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Q6NU08 (MTRAB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 10-B
Gene names
Name:mtmr10-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length764 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 myotubularin phosphatase domain.

Ontologies

Gene Ontology (GO)
   Molecular_functionphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 764764Myotubularin-related protein 10-B
PRO_0000284364

Regions

Domain208 – 649442Myotubularin phosphatase
Compositional bias196 – 1994Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
Q6NU08 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E017E6532F8FDC3C

FASTA76488,058
        10         20         30         40         50         60 
MFSLKQPKPS FKSYLLPLQQ EDKLNPETKI KKLKPVLLPG EIVVNEVNFV RKCIASDTSQ 

        70         80         90        100        110        120 
YDLWGKLVCT NFKISFITEN SVPFQRFHYK NLLLGEHDVP LTCIEQIVVV NDTKRKQKIL 

       130        140        150        160        170        180 
SHNQKLKFNP TELIIYCKDF RILRFRFDEA GPESAKKVCL ALAHYSQPTD LQLLFAFEYV 

       190        200        210        220        230        240 
AQMYHKLDKV NGIDPGGGGD FCQRTPLFES YSDWDREIKR TGASDWRVCS VNEGYMISTC 

       250        260        270        280        290        300 
LPEYFVVPSS LADQDLKQYS HAFVGRRMPL WCWNHSNGSA LVRMASIKDL LQQRKIDQRV 

       310        320        330        340        350        360 
CSGITRSHPL RSEVYKCDLD DNVPSIQDIQ AAFSKLRQLC VNEPFDETEE KWLSSLENTR 

       370        380        390        400        410        420 
WLEFVRMFLK QAAELVYMLD FSRRSVVLQE EEGRDLSCVV ASLVQLMLDP YFRTIIGFQS 

       430        440        450        460        470        480 
LIQKEWVMSA YPFLDRCNHL KRSDKESPLF VLFLDCVWQL LQQYPAAFQF TETYLTVVHD 

       490        500        510        520        530        540 
SSRISLFGTF MFNSPHQRVQ QSTEFAIGKN IQLGEEKGLK FPSVWDWSLQ FSAKDRALFN 

       550        560        570        580        590        600 
NPLYIGKSVP CVQNGAVKSF KRTKKNYSST MRGMPPSVKN GMSIQQEIMP RRNSLILKLK 

       610        620        630        640        650        660 
PEILQQVPVI PGNGFEQYFR DWFSKPADLH GVILPCLHGT HIQIWKLCYL RWTPEAQINH 

       670        680        690        700        710        720 
GGFITAFHKI SLLASEIEVL QSRLRQYRAY PMATVTSPVG EQNQMFFRPD ELHSSNGSLD 

       730        740        750        760 
ILSSSFPFSP IGNLCRRSIL GTPLSKFLNG AKIWLSTETL ANED 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC068794 mRNA. Translation: AAH68794.1.
BC084670 mRNA. Translation: AAH84670.1.
RefSeqNP_001084571.1. NM_001091102.1.
UniGeneXl.18166.

3D structure databases

ProteinModelPortalQ6NU08.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414523.
KEGGxla:414523.

Organism-specific databases

CTD414523.
XenbaseXB-GENE-6252568. mtmr10.

Phylogenomic databases

HOVERGENHBG108154.
KOK18085.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMSSF52799. SSF52799. 2 hits.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTRAB_XENLA
AccessionPrimary (citable) accession number: Q6NU08
Secondary accession number(s): Q5XG01
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families