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Protein

Chondroadherin-like protein

Gene

CHADL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.1 Publication

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen fibril binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin-like protein
Gene namesi
Name:CHADL
Synonyms:SLRR4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:25165. CHADL.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382224.

Polymorphism and mutation databases

BioMutaiCHADL.
DMDMi158563972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 762732Chondroadherin-like proteinPRO_0000299548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi396 ↔ 411By similarity
Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi679 ↔ 722By similarity
Disulfide bondi681 ↔ 701By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6NUI6.
PRIDEiQ6NUI6.

Expressioni

Gene expression databases

BgeeiQ6NUI6.
CleanExiHS_CHADL.
ExpressionAtlasiQ6NUI6. baseline and differential.
GenevestigatoriQ6NUI6.

Organism-specific databases

HPAiHPA005696.
HPA024654.

Interactioni

Subunit structurei

Associates with collagen and binds to collagen fibrils.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000216241.

Structurei

3D structure databases

ProteinModelPortaliQ6NUI6.
SMRiQ6NUI6. Positions 5-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6232LRRNT 1Add
BLAST
Repeati87 – 10822LRR 1Add
BLAST
Repeati111 – 13222LRR 2Add
BLAST
Repeati135 – 15622LRR 3Add
BLAST
Repeati159 – 18022LRR 4Add
BLAST
Repeati183 – 20422LRR 5Add
BLAST
Repeati207 – 22822LRR 6Add
BLAST
Repeati231 – 25222LRR 7Add
BLAST
Repeati255 – 27622LRR 8Add
BLAST
Repeati279 – 30022LRR 9Add
BLAST
Domaini310 – 35950LRRCT 1Add
BLAST
Domaini387 – 42539LRRNT 2Add
BLAST
Repeati426 – 44722LRR 10Add
BLAST
Repeati450 – 47122LRR 11Add
BLAST
Repeati474 – 49522LRR 12Add
BLAST
Repeati498 – 51922LRR 13Add
BLAST
Repeati522 – 54322LRR 14Add
BLAST
Repeati546 – 56621LRR 15Add
BLAST
Repeati570 – 59122LRR 16Add
BLAST
Repeati594 – 61522LRR 17Add
BLAST
Repeati619 – 64022LRR 18Add
BLAST
Repeati644 – 66522LRR 19Add
BLAST
Domaini675 – 72450LRRCT 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 325217Leu-richAdd
BLAST
Compositional biasi364 – 3707Poly-Glu

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 2 LRRNT domains.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG318740.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000111626.
HOVERGENiHBG095510.
InParanoidiQ6NUI6.
OMAiCVPESRH.
PhylomeDBiQ6NUI6.
TreeFamiTF337463.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 7 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
[Graphical view]
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY
60 70 80 90 100
QNLTEVPDAI PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL
110 120 130 140 150
VAEGAFRGLG RLLLLNLASN HLRELPQEAL DGLGSLRRLE LEGNALEELR
160 170 180 190 200
PGTFGALGAL ATLNLAHNAL VYLPAMAFQG LLRVRWLRLS HNALSVLAPE
210 220 230 240 250
ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN PLTYAGEEDG
260 270 280 290 300
LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG
310 320 330 340 350
QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL
360 370 380 390 400
RPWDLRCPGD AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC
410 420 430 440 450
VCVPESRHSS CEGCGLQAVP RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH
460 470 480 490 500
LVSLHLQHCG IAELEAGALA GLGRLIYLYL SDNQLAGLSA AALEGAPRLG
510 520 530 540 550
YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD LGRTRALRWV
560 570 580 590 600
YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL
610 620 630 640 650
SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL
660 670 680 690 700
QKNQLRALPA LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT
710 720 730 740 750
CATPPNARGQ RVKAAAAVFE DCPGWAARKA KRTPASRPSA RRTPIKGRQC
760
GADKVGKEKG RL
Length:762
Mass (Da):82,388
Last modified:September 11, 2007 - v2
Checksum:iBE01DF94D3408A70
GO
Isoform 2 (identifier: Q6NUI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     662-737: Missing.

Note: No experimental confirmation available.

