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Protein

Myotubularin-related protein 10-B

Gene

mtmr10-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

GO - Molecular functioni

  1. phosphatase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10-B
Gene namesi
Name:mtmr10-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252568. mtmr10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Myotubularin-related protein 10-BPRO_0000284364Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6NU08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 649442Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi196 – 1994Poly-Gly

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG108154.
KOiK18085.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NU08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLKQPKPS FKSYLLPLQQ EDKLNPETKI KKLKPVLLPG EIVVNEVNFV
60 70 80 90 100
RKCIASDTSQ YDLWGKLVCT NFKISFITEN SVPFQRFHYK NLLLGEHDVP
110 120 130 140 150
LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA
160 170 180 190 200
GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKLDKV NGIDPGGGGD
210 220 230 240 250
FCQRTPLFES YSDWDREIKR TGASDWRVCS VNEGYMISTC LPEYFVVPSS
260 270 280 290 300
LADQDLKQYS HAFVGRRMPL WCWNHSNGSA LVRMASIKDL LQQRKIDQRV
310 320 330 340 350
CSGITRSHPL RSEVYKCDLD DNVPSIQDIQ AAFSKLRQLC VNEPFDETEE
360 370 380 390 400
KWLSSLENTR WLEFVRMFLK QAAELVYMLD FSRRSVVLQE EEGRDLSCVV
410 420 430 440 450
ASLVQLMLDP YFRTIIGFQS LIQKEWVMSA YPFLDRCNHL KRSDKESPLF
460 470 480 490 500
VLFLDCVWQL LQQYPAAFQF TETYLTVVHD SSRISLFGTF MFNSPHQRVQ
510 520 530 540 550
QSTEFAIGKN IQLGEEKGLK FPSVWDWSLQ FSAKDRALFN NPLYIGKSVP
560 570 580 590 600
CVQNGAVKSF KRTKKNYSST MRGMPPSVKN GMSIQQEIMP RRNSLILKLK
610 620 630 640 650
PEILQQVPVI PGNGFEQYFR DWFSKPADLH GVILPCLHGT HIQIWKLCYL
660 670 680 690 700
RWTPEAQINH GGFITAFHKI SLLASEIEVL QSRLRQYRAY PMATVTSPVG
710 720 730 740 750
EQNQMFFRPD ELHSSNGSLD ILSSSFPFSP IGNLCRRSIL GTPLSKFLNG
760
AKIWLSTETL ANED
Length:764
Mass (Da):88,058
Last modified:July 5, 2004 - v1
Checksum:iE017E6532F8FDC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068794 mRNA. Translation: AAH68794.1.
BC084670 mRNA. Translation: AAH84670.1.
RefSeqiNP_001084571.1. NM_001091102.1.
UniGeneiXl.18166.

Genome annotation databases

GeneIDi414523.
KEGGixla:414523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068794 mRNA. Translation: AAH68794.1.
BC084670 mRNA. Translation: AAH84670.1.
RefSeqiNP_001084571.1. NM_001091102.1.
UniGeneiXl.18166.

3D structure databases

ProteinModelPortaliQ6NU08.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414523.
KEGGixla:414523.

Organism-specific databases

CTDi414523.
XenbaseiXB-GENE-6252568. mtmr10.

Phylogenomic databases

HOVERGENiHBG108154.
KOiK18085.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Spleen.

Entry informationi

Entry nameiMTRAB_XENLA
AccessioniPrimary (citable) accession number: Q6NU08
Secondary accession number(s): Q5XG01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.