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Q6NUN7 (CK063_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C11orf63
Gene names
Name:C11orf63
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length778 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAH09820.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAB15691.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NUN7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NUN7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     289-307: ISYPVRVTDKTSIQNAKEM → VILRVNSLPRDGFKTFWSQ
     308-778: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 778778Uncharacterized protein C11orf63
PRO_0000280764

Natural variations

Alternative sequence289 – 30719ISYPV…NAKEM → VILRVNSLPRDGFKTFWSQ in isoform 2.
VSP_023915
Alternative sequence308 – 778471Missing in isoform 2.
VSP_023916
Natural variant4861H → R.
Corresponds to variant rs33999612 [ dbSNP | Ensembl ].
VAR_050863

Experimental info

Sequence conflict2951V → A in BAB15691. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 200CB1C2263524FE

FASTA77888,569
        10         20         30         40         50         60 
MSKRKLIPKL SIQSPVLHTN LNVQSTHPPL KKEDLHRISK DSLESDSESL TQEIMCHSEF 

        70         80         90        100        110        120 
DDRIRGNGME PDSLDEEESP RWGSLHEMEE EASGKAAQMA REQNHHTWDQ GANNRQQPIE 

       130        140        150        160        170        180 
DKYSDLRYDP NWKSKKEEGQ LLSVEALPES TDSSLENLPL APLYPSQETS MELSGGKGEQ 

       190        200        210        220        230        240 
KESPQSAASL LGSEFLSPNY EHGARRSKPF SELSDSDLEE KSSSLSPYVK SSSSHNEVFL 

       250        260        270        280        290        300 
PGSRGPRRRK SKQHFVEKNK LTLGLPTPKT DSYLQLHNKK RGESHPEQIS YPVRVTDKTS 

       310        320        330        340        350        360 
IQNAKEMENA AIDPEDKWHQ RAQQLKNYQE HWSQYESTKS SNVPRGQPSD MVNDHQPSRR 

       370        380        390        400        410        420 
PAKLKIRKQC KHQNGLKSST TEEVTASQGN QNNPPRQQQN QNKPLDTSTK PESIVIMHAS 

       430        440        450        460        470        480 
NNDVQASRAL RSHNLKETSN TFAPPKQAFD KVLSKNSTGC DSGLNVNKER GHKDQEEKRF 

       490        500        510        520        530        540 
SYQQLHTLSD MDLNNLNELS KRHVLLSQKG SQFVYHINTH GSTKNKKQLK QPYTETKYRN 

       550        560        570        580        590        600 
LEMLWKFHSS SDSQTVRASP DSWLTQIMEQ HQQALVQLTD VQPSEGALSS VTLPPILSRV 

       610        620        630        640        650        660 
ESESQLSSER SQRNQVKISR SNSEGYLFQL EKGKKHKKRS SSKNTKLKGY QKRDVKLGGL 

       670        680        690        700        710        720 
GPDFESIRDK TQKLIQQKEY AKQVKEYNMK TLSILSKPQT EKTQKKSAIP RQKALEYAKT 

       730        740        750        760        770 
IPKPKPSNLT HQASKEQKNP TYAGKEESLP EISLLEILQN RHEREKQAVA AFKVLHIV 

« Hide

Isoform 2 [UniParc].

Checksum: E0C6DEC1BED8F070
Show »

FASTA30734,771

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung and Placenta.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-778 (ISOFORM 2).
Tissue: Lung and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027207 mRNA. Translation: BAB15691.1. Different initiation.
AK291625 mRNA. Translation: BAF84314.1.
CH471065 Genomic DNA. Translation: EAW67533.1.
BC009820 mRNA. Translation: AAH09820.2. Different initiation.
BC068507 mRNA. Translation: AAH68507.1.
RefSeqNP_079082.2. NM_024806.3.
NP_954575.1. NM_199124.2.
XP_005271736.1. XM_005271679.2.
XP_005271737.1. XM_005271680.2.
UniGeneHs.164705.

3D structure databases

ProteinModelPortalQ6NUN7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122952. 4 interactions.
IntActQ6NUN7. 1 interaction.

PTM databases

PhosphoSiteQ6NUN7.

Polymorphism databases

DMDM74736827.

Proteomic databases

PaxDbQ6NUN7.
PRIDEQ6NUN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000227349; ENSP00000227349; ENSG00000109944. [Q6NUN7-1]
ENST00000307257; ENSP00000307695; ENSG00000109944. [Q6NUN7-2]
ENST00000531316; ENSP00000431669; ENSG00000109944. [Q6NUN7-1]
GeneID79864.
KEGGhsa:79864.
UCSCuc001pyl.2. human. [Q6NUN7-2]
uc001pym.4. human. [Q6NUN7-1]

Organism-specific databases

CTD79864.
GeneCardsGC11P122753.
HGNCHGNC:26288. C11orf63.
HPAHPA039612.
HPA040344.
neXtProtNX_Q6NUN7.
PharmGKBPA143485358.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42552.
HOGENOMHOG000013118.
HOVERGENHBG081220.
InParanoidQ6NUN7.
OMATQIMEQH.
OrthoDBEOG7JQBMZ.
PhylomeDBQ6NUN7.
TreeFamTF335473.

Gene expression databases

BgeeQ6NUN7.
CleanExHS_C11orf63.
GenevestigatorQ6NUN7.

Family and domain databases

InterProIPR027968. DUF4591.
[Graphical view]
PfamPF15261. DUF4591. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC11orf63. human.
GenomeRNAi79864.
NextBio69604.

Entry information

Entry nameCK063_HUMAN
AccessionPrimary (citable) accession number: Q6NUN7
Secondary accession number(s): A8K6G0, Q96GB5, Q9H5D6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM