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Q6NT52 (CGB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choriogonadotropin subunit beta variant 2
Gene names
Name:CGB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed in placenta, testis and pituitary. Ref.1 Ref.4

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NT52-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NT52-2)

The sequence of this isoform differs from the canonical sequence as follows:
     21-131: RVDPHFRAPK...CPRGVNPVVS → AAAVAAAEHG...SMCTLPPQHH
     132-195: Missing.
Note: Does not have any homology with the functional beta-subunit. This change has been caused by an inserted DNA fragment within the 5'-UTR of CGB2 providing a novel exon 1 as well as a 1 bp shifted ORF for exons 2 and 3.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 Potential
Chain51 – 195145Choriogonadotropin subunit beta variant 2
PRO_0000342549

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Disulfide bond59 ↔ 107 By similarity
Disulfide bond73 ↔ 122 By similarity
Disulfide bond76 ↔ 160 By similarity
Disulfide bond84 ↔ 138 By similarity
Disulfide bond88 ↔ 140 By similarity
Disulfide bond143 ↔ 150 By similarity

Natural variations

Alternative sequence21 – 131111RVDPH…NPVVS → AAAVAAAEHGRDMGIQGAAS ATVPPHQCHPGCGEGGLPRV HHRQHHHLCRLLPHHDPRAA GGPAGPASGGVQLPRCALRV HPAPWLPARREPRGLLRRGS QLSMCTLPPQHH in isoform 2.
VSP_034492
Alternative sequence132 – 19564Missing in isoform 2.
VSP_034493

Experimental info

Sequence conflict41F → S in AAH69367. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 15, 2009. Version 4.
Checksum: 8FD069D54A10983D

FASTA19521,221
        10         20         30         40         50         60 
MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR 

        70         80         90        100        110        120 
PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP 

       130        140        150        160        170        180 
GCPRGVNPVV SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS 

       190 
PSRLPGPSDT PILPQ 

« Hide

Isoform 2 [UniParc].

Checksum: 3A496CE4E11121A0
Show »

FASTA13214,100

References

« Hide 'large scale' references
[1]"Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Expression of beta-subunit of HCG genes during normal and failed pregnancy."
Rull K., Laan M.
Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008687 Genomic DNA. No translation available.
BC069367 mRNA. Translation: AAH69367.2.
UniGeneHs.567650.

3D structure databases

ProteinModelPortalQ6NT52.
SMRQ6NT52. Positions 52-161.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6NT52.

Polymorphism databases

DMDM281185508.

Proteomic databases

MaxQBQ6NT52.
PaxDbQ6NT52.
PRIDEQ6NT52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC19P049535.
H-InvDBHIX0059836.
HGNCHGNC:16722. CGB2.
HPAHPA038925.
HPA038934.
MIM608824. gene.
neXtProtNX_Q6NT52.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284462.
HOGENOMHOG000116098.
HOVERGENHBG006698.
InParanoidQ6NT52.
PhylomeDBQ6NT52.

Gene expression databases

BgeeQ6NT52.
CleanExHS_CGB2.
GenevestigatorQ6NT52.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERPTHR11515. PTHR11515. 1 hit.
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ6NT52.
SOURCESearch...

Entry information

Entry nameCGB2_HUMAN
AccessionPrimary (citable) accession number: Q6NT52
Secondary accession number(s): B9ZVM5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 79 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM