Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6NUQ1

- RINT1_HUMAN

UniProt

Q6NUQ1 - RINT1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RAD50-interacting protein 1

Gene

RINT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control.3 Publications

GO - Biological processi

  1. G2 DNA damage checkpoint Source: HGNC
  2. protein transport Source: UniProtKB-KW
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
RAD50-interacting protein 1
Alternative name(s):
RAD50 interactor 1
Short name:
HsRINT-1
Short name:
RINT-1
Gene namesi
Name:RINT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21876. RINT1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: HGNC
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 792792RAD50-interacting protein 1PRO_0000097349Add
BLAST

Proteomic databases

MaxQBiQ6NUQ1.
PaxDbiQ6NUQ1.
PRIDEiQ6NUQ1.

PTM databases

PhosphoSiteiQ6NUQ1.

Expressioni

Developmental stagei

Expressed throughout the cell cycle.1 Publication

Gene expression databases

BgeeiQ6NUQ1.
CleanExiHS_RINT1.
ExpressionAtlasiQ6NUQ1. baseline and differential.
GenevestigatoriQ6NUQ1.

Organism-specific databases

HPAiHPA019875.
HPA031646.

Interactioni

Subunit structurei

Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form.4 Publications

Protein-protein interaction databases

BioGridi121942. 16 interactions.
DIPiDIP-36477N.
IntActiQ6NUQ1. 8 interactions.
MINTiMINT-1393029.
STRINGi9606.ENSP00000257700.

Structurei

3D structure databases

ProteinModelPortaliQ6NUQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 792573RINT1/TIP20PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili103 – 12422Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the RINT1 family.Curated
Contains 1 RINT1/TIP20 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG244420.
GeneTreeiENSGT00390000017006.
HOGENOMiHOG000118368.
HOVERGENiHBG057727.
InParanoidiQ6NUQ1.
OMAiQESSCSH.
OrthoDBiEOG70GMFF.
PhylomeDBiQ6NUQ1.
TreeFamiTF324274.

Family and domain databases

InterProiIPR007528. RINT1_TIP1.
[Graphical view]
PfamiPF04437. RINT1_TIP1. 1 hit.
[Graphical view]
PROSITEiPS51386. RINT1_TIP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NUQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG
60 70 80 90 100
DLPSYVSAFI EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP
110 120 130 140 150
KRIRSALKNA EESKQFLNQF LEQETHLFSA INSHLLTAQP WMDDLGTMIS
160 170 180 190 200
QIEEIERHLA YLKWISQIEE LSDNIQQYLM TNNVPEAAST LVSMAELDIK
210 220 230 240 250
LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH WPFIAPPQSQ
260 270 280 290 300
TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP
310 320 330 340 350
SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF
360 370 380 390 400
LDEKIQPILD KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH
410 420 430 440 450
LVDEVLLFER ELHSVHGYPG TFASCMHILS EETCFQRWLT VERKFALQKM
460 470 480 490 500
DSMLSSEAAW VSQYKDITDV DEMKVPDCAE TFMTLLLVIT DRYKNLPTAS
510 520 530 540 550
RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL NAVNYISTVL
560 570 580 590 600
ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE
610 620 630 640 650
RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP
660 670 680 690 700
LLLTLRDHLL QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG
710 720 730 740 750
AAQLQFDMTR NLFPLFSHYC KRPENYFKHI KEACIVLNLN VGSALLLKDV
760 770 780 790
LQSASGQLPA TAALNEVGIY KLAQQDVEIL LNLRTNWPNT GK
Length:792
Mass (Da):90,632
Last modified:July 5, 2004 - v1
Checksum:i6671066FCC5E74D6
GO

Sequence cautioni

The sequence AAG42101.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB13910.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAQ96849.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AAQ96850.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti758 – 7581L → P(PubMed:14702039)Curated
Sequence conflicti759 – 7602PA → ST in AAG42101. (PubMed:11096100)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401S → C.
Corresponds to variant rs11556986 [ dbSNP | Ensembl ].
VAR_051322
Natural varianti668 – 6681F → S.
Corresponds to variant rs35971380 [ dbSNP | Ensembl ].
VAR_034418
Natural varianti759 – 7591P → L.
Corresponds to variant rs34310648 [ dbSNP | Ensembl ].
VAR_034419

