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Q6NUI2

- GPAT2_HUMAN

UniProt

Q6NUI2 - GPAT2_HUMAN

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Protein

Glycerol-3-phosphate acyltransferase 2, mitochondrial

Gene
GPAT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis By similarity.

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.

Pathwayi

GO - Molecular functioni

  1. glycerol-3-phosphate O-acyltransferase activity Source: UniProtKB

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: UniProtKB
  3. glycerophospholipid biosynthetic process Source: Reactome
  4. phosphatidic acid biosynthetic process Source: Reactome
  5. phospholipid metabolic process Source: Reactome
  6. small molecule metabolic process Source: Reactome
  7. triglyceride biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_1190. Triglyceride Biosynthesis.
REACT_120906. Synthesis of PA.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferase 2, mitochondrial (EC:2.3.1.15)
Short name:
GPAT-2
Alternative name(s):
xGPAT1
Gene namesi
Name:GPAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:27168. GPAT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 305305Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei306 – 33227Helical; Reviewed predictionAdd
BLAST
Topological domaini333 – 449117Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei450 – 47223Helical; Reviewed predictionAdd
BLAST
Topological domaini473 – 795323Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: Reactome
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165696677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 795795Glycerol-3-phosphate acyltransferase 2, mitochondrialPRO_0000325853Add
BLAST

Proteomic databases

PaxDbiQ6NUI2.
PRIDEiQ6NUI2.

PTM databases

PhosphoSiteiQ6NUI2.

Expressioni

Gene expression databases

BgeeiQ6NUI2.
GenevestigatoriQ6NUI2.

Organism-specific databases

HPAiHPA036841.

Interactioni

Protein-protein interaction databases

BioGridi127324. 1 interaction.
STRINGi9606.ENSP00000352547.

Structurei

3D structure databases

ProteinModelPortaliQ6NUI2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 331152AcyltransferaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi205 – 2106HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG134494.
KOiK00629.
OMAiCVRVHLA.
OrthoDBiEOG74R1PZ.
PhylomeDBiQ6NUI2.
TreeFamiTF313360.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NUI2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATMLEGRCQ TQPRSSPSGR EASLWSSGFG MKLEAVTPFL GKYRPFVGRC    50
CQTCTPKSWE SLFHRSITDL GFCNVILVKE ENTRFRGWLV RRLCYFLWSL 100
EQHIPPCQDV PQKIMESTGV QNLLSGRVPG GTGEGQVPDL VKKEVQRILG 150
HIQAPPRPFL VRLFSWALLR FLNCLFLNVQ LHKGQMKMVQ KAAQAGLPLV 200
LLSTHKTLLD GILLPFMLLS QGLGVLRVAW DSRACSPALR ALLRKLGGLF 250
LPPEASLSLD SSEGLLARAV VQAVIEQLLV SGQPLLIFLE EPPGALGPRL 300
SALGQAWVGF VVQAVQVGIV PDALLVPVAV TYDLVPDAPC DIDHASAPLG 350
LWTGALAVLR SLWSRWGCSH RICSRVHLAQ PFSLQEYIVS ARSCWGGRQT 400
LEQLLQPIVL GQCTAVPDTE KEQEWTPITG PLLALKEEDQ LLVRRLSCHV 450
LSASVGSSAV MSTAIMATLL LFKHQKLLGE FSWLTEEILL RGFDVGFSGQ 500
LRSLLQHSLS LLRAHVALLR IRQGDLLVVP QPGPGLTHLA QLSAELLPVF 550
LSEAVGACAV RGLLAGRVPP QGPWELQGIL LLSQNELYRQ ILLLMHLLPQ 600
DLLLLKPCQS SYCYCQEVLD RLIQCGLLVA EETPGSRPAC DTGRQRLSRK 650
LLWKPSGDFT DSDSDDFGEA DGRYFRLSQQ SHCPDFFLFL CRLLSPLLKA 700
FAQAAAFLRQ GQLPDTELGY TEQLFQFLQA TAQEEGIFEC ADPKLAISAV 750
WTFRDLGVLQ QTPSPAGPRL HLSPTFASLD NQEKLEQFIR QFICS 795
Length:795
Mass (Da):87,835
Last modified:March 18, 2008 - v2
Checksum:iEE8E387A87A9EE21
GO
Isoform 2 (identifier: Q6NUI2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     633-671: TPGSRPACDT...SDSDDFGEAD → SWATQSSCSS...PSVLSGPSET
     672-795: Missing.

Note: No experimental confirmation available.

Show »
Length:671
Mass (Da):73,521
Checksum:iF44C1200F3AA60A6
GO
Isoform 3 (identifier: Q6NUI2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     476-476: K → KGVFLSQ

Note: No experimental confirmation available.

Show »
Length:801
Mass (Da):88,467
Checksum:i5E29D4F62C9292B0
GO
Isoform 4 (identifier: Q6NUI2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     274-344: Missing.

Note: No experimental confirmation available.

