Q6NUI6 (CHADL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chondroadherin-like protein

Gene names

Name:	CHADL
Synonyms:	SLRR4B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	762 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Sequence similarities	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. Contains 19 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 2 LRRNT domains.
Sequence caution	The sequence AAH19839.1 differs from that shown. Reason: Frameshift at position 504. The sequence AAH68590.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NUI6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NUI6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     662-737: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 762	732	Chondroadherin-like protein		PRO_0000299548
Regions
	Domain	31 – 62	32	LRRNT 1
	Repeat	87 – 108	22	LRR 1
	Repeat	111 – 132	22	LRR 2
	Repeat	135 – 156	22	LRR 3
	Repeat	159 – 180	22	LRR 4
	Repeat	183 – 204	22	LRR 5
	Repeat	207 – 228	22	LRR 6
	Repeat	231 – 252	22	LRR 7
	Repeat	255 – 276	22	LRR 8
	Repeat	279 – 300	22	LRR 9
	Domain	310 – 359	50	LRRCT 1
	Domain	387 – 425	39	LRRNT 2
	Repeat	426 – 447	22	LRR 10
	Repeat	450 – 471	22	LRR 11
	Repeat	474 – 495	22	LRR 12
	Repeat	498 – 519	22	LRR 13
	Repeat	522 – 543	22	LRR 14
	Repeat	546 – 566	21	LRR 15
	Repeat	570 – 591	22	LRR 16
	Repeat	594 – 615	22	LRR 17
	Repeat	619 – 640	22	LRR 18
	Repeat	644 – 665	22	LRR 19
	Domain	675 – 724	50	LRRCT 2
	Compositional bias	109 – 325	217	Leu-rich
	Compositional bias	364 – 370	7	Poly-Glu
Amino acid modifications
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Glycosylation	626	1	N-linked (GlcNAc...) Potential
	Disulfide bond	396 ↔ 411		By similarity
	Disulfide bond	679 ↔ 722		By similarity
	Disulfide bond	681 ↔ 701		By similarity
Natural variations
	Alternative sequence	662 – 737	76	Missing in isoform 2.		VSP_027735
	Natural variant	710	1	Q → R. Corresponds to variant rs9619955 [ dbSNP | Ensembl ].		VAR_059805
	Natural variant	721	1	D → N. Corresponds to variant rs9619954 [ dbSNP | Ensembl ].		VAR_061805
Experimental info
	Sequence conflict	11	1	P → T in AAH40188. Ref.3
	Sequence conflict	30	1	A → T in AAH40188. Ref.3
	Sequence conflict	148	1	E → G in AAH40188. Ref.3
	Sequence conflict	424	1	P → R in AAH68590. Ref.3
	Sequence conflict	478	1	L → V in AAH40188. Ref.3
	Sequence conflict	508	1	R → S in AAH48421. Ref.3
	Sequence conflict	529	1	Q → H in AAH68590. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: BE01DF94D3408A70	FASTA	762	82,388
	10 20 30 40 50 60 MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY QNLTEVPDAI 70 80 90 100 110 120 PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL VAEGAFRGLG RLLLLNLASN 130 140 150 160 170 180 HLRELPQEAL DGLGSLRRLE LEGNALEELR PGTFGALGAL ATLNLAHNAL VYLPAMAFQG 190 200 210 220 230 240 LLRVRWLRLS HNALSVLAPE ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN 250 260 270 280 290 300 PLTYAGEEDG LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG 310 320 330 340 350 360 QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL RPWDLRCPGD 370 380 390 400 410 420 AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC VCVPESRHSS CEGCGLQAVP 430 440 450 460 470 480 RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH LVSLHLQHCG IAELEAGALA GLGRLIYLYL 490 500 510 520 530 540 SDNQLAGLSA AALEGAPRLG YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD 550 560 570 580 590 600 LGRTRALRWV YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL 610 620 630 640 650 660 SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL QKNQLRALPA 670 680 690 700 710 720 LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT CATPPNARGQ RVKAAAAVFE 730 740 750 760 DCPGWAARKA KRTPASRPSA RRTPIKGRQC GADKVGKEKG RL
	Isoform 2 [UniParc]. Checksum: C7BD512ECAC83CC9	FASTA	686	74,155
	10 20 30 40 50 60 MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY QNLTEVPDAI 70 80 90 100 110 120 PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL VAEGAFRGLG RLLLLNLASN 130 140 150 160 170 180 HLRELPQEAL DGLGSLRRLE LEGNALEELR PGTFGALGAL ATLNLAHNAL VYLPAMAFQG 190 200 210 220 230 240 LLRVRWLRLS HNALSVLAPE ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN 250 260 270 280 290 300 PLTYAGEEDG LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG 310 320 330 340 350 360 QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL RPWDLRCPGD 370 380 390 400 410 420 AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC VCVPESRHSS CEGCGLQAVP 430 440 450 460 470 480 RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH LVSLHLQHCG IAELEAGALA GLGRLIYLYL 490 500 510 520 530 540 SDNQLAGLSA AALEGAPRLG YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD 550 560 570 580 590 600 LGRTRALRWV YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL 610 620 630 640 650 660 SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL QKNQLRALPA 670 680 LPSARRTPIK GRQCGADKVG KEKGRL

References

[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035681 Genomic DNA. Translation: CAI22653.1. CH471095 Genomic DNA. Translation: EAW60419.1. BC012882 mRNA. Translation: AAH12882.1. BC019839 mRNA. Translation: AAH19839.1. Frameshift. BC040188 mRNA. Translation: AAH40188.1. BC048421 mRNA. Translation: AAH48421.1. BC068590 mRNA. Translation: AAH68590.1. Different initiation.
IPI	IPI00402280. IPI00855816.
RefSeq	NP_612490.1. NM_138481.1.
UniGene	Hs.344488.
3D structure databases
HSSP	HSSP built from PDB template 1OZN based on UniProtKB Q9BZR6.
ProteinModelPortal	Q6NUI6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000216241.
Polymorphism databases
DMDM	158563972.
Proteomic databases
PaxDb	Q6NUI6.
PRIDE	Q6NUI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216241; ENSP00000216241; ENSG00000100399.
GeneID	150356.
KEGG	hsa:150356.
UCSC	uc003azq.4. human. uc010gyj.3. human.
Organism-specific databases
CTD	150356.
GeneCards	GC22M041625.
HGNC	HGNC:25165. CHADL.
HPA	HPA005696. HPA024654.
neXtProt	NX_Q6NUI6.
PharmGKB	PA162382224.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG318740.
HOGENOM	HOG000111626.
HOVERGEN	HBG095510.
InParanoid	Q6NUI6.
OMA	ICDNSRR.
Gene expression databases
ArrayExpress	Q6NUI6.
Bgee	Q6NUI6.
CleanEx	HS_CHADL.
Genevestigator	Q6NUI6.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
SMART	SM00369. LRR_TYP. 4 hits. SM00082. LRRCT. 2 hits. SM00013. LRRNT. 2 hits. [Graphical view]
PROSITE	PS51450. LRR. 18 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	150356.
NextBio	86414.

Entry information

Entry name

CHADL_HUMAN

Accession

Primary (citable) accession number: Q6NUI6
Secondary accession number(s): Q05CY2 , Q4G0S0, Q5JY13, Q86XY1, Q96E60

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.