Show »
Length:686
Mass (Da):74,155
Checksum:iC7BD512ECAC83CC9
GO

Sequence cautioni

The sequence AAH19839.1 differs from that shown. Reason: Frameshift at position 504. Curated
The sequence AAH68590.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111P → T in AAH40188 (PubMed:15489334).Curated
Sequence conflicti30 – 301A → T in AAH40188 (PubMed:15489334).Curated
Sequence conflicti148 – 1481E → G in AAH40188 (PubMed:15489334).Curated
Sequence conflicti424 – 4241P → R in AAH68590 (PubMed:15489334).Curated
Sequence conflicti478 – 4781L → V in AAH40188 (PubMed:15489334).Curated
Sequence conflicti508 – 5081R → S in AAH48421 (PubMed:15489334).Curated
Sequence conflicti529 – 5291Q → H in AAH68590 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti710 – 7101Q → R.
Corresponds to variant rs9619955 [ dbSNP | Ensembl ].
VAR_059805
Natural varianti721 – 7211D → N.
Corresponds to variant rs9619954 [ dbSNP | Ensembl ].
VAR_061805

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei662 – 73776Missing in isoform 2. 1 PublicationVSP_027735Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035681 Genomic DNA. Translation: CAI22653.1.
CH471095 Genomic DNA. Translation: EAW60419.1.
BC012882 mRNA. Translation: AAH12882.1.
BC019839 mRNA. Translation: AAH19839.1. Frameshift.
BC040188 mRNA. Translation: AAH40188.1.
BC048421 mRNA. Translation: AAH48421.1.
BC068590 mRNA. Translation: AAH68590.1. Different initiation.
CCDSiCCDS46715.1. [Q6NUI6-1]
RefSeqiNP_612490.1. NM_138481.1. [Q6NUI6-1]
UniGeneiHs.344488.

Genome annotation databases

EnsembliENST00000216241; ENSP00000216241; ENSG00000100399. [Q6NUI6-1]
GeneIDi150356.
KEGGihsa:150356.
UCSCiuc003azq.4. human. [Q6NUI6-1]
uc010gyj.3. human. [Q6NUI6-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035681 Genomic DNA. Translation: CAI22653.1.
CH471095 Genomic DNA. Translation: EAW60419.1.
BC012882 mRNA. Translation: AAH12882.1.
BC019839 mRNA. Translation: AAH19839.1. Frameshift.
BC040188 mRNA. Translation: AAH40188.1.
BC048421 mRNA. Translation: AAH48421.1.
BC068590 mRNA. Translation: AAH68590.1. Different initiation.
CCDSiCCDS46715.1. [Q6NUI6-1]
RefSeqiNP_612490.1. NM_138481.1. [Q6NUI6-1]
UniGeneiHs.344488.

3D structure databases

ProteinModelPortaliQ6NUI6.
SMRiQ6NUI6. Positions 5-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216241.

Polymorphism and mutation databases

BioMutaiCHADL.
DMDMi158563972.

Proteomic databases

PaxDbiQ6NUI6.
PRIDEiQ6NUI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216241; ENSP00000216241; ENSG00000100399. [Q6NUI6-1]
GeneIDi150356.
KEGGihsa:150356.
UCSCiuc003azq.4. human. [Q6NUI6-1]
uc010gyj.3. human. [Q6NUI6-2]

Organism-specific databases

CTDi150356.
GeneCardsiGC22M041625.
HGNCiHGNC:25165. CHADL.
HPAiHPA005696.
HPA024654.
MIMi616236. gene.
neXtProtiNX_Q6NUI6.
PharmGKBiPA162382224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG318740.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000111626.
HOVERGENiHBG095510.
InParanoidiQ6NUI6.
OMAiCVPESRH.
PhylomeDBiQ6NUI6.
TreeFamiTF337463.

Miscellaneous databases

GenomeRNAii150356.
NextBioi86414.
PROiQ6NUI6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NUI6.
CleanExiHS_CHADL.
ExpressionAtlasiQ6NUI6. baseline and differential.
GenevestigatoriQ6NUI6.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 7 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 2 hits.
[Graphical view]
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  4. "The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation."
    Tillgren V., Ho J.C., Oennerfjord P., Kalamajski S.
    J. Biol. Chem. 290:918-925(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH COLLAGEN AND COLLAGEN FIBRILS, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCHADL_HUMAN
AccessioniPrimary (citable) accession number: Q6NUI6
Secondary accession number(s): Q05CY2
, Q4G0S0, Q5JY13, Q86XY1, Q96E60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 27, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.