Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6NUN7

- CK063_HUMAN

UniProt

Q6NUN7 - CK063_HUMAN

Protein

Uncharacterized protein C11orf63

Gene

C11orf63

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C11orf63
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:26288. C11orf63.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485358.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 778778Uncharacterized protein C11orf63PRO_0000280764Add
    BLAST

    Proteomic databases

    PaxDbiQ6NUN7.
    PRIDEiQ6NUN7.

    PTM databases

    PhosphoSiteiQ6NUN7.

    Expressioni

    Gene expression databases

    BgeeiQ6NUN7.
    CleanExiHS_C11orf63.
    GenevestigatoriQ6NUN7.

    Organism-specific databases

    HPAiHPA039612.
    HPA040344.

    Interactioni

    Protein-protein interaction databases

    BioGridi122952. 4 interactions.
    IntActiQ6NUN7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NUN7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG42552.
    HOGENOMiHOG000013118.
    HOVERGENiHBG081220.
    InParanoidiQ6NUN7.
    OMAiTQIMEQH.
    OrthoDBiEOG7JQBMZ.
    PhylomeDBiQ6NUN7.
    TreeFamiTF335473.

    Family and domain databases

    InterProiIPR027968. DUF4591.
    [Graphical view]
    PfamiPF15261. DUF4591. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NUN7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKRKLIPKL SIQSPVLHTN LNVQSTHPPL KKEDLHRISK DSLESDSESL    50
    TQEIMCHSEF DDRIRGNGME PDSLDEEESP RWGSLHEMEE EASGKAAQMA 100
    REQNHHTWDQ GANNRQQPIE DKYSDLRYDP NWKSKKEEGQ LLSVEALPES 150
    TDSSLENLPL APLYPSQETS MELSGGKGEQ KESPQSAASL LGSEFLSPNY 200
    EHGARRSKPF SELSDSDLEE KSSSLSPYVK SSSSHNEVFL PGSRGPRRRK 250
    SKQHFVEKNK LTLGLPTPKT DSYLQLHNKK RGESHPEQIS YPVRVTDKTS 300
    IQNAKEMENA AIDPEDKWHQ RAQQLKNYQE HWSQYESTKS SNVPRGQPSD 350
    MVNDHQPSRR PAKLKIRKQC KHQNGLKSST TEEVTASQGN QNNPPRQQQN 400
    QNKPLDTSTK PESIVIMHAS NNDVQASRAL RSHNLKETSN TFAPPKQAFD 450
    KVLSKNSTGC DSGLNVNKER GHKDQEEKRF SYQQLHTLSD MDLNNLNELS 500
    KRHVLLSQKG SQFVYHINTH GSTKNKKQLK QPYTETKYRN LEMLWKFHSS 550
    SDSQTVRASP DSWLTQIMEQ HQQALVQLTD VQPSEGALSS VTLPPILSRV 600
    ESESQLSSER SQRNQVKISR SNSEGYLFQL EKGKKHKKRS SSKNTKLKGY 650
    QKRDVKLGGL GPDFESIRDK TQKLIQQKEY AKQVKEYNMK TLSILSKPQT 700
    EKTQKKSAIP RQKALEYAKT IPKPKPSNLT HQASKEQKNP TYAGKEESLP 750
    EISLLEILQN RHEREKQAVA AFKVLHIV 778
    Length:778
    Mass (Da):88,569
    Last modified:July 5, 2004 - v1
    Checksum:i200CB1C2263524FE
    GO
    Isoform 2 (identifier: Q6NUN7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         289-307: ISYPVRVTDKTSIQNAKEM → VILRVNSLPRDGFKTFWSQ
         308-778: Missing.

    Show »
    Length:307
    Mass (Da):34,771
    Checksum:iE0C6DEC1BED8F070
    GO

    Sequence cautioni

    The sequence AAH09820.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15691.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951V → A in BAB15691. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti486 – 4861H → R.
    Corresponds to variant rs33999612 [ dbSNP | Ensembl ].
    VAR_050863

