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Q6NUI6 (CHADL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chondroadherin-like protein
Gene names
Name:CHADL
Synonyms:SLRR4B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length762 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.

Contains 19 LRR (leucine-rich) repeats.

Contains 2 LRRCT domains.

Contains 2 LRRNT domains.

Sequence caution

The sequence AAH19839.1 differs from that shown. Reason: Frameshift at position 504.

The sequence AAH68590.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainLeucine-rich repeat
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NUI6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NUI6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     662-737: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 762732Chondroadherin-like protein
PRO_0000299548

Regions

Domain31 – 6232LRRNT 1
Repeat87 – 10822LRR 1
Repeat111 – 13222LRR 2
Repeat135 – 15622LRR 3
Repeat159 – 18022LRR 4
Repeat183 – 20422LRR 5
Repeat207 – 22822LRR 6
Repeat231 – 25222LRR 7
Repeat255 – 27622LRR 8
Repeat279 – 30022LRR 9
Domain310 – 35950LRRCT 1
Domain387 – 42539LRRNT 2
Repeat426 – 44722LRR 10
Repeat450 – 47122LRR 11
Repeat474 – 49522LRR 12
Repeat498 – 51922LRR 13
Repeat522 – 54322LRR 14
Repeat546 – 56621LRR 15
Repeat570 – 59122LRR 16
Repeat594 – 61522LRR 17
Repeat619 – 64022LRR 18
Repeat644 – 66522LRR 19
Domain675 – 72450LRRCT 2
Compositional bias109 – 325217Leu-rich
Compositional bias364 – 3707Poly-Glu

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Disulfide bond396 ↔ 411 By similarity
Disulfide bond679 ↔ 722 By similarity
Disulfide bond681 ↔ 701 By similarity

Natural variations

Alternative sequence662 – 73776Missing in isoform 2.
VSP_027735
Natural variant7101Q → R.
Corresponds to variant rs9619955 [ dbSNP | Ensembl ].
VAR_059805
Natural variant7211D → N.
Corresponds to variant rs9619954 [ dbSNP | Ensembl ].
VAR_061805

Experimental info

Sequence conflict111P → T in AAH40188. Ref.3
Sequence conflict301A → T in AAH40188. Ref.3
Sequence conflict1481E → G in AAH40188. Ref.3
Sequence conflict4241P → R in AAH68590. Ref.3
Sequence conflict4781L → V in AAH40188. Ref.3
Sequence conflict5081R → S in AAH48421. Ref.3
Sequence conflict5291Q → H in AAH68590. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: BE01DF94D3408A70

FASTA76282,388
        10         20         30         40         50         60 
MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY QNLTEVPDAI 

        70         80         90        100        110        120 
PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL VAEGAFRGLG RLLLLNLASN 

       130        140        150        160        170        180 
HLRELPQEAL DGLGSLRRLE LEGNALEELR PGTFGALGAL ATLNLAHNAL VYLPAMAFQG 

       190        200        210        220        230        240 
LLRVRWLRLS HNALSVLAPE ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN 

       250        260        270        280        290        300 
PLTYAGEEDG LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG 

       310        320        330        340        350        360 
QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL RPWDLRCPGD 

       370        380        390        400        410        420 
AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC VCVPESRHSS CEGCGLQAVP 

       430        440        450        460        470        480 
RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH LVSLHLQHCG IAELEAGALA GLGRLIYLYL 

       490        500        510        520        530        540 
SDNQLAGLSA AALEGAPRLG YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD 

       550        560        570        580        590        600 
LGRTRALRWV YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL 

       610        620        630        640        650        660 
SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL QKNQLRALPA 

       670        680        690        700        710        720 
LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT CATPPNARGQ RVKAAAAVFE 

       730        740        750        760 
DCPGWAARKA KRTPASRPSA RRTPIKGRQC GADKVGKEKG RL 

« Hide

Isoform 2 [UniParc].

Checksum: C7BD512ECAC83CC9
Show »

FASTA68674,155

References

[1]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL035681 Genomic DNA. Translation: CAI22653.1.
CH471095 Genomic DNA. Translation: EAW60419.1.
BC012882 mRNA. Translation: AAH12882.1.
BC019839 mRNA. Translation: AAH19839.1. Frameshift.
BC040188 mRNA. Translation: AAH40188.1.
BC048421 mRNA. Translation: AAH48421.1.
BC068590 mRNA. Translation: AAH68590.1. Different initiation.
CCDSCCDS46715.1. [Q6NUI6-1]
RefSeqNP_612490.1. NM_138481.1. [Q6NUI6-1]
UniGeneHs.344488.

3D structure databases

ProteinModelPortalQ6NUI6.
SMRQ6NUI6. Positions 31-712.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000216241.

Polymorphism databases

DMDM158563972.

Proteomic databases

PaxDbQ6NUI6.
PRIDEQ6NUI6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216241; ENSP00000216241; ENSG00000100399. [Q6NUI6-1]
GeneID150356.
KEGGhsa:150356.
UCSCuc003azq.4. human. [Q6NUI6-1]
uc010gyj.3. human. [Q6NUI6-2]

Organism-specific databases

CTD150356.
GeneCardsGC22M041625.
HGNCHGNC:25165. CHADL.
HPAHPA005696.
HPA024654.
neXtProtNX_Q6NUI6.
PharmGKBPA162382224.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318740.
HOGENOMHOG000111626.
HOVERGENHBG095510.
InParanoidQ6NUI6.
OMAQDNAVDR.
PhylomeDBQ6NUI6.
TreeFamTF337463.

Gene expression databases

ArrayExpressQ6NUI6.
BgeeQ6NUI6.
CleanExHS_CHADL.
GenevestigatorQ6NUI6.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF13855. LRR_8. 7 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
[Graphical view]
PROSITEPS51450. LRR. 18 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi150356.
NextBio86414.
PROQ6NUI6.

Entry information

Entry nameCHADL_HUMAN
AccessionPrimary (citable) accession number: Q6NUI6
Secondary accession number(s): Q05CY2 expand/collapse secondary AC list , Q4G0S0, Q5JY13, Q86XY1, Q96E60
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM