Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6NTW5 (IMPA3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol monophosphatase 3
Short name=IMP 3
Short name=IMPase 3
EC=3.1.3.25
Alternative name(s):
Inositol monophosphatase domain-containing protein 1
Inositol-1(or 4)-monophosphatase 3
Myo-inositol monophosphatase A3
Gene names
Name:impad1
Synonyms:impa3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the inositol monophosphatase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioninositol monophosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Inositol monophosphatase 3
PRO_0000289044

Regions

Transmembrane11 – 3121Helical; Potential
Region164 – 1674Substrate binding By similarity

Sites

Metal binding1211Magnesium 1 By similarity
Metal binding1621Magnesium 1 By similarity
Metal binding1621Magnesium 2 By similarity
Metal binding1641Magnesium 1; via carbonyl oxygen By similarity
Metal binding1651Magnesium 2 By similarity
Metal binding2881Magnesium 2 By similarity
Binding site1211Substrate By similarity
Binding site2881Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NTW5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2599E44B71C40E6C

FASTA35138,118
        10         20         30         40         50         60 
MAPMGIRLSP LGIGVFCLLA LGVLYHVYSG FLTGRFAAFL LGDRAGDTVD LRELLAVSVR 

        70         80         90        100        110        120 
AAELGGVEVK KVRESNSLNE KAKGKTREGE DEKMTSGDVL SNKKMYHLIK NAFPAVLVNT 

       130        140        150        160        170        180 
EEQVDPDEED AVSWDHDIPD EIKDKIKTSK PVSSESITIW IDPLDATHEY AENLVKYVTT 

       190        200        210        220        230        240 
MVCVAVNGKP VIGVIHKPFT GYTAWAMVDE GANIKKRSSY NEKTPTFIVS RSHSGEVKEV 

       250        260        270        280        290        300 
TRQTFGNKTE IISAGGAGYK VLSLLDVTAD EQEKADVYIH VTYIKKWDIC AGNAILNALG 

       310        320        330        340        350 
GHMTTLKGEE ISYTGSEQNE GGLLASIGMD HSALVGKLAE KISVNAKKPA K

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC068839 mRNA. Translation: AAH68839.1.
RefSeqNP_001084511.1. NM_001091042.1.
UniGeneXl.50514.

3D structure databases

HSSPHSSP built from PDB template 1JP4 based on UniProtKB Q9Z1N4.
ProteinModelPortalQ6NTW5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414458.
KEGGxla:414458.

Organism-specific databases

CTD54928.
XenbaseXB-GENE-5751113. impad1.

Phylogenomic databases

HOVERGENHBG062091.

Family and domain databases

InterProIPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEPS00629. IMP_1. False negative.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIMPA3_XENLA
AccessionPrimary (citable) accession number: Q6NTW5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: October 19, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents