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Q6NUN7

- CK063_HUMAN

UniProt

Q6NUN7 - CK063_HUMAN

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Protein

Uncharacterized protein C11orf63

Gene

C11orf63

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. axoneme assembly Source: Ensembl
  2. brain development Source: Ensembl
  3. cerebrospinal fluid secretion Source: Ensembl
  4. ciliary basal body organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C11orf63
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:26288. C11orf63.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 778778Uncharacterized protein C11orf63PRO_0000280764Add
BLAST

Proteomic databases

PaxDbiQ6NUN7.
PRIDEiQ6NUN7.

PTM databases

PhosphoSiteiQ6NUN7.

Expressioni

Gene expression databases

BgeeiQ6NUN7.
CleanExiHS_C11orf63.
GenevestigatoriQ6NUN7.

Organism-specific databases

HPAiHPA039612.
HPA040344.

Interactioni

Protein-protein interaction databases

BioGridi122952. 4 interactions.
IntActiQ6NUN7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6NUN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG42552.
GeneTreeiENSGT00390000002823.
HOGENOMiHOG000013118.
HOVERGENiHBG081220.
InParanoidiQ6NUN7.
OMAiTQIMEQH.
OrthoDBiEOG7JQBMZ.
PhylomeDBiQ6NUN7.
TreeFamiTF335473.

Family and domain databases

InterProiIPR027968. DUF4591.
[Graphical view]
PfamiPF15261. DUF4591. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NUN7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKRKLIPKL SIQSPVLHTN LNVQSTHPPL KKEDLHRISK DSLESDSESL
60 70 80 90 100
TQEIMCHSEF DDRIRGNGME PDSLDEEESP RWGSLHEMEE EASGKAAQMA
110 120 130 140 150
REQNHHTWDQ GANNRQQPIE DKYSDLRYDP NWKSKKEEGQ LLSVEALPES
160 170 180 190 200
TDSSLENLPL APLYPSQETS MELSGGKGEQ KESPQSAASL LGSEFLSPNY
210 220 230 240 250
EHGARRSKPF SELSDSDLEE KSSSLSPYVK SSSSHNEVFL PGSRGPRRRK
260 270 280 290 300
SKQHFVEKNK LTLGLPTPKT DSYLQLHNKK RGESHPEQIS YPVRVTDKTS
310 320 330 340 350
IQNAKEMENA AIDPEDKWHQ RAQQLKNYQE HWSQYESTKS SNVPRGQPSD
360 370 380 390 400
MVNDHQPSRR PAKLKIRKQC KHQNGLKSST TEEVTASQGN QNNPPRQQQN
410 420 430 440 450
QNKPLDTSTK PESIVIMHAS NNDVQASRAL RSHNLKETSN TFAPPKQAFD
460 470 480 490 500
KVLSKNSTGC DSGLNVNKER GHKDQEEKRF SYQQLHTLSD MDLNNLNELS
510 520 530 540 550
KRHVLLSQKG SQFVYHINTH GSTKNKKQLK QPYTETKYRN LEMLWKFHSS
560 570 580 590 600
SDSQTVRASP DSWLTQIMEQ HQQALVQLTD VQPSEGALSS VTLPPILSRV
610 620 630 640 650
ESESQLSSER SQRNQVKISR SNSEGYLFQL EKGKKHKKRS SSKNTKLKGY
660 670 680 690 700
QKRDVKLGGL GPDFESIRDK TQKLIQQKEY AKQVKEYNMK TLSILSKPQT
710 720 730 740 750
EKTQKKSAIP RQKALEYAKT IPKPKPSNLT HQASKEQKNP TYAGKEESLP
760 770
EISLLEILQN RHEREKQAVA AFKVLHIV
Length:778
Mass (Da):88,569
Last modified:July 5, 2004 - v1
Checksum:i200CB1C2263524FE
GO
Isoform 2 (identifier: Q6NUN7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-307: ISYPVRVTDKTSIQNAKEM → VILRVNSLPRDGFKTFWSQ
     308-778: Missing.

