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Q6NUI2

- GPAT2_HUMAN

UniProt

Q6NUI2 - GPAT2_HUMAN

Protein

Glycerol-3-phosphate acyltransferase 2, mitochondrial

Gene

GPAT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.By similarity

    Catalytic activityi

    Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. glycerol-3-phosphate O-acyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
    2. glycerol-3-phosphate metabolic process Source: UniProtKB
    3. glycerophospholipid biosynthetic process Source: Reactome
    4. phosphatidic acid biosynthetic process Source: Reactome
    5. phospholipid metabolic process Source: Reactome
    6. small molecule metabolic process Source: Reactome
    7. triglyceride biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_1190. Triglyceride Biosynthesis.
    REACT_120906. Synthesis of PA.
    UniPathwayiUPA00557; UER00612.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate acyltransferase 2, mitochondrial (EC:2.3.1.15)
    Short name:
    GPAT-2
    Alternative name(s):
    xGPAT1
    Gene namesi
    Name:GPAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:27168. GPAT2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: Reactome
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165696677.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 795795Glycerol-3-phosphate acyltransferase 2, mitochondrialPRO_0000325853Add
    BLAST

    Proteomic databases

    PaxDbiQ6NUI2.
    PRIDEiQ6NUI2.

    PTM databases

    PhosphoSiteiQ6NUI2.

    Expressioni

    Gene expression databases

    BgeeiQ6NUI2.
    GenevestigatoriQ6NUI2.

    Organism-specific databases

    HPAiHPA036841.

    Interactioni

    Protein-protein interaction databases

    BioGridi127324. 1 interaction.
    STRINGi9606.ENSP00000352547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NUI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 305305CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini333 – 449117Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini473 – 795323CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei306 – 33227HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47223HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 331152AcyltransferaseAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi205 – 2106HXXXXD motif

    Domaini

    The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

    Sequence similaritiesi

    Belongs to the GPAT/DAPAT family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG134494.
    KOiK00629.
    OMAiCVRVHLA.
    OrthoDBiEOG74R1PZ.
    PhylomeDBiQ6NUI2.
    TreeFamiTF313360.

    Family and domain databases

    InterProiIPR022284. GPAT/DHAPAT.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PANTHERiPTHR12563. PTHR12563. 1 hit.
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NUI2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATMLEGRCQ TQPRSSPSGR EASLWSSGFG MKLEAVTPFL GKYRPFVGRC    50
    CQTCTPKSWE SLFHRSITDL GFCNVILVKE ENTRFRGWLV RRLCYFLWSL 100
    EQHIPPCQDV PQKIMESTGV QNLLSGRVPG GTGEGQVPDL VKKEVQRILG 150
    HIQAPPRPFL VRLFSWALLR FLNCLFLNVQ LHKGQMKMVQ KAAQAGLPLV 200
    LLSTHKTLLD GILLPFMLLS QGLGVLRVAW DSRACSPALR ALLRKLGGLF 250
    LPPEASLSLD SSEGLLARAV VQAVIEQLLV SGQPLLIFLE EPPGALGPRL 300
    SALGQAWVGF VVQAVQVGIV PDALLVPVAV TYDLVPDAPC DIDHASAPLG 350
    LWTGALAVLR SLWSRWGCSH RICSRVHLAQ PFSLQEYIVS ARSCWGGRQT 400
    LEQLLQPIVL GQCTAVPDTE KEQEWTPITG PLLALKEEDQ LLVRRLSCHV 450
    LSASVGSSAV MSTAIMATLL LFKHQKLLGE FSWLTEEILL RGFDVGFSGQ 500
    LRSLLQHSLS LLRAHVALLR IRQGDLLVVP QPGPGLTHLA QLSAELLPVF 550
    LSEAVGACAV RGLLAGRVPP QGPWELQGIL LLSQNELYRQ ILLLMHLLPQ 600
    DLLLLKPCQS SYCYCQEVLD RLIQCGLLVA EETPGSRPAC DTGRQRLSRK 650
    LLWKPSGDFT DSDSDDFGEA DGRYFRLSQQ SHCPDFFLFL CRLLSPLLKA 700
    FAQAAAFLRQ GQLPDTELGY TEQLFQFLQA TAQEEGIFEC ADPKLAISAV 750
    WTFRDLGVLQ QTPSPAGPRL HLSPTFASLD NQEKLEQFIR QFICS 795
    Length:795
    Mass (Da):87,835
    Last modified:March 18, 2008 - v2
    Checksum:iEE8E387A87A9EE21
    GO
    Isoform 2 (identifier: Q6NUI2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         633-671: TPGSRPACDT...SDSDDFGEAD → SWATQSSCSS...PSVLSGPSET
         672-795: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:671
    Mass (Da):73,521
    Checksum:iF44C1200F3AA60A6
    GO
    Isoform 3 (identifier: Q6NUI2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         476-476: K → KGVFLSQ

    Note: No experimental confirmation available.

