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Protein

Myotubularin-related protein 10-B

Gene

mtmr10-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10-B
Gene namesi
Name:mtmr10-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252568. mtmr10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843641 – 764Myotubularin-related protein 10-BAdd BLAST764

Interactioni

Protein-protein interaction databases

BioGridi100945. 1 interactor.
IntActiQ6NU08. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6NU08.
SMRiQ6NU08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 649Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST442

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 199Poly-Gly4

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG108154.
KOiK18085.

Family and domain databases

CDDicd13346. PH-GRAM_MTMR10. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR030573. MTMR10.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR035660. PH-GRAM_MTMR10.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF90. PTHR10807:SF90. 1 hit.
PfamiView protein in Pfam
PF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiView protein in PROSITE
PS51339. PPASE_MYOTUBULARIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NU08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLKQPKPS FKSYLLPLQQ EDKLNPETKI KKLKPVLLPG EIVVNEVNFV
60 70 80 90 100
RKCIASDTSQ YDLWGKLVCT NFKISFITEN SVPFQRFHYK NLLLGEHDVP
110 120 130 140 150
LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA
160 170 180 190 200
GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKLDKV NGIDPGGGGD
210 220 230 240 250
FCQRTPLFES YSDWDREIKR TGASDWRVCS VNEGYMISTC LPEYFVVPSS
260 270 280 290 300
LADQDLKQYS HAFVGRRMPL WCWNHSNGSA LVRMASIKDL LQQRKIDQRV
310 320 330 340 350
CSGITRSHPL RSEVYKCDLD DNVPSIQDIQ AAFSKLRQLC VNEPFDETEE
360 370 380 390 400
KWLSSLENTR WLEFVRMFLK QAAELVYMLD FSRRSVVLQE EEGRDLSCVV
410 420 430 440 450
ASLVQLMLDP YFRTIIGFQS LIQKEWVMSA YPFLDRCNHL KRSDKESPLF
460 470 480 490 500
VLFLDCVWQL LQQYPAAFQF TETYLTVVHD SSRISLFGTF MFNSPHQRVQ
510 520 530 540 550
QSTEFAIGKN IQLGEEKGLK FPSVWDWSLQ FSAKDRALFN NPLYIGKSVP
560 570 580 590 600
CVQNGAVKSF KRTKKNYSST MRGMPPSVKN GMSIQQEIMP RRNSLILKLK
610 620 630 640 650
PEILQQVPVI PGNGFEQYFR DWFSKPADLH GVILPCLHGT HIQIWKLCYL
660 670 680 690 700
RWTPEAQINH GGFITAFHKI SLLASEIEVL QSRLRQYRAY PMATVTSPVG
710 720 730 740 750
EQNQMFFRPD ELHSSNGSLD ILSSSFPFSP IGNLCRRSIL GTPLSKFLNG
760
AKIWLSTETL ANED
Length:764
Mass (Da):88,058
Last modified:July 5, 2004 - v1
Checksum:iE017E6532F8FDC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068794 mRNA. Translation: AAH68794.1.
BC084670 mRNA. Translation: AAH84670.1.
RefSeqiNP_001084571.1. NM_001091102.1.
UniGeneiXl.18166.

Genome annotation databases

GeneIDi414523.
KEGGixla:414523.

Similar proteinsi

Entry informationi

Entry nameiMTRAB_XENLA
AccessioniPrimary (citable) accession number: Q6NU08
Secondary accession number(s): Q5XG01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families