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Protein

Proactivator polypeptide-like 1

Gene

PSAPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May activate the lysosomal degradation of sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Proactivator polypeptide-like 1
Cleaved into the following 5 chains:
Gene namesi
Name:PSAPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:33131. PSAPL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400215.

Polymorphism and mutation databases

BioMutaiPSAPL1.
DMDMi134035030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Propeptidei18 – 5942By similarityPRO_0000280305Add
BLAST
Chaini61 – 14484Saposin A-likeBy similarityPRO_0000280306Add
BLAST
Propeptidei146 – 18035By similarityPRO_0000280307Add
BLAST
Chaini181 – 25777Saposin B-Val-likeBy similarityPRO_0000280308Add
BLAST
Chaini181 – 25676Saposin B-likeBy similarityPRO_0000280309Add
BLAST
Propeptidei259 – 28830By similarityPRO_0000280310Add
BLAST
Chaini290 – 36980Saposin C-likeBy similarityPRO_0000280311Add
BLAST
Propeptidei370 – 39122By similarityPRO_0000280312Add
BLAST
Chaini392 – 47382Saposin D-likeBy similarityPRO_0000280313Add
BLAST
Propeptidei474 – 52148By similarityPRO_0000280314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 140PROSITE-ProRule annotation
Disulfide bondi67 ↔ 134PROSITE-ProRule annotation
Disulfide bondi95 ↔ 107PROSITE-ProRule annotation
Disulfide bondi184 ↔ 254PROSITE-ProRule annotation
Disulfide bondi187 ↔ 248PROSITE-ProRule annotation
Glycosylationi201 – 2011N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi213 ↔ 224PROSITE-ProRule annotation
Disulfide bondi294 ↔ 366PROSITE-ProRule annotation
Disulfide bondi297 ↔ 360PROSITE-ProRule annotation
Glycosylationi311 – 3111N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi325 ↔ 336PROSITE-ProRule annotation
Disulfide bondi396 ↔ 469PROSITE-ProRule annotation
Disulfide bondi399 ↔ 463PROSITE-ProRule annotation
Disulfide bondi427 ↔ 438PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6NUJ1.
MaxQBiQ6NUJ1.
PaxDbiQ6NUJ1.
PRIDEiQ6NUJ1.

PTM databases

iPTMnetiQ6NUJ1.
PhosphoSiteiQ6NUJ1.

Expressioni

Gene expression databases

BgeeiQ6NUJ1.
CleanExiHS_PSAPL1.
GenevisibleiQ6NUJ1. HS.

Organism-specific databases

HPAiHPA038013.
HPA038482.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317445.

Structurei

3D structure databases

ProteinModelPortaliQ6NUJ1.
SMRiQ6NUJ1. Positions 61-141, 181-255, 292-366, 395-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 5941Saposin A-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 14485Saposin B-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini180 – 25879Saposin B-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini290 – 37081Saposin B-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 47382Saposin B-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini475 – 51541Saposin A-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 saposin A-type domains.PROSITE-ProRule annotation
Contains 4 saposin B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiQ6NUJ1.
KOiK12382.
OMAiKTCEWLP.
OrthoDBiEOG7ZSHSC.
PhylomeDBiQ6NUJ1.
TreeFamiTF316942.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 2 hits.
PF03489. SapB_2. 2 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 4 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NUJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCALLLLPS LLGATRASPT SGPQECAKGS TVWCQDLQTA ARCGAVGYCQ
60 70 80 90 100
GAVWNKPTAK SLPCDVCQDI AAAAGNGLNP DATESDILAL VMKTCEWLPS
110 120 130 140 150
QESSAGCKWM VDAHSSAILS MLRGAPDSAP AQVCTALSLC EPLQRHLATL
160 170 180 190 200
RPLSKEDTFE AVAPFMANGP LTFHPRQAPE GALCQDCVRQ VSRLQEAVRS
210 220 230 240 250
NLTLADLNIQ EQCESLGPGL AVLCKNYLFQ FFVPADQALR LLPPQELCRK
260 270 280 290 300
GGFCEELGAP ARLTQVVAMD GVPSLELGLP RKQSEMQMKA GVTCEVCMNV
310 320 330 340 350
VQKLDHWLMS NSSELMITHA LERVCSVMPA SITKECIILV DTYSPSLVQL
360 370 380 390 400
VAKITPEKVC KFIRLCGNRR RARAVHDAYA IVPSPEWDAE NQGSFCNGCK
410 420 430 440 450
RLLTVSSHNL ESKSTKRDIL VAFKGGCSIL PLPYMIQCKH FVTQYEPVLI
460 470 480 490 500
ESLKDMMDPV AVCKKVGACH GPRTPLLGTD QCALGPSFWC RSQEAAKLCN
510 520
AVQHCQKHVW KEMHLHAGEH A
Length:521
Mass (Da):56,627
Last modified:March 20, 2007 - v2
Checksum:i0E1ED7B942D1ECB2
GO

