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Protein

Choriogonadotropin subunit beta variant 2

Gene

CGB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. hormone activity Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta variant 2
Gene namesi
Name:CGB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16722. CGB2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050Sequence AnalysisAdd
BLAST
Chaini51 – 195145Choriogonadotropin subunit beta variant 2PRO_0000342549Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 107By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi73 ↔ 122By similarity
Disulfide bondi76 ↔ 160By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi84 ↔ 138By similarity
Disulfide bondi88 ↔ 140By similarity
Disulfide bondi143 ↔ 150By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6NT52.
PaxDbiQ6NT52.
PRIDEiQ6NT52.

PTM databases

PhosphoSiteiQ6NT52.

Expressioni

Tissue specificityi

Expressed in placenta, testis and pituitary.2 Publications

Gene expression databases

BgeeiQ6NT52.
CleanExiHS_CGB2.
ExpressionAtlasiQ6NT52. baseline.
GenevestigatoriQ6NT52.

Organism-specific databases

HPAiCAB000042.
CAB010884.
HPA038925.
HPA038934.

Structurei

3D structure databases

SMRiQ6NT52. Positions 52-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284462.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiQ6NT52.
PhylomeDBiQ6NT52.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NT52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQGLLLL LLLSMGGTWA
60 70 80 90 100
SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP
110 120 130 140 150
ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC
160 170 180 190
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ
Length:195
Mass (Da):21,221
Last modified:December 15, 2009 - v4
Checksum:i8FD069D54A10983D
GO
Isoform 2 (identifier: Q6NT52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-131: RVDPHFRAPK...CPRGVNPVVS → AAAVAAAEHG...SMCTLPPQHH
     132-195: Missing.

Note: Does not have any homology with the functional beta-subunit. This change has been caused by an inserted DNA fragment within the 5'-UTR of CGB2 providing a novel exon 1 as well as a 1 bp shifted ORF for exons 2 and 3.

Show »
Length:132
Mass (Da):14,100
Checksum:i3A496CE4E11121A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41F → S in AAH69367 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei21 – 131111RVDPH…NPVVS → AAAVAAAEHGRDMGIQGAAS ATVPPHQCHPGCGEGGLPRV HHRQHHHLCRLLPHHDPRAA GGPAGPASGGVQLPRCALRV HPAPWLPARREPRGLLRRGS QLSMCTLPPQHH in isoform 2. 1 PublicationVSP_034492Add
BLAST
Alternative sequencei132 – 19564Missing in isoform 2. 1 PublicationVSP_034493Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA. No translation available.
BC069367 mRNA. Translation: AAH69367.2.
UniGeneiHs.567650.

Polymorphism databases

DMDMi281185508.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA. No translation available.
BC069367 mRNA. Translation: AAH69367.2.
UniGeneiHs.567650.

3D structure databases

SMRiQ6NT52. Positions 52-161.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6NT52.

Polymorphism databases

DMDMi281185508.

Proteomic databases

MaxQBiQ6NT52.
PaxDbiQ6NT52.
PRIDEiQ6NT52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC19P049535.
H-InvDBHIX0059836.
HGNCiHGNC:16722. CGB2.
HPAiCAB000042.
CAB010884.
HPA038925.
HPA038934.
MIMi608824. gene.
neXtProtiNX_Q6NT52.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284462.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiQ6NT52.
PhylomeDBiQ6NT52.

Miscellaneous databases

PROiQ6NT52.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NT52.
CleanExiHS_CGB2.
ExpressionAtlasiQ6NT52. baseline.
GenevestigatoriQ6NT52.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
    Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
    Mol. Hum. Reprod. 14:23-31(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Expression of beta-subunit of HCG genes during normal and failed pregnancy."
    Rull K., Laan M.
    Hum. Reprod. 20:3360-3368(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCGB2_HUMAN
AccessioniPrimary (citable) accession number: Q6NT52
Secondary accession number(s): B9ZVM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 15, 2009
Last modified: April 1, 2015
This is version 84 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.