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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 4

Gene

PPP4R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of serine/threonine-protein phosphatase 4.

GO - Molecular functioni

  • protein phosphatase regulator activity Source: MGI

GO - Biological processi

  • negative regulation of phosphoprotein phosphatase activity Source: MGI
  • regulation of protein serine/threonine phosphatase activity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 4
Gene namesi
Name:PPP4R4
Synonyms:KIAA1622, PP4R4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23788. PPP4R4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • protein serine/threonine phosphatase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi501R → W: Abolishes interaction with PPP4C. 1 Publication1
Mutagenesisi618V → A: Diminishes interaction with PPP4C. 1 Publication1
Mutagenesisi618V → D: Abolishes interaction with PPP4C. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000119698.
ENSG00000278326.
PharmGKBiPA164724938.

Polymorphism and mutation databases

BioMutaiPPP4R4.
DMDMi74736832.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118501 – 873Serine/threonine-protein phosphatase 4 regulatory subunit 4Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei775PhosphoserineBy similarity1
Modified residuei797PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NUP7.
MaxQBiQ6NUP7.
PaxDbiQ6NUP7.
PeptideAtlasiQ6NUP7.
PRIDEiQ6NUP7.

PTM databases

iPTMnetiQ6NUP7.
PhosphoSitePlusiQ6NUP7.

Expressioni

Gene expression databases

BgeeiENSG00000119698.
CleanExiHS_PPP4R4.
ExpressionAtlasiQ6NUP7. baseline and differential.
GenevisibleiQ6NUP7. HS.

Organism-specific databases

HPAiHPA041866.
HPA050321.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP4CP605106EBI-1774189,EBI-1046072

Protein-protein interaction databases

BioGridi121741. 3 interactors.
IntActiQ6NUP7. 3 interactors.
MINTiMINT-4905889.
STRINGi9606.ENSP00000305924.

Structurei

3D structure databases

ProteinModelPortaliQ6NUP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati213 – 251HEAT 1Add BLAST39
Repeati252 – 290HEAT 2Add BLAST39
Repeati392 – 427HEAT 3Add BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili686 – 720Sequence analysisAdd BLAST35

Sequence similaritiesi

Contains 3 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IUDH. Eukaryota.
ENOG410XPMD. LUCA.
GeneTreeiENSGT00510000047895.
HOGENOMiHOG000115653.
HOVERGENiHBG098096.
InParanoidiQ6NUP7.
KOiK15426.
OMAiLYGIFTP.
OrthoDBiEOG091G08F6.
PhylomeDBiQ6NUP7.
TreeFamiTF313717.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPPPPAAAM DFSQNSLFGY MEDLQELTII ERPVRRSLKT PEEIERLTVD
60 70 80 90 100
EDLSDIERAV YLLSAGQDVQ GTSVIANLPF LMRQNPTETL RRVLPKVREA
110 120 130 140 150
LHVAGVEMQL TAAMSFLTIL QDESVSIHAY THSFLQVILL HLEHRDTGVS
160 170 180 190 200
NAWLETLLSV IEVLPKETLR HEILNPLVSK AQLSQTVQSR LVSCKILGKL
210 220 230 240 250
TNKFDAHTIK REILPLVKSL CQDVEYEVRS CMCRQLENIA QGIGTELTKS
260 270 280 290 300
VVLPELIELS RDEGSSVRLA AFETLVNLLD IFDTDDRSQT ILPLVKSFCE
310 320 330 340 350
KSFKADESIL ISLSFHLGKL CHGLYGIFTP DQHLRFLEFY KKLCTLGLQQ
360 370 380 390 400
ENGHNENQIP PQILEQEKKY ISVRKNCAYN FPAMIVFVDP KNFHMELYST
410 420 430 440 450
FFCLCHDPEV PVRYTIAICF YEVSKLLNSG VYLIHKELIT LLQDESLEVL
460 470 480 490 500
DALIDHLPEI LELMSTGGES SVQENKLSSL PDLIPALTAA EQRAAASLKW
510 520 530 540 550
RTHEKLLQKY ACLPHVISSD QIYYRFLQRM FTIMMTNNVL PVQKAASRTL
560 570 580 590 600
CIFLRYNRKQ EQRHEVIQKL IEQLGQGKSY WNRLRFLDTC EFIIEIFSKS
610 620 630 640 650
FFCKYFFLPA IELTHDPVAN VRMKLCYLLP KVKSTLKIPA DKHLLQQLEM
660 670 680 690 700
CVRKLLCQEK DKDVLAIVKR TVLELDRMEM SMDAFQKKFY EKDLLDQEKE
710 720 730 740 750
REELLLLEME QLEKEKQQND GRPMSDKMFE KKRRDTKTPT QSLPKNIPIS
760 770 780 790 800
VPGPSSVTPS TSKEIKKSKL IRSQSFNNQA FHAKYGNLEK CASKSSTTGY
810 820 830 840 850
TTSVSGLGKT SVLSLADDSF RTRNASSVPS SFSPNTPLPS TSRGTGNSVD
860 870
PKSSGSKDTQ PRKATLKSRK SNP
Length:873
Mass (Da):99,452
Last modified:July 5, 2004 - v1
Checksum:i9C1A9CD4584447C1
GO
Isoform 2 (identifier: Q6NUP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-120: EALHVAGVEMQLTAAMSFLTIL → VHEDAHLFIQRVWISHMFVQRV
     121-873: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,894
Checksum:i0B935EB2909EBB6A
GO

