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Protein

Proactivator polypeptide-like 1

Gene

PSAPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May activate the lysosomal degradation of sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Proactivator polypeptide-like 1
Cleaved into the following 5 chains:
Gene namesi
Name:PSAPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:33131. PSAPL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178597.
PharmGKBiPA162400215.

Polymorphism and mutation databases

BioMutaiPSAPL1.
DMDMi134035030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000028030518 – 59By similarityAdd BLAST42
ChainiPRO_000028030661 – 144Saposin A-likeBy similarityAdd BLAST84
PropeptideiPRO_0000280307146 – 180By similarityAdd BLAST35
ChainiPRO_0000280308181 – 257Saposin B-Val-likeBy similarityAdd BLAST77
ChainiPRO_0000280309181 – 256Saposin B-likeBy similarityAdd BLAST76
PropeptideiPRO_0000280310259 – 288By similarityAdd BLAST30
ChainiPRO_0000280311290 – 369Saposin C-likeBy similarityAdd BLAST80
PropeptideiPRO_0000280312370 – 391By similarityAdd BLAST22
ChainiPRO_0000280313392 – 473Saposin D-likeBy similarityAdd BLAST82
PropeptideiPRO_0000280314474 – 521By similarityAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 140PROSITE-ProRule annotation
Disulfide bondi67 ↔ 134PROSITE-ProRule annotation
Disulfide bondi95 ↔ 107PROSITE-ProRule annotation
Disulfide bondi184 ↔ 254PROSITE-ProRule annotation
Disulfide bondi187 ↔ 248PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi213 ↔ 224PROSITE-ProRule annotation
Disulfide bondi294 ↔ 366PROSITE-ProRule annotation
Disulfide bondi297 ↔ 360PROSITE-ProRule annotation
Glycosylationi311N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi325 ↔ 336PROSITE-ProRule annotation
Disulfide bondi396 ↔ 469PROSITE-ProRule annotation
Disulfide bondi399 ↔ 463PROSITE-ProRule annotation
Disulfide bondi427 ↔ 438PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6NUJ1.
PaxDbiQ6NUJ1.
PeptideAtlasiQ6NUJ1.
PRIDEiQ6NUJ1.

PTM databases

iPTMnetiQ6NUJ1.
PhosphoSitePlusiQ6NUJ1.

Expressioni

Gene expression databases

BgeeiENSG00000178597.
CleanExiHS_PSAPL1.
GenevisibleiQ6NUJ1. HS.

Organism-specific databases

HPAiHPA038013.
HPA038482.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317445.

Structurei

3D structure databases

ProteinModelPortaliQ6NUJ1.
SMRiQ6NUJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 59Saposin A-type 1PROSITE-ProRule annotationAdd BLAST41
Domaini60 – 144Saposin B-type 1PROSITE-ProRule annotationAdd BLAST85
Domaini180 – 258Saposin B-type 2PROSITE-ProRule annotationAdd BLAST79
Domaini290 – 370Saposin B-type 3PROSITE-ProRule annotationAdd BLAST81
Domaini392 – 473Saposin B-type 4PROSITE-ProRule annotationAdd BLAST82
Domaini475 – 515Saposin A-type 2PROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Contains 2 saposin A-type domains.PROSITE-ProRule annotation
Contains 4 saposin B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiQ6NUJ1.
KOiK12382.
OMAiKTCEWLP.
OrthoDBiEOG091G0K86.
PhylomeDBiQ6NUJ1.
TreeFamiTF316942.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 2 hits.
PF03489. SapB_2. 2 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 4 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NUJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCALLLLPS LLGATRASPT SGPQECAKGS TVWCQDLQTA ARCGAVGYCQ
60 70 80 90 100
GAVWNKPTAK SLPCDVCQDI AAAAGNGLNP DATESDILAL VMKTCEWLPS
110 120 130 140 150
QESSAGCKWM VDAHSSAILS MLRGAPDSAP AQVCTALSLC EPLQRHLATL
160 170 180 190 200
RPLSKEDTFE AVAPFMANGP LTFHPRQAPE GALCQDCVRQ VSRLQEAVRS
210 220 230 240 250
NLTLADLNIQ EQCESLGPGL AVLCKNYLFQ FFVPADQALR LLPPQELCRK
260 270 280 290 300
GGFCEELGAP ARLTQVVAMD GVPSLELGLP RKQSEMQMKA GVTCEVCMNV
310 320 330 340 350
VQKLDHWLMS NSSELMITHA LERVCSVMPA SITKECIILV DTYSPSLVQL
360 370 380 390 400
VAKITPEKVC KFIRLCGNRR RARAVHDAYA IVPSPEWDAE NQGSFCNGCK
410 420 430 440 450
RLLTVSSHNL ESKSTKRDIL VAFKGGCSIL PLPYMIQCKH FVTQYEPVLI
460 470 480 490 500
ESLKDMMDPV AVCKKVGACH GPRTPLLGTD QCALGPSFWC RSQEAAKLCN
510 520
AVQHCQKHVW KEMHLHAGEH A
Length:521
Mass (Da):56,627
Last modified:March 20, 2007 - v2
Checksum:i0E1ED7B942D1ECB2
GO