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317622 mRNA. Translation: AAG42101.1. Different initiation.
AC073073 Genomic DNA. Translation: AAQ96849.1. Sequence problems.
AC073073 Genomic DNA. Translation: AAQ96850.1. Sequence problems.
BC007120 mRNA. Translation: AAH07120.2.
BC068483 mRNA. Translation: AAH68483.1.
AK021847 mRNA. Translation: BAB13910.1. Different initiation.
CCDSiCCDS34726.1.
RefSeqiNP_068749.3. NM_021930.4.
UniGeneiHs.531388.

Genome annotation databases

EnsembliENST00000257700; ENSP00000257700; ENSG00000135249.
GeneIDi60561.
KEGGihsa:60561.
UCSCiuc003vda.1. human.

Polymorphism databases

DMDMi71152944.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317622 mRNA. Translation: AAG42101.1 . Different initiation.
AC073073 Genomic DNA. Translation: AAQ96849.1 . Sequence problems.
AC073073 Genomic DNA. Translation: AAQ96850.1 . Sequence problems.
BC007120 mRNA. Translation: AAH07120.2 .
BC068483 mRNA. Translation: AAH68483.1 .
AK021847 mRNA. Translation: BAB13910.1 . Different initiation.
CCDSi CCDS34726.1.
RefSeqi NP_068749.3. NM_021930.4.
UniGenei Hs.531388.

3D structure databases

ProteinModelPortali Q6NUQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121942. 16 interactions.
DIPi DIP-36477N.
IntActi Q6NUQ1. 8 interactions.
MINTi MINT-1393029.
STRINGi 9606.ENSP00000257700.

PTM databases

PhosphoSitei Q6NUQ1.

Polymorphism databases

DMDMi 71152944.

Proteomic databases

MaxQBi Q6NUQ1.
PaxDbi Q6NUQ1.
PRIDEi Q6NUQ1.

Protocols and materials databases

DNASUi 60561.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257700 ; ENSP00000257700 ; ENSG00000135249 .
GeneIDi 60561.
KEGGi hsa:60561.
UCSCi uc003vda.1. human.

Organism-specific databases

CTDi 60561.
GeneCardsi GC07P105172.
H-InvDB HIX0033650.
HGNCi HGNC:21876. RINT1.
HPAi HPA019875.
HPA031646.
MIMi 610089. gene.
neXtProti NX_Q6NUQ1.
PharmGKBi PA143485595.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244420.
GeneTreei ENSGT00390000017006.
HOGENOMi HOG000118368.
HOVERGENi HBG057727.
InParanoidi Q6NUQ1.
OMAi QESSCSH.
OrthoDBi EOG70GMFF.
PhylomeDBi Q6NUQ1.
TreeFami TF324274.

Miscellaneous databases

GeneWikii RINT1.
GenomeRNAii 60561.
NextBioi 65449.
PROi Q6NUQ1.
SOURCEi Search...

Gene expression databases

Bgeei Q6NUQ1.
CleanExi HS_RINT1.
ExpressionAtlasi Q6NUQ1. baseline and differential.
Genevestigatori Q6NUQ1.

Family and domain databases

InterProi IPR007528. RINT1_TIP1.
[Graphical view ]
Pfami PF04437. RINT1_TIP1. 1 hit.
[Graphical view ]
PROSITEi PS51386. RINT1_TIP20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control."
    Xiao J., Liu C.-C., Chen P.-L., Lee W.-H.
    J. Biol. Chem. 276:6105-6111(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, INTERACTION WITH RAD50.
    Tissue: B-cell.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 367-792.
    Tissue: Embryo.
  5. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
    Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
    EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH SEC22B; STX18; USE1L AND ZW10.
  6. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
    Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
    EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BNIP1.
  7. "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1."
    Kong L.-J., Meloni A.R., Nevins J.R.
    Mol. Cell 22:63-71(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RBL2.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRINT1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUQ1
Secondary accession number(s): Q75MG9
, Q75MH0, Q96IW8, Q9H229, Q9HAD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

According to PubMed:11096100, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3