Show »
Length:307
Mass (Da):34,771
Checksum:iE0C6DEC1BED8F070
GO

Sequence cautioni

The sequence AAH09820.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15691.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951V → A in BAB15691. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti486 – 4861H → R.
Corresponds to variant rs33999612 [ dbSNP | Ensembl ].
VAR_050863

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei289 – 30719ISYPV…NAKEM → VILRVNSLPRDGFKTFWSQ in isoform 2. 1 PublicationVSP_023915Add
BLAST
Alternative sequencei308 – 778471Missing in isoform 2. 1 PublicationVSP_023916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027207 mRNA. Translation: BAB15691.1. Different initiation.
AK291625 mRNA. Translation: BAF84314.1.
CH471065 Genomic DNA. Translation: EAW67533.1.
BC009820 mRNA. Translation: AAH09820.2. Different initiation.
BC068507 mRNA. Translation: AAH68507.1.
CCDSiCCDS8438.1. [Q6NUN7-1]
CCDS8439.1. [Q6NUN7-2]
RefSeqiNP_079082.2. NM_024806.3. [Q6NUN7-1]
NP_954575.1. NM_199124.2. [Q6NUN7-2]
XP_005271736.1. XM_005271679.2. [Q6NUN7-1]
XP_005271737.1. XM_005271680.2. [Q6NUN7-1]
UniGeneiHs.164705.

Genome annotation databases

EnsembliENST00000227349; ENSP00000227349; ENSG00000109944. [Q6NUN7-1]
ENST00000307257; ENSP00000307695; ENSG00000109944. [Q6NUN7-2]
ENST00000531316; ENSP00000431669; ENSG00000109944. [Q6NUN7-1]
GeneIDi79864.
KEGGihsa:79864.
UCSCiuc001pyl.2. human. [Q6NUN7-2]
uc001pym.4. human. [Q6NUN7-1]

Polymorphism databases

DMDMi74736827.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027207 mRNA. Translation: BAB15691.1 . Different initiation.
AK291625 mRNA. Translation: BAF84314.1 .
CH471065 Genomic DNA. Translation: EAW67533.1 .
BC009820 mRNA. Translation: AAH09820.2 . Different initiation.
BC068507 mRNA. Translation: AAH68507.1 .
CCDSi CCDS8438.1. [Q6NUN7-1 ]
CCDS8439.1. [Q6NUN7-2 ]
RefSeqi NP_079082.2. NM_024806.3. [Q6NUN7-1 ]
NP_954575.1. NM_199124.2. [Q6NUN7-2 ]
XP_005271736.1. XM_005271679.2. [Q6NUN7-1 ]
XP_005271737.1. XM_005271680.2. [Q6NUN7-1 ]
UniGenei Hs.164705.

3D structure databases

ProteinModelPortali Q6NUN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122952. 4 interactions.
IntActi Q6NUN7. 1 interaction.

PTM databases

PhosphoSitei Q6NUN7.

Polymorphism databases

DMDMi 74736827.

Proteomic databases

PaxDbi Q6NUN7.
PRIDEi Q6NUN7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227349 ; ENSP00000227349 ; ENSG00000109944 . [Q6NUN7-1 ]
ENST00000307257 ; ENSP00000307695 ; ENSG00000109944 . [Q6NUN7-2 ]
ENST00000531316 ; ENSP00000431669 ; ENSG00000109944 . [Q6NUN7-1 ]
GeneIDi 79864.
KEGGi hsa:79864.
UCSCi uc001pyl.2. human. [Q6NUN7-2 ]
uc001pym.4. human. [Q6NUN7-1 ]

Organism-specific databases

CTDi 79864.
GeneCardsi GC11P122753.
HGNCi HGNC:26288. C11orf63.
HPAi HPA039612.
HPA040344.
neXtProti NX_Q6NUN7.
PharmGKBi PA143485358.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42552.
GeneTreei ENSGT00390000002823.
HOGENOMi HOG000013118.
HOVERGENi HBG081220.
InParanoidi Q6NUN7.
OMAi TQIMEQH.
OrthoDBi EOG7JQBMZ.
PhylomeDBi Q6NUN7.
TreeFami TF335473.

Miscellaneous databases

ChiTaRSi C11orf63. human.
GenomeRNAii 79864.
NextBioi 69604.

Gene expression databases

Bgeei Q6NUN7.
CleanExi HS_C11orf63.
Genevestigatori Q6NUN7.

Family and domain databases

InterProi IPR027968. DUF4591.
[Graphical view ]
Pfami PF15261. DUF4591. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-778 (ISOFORM 2).
    Tissue: Lung and Testis.

Entry informationi

Entry nameiCK063_HUMAN
AccessioniPrimary (citable) accession number: Q6NUN7
Secondary accession number(s): A8K6G0, Q96GB5, Q9H5D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3