ID   MTRAB_XENLA             Reviewed;         764 AA.
AC   Q6NU08; Q5XG01;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=Myotubularin-related protein 10-B;
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 10-B {ECO:0000305};
GN   Name=mtmr10-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC       subfamily, lacks the conserved active site cysteine residue at position
CC       390 in the dsPTPase catalytic loop, suggesting that it has no
CC       phosphatase activity. {ECO:0000305}.
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DR   EMBL; BC068794; AAH68794.1; -; mRNA.
DR   EMBL; BC084670; AAH84670.1; -; mRNA.
DR   RefSeq; NP_001084571.1; NM_001091102.1.
DR   AlphaFoldDB; Q6NU08; -.
DR   SMR; Q6NU08; -.
DR   BioGRID; 100945; 1.
DR   IntAct; Q6NU08; 1.
DR   DNASU; 414523; -.
DR   GeneID; 414523; -.
DR   KEGG; xla:414523; -.
DR   AGR; Xenbase:XB-GENE-6252568; -.
DR   CTD; 414523; -.
DR   Xenbase; XB-GENE-6252568; mtmr10.L.
DR   OrthoDB; 5474662at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 414523; Expressed in blastula and 19 other cell types or tissues.
DR   CDD; cd13346; PH-GRAM_MTMR10; 1.
DR   CDD; cd14593; PTP-MTMR10; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR036004; MTMR10_PH-GRAM.
DR   InterPro; IPR030573; MTMR10_PTP.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF39; MYOTUBULARIN-RELATED PROTEIN 10; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..764
FT                   /note="Myotubularin-related protein 10-B"
FT                   /id="PRO_0000284364"
FT   DOMAIN          208..649
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
SQ   SEQUENCE   764 AA;  88058 MW;  E017E6532F8FDC3C CRC64;
     MFSLKQPKPS FKSYLLPLQQ EDKLNPETKI KKLKPVLLPG EIVVNEVNFV RKCIASDTSQ
     YDLWGKLVCT NFKISFITEN SVPFQRFHYK NLLLGEHDVP LTCIEQIVVV NDTKRKQKIL
     SHNQKLKFNP TELIIYCKDF RILRFRFDEA GPESAKKVCL ALAHYSQPTD LQLLFAFEYV
     AQMYHKLDKV NGIDPGGGGD FCQRTPLFES YSDWDREIKR TGASDWRVCS VNEGYMISTC
     LPEYFVVPSS LADQDLKQYS HAFVGRRMPL WCWNHSNGSA LVRMASIKDL LQQRKIDQRV
     CSGITRSHPL RSEVYKCDLD DNVPSIQDIQ AAFSKLRQLC VNEPFDETEE KWLSSLENTR
     WLEFVRMFLK QAAELVYMLD FSRRSVVLQE EEGRDLSCVV ASLVQLMLDP YFRTIIGFQS
     LIQKEWVMSA YPFLDRCNHL KRSDKESPLF VLFLDCVWQL LQQYPAAFQF TETYLTVVHD
     SSRISLFGTF MFNSPHQRVQ QSTEFAIGKN IQLGEEKGLK FPSVWDWSLQ FSAKDRALFN
     NPLYIGKSVP CVQNGAVKSF KRTKKNYSST MRGMPPSVKN GMSIQQEIMP RRNSLILKLK
     PEILQQVPVI PGNGFEQYFR DWFSKPADLH GVILPCLHGT HIQIWKLCYL RWTPEAQINH
     GGFITAFHKI SLLASEIEVL QSRLRQYRAY PMATVTSPVG EQNQMFFRPD ELHSSNGSLD
     ILSSSFPFSP IGNLCRRSIL GTPLSKFLNG AKIWLSTETL ANED
//