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei289 – 30719ISYPV…NAKEM → VILRVNSLPRDGFKTFWSQ in isoform 2. 1 PublicationVSP_023915Add
    BLAST
    Alternative sequencei308 – 778471Missing in isoform 2. 1 PublicationVSP_023916Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027207 mRNA. Translation: BAB15691.1. Different initiation.
    AK291625 mRNA. Translation: BAF84314.1.
    CH471065 Genomic DNA. Translation: EAW67533.1.
    BC009820 mRNA. Translation: AAH09820.2. Different initiation.
    BC068507 mRNA. Translation: AAH68507.1.
    CCDSiCCDS8438.1. [Q6NUN7-1]
    CCDS8439.1. [Q6NUN7-2]
    RefSeqiNP_079082.2. NM_024806.3. [Q6NUN7-1]
    NP_954575.1. NM_199124.2. [Q6NUN7-2]
    XP_005271736.1. XM_005271679.2. [Q6NUN7-1]
    XP_005271737.1. XM_005271680.2. [Q6NUN7-1]
    UniGeneiHs.164705.

    Genome annotation databases

    EnsembliENST00000227349; ENSP00000227349; ENSG00000109944. [Q6NUN7-1]
    ENST00000307257; ENSP00000307695; ENSG00000109944. [Q6NUN7-2]
    ENST00000531316; ENSP00000431669; ENSG00000109944. [Q6NUN7-1]
    GeneIDi79864.
    KEGGihsa:79864.
    UCSCiuc001pyl.2. human. [Q6NUN7-2]
    uc001pym.4. human. [Q6NUN7-1]

    Polymorphism databases

    DMDMi74736827.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027207 mRNA. Translation: BAB15691.1 . Different initiation.
    AK291625 mRNA. Translation: BAF84314.1 .
    CH471065 Genomic DNA. Translation: EAW67533.1 .
    BC009820 mRNA. Translation: AAH09820.2 . Different initiation.
    BC068507 mRNA. Translation: AAH68507.1 .
    CCDSi CCDS8438.1. [Q6NUN7-1 ]
    CCDS8439.1. [Q6NUN7-2 ]
    RefSeqi NP_079082.2. NM_024806.3. [Q6NUN7-1 ]
    NP_954575.1. NM_199124.2. [Q6NUN7-2 ]
    XP_005271736.1. XM_005271679.2. [Q6NUN7-1 ]
    XP_005271737.1. XM_005271680.2. [Q6NUN7-1 ]
    UniGenei Hs.164705.

    3D structure databases

    ProteinModelPortali Q6NUN7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122952. 4 interactions.
    IntActi Q6NUN7. 1 interaction.

    PTM databases

    PhosphoSitei Q6NUN7.

    Polymorphism databases

    DMDMi 74736827.

    Proteomic databases

    PaxDbi Q6NUN7.
    PRIDEi Q6NUN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227349 ; ENSP00000227349 ; ENSG00000109944 . [Q6NUN7-1 ]
    ENST00000307257 ; ENSP00000307695 ; ENSG00000109944 . [Q6NUN7-2 ]
    ENST00000531316 ; ENSP00000431669 ; ENSG00000109944 . [Q6NUN7-1 ]
    GeneIDi 79864.
    KEGGi hsa:79864.
    UCSCi uc001pyl.2. human. [Q6NUN7-2 ]
    uc001pym.4. human. [Q6NUN7-1 ]

    Organism-specific databases

    CTDi 79864.
    GeneCardsi GC11P122753.
    HGNCi HGNC:26288. C11orf63.
    HPAi HPA039612.
    HPA040344.
    neXtProti NX_Q6NUN7.
    PharmGKBi PA143485358.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42552.
    HOGENOMi HOG000013118.
    HOVERGENi HBG081220.
    InParanoidi Q6NUN7.
    OMAi TQIMEQH.
    OrthoDBi EOG7JQBMZ.
    PhylomeDBi Q6NUN7.
    TreeFami TF335473.

    Miscellaneous databases

    ChiTaRSi C11orf63. human.
    GenomeRNAii 79864.
    NextBioi 69604.

    Gene expression databases

    Bgeei Q6NUN7.
    CleanExi HS_C11orf63.
    Genevestigatori Q6NUN7.

    Family and domain databases

    InterProi IPR027968. DUF4591.
    [Graphical view ]
    Pfami PF15261. DUF4591. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-778 (ISOFORM 2).
      Tissue: Lung and Testis.

    Entry informationi

    Entry nameiCK063_HUMAN
    AccessioniPrimary (citable) accession number: Q6NUN7
    Secondary accession number(s): A8K6G0, Q96GB5, Q9H5D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3