactions.
MINT	MINT-1393029.
STRING	9606.ENSP00000257700.
PTM databases
PhosphoSite	Q6NUQ1.
Polymorphism databases
DMDM	71152944.
Proteomic databases
PaxDb	Q6NUQ1.
PRIDE	Q6NUQ1.
Protocols and materials databases
DNASU	60561.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257700; ENSP00000257700; ENSG00000135249.
GeneID	60561.
KEGG	hsa:60561.
UCSC	uc003vda.1. human.
Organism-specific databases
CTD	60561.
GeneCards	GC07P105172.
H-InvDB	HIX0033650.
HGNC	HGNC:21876. RINT1.
HPA	HPA019875.
MIM	610089. gene.
neXtProt	NX_Q6NUQ1.
PharmGKB	PA143485595.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG244420.
HOGENOM	HOG000118368.
HOVERGEN	HBG057727.
InParanoid	Q6NUQ1.
OMA	NIQQYLM.
OrthoDB	EOG47SSD3.
Gene expression databases
ArrayExpress	Q6NUQ1.
Bgee	Q6NUQ1.
CleanEx	HS_RINT1.
Genevestigator	Q6NUQ1.
GermOnline	ENSG00000135249. Homo sapiens.
Family and domain databases
InterPro	IPR007528. RINT1_TIP1. [Graphical view]
Pfam	PF04437. RINT1_TIP1. 1 hit. [Graphical view]
PROSITE	PS51386. RINT1_TIP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	60561.
NextBio	65449.
SOURCE	Search...

Entry information

Entry name

RINT1_HUMAN

Accession

Primary (citable) accession number: Q6NUQ1
Secondary accession number(s): Q75MG9 , Q75MH0, Q96IW8, Q9H229, Q9HAD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.