Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chondroadherin-like protein

Gene

CHADL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.1 Publication

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen fibril binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin-like protein
Gene namesi
Name:CHADL
Synonyms:SLRR4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:25165. CHADL.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100399.
PharmGKBiPA162382224.

Polymorphism and mutation databases

BioMutaiCHADL.
DMDMi158563972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000029954831 – 762Chondroadherin-like proteinAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi396 ↔ 411By similarity
Glycosylationi626N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi679 ↔ 722By similarity
Disulfide bondi681 ↔ 701By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6NUI6.
PeptideAtlasiQ6NUI6.
PRIDEiQ6NUI6.

PTM databases

iPTMnetiQ6NUI6.
PhosphoSitePlusiQ6NUI6.

Expressioni

Gene expression databases

BgeeiENSG00000100399.
CleanExiHS_CHADL.
ExpressionAtlasiQ6NUI6. baseline and differential.
GenevisibleiQ6NUI6. HS.

Organism-specific databases

HPAiHPA005696.
HPA024654.

Interactioni

Subunit structurei

Associates with collagen and binds to collagen fibrils.1 Publication

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen fibril binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000216241.

Structurei

3D structure databases

ProteinModelPortaliQ6NUI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 62LRRNT 1Add BLAST32
Repeati87 – 108LRR 1Add BLAST22
Repeati111 – 132LRR 2Add BLAST22
Repeati135 – 156LRR 3Add BLAST22
Repeati159 – 180LRR 4Add BLAST22
Repeati183 – 204LRR 5Add BLAST22
Repeati207 – 228LRR 6Add BLAST22
Repeati231 – 252LRR 7Add BLAST22
Repeati255 – 276LRR 8Add BLAST22
Repeati279 – 300LRR 9Add BLAST22
Domaini310 – 359LRRCT 1Add BLAST50
Domaini387 – 425LRRNT 2Add BLAST39
Repeati426 – 447LRR 10Add BLAST22
Repeati450 – 471LRR 11Add BLAST22
Repeati474 – 495LRR 12Add BLAST22
Repeati498 – 519LRR 13Add BLAST22
Repeati522 – 543LRR 14Add BLAST22
Repeati546 – 566LRR 15Add BLAST21
Repeati570 – 591LRR 16Add BLAST22
Repeati594 – 615LRR 17Add BLAST22
Repeati619 – 640LRR 18Add BLAST22
Repeati644 – 665LRR 19Add BLAST22
Domaini675 – 724LRRCT 2Add BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 325Leu-richAdd BLAST217
Compositional biasi364 – 370Poly-Glu7

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 2 LRRNT domains.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000111626.
HOVERGENiHBG095510.
InParanoidiQ6NUI6.
OMAiCVPESRH.
OrthoDBiEOG091G0AYL.
PhylomeDBiQ6NUI6.
TreeFamiTF337463.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 6 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY
60 70 80 90 100
QNLTEVPDAI PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL
110 120 130 140 150
VAEGAFRGLG RLLLLNLASN HLRELPQEAL DGLGSLRRLE LEGNALEELR
160 170 180 190 200
PGTFGALGAL ATLNLAHNAL VYLPAMAFQG LLRVRWLRLS HNALSVLAPE
210 220 230 240 250
ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN PLTYAGEEDG
260 270 280 290 300
LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG
310 320 330 340 350
QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL
360 370 380 390 400
RPWDLRCPGD AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC
410 420 430 440 450
VCVPESRHSS CEGCGLQAVP RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH
460 470 480 490 500
LVSLHLQHCG IAELEAGALA GLGRLIYLYL SDNQLAGLSA AALEGAPRLG
510 520 530 540 550
YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD LGRTRALRWV
560 570 580 590 600
YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL
610 620 630 640 650
SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL
660 670 680 690 700
QKNQLRALPA LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT
710 720 730 740 750
CATPPNARGQ RVKAAAAVFE DCPGWAARKA KRTPASRPSA RRTPIKGRQC
760
GADKVGKEKG RL
Length:762
Mass (Da):82,388
Last modified:September 11, 2007 - v2
Checksum:iBE01DF94D3408A70
GO
Isoform 2 (identifier: Q6NUI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     662-737: Missing.

