##gff-version 3 Q6NT76 UniProtKB Chain 1 420 . . . ID=PRO_0000233287;Note=Homeobox-containing protein 1 Q6NT76 UniProtKB Domain 18 49 . . . Note=HNF-p1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01286 Q6NT76 UniProtKB Domain 145 241 . . . Note=POU-specific atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01285 Q6NT76 UniProtKB DNA binding 267 341 . . . Note=Homeobox;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00108,ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Region 56 139 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NT76 UniProtKB Region 353 385 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NT76 UniProtKB Compositional bias 64 139 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NT76 UniProtKB Site 335 335 . . . Note=Critical for recognition and binding of 5'-TTAGGG-3' motifs in telomeric DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Modified residue 148 148 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NT76 UniProtKB Modified residue 170 170 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NT76 UniProtKB Cross-link 60 60 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q6NT76 UniProtKB Cross-link 131 131 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q6NT76 UniProtKB Cross-link 161 161 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733 Q6NT76 UniProtKB Cross-link 174 174 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733 Q6NT76 UniProtKB Cross-link 217 217 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733 Q6NT76 UniProtKB Cross-link 310 310 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q6NT76 UniProtKB Cross-link 413 413 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 Q6NT76 UniProtKB Cross-link 413 413 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733 Q6NT76 UniProtKB Alternative sequence 284 304 . . . ID=VSP_038983;Note=In isoform 4. SYFNENQYPDEAKREEIANAC->RNTWSPERRMEENKWKLLSAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19757162;Dbxref=PMID:19757162 Q6NT76 UniProtKB Alternative sequence 305 420 . . . ID=VSP_038984;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19757162;Dbxref=PMID:19757162 Q6NT76 UniProtKB Alternative sequence 344 345 . . . ID=VSP_018111;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6 Q6NT76 UniProtKB Alternative sequence 344 344 . . . ID=VSP_018112;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q6NT76 UniProtKB Alternative sequence 375 375 . . . ID=VSP_038985;Note=In isoform 5. Q->QDTWQVRNGEEEEGRSSEGGREAEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q6NT76 UniProtKB Alternative sequence 377 420 . . . ID=VSP_018113;Note=In isoform 2. DSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD->TWQVRNGEEEEGRSSEGGREAEKVEEERRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q6NT76 UniProtKB Mutagenesis 271 271 . . . Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Mutagenesis 325 325 . . . Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Mutagenesis 327 327 . . . Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Mutagenesis 334 334 . . . Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Mutagenesis 335 335 . . . Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. Confers binding to the non-telomeric 5'-GTGAGT-3' motif. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Mutagenesis 338 338 . . . Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Mutagenesis 339 339 . . . Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356 Q6NT76 UniProtKB Sequence conflict 167 167 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NT76 UniProtKB Helix 276 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J19 Q6NT76 UniProtKB Helix 294 308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J19 Q6NT76 UniProtKB Turn 317 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J19 Q6NT76 UniProtKB Helix 323 343 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J19