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Protein

Dual specificity protein phosphatase 23

Gene

Dusp23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 23 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Low molecular mass dual specificity phosphatase 3
Short name:
LDP-3
Gene namesi
Name:Dusp23
Synonyms:Ldp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915690. Dusp23.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity

  • Note: Mainly cytosolic. Weakly nuclear (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000948362 – 150Dual specificity protein phosphatase 23Add BLAST149

Proteomic databases

MaxQBiQ6NT99.
PaxDbiQ6NT99.
PeptideAtlasiQ6NT99.
PRIDEiQ6NT99.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000026544.
CleanExiMM_DUSP23.
GenevisibleiQ6NT99. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027826.

Structurei

3D structure databases

ProteinModelPortaliQ6NT99.
SMRiQ6NT99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 140Tyrosine-protein phosphataseAdd BLAST66

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1720. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000010254.
HOGENOMiHOG000108423.
HOVERGENiHBG056524.
InParanoidiQ6NT99.
KOiK14165.
OMAiAVHCMHG.
OrthoDBiEOG091G0XEO.
PhylomeDBiQ6NT99.
TreeFamiTF105125.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NT99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDQGVRHLV SLTERGPPHS
60 70 80 90 100
DSCPGLTLHR MRIPDFCPPS PEQIDQFVKI VDEANARGEA VGVHCALGFG
110 120 130 140 150
RTGTMLACYL VKERALAAGD AIAEIRRLRP GSIETYEQEK AVFQFYQRTK
Length:150
Mass (Da):16,637
Last modified:July 5, 2004 - v1
Checksum:i00EFC7D3F275CA66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13P → L in BAB23663 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183013 mRNA. Translation: BAD26711.1.
BC069187 mRNA. Translation: AAH69187.1.
AK004912 mRNA. Translation: BAB23663.1.
CCDSiCCDS15518.1.
RefSeqiNP_081001.1. NM_026725.2.
UniGeneiMm.33024.

Genome annotation databases

EnsembliENSMUST00000027826; ENSMUSP00000027826; ENSMUSG00000026544.
GeneIDi68440.
KEGGimmu:68440.
UCSCiuc007dqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183013 mRNA. Translation: BAD26711.1.
BC069187 mRNA. Translation: AAH69187.1.
AK004912 mRNA. Translation: BAB23663.1.
CCDSiCCDS15518.1.
RefSeqiNP_081001.1. NM_026725.2.
UniGeneiMm.33024.

3D structure databases

ProteinModelPortaliQ6NT99.
SMRiQ6NT99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027826.

Proteomic databases

MaxQBiQ6NT99.
PaxDbiQ6NT99.
PeptideAtlasiQ6NT99.
PRIDEiQ6NT99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027826; ENSMUSP00000027826; ENSMUSG00000026544.
GeneIDi68440.
KEGGimmu:68440.
UCSCiuc007dqw.1. mouse.

Organism-specific databases

CTDi54935.
MGIiMGI:1915690. Dusp23.

Phylogenomic databases

eggNOGiKOG1720. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000010254.
HOGENOMiHOG000108423.
HOVERGENiHBG056524.
InParanoidiQ6NT99.
KOiK14165.
OMAiAVHCMHG.
OrthoDBiEOG091G0XEO.
PhylomeDBiQ6NT99.
TreeFamiTF105125.

Miscellaneous databases

PROiQ6NT99.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026544.
CleanExiMM_DUSP23.
GenevisibleiQ6NT99. MM.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS23_MOUSE
AccessioniPrimary (citable) accession number: Q6NT99
Secondary accession number(s): Q9CW48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.