Show »
Length:508
Mass (Da):56,052
Checksum:iD405B71CFA1125F1
GO

Sequence cautioni

The sequence AAH68596.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD18392.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 216216Missing in isoform 4. VSP_032450Add
BLAST
Alternative sequencei274 – 34471Missing in isoform 4. VSP_032451Add
BLAST
Alternative sequencei476 – 4761K → KGVFLSQ in isoform 3. VSP_032452
Alternative sequencei633 – 67139TPGSR…FGEAD → SWATQSSCSSSCRPPPRKKG SSSVRTQSSPSVLSGPSET in isoform 2. VSP_032453Add
BLAST
Alternative sequencei672 – 795124Missing in isoform 2. VSP_032454Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361P → Q in AAH68596. 1 Publication
Sequence conflicti689 – 6891F → L in BAC85508. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122734 mRNA. Translation: BAC85508.1.
AK131194 mRNA. Translation: BAD18390.1.
AK131197 mRNA. Translation: BAD18392.1. Different initiation.
BC068596 mRNA. Translation: AAH68596.1. Different initiation.
CCDSiCCDS42714.1. [Q6NUI2-1]
RefSeqiNP_997211.2. NM_207328.2. [Q6NUI2-1]
XP_005263941.1. XM_005263884.1. [Q6NUI2-4]
XP_005263945.1. XM_005263888.1. [Q6NUI2-3]
XP_006712378.1. XM_006712315.1. [Q6NUI2-3]
UniGeneiHs.348629.
Hs.679801.

Genome annotation databases

EnsembliENST00000359548; ENSP00000352547; ENSG00000186281. [Q6NUI2-1]
ENST00000377137; ENSP00000366341; ENSG00000186281. [Q6NUI2-3]
ENST00000434632; ENSP00000389395; ENSG00000186281. [Q6NUI2-1]
GeneIDi150763.
KEGGihsa:150763.
UCSCiuc002svd.3. human. [Q6NUI2-4]
uc002svf.3. human. [Q6NUI2-1]
uc002svh.3. human. [Q6NUI2-3]

Polymorphism databases

DMDMi172046129.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122734 mRNA. Translation: BAC85508.1 .
AK131194 mRNA. Translation: BAD18390.1 .
AK131197 mRNA. Translation: BAD18392.1 . Different initiation.
BC068596 mRNA. Translation: AAH68596.1 . Different initiation.
CCDSi CCDS42714.1. [Q6NUI2-1 ]
RefSeqi NP_997211.2. NM_207328.2. [Q6NUI2-1 ]
XP_005263941.1. XM_005263884.1. [Q6NUI2-4 ]
XP_005263945.1. XM_005263888.1. [Q6NUI2-3 ]
XP_006712378.1. XM_006712315.1. [Q6NUI2-3 ]
UniGenei Hs.348629.
Hs.679801.

3D structure databases

ProteinModelPortali Q6NUI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127324. 1 interaction.
STRINGi 9606.ENSP00000352547.

PTM databases

PhosphoSitei Q6NUI2.

Polymorphism databases

DMDMi 172046129.

Proteomic databases

PaxDbi Q6NUI2.
PRIDEi Q6NUI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359548 ; ENSP00000352547 ; ENSG00000186281 . [Q6NUI2-1 ]
ENST00000377137 ; ENSP00000366341 ; ENSG00000186281 . [Q6NUI2-3 ]
ENST00000434632 ; ENSP00000389395 ; ENSG00000186281 . [Q6NUI2-1 ]
GeneIDi 150763.
KEGGi hsa:150763.
UCSCi uc002svd.3. human. [Q6NUI2-4 ]
uc002svf.3. human. [Q6NUI2-1 ]
uc002svh.3. human. [Q6NUI2-3 ]

Organism-specific databases

CTDi 150763.
GeneCardsi GC02M096687.
HGNCi HGNC:27168. GPAT2.
HPAi HPA036841.
neXtProti NX_Q6NUI2.
PharmGKBi PA165696677.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG134494.
KOi K00629.
OMAi CVRVHLA.
OrthoDBi EOG74R1PZ.
PhylomeDBi Q6NUI2.
TreeFami TF313360.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00612 .
Reactomei REACT_1190. Triglyceride Biosynthesis.
REACT_120906. Synthesis of PA.

Miscellaneous databases

GenomeRNAii 150763.
NextBioi 86529.
PROi Q6NUI2.

Gene expression databases

Bgeei Q6NUI2.
Genevestigatori Q6NUI2.

Family and domain databases

InterProi IPR022284. GPAT/DHAPAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
PANTHERi PTHR12563. PTHR12563. 1 hit.
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-795 (ISOFORM 3).
    Tissue: Brain, Heart and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiGPAT2_HUMAN
AccessioniPrimary (citable) accession number: Q6NUI2
Secondary accession number(s): Q6P2E4
, Q6ZNI3, Q6ZNI5, Q6ZWJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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