Note: No experimental confirmation available.
Show »
Length:686
Mass (Da):74,155
Checksum:iC7BD512ECAC83CC9
GO

Sequence cautioni

The sequence AAH19839 differs from that shown. Reason: Frameshift at position 504.Curated
The sequence AAH68590 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11P → T in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti30A → T in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti148E → G in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti424P → R in AAH68590 (PubMed:15489334).Curated1
Sequence conflicti478L → V in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti508R → S in AAH48421 (PubMed:15489334).Curated1
Sequence conflicti529Q → H in AAH68590 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059805710Q → R.Corresponds to variant rs9619955dbSNPEnsembl.1
Natural variantiVAR_061805721D → N.Corresponds to variant rs9619954dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027735662 – 737Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035681 Genomic DNA. Translation: CAI22653.1.
CH471095 Genomic DNA. Translation: EAW60419.1.
BC012882 mRNA. Translation: AAH12882.1.
BC019839 mRNA. Translation: AAH19839.1. Frameshift.
BC040188 mRNA. Translation: AAH40188.1.
BC048421 mRNA. Translation: AAH48421.1.
BC068590 mRNA. Translation: AAH68590.1. Different initiation.
CCDSiCCDS46715.1. [Q6NUI6-1]
RefSeqiNP_612490.1. NM_138481.1. [Q6NUI6-1]
UniGeneiHs.344488.

Genome annotation databases

EnsembliENST00000216241; ENSP00000216241; ENSG00000100399. [Q6NUI6-1]
GeneIDi150356.
KEGGihsa:150356.
UCSCiuc003azq.5. human. [Q6NUI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035681 Genomic DNA. Translation: CAI22653.1.
CH471095 Genomic DNA. Translation: EAW60419.1.
BC012882 mRNA. Translation: AAH12882.1.
BC019839 mRNA. Translation: AAH19839.1. Frameshift.
BC040188 mRNA. Translation: AAH40188.1.
BC048421 mRNA. Translation: AAH48421.1.
BC068590 mRNA. Translation: AAH68590.1. Different initiation.
CCDSiCCDS46715.1. [Q6NUI6-1]
RefSeqiNP_612490.1. NM_138481.1. [Q6NUI6-1]
UniGeneiHs.344488.

3D structure databases

ProteinModelPortaliQ6NUI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216241.

PTM databases

iPTMnetiQ6NUI6.
PhosphoSitePlusiQ6NUI6.

Polymorphism and mutation databases

BioMutaiCHADL.
DMDMi158563972.

Proteomic databases

PaxDbiQ6NUI6.
PeptideAtlasiQ6NUI6.
PRIDEiQ6NUI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216241; ENSP00000216241; ENSG00000100399. [Q6NUI6-1]
GeneIDi150356.
KEGGihsa:150356.
UCSCiuc003azq.5. human. [Q6NUI6-1]

Organism-specific databases

CTDi150356.
GeneCardsiCHADL.
HGNCiHGNC:25165. CHADL.
HPAiHPA005696.
HPA024654.
MIMi616236. gene.
neXtProtiNX_Q6NUI6.
OpenTargetsiENSG00000100399.
PharmGKBiPA162382224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000111626.
HOVERGENiHBG095510.
InParanoidiQ6NUI6.
OMAiCVPESRH.
OrthoDBiEOG091G0AYL.
PhylomeDBiQ6NUI6.
TreeFamiTF337463.

Miscellaneous databases

GenomeRNAii150356.
PROiQ6NUI6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100399.
CleanExiHS_CHADL.
ExpressionAtlasiQ6NUI6. baseline and differential.
GenevisibleiQ6NUI6. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 6 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHADL_HUMAN
AccessioniPrimary (citable) accession number: Q6NUI6
Secondary accession number(s): Q05CY2
, Q4G0S0, Q5JY13, Q86XY1, Q96E60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.