Q6NUK4 (REEP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor expression-enhancing protein 3

Gene names

Name:	REEP3
Synonyms:	C10orf74

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May enhance the cell surface expression of odorant receptors By similarity.
Subunit structure	Interacts with odorant receptor proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the DP1 family.
Sequence caution	The sequence AAH10040.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NUK4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NUK4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     140-170: SQGAITERLRSFSMHDLTTIQGDEPVGQRPY → VIVHLPF
     171-255: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Receptor expression-enhancing protein 3		PRO_0000101826
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
Amino acid modifications
	Modified residue	150	1	Phosphoserine By similarity
	Modified residue	152	1	Phosphoserine By similarity
	Modified residue	201	1	Phosphothreonine Ref.5
	Modified residue	210	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	140 – 170	31	SQGAI…GQRPY → VIVHLPF in isoform 2.		VSP_016634
	Alternative sequence	171 – 255	85	Missing in isoform 2.		VSP_016635
	Natural variant	171	1	Q → R. Corresponds to variant rs10995569 [ dbSNP | Ensembl ].		VAR_048926

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 83E4D6E153DDE3EB	FASTA	255	29,264
	10 20 30 40 50 60 MVSWMISRAV VLVFGMLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALYTV IETVADQTVA 70 80 90 100 110 120 WFPLYYELKI AFVIWLLSPY TKGASLIYRK FLHPLLSSKE REIDDYIVQA KERGYETMVN 130 140 150 160 170 180 FGRQGLNLAA TAAVTAAVKS QGAITERLRS FSMHDLTTIQ GDEPVGQRPY QPLPEAKKKS 190 200 210 220 230 240 KPAPSESAGY GIPLKDGDEK TDEEAEGPYS DNEMLTHKGL RRSQSMKSVK TTKGRKEVRY 250 GSLKYKVKKR PQVYF
	Isoform 2 [UniParc]. Checksum: 3EA4DBA71A853ACC	FASTA	146	16,999
	10 20 30 40 50 60 MVSWMISRAV VLVFGMLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALYTV IETVADQTVA 70 80 90 100 110 120 WFPLYYELKI AFVIWLLSPY TKGASLIYRK FLHPLLSSKE REIDDYIVQA KERGYETMVN 130 140 FGRQGLNLAA TAAVTAAVKV IVHLPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RTP family members induce functional expression of mammalian odorant receptors." Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H. Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta and Uterus.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-201 AND SER-210, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY562241 mRNA. Translation: AAT70686.1. AC022022 Genomic DNA. No translation available. AL607062 Genomic DNA. Translation: CAI40732.1. BC010040 mRNA. Translation: AAH10040.1. Sequence problems. BC057832 mRNA. Translation: AAH57832.1. BC068557 mRNA. Translation: AAH68557.1.
IPI	IPI00164434. IPI00658022.
RefSeq	NP_001001330.1. NM_001001330.2.
UniGene	Hs.499833.
3D structure databases
ProteinModelPortal	Q6NUK4.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-3976601.
STRING	9606.ENSP00000362863.
PTM databases
PhosphoSite	Q6NUK4.
Polymorphism databases
DMDM	74736808.
Proteomic databases
PaxDb	Q6NUK4.
PRIDE	Q6NUK4.
Protocols and materials databases
DNASU	221035.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298249; ENSP00000298249; ENSG00000165476. ENST00000373758; ENSP00000362863; ENSG00000165476.
GeneID	221035.
KEGG	hsa:221035.
UCSC	uc001jmt.3. human. uc009xpl.2. human.
Organism-specific databases
CTD	221035.
GeneCards	GC10P065281.
HGNC	HGNC:23711. REEP3.
MIM	609348. gene.
neXtProt	NX_Q6NUK4.
PharmGKB	PA134863406.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5052.
HOGENOM	HOG000007472.
HOVERGEN	HBG056861.
InParanoid	Q6NUK4.
Gene expression databases
Bgee	Q6NUK4.
CleanEx	HS_REEP3.
Genevestigator	Q6NUK4.
GermOnline	ENSG00000165476. Homo sapiens.
Family and domain databases
InterPro	IPR004345. TB2_DP1_HVA22. [Graphical view]
PANTHER	PTHR12300. PTHR12300. 1 hit.
Pfam	PF03134. TB2_DP1_HVA22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	REEP3. human.
GenomeRNAi	221035.
NextBio	91157.
SOURCE	Search...

Entry information

Entry name

REEP3_HUMAN

Accession

Primary (citable) accession number: Q6NUK4
Secondary accession number(s): Q5JQR5 , Q5QGT2, Q6PEW8, Q6PJY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.