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Protein

Choriogonadotropin subunit beta variant 2

Gene

CGB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • hormone activity Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta variant 2
Gene namesi
Name:CGB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000104818.14
HGNCiHGNC:16722 CGB2
MIMi608824 gene
neXtProtiNX_Q6NT52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114336
OpenTargetsiENSG00000104818

Polymorphism and mutation databases

DMDMi281185508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000034254919 – 163Choriogonadotropin subunit beta variant 2Sequence analysisAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 75By similarity
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi41 ↔ 90By similarity
Disulfide bondi44 ↔ 128By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi52 ↔ 106By similarity
Disulfide bondi56 ↔ 108By similarity
Disulfide bondi111 ↔ 118By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6NT52
PaxDbiQ6NT52
PeptideAtlasiQ6NT52
PRIDEiQ6NT52

PTM databases

iPTMnetiQ6NT52
PhosphoSitePlusiQ6NT52

Expressioni

Tissue specificityi

Expressed in placenta, testis and pituitary.2 Publications

Gene expression databases

CleanExiHS_CGB2

Organism-specific databases

HPAiHPA038925
HPA038934

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • hormone activity Source: AgBase

Protein-protein interaction databases

IntActiQ6NT52, 36 interactors
STRINGi9606.ENSP00000403649

Structurei

3D structure databases

ProteinModelPortaliQ6NT52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiQ6NT52
OMAiNSICAGY
PhylomeDBiQ6NT52

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NT52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGLLLLLL LSMGGTWASK EPLRPRCRPI NATLAVEKEG CPVCITVNTT
60 70 80 90 100
ICAGYCPTMT RVLQGVLPAL PQVVCNYRDV RFESIRLPGC PRGVNPVVSY
110 120 130 140 150
AVALSCQCAL CRRSTTDCGG PKDHPLTCDD PRFQASSSSK APPPSLPSPS
160
RLPGPSDTPI LPQ
Length:163
Mass (Da):17,374
Last modified:March 28, 2018 - v5
Checksum:i823CEF334B9183F6
GO

Sequence cautioni

The sequence AAH69367 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA No translation available.
BC069367 mRNA Translation: AAH69367.2 Sequence problems.
CCDSiCCDS12750.2
RefSeqiNP_203696.2, NM_033378.1
UniGeneiHs.567650

Genome annotation databases

EnsembliENST00000359342; ENSP00000352295; ENSG00000104818
GeneIDi114336

Entry informationi

Entry nameiCGB2_HUMAN
AccessioniPrimary (citable) accession number: Q6NT52
Secondary accession number(s): B9ZVM5, H9KV56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 103 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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