Sequence cautioni

The sequence AAH68579 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05143 differs from that shown. Reason: Erroneous termination at position 510. Translated as Trp.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06178041A → S.Corresponds to variant rs11548325dbSNPEnsembl.1
Natural variantiVAR_06178144G → R.Corresponds to variant rs58482081dbSNPEnsembl.1
Natural variantiVAR_06178259A → T.Corresponds to variant rs56737582dbSNPEnsembl.1
Natural variantiVAR_051895268A → S.Corresponds to variant rs3796905dbSNPEnsembl.1
Natural variantiVAR_051896296V → M.Corresponds to variant rs6850206dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991252 mRNA. Translation: ABJ55983.1.
BC068579 mRNA. Translation: AAH68579.1. Different initiation.
AK097698 mRNA. Translation: BAC05143.1. Sequence problems.
CCDSiCCDS47009.1.
RefSeqiNP_001078851.1. NM_001085382.1.
UniGeneiHs.662523.

Genome annotation databases

EnsembliENST00000319098; ENSP00000317445; ENSG00000178597.
GeneIDi768239.
KEGGihsa:768239.
UCSCiuc011bwj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991252 mRNA. Translation: ABJ55983.1.
BC068579 mRNA. Translation: AAH68579.1. Different initiation.
AK097698 mRNA. Translation: BAC05143.1. Sequence problems.
CCDSiCCDS47009.1.
RefSeqiNP_001078851.1. NM_001085382.1.
UniGeneiHs.662523.

3D structure databases

ProteinModelPortaliQ6NUJ1.
SMRiQ6NUJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317445.

PTM databases

iPTMnetiQ6NUJ1.
PhosphoSitePlusiQ6NUJ1.

Polymorphism and mutation databases

BioMutaiPSAPL1.
DMDMi134035030.

Proteomic databases

MaxQBiQ6NUJ1.
PaxDbiQ6NUJ1.
PeptideAtlasiQ6NUJ1.
PRIDEiQ6NUJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319098; ENSP00000317445; ENSG00000178597.
GeneIDi768239.
KEGGihsa:768239.
UCSCiuc011bwj.3. human.

Organism-specific databases

CTDi768239.
GeneCardsiPSAPL1.
HGNCiHGNC:33131. PSAPL1.
HPAiHPA038013.
HPA038482.
neXtProtiNX_Q6NUJ1.
OpenTargetsiENSG00000178597.
PharmGKBiPA162400215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiQ6NUJ1.
KOiK12382.
OMAiKTCEWLP.
OrthoDBiEOG091G0K86.
PhylomeDBiQ6NUJ1.
TreeFamiTF316942.

Miscellaneous databases

GenomeRNAii768239.
PROiQ6NUJ1.

Gene expression databases

BgeeiENSG00000178597.
CleanExiHS_PSAPL1.
GenevisibleiQ6NUJ1. HS.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 2 hits.
PF03489. SapB_2. 2 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 4 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAPL1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUJ1
Secondary accession number(s): A0A184, Q8N7T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.