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Q6NU08

- MTRAB_XENLA

UniProt

Q6NU08 - MTRAB_XENLA

Protein

Myotubularin-related protein 10-B

Gene

mtmr10-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.Curated

    GO - Molecular functioni

    1. phosphatase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 10-B
    Gene namesi
    Name:mtmr10-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252568. mtmr10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Myotubularin-related protein 10-BPRO_0000284364Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NU08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini208 – 649442Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi196 – 1994Poly-Gly

    Sequence similaritiesi

    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG108154.
    KOiK18085.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR022587. Myotubularin_assoc.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    [Graphical view]
    PfamiPF12578. 3-PAP. 1 hit.
    PF06602. Myotub-related. 2 hits.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NU08-1 [UniParc]FASTAAdd to Basket

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    MFSLKQPKPS FKSYLLPLQQ EDKLNPETKI KKLKPVLLPG EIVVNEVNFV    50
    RKCIASDTSQ YDLWGKLVCT NFKISFITEN SVPFQRFHYK NLLLGEHDVP 100
    LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA 150
    GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKLDKV NGIDPGGGGD 200
    FCQRTPLFES YSDWDREIKR TGASDWRVCS VNEGYMISTC LPEYFVVPSS 250
    LADQDLKQYS HAFVGRRMPL WCWNHSNGSA LVRMASIKDL LQQRKIDQRV 300
    CSGITRSHPL RSEVYKCDLD DNVPSIQDIQ AAFSKLRQLC VNEPFDETEE 350
    KWLSSLENTR WLEFVRMFLK QAAELVYMLD FSRRSVVLQE EEGRDLSCVV 400
    ASLVQLMLDP YFRTIIGFQS LIQKEWVMSA YPFLDRCNHL KRSDKESPLF 450
    VLFLDCVWQL LQQYPAAFQF TETYLTVVHD SSRISLFGTF MFNSPHQRVQ 500
    QSTEFAIGKN IQLGEEKGLK FPSVWDWSLQ FSAKDRALFN NPLYIGKSVP 550
    CVQNGAVKSF KRTKKNYSST MRGMPPSVKN GMSIQQEIMP RRNSLILKLK 600
    PEILQQVPVI PGNGFEQYFR DWFSKPADLH GVILPCLHGT HIQIWKLCYL 650
    RWTPEAQINH GGFITAFHKI SLLASEIEVL QSRLRQYRAY PMATVTSPVG 700
    EQNQMFFRPD ELHSSNGSLD ILSSSFPFSP IGNLCRRSIL GTPLSKFLNG 750
    AKIWLSTETL ANED 764
    Length:764
    Mass (Da):88,058
    Last modified:July 5, 2004 - v1
    Checksum:iE017E6532F8FDC3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC068794 mRNA. Translation: AAH68794.1.
    BC084670 mRNA. Translation: AAH84670.1.
    RefSeqiNP_001084571.1. NM_001091102.1.
    UniGeneiXl.18166.

    Genome annotation databases

    GeneIDi414523.
    KEGGixla:414523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC068794 mRNA. Translation: AAH68794.1 .
    BC084670 mRNA. Translation: AAH84670.1 .
    RefSeqi NP_001084571.1. NM_001091102.1.
    UniGenei Xl.18166.

    3D structure databases

    ProteinModelPortali Q6NU08.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414523.
    KEGGi xla:414523.

    Organism-specific databases

    CTDi 414523.
    Xenbasei XB-GENE-6252568. mtmr10.

    Phylogenomic databases

    HOVERGENi HBG108154.
    KOi K18085.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR022587. Myotubularin_assoc.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    [Graphical view ]
    Pfami PF12578. 3-PAP. 1 hit.
    PF06602. Myotub-related. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Spleen.

    Entry informationi

    Entry nameiMTRAB_XENLA
    AccessioniPrimary (citable) accession number: Q6NU08
    Secondary accession number(s): Q5XG01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3