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Q6NT89

- TRNP1_HUMAN

UniProt

Q6NT89 - TRNP1_HUMAN

Protein

TMF-regulated nuclear protein 1

Gene

TRNP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cerebellar cortex morphogenesis Source: UniProtKB
    3. neural precursor cell proliferation Source: UniProtKB
    4. regulation of cell cycle Source: UniProtKB
    5. regulation of cell proliferation Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell cycle, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TMF-regulated nuclear protein 1
    Gene namesi
    Name:TRNP1
    Synonyms:C1orf225, TRNP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:34348. TRNP1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nuclear euchromatin Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164727311.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227TMF-regulated nuclear protein 1PRO_0000336088Add
    BLAST

    Post-translational modificationi

    Ubiquitinated, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ6NT89.

    PTM databases

    PhosphoSiteiQ6NT89.

    Expressioni

    Developmental stagei

    Expression is detected in the ventricular zone and neuronal layers of the developing cerebral cortex at 12, 18 and 21 gestation weeks. Differences in regional expression seem to correlate with the process of gyrification of the cortex. Highly expressed in germinal layers of the precentral and parahippocampal gyri, that exhibit little radial expansion and folding, and weakly expressed in germinal layers of the occipital and temporal lobes, that undergo greater expansion and folding.1 Publication

    Gene expression databases

    BgeeiQ6NT89.
    CleanExiHS_C1orf225.
    GenevestigatoriQ6NT89.

    Interactioni

    Subunit structurei

    Interacts with TMF1; may regulate TRNP1 proteasomal degradation.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NT89.
    SMRiQ6NT89. Positions 96-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 5533Pro-richAdd
    BLAST

    Phylogenomic databases

    HOGENOMiHOG000154686.
    InParanoidiQ6NT89.
    OMAiCVPWGAG.
    OrthoDBiEOG7FZ024.
    PhylomeDBiQ6NT89.
    TreeFamiTF338814.

    Sequencei

    Sequence statusi: Complete.

    Q6NT89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGCRISACG PGAQEGTAEQ RSPPPPWDPM PSSQPPPPTP TLTPTPTPGQ    50
    SPPLPDAAGA SAGAAEDQEL QRWRQGASGI AGLAGPGGGS GAAAGAGGRA 100
    LELAEARRRL LEVEGRRRLV SELESRVLQL HRVFLAAELR LAHRAESLSR 150
    LSGGVAQAEL YLAAHGSRLK KGPRRGRRGR PPALLASALG LGGCVPWGAG 200
    RLRRGHGPEP DSPFRRSPPR GPASPQR 227
    Length:227
    Mass (Da):23,482
    Last modified:March 3, 2009 - v2
    Checksum:i01FBA6DC86CCD7CA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271W → R.1 Publication
    Corresponds to variant rs6689941 [ dbSNP | Ensembl ].
    VAR_043545

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356390 Genomic DNA. No translation available.
    BC069216 mRNA. Translation: AAH69216.1.
    CCDSiCCDS41289.1.
    RefSeqiNP_001013664.1. NM_001013642.2.
    XP_005245924.1. XM_005245867.1.
    UniGeneiHs.355747.

    Genome annotation databases

    EnsembliENST00000522111; ENSP00000429216; ENSG00000253368.
    GeneIDi388610.
    KEGGihsa:388610.
    UCSCiuc001bnj.4. human.

    Polymorphism databases

    DMDMi224471860.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    the geometry of intelligence - Issue 152 of August 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356390 Genomic DNA. No translation available.
    BC069216 mRNA. Translation: AAH69216.1 .
    CCDSi CCDS41289.1.
    RefSeqi NP_001013664.1. NM_001013642.2.
    XP_005245924.1. XM_005245867.1.
    UniGenei Hs.355747.

    3D structure databases

    ProteinModelPortali Q6NT89.
    SMRi Q6NT89. Positions 96-174.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6NT89.

    Polymorphism databases

    DMDMi 224471860.

    Proteomic databases

    PRIDEi Q6NT89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000522111 ; ENSP00000429216 ; ENSG00000253368 .
    GeneIDi 388610.
    KEGGi hsa:388610.
    UCSCi uc001bnj.4. human.

    Organism-specific databases

    CTDi 388610.
    GeneCardsi GC01P027320.
    HGNCi HGNC:34348. TRNP1.
    neXtProti NX_Q6NT89.
    PharmGKBi PA164727311.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000154686.
    InParanoidi Q6NT89.
    OMAi CVPWGAG.
    OrthoDBi EOG7FZ024.
    PhylomeDBi Q6NT89.
    TreeFami TF338814.

    Miscellaneous databases

    NextBioi 102215.
    PROi Q6NT89.

    Gene expression databases

    Bgeei Q6NT89.
    CleanExi HS_C1orf225.
    Genevestigatori Q6NT89.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-27.
      Tissue: Eye.
    3. "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate."
      Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M., Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.
      Cell 153:535-549(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTRNP1_HUMAN
    AccessioniPrimary (citable) accession number: Q6NT89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3