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Q6NT52

- CGB2_HUMAN

UniProt

Q6NT52 - CGB2_HUMAN

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Protein

Choriogonadotropin subunit beta variant 2

Gene
CGB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta variant 2
Gene namesi
Name:CGB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:16722. CGB2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050 Reviewed predictionAdd
BLAST
Chaini51 – 195145Choriogonadotropin subunit beta variant 2PRO_0000342549Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 107 By similarity
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi73 ↔ 122 By similarity
Disulfide bondi76 ↔ 160 By similarity
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi84 ↔ 138 By similarity
Disulfide bondi88 ↔ 140 By similarity
Disulfide bondi143 ↔ 150 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6NT52.
PaxDbiQ6NT52.
PRIDEiQ6NT52.

PTM databases

PhosphoSiteiQ6NT52.

Expressioni

Tissue specificityi

Expressed in placenta, testis and pituitary.2 Publications

Gene expression databases

BgeeiQ6NT52.
CleanExiHS_CGB2.
GenevestigatoriQ6NT52.

Organism-specific databases

HPAiHPA038925.
HPA038934.

Structurei

3D structure databases

ProteinModelPortaliQ6NT52.
SMRiQ6NT52. Positions 52-161.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284462.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiQ6NT52.
PhylomeDBiQ6NT52.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NT52-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQGLLLL LLLSMGGTWA    50
SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP 100
ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC 150
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ 195
Length:195
Mass (Da):21,221
Last modified:December 15, 2009 - v4
Checksum:i8FD069D54A10983D
GO
Isoform 2 (identifier: Q6NT52-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-131: RVDPHFRAPK...CPRGVNPVVS → AAAVAAAEHG...SMCTLPPQHH
     132-195: Missing.

Note: Does not have any homology with the functional beta-subunit. This change has been caused by an inserted DNA fragment within the 5'-UTR of CGB2 providing a novel exon 1 as well as a 1 bp shifted ORF for exons 2 and 3.

Show »
Length:132
Mass (Da):14,100
Checksum:i3A496CE4E11121A0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei21 – 131111RVDPH…NPVVS → AAAVAAAEHGRDMGIQGAAS ATVPPHQCHPGCGEGGLPRV HHRQHHHLCRLLPHHDPRAA GGPAGPASGGVQLPRCALRV HPAPWLPARREPRGLLRRGS QLSMCTLPPQHH in isoform 2. VSP_034492Add
BLAST
Alternative sequencei132 – 19564Missing in isoform 2. VSP_034493Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41F → S in AAH69367. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008687 Genomic DNA. No translation available.
BC069367 mRNA. Translation: AAH69367.2.
UniGeneiHs.567650.

Polymorphism databases

DMDMi281185508.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008687 Genomic DNA. No translation available.
BC069367 mRNA. Translation: AAH69367.2 .
UniGenei Hs.567650.

3D structure databases

ProteinModelPortali Q6NT52.
SMRi Q6NT52. Positions 52-161.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6NT52.

Polymorphism databases

DMDMi 281185508.

Proteomic databases

MaxQBi Q6NT52.
PaxDbi Q6NT52.
PRIDEi Q6NT52.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC19P049535.
H-InvDB HIX0059836.
HGNCi HGNC:16722. CGB2.
HPAi HPA038925.
HPA038934.
MIMi 608824. gene.
neXtProti NX_Q6NT52.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284462.
HOGENOMi HOG000116098.
HOVERGENi HBG006698.
InParanoidi Q6NT52.
PhylomeDBi Q6NT52.

Miscellaneous databases

PROi Q6NT52.
SOURCEi Search...

Gene expression databases

Bgeei Q6NT52.
CleanExi HS_CGB2.
Genevestigatori Q6NT52.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view ]
PANTHERi PTHR11515. PTHR11515. 1 hit.
Pfami PF00007. Cys_knot. 1 hit.
[Graphical view ]
SMARTi SM00068. GHB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
    Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
    Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Expression of beta-subunit of HCG genes during normal and failed pregnancy."
    Rull K., Laan M.
    Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCGB2_HUMAN
AccessioniPrimary (citable) accession number: Q6NT52
Secondary accession number(s): B9ZVM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 79 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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