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Q6NU94

- TRMB_XENLA

UniProt

Q6NU94 - TRMB_XENLA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

mettl1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei162 – 1621S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Active sitei165 – 1651UniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
    2. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA (guanine-N7)-methylation Source: GOC
    2. tRNA modification Source: UniProtKB

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine, tRNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    Methyltransferase-like protein 1UniRule annotation
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:mettl1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252283. mettl1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273tRNA (guanine-N(7)-)-methyltransferasePRO_0000370559Add
    BLAST

    Proteomic databases

    PRIDEiQ6NU94.

    Interactioni

    Subunit structurei

    Forms a complex with wdr4.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NU94.
    SMRiQ6NU94. Positions 39-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni109 – 1102S-adenosyl-L-methionine bindingUniRule annotation
    Regioni142 – 1432S-adenosyl-L-methionine bindingUniRule annotation
    Regioni240 – 2423S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    KOiK03439.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NU94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADTQAMASD RGVAVTLPQK RYYRQRAHSN PMADHTFQYP VKPEVMDWSE    50
    YYPEFFKPLV PDCAHDDAKD LQERKEQHQV EFADVGCGYG GLLVALSPLF 100
    PNTLMLGLEI RVKVSDYVQD RIKSLRASHL GQYQNIACIR SNAMKYLPNF 150
    FKKGQLSKMF FLFPDPHFKK TKHKWRIISP TLLAEYSYAL RVGGMVYTIT 200
    DVEEVHEWMV KHFTEHPLFE RVEKEELVSD IIVDKLGTST EEGKKVQRNK 250
    GQNFLAVFRR IENRTFIQRD SQQ 273
    Length:273
    Mass (Da):31,843
    Last modified:July 5, 2004 - v1
    Checksum:i9E0BE0D49811ADAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC068703 mRNA. Translation: AAH68703.1.
    RefSeqiNP_001084693.1. NM_001091224.1.
    UniGeneiXl.43809.

    Genome annotation databases

    GeneIDi414654.
    KEGGixla:414654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC068703 mRNA. Translation: AAH68703.1 .
    RefSeqi NP_001084693.1. NM_001091224.1.
    UniGenei Xl.43809.

    3D structure databases

    ProteinModelPortali Q6NU94.
    SMRi Q6NU94. Positions 39-263.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6NU94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414654.
    KEGGi xla:414654.

    Organism-specific databases

    CTDi 4234.
    Xenbasei XB-GENE-6252283. mettl1.

    Phylogenomic databases

    KOi K03439.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiTRMB_XENLA
    AccessioniPrimary (citable) accession number: Q6NU94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3