    Show »
    Length:801
    Mass (Da):88,467
    Checksum:i5E29D4F62C9292B0
    GO
    Isoform 4 (identifier: Q6NUI2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-216: Missing.
         274-344: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:508
    Mass (Da):56,052
    Checksum:iD405B71CFA1125F1
    GO

    Sequence cautioni

    The sequence AAH68596.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD18392.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti336 – 3361P → Q in AAH68596. (PubMed:15489334)Curated
    Sequence conflicti689 – 6891F → L in BAC85508. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 216216Missing in isoform 4. 1 PublicationVSP_032450Add
    BLAST
    Alternative sequencei274 – 34471Missing in isoform 4. 1 PublicationVSP_032451Add
    BLAST
    Alternative sequencei476 – 4761K → KGVFLSQ in isoform 3. 1 PublicationVSP_032452
    Alternative sequencei633 – 67139TPGSR…FGEAD → SWATQSSCSSSCRPPPRKKG SSSVRTQSSPSVLSGPSET in isoform 2. 1 PublicationVSP_032453Add
    BLAST
    Alternative sequencei672 – 795124Missing in isoform 2. 1 PublicationVSP_032454Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122734 mRNA. Translation: BAC85508.1.
    AK131194 mRNA. Translation: BAD18390.1.
    AK131197 mRNA. Translation: BAD18392.1. Different initiation.
    BC068596 mRNA. Translation: AAH68596.1. Different initiation.
    CCDSiCCDS42714.1. [Q6NUI2-1]
    RefSeqiNP_997211.2. NM_207328.2. [Q6NUI2-1]
    XP_005263941.1. XM_005263884.1. [Q6NUI2-4]
    XP_005263945.1. XM_005263888.1. [Q6NUI2-3]
    XP_006712378.1. XM_006712315.1. [Q6NUI2-3]
    UniGeneiHs.348629.
    Hs.679801.

    Genome annotation databases

    EnsembliENST00000359548; ENSP00000352547; ENSG00000186281. [Q6NUI2-1]
    ENST00000434632; ENSP00000389395; ENSG00000186281. [Q6NUI2-1]
    GeneIDi150763.
    KEGGihsa:150763.
    UCSCiuc002svd.3. human. [Q6NUI2-4]
    uc002svf.3. human. [Q6NUI2-1]
    uc002svh.3. human. [Q6NUI2-3]

    Polymorphism databases

    DMDMi172046129.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122734 mRNA. Translation: BAC85508.1 .
    AK131194 mRNA. Translation: BAD18390.1 .
    AK131197 mRNA. Translation: BAD18392.1 . Different initiation.
    BC068596 mRNA. Translation: AAH68596.1 . Different initiation.
    CCDSi CCDS42714.1. [Q6NUI2-1 ]
    RefSeqi NP_997211.2. NM_207328.2. [Q6NUI2-1 ]
    XP_005263941.1. XM_005263884.1. [Q6NUI2-4 ]
    XP_005263945.1. XM_005263888.1. [Q6NUI2-3 ]
    XP_006712378.1. XM_006712315.1. [Q6NUI2-3 ]
    UniGenei Hs.348629.
    Hs.679801.

    3D structure databases

    ProteinModelPortali Q6NUI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127324. 1 interaction.
    STRINGi 9606.ENSP00000352547.

    PTM databases

    PhosphoSitei Q6NUI2.

    Polymorphism databases

    DMDMi 172046129.

    Proteomic databases

    PaxDbi Q6NUI2.
    PRIDEi Q6NUI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359548 ; ENSP00000352547 ; ENSG00000186281 . [Q6NUI2-1 ]
    ENST00000434632 ; ENSP00000389395 ; ENSG00000186281 . [Q6NUI2-1 ]
    GeneIDi 150763.
    KEGGi hsa:150763.
    UCSCi uc002svd.3. human. [Q6NUI2-4 ]
    uc002svf.3. human. [Q6NUI2-1 ]
    uc002svh.3. human. [Q6NUI2-3 ]

    Organism-specific databases

    CTDi 150763.
    GeneCardsi GC02M096687.
    HGNCi HGNC:27168. GPAT2.
    HPAi HPA036841.
    neXtProti NX_Q6NUI2.
    PharmGKBi PA165696677.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG134494.
    KOi K00629.
    OMAi CVRVHLA.
    OrthoDBi EOG74R1PZ.
    PhylomeDBi Q6NUI2.
    TreeFami TF313360.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00612 .
    Reactomei REACT_1190. Triglyceride Biosynthesis.
    REACT_120906. Synthesis of PA.

    Miscellaneous databases

    GenomeRNAii 150763.
    NextBioi 86529.
    PROi Q6NUI2.

    Gene expression databases

    Bgeei Q6NUI2.
    Genevestigatori Q6NUI2.

    Family and domain databases

    InterProi IPR022284. GPAT/DHAPAT.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    PANTHERi PTHR12563. PTHR12563. 1 hit.
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-795 (ISOFORM 3).
      Tissue: Brain, Heart and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiGPAT2_HUMAN
    AccessioniPrimary (citable) accession number: Q6NUI2
    Secondary accession number(s): Q6P2E4
    , Q6ZNI3, Q6ZNI5, Q6ZWJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3