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Q6NUI6

- CHADL_HUMAN

UniProt

Q6NUI6 - CHADL_HUMAN

Protein

Chondroadherin-like protein

Gene

CHADL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chondroadherin-like protein
    Gene namesi
    Name:CHADL
    Synonyms:SLRR4B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:25165. CHADL.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382224.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 762732Chondroadherin-like proteinPRO_0000299548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi396 ↔ 411By similarity
    Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi679 ↔ 722By similarity
    Disulfide bondi681 ↔ 701By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6NUI6.
    PRIDEiQ6NUI6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NUI6.
    BgeeiQ6NUI6.
    CleanExiHS_CHADL.
    GenevestigatoriQ6NUI6.

    Organism-specific databases

    HPAiHPA005696.
    HPA024654.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000216241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NUI6.
    SMRiQ6NUI6. Positions 31-712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 6232LRRNT 1Add
    BLAST
    Repeati87 – 10822LRR 1Add
    BLAST
    Repeati111 – 13222LRR 2Add
    BLAST
    Repeati135 – 15622LRR 3Add
    BLAST
    Repeati159 – 18022LRR 4Add
    BLAST
    Repeati183 – 20422LRR 5Add
    BLAST
    Repeati207 – 22822LRR 6Add
    BLAST
    Repeati231 – 25222LRR 7Add
    BLAST
    Repeati255 – 27622LRR 8Add
    BLAST
    Repeati279 – 30022LRR 9Add
    BLAST
    Domaini310 – 35950LRRCT 1Add
    BLAST
    Domaini387 – 42539LRRNT 2Add
    BLAST
    Repeati426 – 44722LRR 10Add
    BLAST
    Repeati450 – 47122LRR 11Add
    BLAST
    Repeati474 – 49522LRR 12Add
    BLAST
    Repeati498 – 51922LRR 13Add
    BLAST
    Repeati522 – 54322LRR 14Add
    BLAST
    Repeati546 – 56621LRR 15Add
    BLAST
    Repeati570 – 59122LRR 16Add
    BLAST
    Repeati594 – 61522LRR 17Add
    BLAST
    Repeati619 – 64022LRR 18Add
    BLAST
    Repeati644 – 66522LRR 19Add
    BLAST
    Domaini675 – 72450LRRCT 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi109 – 325217Leu-richAdd
    BLAST
    Compositional biasi364 – 3707Poly-Glu

    Sequence similaritiesi

    Contains 19 LRR (leucine-rich) repeats.Curated
    Contains 2 LRRCT domains.Curated
    Contains 2 LRRNT domains.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG318740.
    HOGENOMiHOG000111626.
    HOVERGENiHBG095510.
    InParanoidiQ6NUI6.
    OMAiQDNAVDR.
    PhylomeDBiQ6NUI6.
    TreeFamiTF337463.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 7 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 2 hits.
    SM00013. LRRNT. 2 hits.
    [Graphical view]
    PROSITEiPS51450. LRR. 18 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NUI6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY    50
    QNLTEVPDAI PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL 100
    VAEGAFRGLG RLLLLNLASN HLRELPQEAL DGLGSLRRLE LEGNALEELR 150
    PGTFGALGAL ATLNLAHNAL VYLPAMAFQG LLRVRWLRLS HNALSVLAPE 200
    ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN PLTYAGEEDG 250
    LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG 300
    QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL 350
    RPWDLRCPGD AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC 400
    VCVPESRHSS CEGCGLQAVP RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH 450
    LVSLHLQHCG IAELEAGALA GLGRLIYLYL SDNQLAGLSA AALEGAPRLG 500
    YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD LGRTRALRWV 550
    YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL 600
    SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL 650
    QKNQLRALPA LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT 700
    CATPPNARGQ RVKAAAAVFE DCPGWAARKA KRTPASRPSA RRTPIKGRQC 750
    GADKVGKEKG RL 762
    Length:762
    Mass (Da):82,388
    Last modified:September 11, 2007 - v2
    Checksum:iBE01DF94D3408A70
    GO
    Isoform 2 (identifier: Q6NUI6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         662-737: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:686
    Mass (Da):74,155
    Checksum:iC7BD512ECAC83CC9
    GO

