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Protein

PWWP domain-containing protein 2B

Gene

PWWP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein 2B
Gene namesi
Name:PWWP2B
Synonyms:PWWP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25150. PWWP2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400513.

Polymorphism and mutation databases

BioMutaiPWWP2B.
DMDMi160140805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590PWWP domain-containing protein 2BPRO_0000240878Add
BLAST

Proteomic databases

MaxQBiQ6NUJ5.
PaxDbiQ6NUJ5.
PRIDEiQ6NUJ5.

PTM databases

iPTMnetiQ6NUJ5.
PhosphoSiteiQ6NUJ5.

Expressioni

Gene expression databases

BgeeiQ6NUJ5.
CleanExiHS_PWWP2B.
GenevisibleiQ6NUJ5. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-10251192,EBI-348380

Protein-protein interaction databases

BioGridi128004. 4 interactions.
IntActiQ6NUJ5. 2 interactions.
STRINGi9606.ENSP00000306324.

Structurei

Secondary structure

1
590
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi475 – 4817Combined sources
Beta strandi487 – 4893Combined sources
Beta strandi493 – 4964Combined sources
Beta strandi504 – 51310Combined sources
Beta strandi518 – 5203Combined sources
Beta strandi524 – 5307Combined sources
Beta strandi536 – 5405Combined sources
Helixi541 – 5433Combined sources
Beta strandi544 – 5463Combined sources
Turni547 – 5504Combined sources
Helixi551 – 5544Combined sources
Helixi562 – 57312Combined sources
Turni574 – 5774Combined sources
Helixi579 – 58810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LD6X-ray1.70A475-590[»]
ProteinModelPortaliQ6NUJ5.
SMRiQ6NUJ5. Positions 475-590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini490 – 55061PWWPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 14561Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIF8. Eukaryota.
ENOG410XSSY. LUCA.
GeneTreeiENSGT00530000063940.
HOGENOMiHOG000054216.
HOVERGENiHBG062115.
InParanoidiQ6NUJ5.
OMAiLWLRNTY.
OrthoDBiEOG77DJ5N.
PhylomeDBiQ6NUJ5.
TreeFamiTF331271.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRAGCRLP VRVEQVVNGA LVVTVSCGER SFAGILLDCT KKSGLFGLPP
60 70 80 90 100
LAPLPQVDES PVNDSHGRAP EEGDAEVMQL GSSSPPPARG VQPPETTRPE
110 120 130 140 150
PPPPLVPPLP AGSLPPYPPY FEGAPFPHPL WLRDTYKLWV PQPPPRTIKR
160 170 180 190 200
TRRRLSRNRD PGRLILSTIR LRPRQVLCEK CKSTLSPPEA SPGPPAAPRA
210 220 230 240 250
RRRLGSGPDR ELRKPEEPEN GEPTAAATAR RSKRERREED RAPAEQVPRS
260 270 280 290 300
PVIKISYSTP QGKGEVVKIP SRVHGSLEPF RPQQAPQDDG SQDPEVLDRE
310 320 330 340 350
SRDRPSCAPS ASIPKLKLTR PVPAGADLPP PKIRLKPHRL GDSEHEPVYR
360 370 380 390 400
AELVGELNGY LRDSSPAPCA DGPAGGLADL SSGSSGEDDD FKSCPQGPQG
410 420 430 440 450
REGLAFLVSC PEGRADCASE SACSSDSLDE ARSSGSEGTP ADTGDLSPGH
460 470 480 490 500
GASAPSVSRE ARQTVPPLTV RLHTQSVSEC ITEDGRTVAV GDIVWGKIHG
510 520 530 540 550
FPWWPARVLD ISLGQKEDGE PSWREAKVSW FGSPTTSFLS ISKLSPFSEF
560 570 580 590
FKLRFNRKKK GMYRKAITEA ANAARHVAPE IRELLTQFET
Length:590
Mass (Da):63,967
Last modified:November 13, 2007 - v3
Checksum:i67C9124B40258EC4
GO
Isoform 2 (identifier: Q6NUJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-499: KIH → HRR
     500-590: Missing.

