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Protein

Tyrosine-protein kinase

Gene

LYN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LYNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

MaxQBiQ6NUK7
PRIDEiQ6NUK7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 193SH3InterPro annotationAdd BLAST61
Domaini199 – 296SH2InterPro annotationAdd BLAST98
Domaini317 – 571Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233858
HOVERGENiHBG008761
KOiK05854

Family and domain databases

CDDicd10364 SH2_Src_Lyn, 1 hit
cd12004 SH3_Lyn, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR035852 Lyn_SH2
IPR035748 Lyn_SH3
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Fragment.

Q6NUK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VPLPPRRAAL PLAPRPWRLR ARRAAASSPR QAGRPRHPRP RASSPSPRVQ
60 70 80 90 100
RSRPAASPYA GPAGPPRRAP HSELKSPWSS AAPKLSPRAG NMGCIKSKGK
110 120 130 140 150
DSLSDDGVDL KTQPVPESQL LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD
160 170 180 190 200
DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK LNTLETEEWF
210 220 230 240 250
FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI
260 270 280 290 300
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK
310 320 330 340 350
PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG
360 370 380 390 400
TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT REEPIYIITE YMAKGSLLDF
410 420 430 440 450
LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM
460 470 480 490 500
CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG
510 520 530 540 550
ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW
560 570 580
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP
Length:582
Mass (Da):65,809
Last modified:July 5, 2004 - v1
Checksum:i1CFF99768C28E9BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059394 mRNA Translation: AAH59394.1
BC068551 mRNA Translation: AAH68551.1
RefSeqiNP_001104567.1, NM_001111097.2
NP_002341.1, NM_002350.3
UniGeneiHs.491767
Hs.545418

Genome annotation databases

GeneIDi4067
KEGGihsa:4067

Similar proteinsi

Entry informationi

Entry nameiQ6NUK7_HUMAN
AccessioniPrimary (citable) accession number: Q6NUK7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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