Q6NT52 (CGB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choriogonadotropin subunit beta variant 2

Gene names

Name:

CGB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed in placenta, testis and pituitary. Ref.1 Ref.4
Sequence similarities	Belongs to the glycoprotein hormones subunit beta family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NT52-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NT52-2)

The sequence of this isoform differs from the canonical sequence as follows:
     21-131: RVDPHFRAPK...CPRGVNPVVS → AAAVAAAEHG...SMCTLPPQHH
     132-195: Missing.

Note: Does not have any homology with the functional beta-subunit. This change has been caused by an inserted DNA fragment within the 5'-UTR of CGB2 providing a novel exon 1 as well as a 1 bp shifted ORF for exons 2 and 3.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 50	50	Potential
	Chain	51 – 195	145	Choriogonadotropin subunit beta variant 2		PRO_0000342549
Amino acid modifications
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Disulfide bond	59 ↔ 107		By similarity
	Disulfide bond	73 ↔ 122		By similarity
	Disulfide bond	76 ↔ 160		By similarity
	Disulfide bond	84 ↔ 138		By similarity
	Disulfide bond	88 ↔ 140		By similarity
	Disulfide bond	143 ↔ 150		By similarity
Natural variations
	Alternative sequence	21 – 131	111	RVDPH…NPVVS → AAAVAAAEHGRDMGIQGAAS ATVPPHQCHPGCGEGGLPRV HHRQHHHLCRLLPHHDPRAA GGPAGPASGGVQLPRCALRV HPAPWLPARREPRGLLRRGS QLSMCTLPPQHH in isoform 2.		VSP_034492
	Alternative sequence	132 – 195	64	Missing in isoform 2.		VSP_034493
Experimental info
	Sequence conflict	4	1	F → S in AAH69367. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 15, 2009. Version 4. Checksum: 8FD069D54A10983D	FASTA	195	21,221
	10 20 30 40 50 60 MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR 70 80 90 100 110 120 PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP 130 140 150 160 170 180 GCPRGVNPVV SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS 190 PSRLPGPSDT PILPQ
	Isoform 2 [UniParc]. Checksum: 3A496CE4E11121A0	FASTA	132	14,100
	10 20 30 40 50 60 MSTFPVLAED IPLRERHVKG AAAVAAAEHG RDMGIQGAAS ATVPPHQCHP GCGEGGLPRV 70 80 90 100 110 120 HHRQHHHLCR LLPHHDPRAA GGPAGPASGG VQLPRCALRV HPAPWLPARR EPRGLLRRGS 130 QLSMCTLPPQ HH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues." Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M. Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Expression of beta-subunit of HCG genes during normal and failed pregnancy." Rull K., Laan M. Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008687 Genomic DNA. No translation available. BC069367 mRNA. Translation: AAH69367.2.
IPI	IPI00555688. IPI00746788.
UniGene	Hs.567650.
3D structure databases
ProteinModelPortal	Q6NT52.
SMR	Q6NT52. Positions 52-161.
ModBase	Search...
PTM databases
PhosphoSite	Q6NT52.
Polymorphism databases
DMDM	281185508.
Proteomic databases
PaxDb	Q6NT52.
PRIDE	Q6NT52.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC19P049535.
H-InvDB	HIX0059836.
HGNC	HGNC:16722. CGB2.
HPA	HPA038925. HPA038934.
MIM	608824. gene.
neXtProt	NX_Q6NT52.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284462.
HOGENOM	HOG000116098.
HOVERGEN	HBG006698.
InParanoid	Q6NT52.
Gene expression databases
ArrayExpress	Q6NT52.
Bgee	Q6NT52.
CleanEx	HS_CGB2.
Genevestigator	Q6NT52.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR001545. Gonadotropin_bsu. IPR018245. Gonadotropin_bsu_CS. [Graphical view]
PANTHER	PTHR11515. PTHR11515. 1 hit.
Pfam	PF00007. Cys_knot. 1 hit. [Graphical view]
SMART	SM00068. GHB. 1 hit. [Graphical view]
PROSITE	PS00261. GLYCO_HORMONE_BETA_1. 1 hit. PS00689. GLYCO_HORMONE_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CGB2_HUMAN

Accession

Primary (citable) accession number: Q6NT52
Secondary accession number(s): B9ZVM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	December 15, 2009
Last modified:	April 3, 2013
This is version 74 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.