Show »
Length:499
Mass (Da):53,550
Checksum:i9AD9EB51C343A3E7
GO

Sequence cautioni

The sequence AAH68574.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AK128663 differs from that shown. Reason: Frameshift at position 342. Curated
The sequence AK128663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → C.2 Publications
Corresponds to variant rs11146363 [ dbSNP | Ensembl ].
VAR_037233
Natural varianti98 – 981R → G.1 Publication
Corresponds to variant rs10747057 [ dbSNP | Ensembl ].
VAR_037234

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei497 – 4993KIH → HRR in isoform 2. CuratedVSP_054223
Alternative sequencei500 – 59091Missing in isoform 2. CuratedVSP_054224Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590105 Genomic DNA. Translation: CAI13020.2.
BC011630 mRNA. Translation: AAH11630.2.
BC068574 mRNA. Translation: AAH68574.1. Different initiation.
AK128663 mRNA. No translation available.
CCDSiCCDS44497.1. [Q6NUJ5-2]
CCDS7667.2. [Q6NUJ5-1]
RefSeqiNP_001092107.1. NM_001098637.1. [Q6NUJ5-2]
NP_612508.3. NM_138499.3. [Q6NUJ5-1]
XP_006717722.1. XM_006717659.2. [Q6NUJ5-1]
UniGeneiHs.527751.

Genome annotation databases

EnsembliENST00000305233; ENSP00000306324; ENSG00000171813. [Q6NUJ5-1]
ENST00000631148; ENSP00000486501; ENSG00000171813. [Q6NUJ5-2]
GeneIDi170394.
KEGGihsa:170394.
UCSCiuc001lll.5. human. [Q6NUJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590105 Genomic DNA. Translation: CAI13020.2.
BC011630 mRNA. Translation: AAH11630.2.
BC068574 mRNA. Translation: AAH68574.1. Different initiation.
AK128663 mRNA. No translation available.
CCDSiCCDS44497.1. [Q6NUJ5-2]
CCDS7667.2. [Q6NUJ5-1]
RefSeqiNP_001092107.1. NM_001098637.1. [Q6NUJ5-2]
NP_612508.3. NM_138499.3. [Q6NUJ5-1]
XP_006717722.1. XM_006717659.2. [Q6NUJ5-1]
UniGeneiHs.527751.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LD6X-ray1.70A475-590[»]
ProteinModelPortaliQ6NUJ5.
SMRiQ6NUJ5. Positions 475-590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128004. 4 interactions.
IntActiQ6NUJ5. 2 interactions.
STRINGi9606.ENSP00000306324.

PTM databases

iPTMnetiQ6NUJ5.
PhosphoSiteiQ6NUJ5.

Polymorphism and mutation databases

BioMutaiPWWP2B.
DMDMi160140805.

Proteomic databases

MaxQBiQ6NUJ5.
PaxDbiQ6NUJ5.
PRIDEiQ6NUJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305233; ENSP00000306324; ENSG00000171813. [Q6NUJ5-1]
ENST00000631148; ENSP00000486501; ENSG00000171813. [Q6NUJ5-2]
GeneIDi170394.
KEGGihsa:170394.
UCSCiuc001lll.5. human. [Q6NUJ5-1]

Organism-specific databases

CTDi170394.
GeneCardsiPWWP2B.
H-InvDBHIX0017401.
HGNCiHGNC:25150. PWWP2B.
neXtProtiNX_Q6NUJ5.
PharmGKBiPA162400513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIF8. Eukaryota.
ENOG410XSSY. LUCA.
GeneTreeiENSGT00530000063940.
HOGENOMiHOG000054216.
HOVERGENiHBG062115.
InParanoidiQ6NUJ5.
OMAiLWLRNTY.
OrthoDBiEOG77DJ5N.
PhylomeDBiQ6NUJ5.
TreeFamiTF331271.

Miscellaneous databases

ChiTaRSiPWWP2B. human.
GenomeRNAii170394.
NextBioi88919.
PROiQ6NUJ5.

Gene expression databases

BgeeiQ6NUJ5.
CleanExiHS_PWWP2B.
GenevisibleiQ6NUJ5. HS.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-89 AND GLY-98.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-590 (ISOFORM 1), VARIANT CYS-89.
    Tissue: Uterus.
  4. "Crystal structure of PWWP domain of human PWWP domain-containing protein 2b."
    Structural genomics consortium (SGC)
    Submitted (JUL-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 475-590.

Entry informationi

Entry nameiPWP2B_HUMAN
AccessioniPrimary (citable) accession number: Q6NUJ5
Secondary accession number(s): A6NM90
, B5MDQ1, H9KV61, Q5SZI0, Q6ZQX5, Q96F43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 13, 2007
Last modified: May 11, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.