Sequence cautioni

The sequence AAH68579.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC05143.1 differs from that shown. Reason: Erroneous termination at position 510. Translated as Trp.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411A → S.
Corresponds to variant rs11548325 [ dbSNP | Ensembl ].
VAR_061780
Natural varianti44 – 441G → R.
Corresponds to variant rs58482081 [ dbSNP | Ensembl ].
VAR_061781
Natural varianti59 – 591A → T.
Corresponds to variant rs56737582 [ dbSNP | Ensembl ].
VAR_061782
Natural varianti268 – 2681A → S.
Corresponds to variant rs3796905 [ dbSNP | Ensembl ].
VAR_051895
Natural varianti296 – 2961V → M.
Corresponds to variant rs6850206 [ dbSNP | Ensembl ].
VAR_051896

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991252 mRNA. Translation: ABJ55983.1.
BC068579 mRNA. Translation: AAH68579.1. Different initiation.
AK097698 mRNA. Translation: BAC05143.1. Sequence problems.
CCDSiCCDS47009.1.
RefSeqiNP_001078851.1. NM_001085382.1.
UniGeneiHs.662523.

Genome annotation databases

EnsembliENST00000319098; ENSP00000317445; ENSG00000178597.
GeneIDi768239.
KEGGihsa:768239.
UCSCiuc011bwj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991252 mRNA. Translation: ABJ55983.1.
BC068579 mRNA. Translation: AAH68579.1. Different initiation.
AK097698 mRNA. Translation: BAC05143.1. Sequence problems.
CCDSiCCDS47009.1.
RefSeqiNP_001078851.1. NM_001085382.1.
UniGeneiHs.662523.

3D structure databases

ProteinModelPortaliQ6NUJ1.
SMRiQ6NUJ1. Positions 61-141, 181-255, 292-366, 395-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317445.

PTM databases

iPTMnetiQ6NUJ1.
PhosphoSiteiQ6NUJ1.

Polymorphism and mutation databases

BioMutaiPSAPL1.
DMDMi134035030.

Proteomic databases

EPDiQ6NUJ1.
MaxQBiQ6NUJ1.
PaxDbiQ6NUJ1.
PRIDEiQ6NUJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319098; ENSP00000317445; ENSG00000178597.
GeneIDi768239.
KEGGihsa:768239.
UCSCiuc011bwj.3. human.

Organism-specific databases

CTDi768239.
GeneCardsiPSAPL1.
HGNCiHGNC:33131. PSAPL1.
HPAiHPA038013.
HPA038482.
neXtProtiNX_Q6NUJ1.
PharmGKBiPA162400215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiQ6NUJ1.
KOiK12382.
OMAiKTCEWLP.
OrthoDBiEOG7ZSHSC.
PhylomeDBiQ6NUJ1.
TreeFamiTF316942.

Miscellaneous databases

GenomeRNAii768239.
PROiQ6NUJ1.

Gene expression databases

BgeeiQ6NUJ1.
CleanExiHS_PSAPL1.
GenevisibleiQ6NUJ1. HS.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 2 hits.
PF03489. SapB_2. 2 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 4 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large scale analysis of gene expression in the course of epidermal differentiation."
    Toulza E., Guerrin M.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-521.
    Tissue: Testis.

Entry informationi

Entry nameiSAPL1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUJ1
Secondary accession number(s): A0A184, Q8N7T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.