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Protein

Myotubularin-related protein 10-B

Gene

mtmr10-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10-B
Gene namesi
Name:mtmr10-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252568 mtmr10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843641 – 764Myotubularin-related protein 10-BAdd BLAST764

Proteomic databases

PRIDEiQ6NU08

Interactioni

Protein-protein interaction databases

BioGridi100945, 1 interactor
IntActiQ6NU08, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6NU08
SMRiQ6NU08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 649Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST442

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 199Poly-Gly4

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG108154
KOiK18085

Family and domain databases

CDDicd13346 PH-GRAM_MTMR10, 1 hit
InterProiView protein in InterPro
IPR030573 MTMR10
IPR036004 MTMR10_PH-GRAM
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF39 PTHR10807:SF39, 1 hit
PfamiView protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 2 hits
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NU08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLKQPKPS FKSYLLPLQQ EDKLNPETKI KKLKPVLLPG EIVVNEVNFV
60 70 80 90 100
RKCIASDTSQ YDLWGKLVCT NFKISFITEN SVPFQRFHYK NLLLGEHDVP
110 120 130 140 150
LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA
160 170 180 190 200
GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKLDKV NGIDPGGGGD
210 220 230 240 250
FCQRTPLFES YSDWDREIKR TGASDWRVCS VNEGYMISTC LPEYFVVPSS
260 270 280 290 300
LADQDLKQYS HAFVGRRMPL WCWNHSNGSA LVRMASIKDL LQQRKIDQRV
310 320 330 340 350
CSGITRSHPL RSEVYKCDLD DNVPSIQDIQ AAFSKLRQLC VNEPFDETEE
360 370 380 390 400
KWLSSLENTR WLEFVRMFLK QAAELVYMLD FSRRSVVLQE EEGRDLSCVV
410 420 430 440 450
ASLVQLMLDP YFRTIIGFQS LIQKEWVMSA YPFLDRCNHL KRSDKESPLF
460 470 480 490 500
VLFLDCVWQL LQQYPAAFQF TETYLTVVHD SSRISLFGTF MFNSPHQRVQ
510 520 530 540 550
QSTEFAIGKN IQLGEEKGLK FPSVWDWSLQ FSAKDRALFN NPLYIGKSVP
560 570 580 590 600
CVQNGAVKSF KRTKKNYSST MRGMPPSVKN GMSIQQEIMP RRNSLILKLK
610 620 630 640 650
PEILQQVPVI PGNGFEQYFR DWFSKPADLH GVILPCLHGT HIQIWKLCYL
660 670 680 690 700
RWTPEAQINH GGFITAFHKI SLLASEIEVL QSRLRQYRAY PMATVTSPVG
710 720 730 740 750
EQNQMFFRPD ELHSSNGSLD ILSSSFPFSP IGNLCRRSIL GTPLSKFLNG
760
AKIWLSTETL ANED
Length:764
Mass (Da):88,058
Last modified:July 5, 2004 - v1
Checksum:iE017E6532F8FDC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068794 mRNA Translation: AAH68794.1
BC084670 mRNA Translation: AAH84670.1
RefSeqiNP_001084571.1, NM_001091102.1
UniGeneiXl.18166

Genome annotation databases

GeneIDi414523
KEGGixla:414523

Similar proteinsi

Entry informationi

Entry nameiMTRAB_XENLA
AccessioniPrimary (citable) accession number: Q6NU08
Secondary accession number(s): Q5XG01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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