Sequence cautioni

The sequence BAB13448 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02961699 – 120EALHV…FLTIL → VHEDAHLFIQRVWISHMFVQ RV in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_029617121 – 873Missing in isoform 2. 1 PublicationAdd BLAST753

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046842 mRNA. Translation: BAB13448.1. Different initiation.
CH471061 Genomic DNA. Translation: EAW81561.1.
CH471061 Genomic DNA. Translation: EAW81562.1.
BC002650 mRNA. Translation: AAH02650.2.
BC068491 mRNA. Translation: AAH68491.1.
CCDSiCCDS9921.1. [Q6NUP7-1]
CCDS9922.1. [Q6NUP7-2]
RefSeqiNP_066009.2. NM_020958.2. [Q6NUP7-2]
NP_478144.1. NM_058237.1. [Q6NUP7-1]
UniGeneiHs.259599.

Genome annotation databases

EnsembliENST00000304338; ENSP00000305924; ENSG00000119698. [Q6NUP7-1]
ENST00000328839; ENSP00000330831; ENSG00000119698. [Q6NUP7-2]
ENST00000614957; ENSP00000482849; ENSG00000278326. [Q6NUP7-2]
ENST00000619905; ENSP00000480902; ENSG00000278326. [Q6NUP7-1]
GeneIDi57718.
KEGGihsa:57718.
UCSCiuc001ycr.4. human. [Q6NUP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046842 mRNA. Translation: BAB13448.1. Different initiation.
CH471061 Genomic DNA. Translation: EAW81561.1.
CH471061 Genomic DNA. Translation: EAW81562.1.
BC002650 mRNA. Translation: AAH02650.2.
BC068491 mRNA. Translation: AAH68491.1.
CCDSiCCDS9921.1. [Q6NUP7-1]
CCDS9922.1. [Q6NUP7-2]
RefSeqiNP_066009.2. NM_020958.2. [Q6NUP7-2]
NP_478144.1. NM_058237.1. [Q6NUP7-1]
UniGeneiHs.259599.

3D structure databases

ProteinModelPortaliQ6NUP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121741. 3 interactors.
IntActiQ6NUP7. 3 interactors.
MINTiMINT-4905889.
STRINGi9606.ENSP00000305924.

PTM databases

iPTMnetiQ6NUP7.
PhosphoSitePlusiQ6NUP7.

Polymorphism and mutation databases

BioMutaiPPP4R4.
DMDMi74736832.

Proteomic databases

EPDiQ6NUP7.
MaxQBiQ6NUP7.
PaxDbiQ6NUP7.
PeptideAtlasiQ6NUP7.
PRIDEiQ6NUP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304338; ENSP00000305924; ENSG00000119698. [Q6NUP7-1]
ENST00000328839; ENSP00000330831; ENSG00000119698. [Q6NUP7-2]
ENST00000614957; ENSP00000482849; ENSG00000278326. [Q6NUP7-2]
ENST00000619905; ENSP00000480902; ENSG00000278326. [Q6NUP7-1]
GeneIDi57718.
KEGGihsa:57718.
UCSCiuc001ycr.4. human. [Q6NUP7-1]

Organism-specific databases

CTDi57718.
GeneCardsiPPP4R4.
HGNCiHGNC:23788. PPP4R4.
HPAiHPA041866.
HPA050321.
neXtProtiNX_Q6NUP7.
OpenTargetsiENSG00000119698.
ENSG00000278326.
PharmGKBiPA164724938.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUDH. Eukaryota.
ENOG410XPMD. LUCA.
GeneTreeiENSGT00510000047895.
HOGENOMiHOG000115653.
HOVERGENiHBG098096.
InParanoidiQ6NUP7.
KOiK15426.
OMAiLYGIFTP.
OrthoDBiEOG091G08F6.
PhylomeDBiQ6NUP7.
TreeFamiTF313717.

Miscellaneous databases

GenomeRNAii57718.
PROiQ6NUP7.

Gene expression databases

BgeeiENSG00000119698.
CleanExiHS_PPP4R4.
ExpressionAtlasiQ6NUP7. baseline and differential.
GenevisibleiQ6NUP7. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP4R4_HUMAN
AccessioniPrimary (citable) accession number: Q6NUP7
Secondary accession number(s): Q9BUF8, Q9HCF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.