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Q6NU94

- TRMB_XENLA

UniProt

Q6NU94 - TRMB_XENLA

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
mettl1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei162 – 1621S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA (guanine-N7)-methylation Source: GOC
  2. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
Methyltransferase-like protein 1
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:mettl1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252283. mettl1.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000370559Add
BLAST

Proteomic databases

PRIDEiQ6NU94.

Interactioni

Subunit structurei

Forms a complex with wdr4 By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NU94.
SMRiQ6NU94. Positions 39-263.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1102S-adenosyl-L-methionine binding By similarity
Regioni142 – 1432S-adenosyl-L-methionine binding By similarity
Regioni240 – 2423S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK03439.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NU94-1 [UniParc]FASTAAdd to Basket

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MADTQAMASD RGVAVTLPQK RYYRQRAHSN PMADHTFQYP VKPEVMDWSE    50
YYPEFFKPLV PDCAHDDAKD LQERKEQHQV EFADVGCGYG GLLVALSPLF 100
PNTLMLGLEI RVKVSDYVQD RIKSLRASHL GQYQNIACIR SNAMKYLPNF 150
FKKGQLSKMF FLFPDPHFKK TKHKWRIISP TLLAEYSYAL RVGGMVYTIT 200
DVEEVHEWMV KHFTEHPLFE RVEKEELVSD IIVDKLGTST EEGKKVQRNK 250
GQNFLAVFRR IENRTFIQRD SQQ 273
Length:273
Mass (Da):31,843
Last modified:July 5, 2004 - v1
Checksum:i9E0BE0D49811ADAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC068703 mRNA. Translation: AAH68703.1.
RefSeqiNP_001084693.1. NM_001091224.1.
UniGeneiXl.43809.

Genome annotation databases

GeneIDi414654.
KEGGixla:414654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC068703 mRNA. Translation: AAH68703.1 .
RefSeqi NP_001084693.1. NM_001091224.1.
UniGenei Xl.43809.

3D structure databases

ProteinModelPortali Q6NU94.
SMRi Q6NU94. Positions 39-263.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6NU94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414654.
KEGGi xla:414654.

Organism-specific databases

CTDi 4234.
Xenbasei XB-GENE-6252283. mettl1.

Phylogenomic databases

KOi K03439.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiTRMB_XENLA
AccessioniPrimary (citable) accession number: Q6NU94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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