    Sequence cautioni

    The sequence AAH19839.1 differs from that shown. Reason: Frameshift at position 504.
    The sequence AAH68590.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111P → T in AAH40188. (PubMed:15489334)Curated
    Sequence conflicti30 – 301A → T in AAH40188. (PubMed:15489334)Curated
    Sequence conflicti148 – 1481E → G in AAH40188. (PubMed:15489334)Curated
    Sequence conflicti424 – 4241P → R in AAH68590. (PubMed:15489334)Curated
    Sequence conflicti478 – 4781L → V in AAH40188. (PubMed:15489334)Curated
    Sequence conflicti508 – 5081R → S in AAH48421. (PubMed:15489334)Curated
    Sequence conflicti529 – 5291Q → H in AAH68590. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti710 – 7101Q → R.
    Corresponds to variant rs9619955 [ dbSNP | Ensembl ].
    VAR_059805
    Natural varianti721 – 7211D → N.
    Corresponds to variant rs9619954 [ dbSNP | Ensembl ].
    VAR_061805

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei662 – 73776Missing in isoform 2. 1 PublicationVSP_027735Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035681 Genomic DNA. Translation: CAI22653.1.
    CH471095 Genomic DNA. Translation: EAW60419.1.
    BC012882 mRNA. Translation: AAH12882.1.
    BC019839 mRNA. Translation: AAH19839.1. Frameshift.
    BC040188 mRNA. Translation: AAH40188.1.
    BC048421 mRNA. Translation: AAH48421.1.
    BC068590 mRNA. Translation: AAH68590.1. Different initiation.
    CCDSiCCDS46715.1. [Q6NUI6-1]
    RefSeqiNP_612490.1. NM_138481.1. [Q6NUI6-1]
    UniGeneiHs.344488.

    Genome annotation databases

    EnsembliENST00000216241; ENSP00000216241; ENSG00000100399. [Q6NUI6-1]
    GeneIDi150356.
    KEGGihsa:150356.
    UCSCiuc003azq.4. human. [Q6NUI6-1]
    uc010gyj.3. human. [Q6NUI6-2]

    Polymorphism databases

    DMDMi158563972.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035681 Genomic DNA. Translation: CAI22653.1 .
    CH471095 Genomic DNA. Translation: EAW60419.1 .
    BC012882 mRNA. Translation: AAH12882.1 .
    BC019839 mRNA. Translation: AAH19839.1 . Frameshift.
    BC040188 mRNA. Translation: AAH40188.1 .
    BC048421 mRNA. Translation: AAH48421.1 .
    BC068590 mRNA. Translation: AAH68590.1 . Different initiation.
    CCDSi CCDS46715.1. [Q6NUI6-1 ]
    RefSeqi NP_612490.1. NM_138481.1. [Q6NUI6-1 ]
    UniGenei Hs.344488.

    3D structure databases

    ProteinModelPortali Q6NUI6.
    SMRi Q6NUI6. Positions 31-712.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000216241.

    Polymorphism databases

    DMDMi 158563972.

    Proteomic databases

    PaxDbi Q6NUI6.
    PRIDEi Q6NUI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216241 ; ENSP00000216241 ; ENSG00000100399 . [Q6NUI6-1 ]
    GeneIDi 150356.
    KEGGi hsa:150356.
    UCSCi uc003azq.4. human. [Q6NUI6-1 ]
    uc010gyj.3. human. [Q6NUI6-2 ]

    Organism-specific databases

    CTDi 150356.
    GeneCardsi GC22M041625.
    HGNCi HGNC:25165. CHADL.
    HPAi HPA005696.
    HPA024654.
    neXtProti NX_Q6NUI6.
    PharmGKBi PA162382224.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318740.
    HOGENOMi HOG000111626.
    HOVERGENi HBG095510.
    InParanoidi Q6NUI6.
    OMAi QDNAVDR.
    PhylomeDBi Q6NUI6.
    TreeFami TF337463.

    Miscellaneous databases

    GenomeRNAii 150356.
    NextBioi 86414.
    PROi Q6NUI6.

    Gene expression databases

    ArrayExpressi Q6NUI6.
    Bgeei Q6NUI6.
    CleanExi HS_CHADL.
    Genevestigatori Q6NUI6.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 7 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 2 hits.
    SM00013. LRRNT. 2 hits.
    [Graphical view ]
    PROSITEi PS51450. LRR. 18 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiCHADL_HUMAN
    AccessioniPrimary (citable) accession number: Q6NUI6
    Secondary accession number(s): Q05CY2
    , Q4G0S0, Q5JY13, Q86XY1, Q96E60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3