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Q6NTR6 (UP44A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 44-A

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 44-A
Ubiquitin thioesterase 44-A
Ubiquitin-specific-processing protease 44-A
Gene names
Name:usp44-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP44 subfamily.

Contains 1 UBP-type zinc finger.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 690690Ubiquitin carboxyl-terminal hydrolase 44-A
PRO_0000395813

Regions

Domain274 – 667394USP
Zinc finger24 – 8562UBP-type

Sites

Active site2831Nucleophile By similarity
Active site6251Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NTR6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 77A3C98DB6F8E5BA

FASTA69079,011
        10         20         30         40         50         60 
MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI EEHALRHFQD 

        70         80         90        100        110        120 
SKHPLALEVN ELYVFCYLCD DYVLNDNTTG DLKLLRSTLS AIKSQNYDCT TRSGRTLRSM 

       130        140        150        160        170        180 
VTADDSFISH EGAQAFLQNE DRAFTALWHR RHALLGKVFR SWFALTPKGK QRLEEERLRE 

       190        200        210        220        230        240 
EAEQKREEAR KKRQQLKRKL KEEMESTSPR KSSRLQHQIQ PSPKTELPSV QKMNQKNSPT 

       250        260        270        280        290        300 
TKQKTPAPTS DKACFKKIGN SPIKRKPTVT PGVTGLRNLG NTCYMNSILQ ILSHLHVFRE 

       310        320        330        340        350        360 
CFLQLDLNQT QELLAAAGSG KTRLSSKYPP GAELPRVTQK HTKVQRSLAR RQSFSLGLSG 

       370        380        390        400        410        420 
GASNSRNMEL IQPKEPSSKH ISLCHELHTL FQVMWSGKWA LVSPFAMLHS VWRLIPAFRG 

       430        440        450        460        470        480 
YAQQDAQEFL CELLDKVQQE LETTGTRYPA LIPTSQRKLI KQVLNVVNNI FHGQLLSQVT 

       490        500        510        520        530        540 
CLVCDHKSNT IEPFWDLSLE FPERYHFNGK ETASQRPCLL TEMLAKFTET EALEGKIYAC 

       550        560        570        580        590        600 
DQCNKAQKQL MVCRLPQVLR LHLKRFRWSG RNHREKIGVH VRFDQMLNME PYCCRESTAA 

       610        620        630        640        650        660 
LRADCFIYDL SSVVMHHGKG FGSGHYTAFC YNPEGGFWVH CNDSKLHSCT VEEVCKAQAY 

       670        680        690 
ILFYTQRVTQ ENGHLSDTLP VHGSPQSPPR 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC068889 mRNA. Translation: AAH68889.1.
RefSeqNP_001084641.1. NM_001091172.1.
UniGeneXl.6668.

3D structure databases

ProteinModelPortalQ6NTR6.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6NTR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414600.
KEGGxla:414600.

Organism-specific databases

CTD414600.
XenbaseXB-GENE-1014118. usp44.

Phylogenomic databases

HOVERGENHBG018027.
KOK11834.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUP44A_XENLA
AccessionPrimary (citable) accession number: Q6NTR6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries