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Protein

G antigen 2A

Gene

GAGE2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2A
Short name:
GAGE-2A
Gene namesi
Name:GAGE2A
Synonyms:GAGE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189064.8.
HGNCiHGNC:4099. GAGE2A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189064.
PharmGKBiPA162389230.

Polymorphism and mutation databases

BioMutaiGAGE2A.
DMDMi74736753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954451 – 116G antigen 2AAdd BLAST116

Proteomic databases

MaxQBiQ6NT46.
PaxDbiQ6NT46.
PeptideAtlasiQ6NT46.
PRIDEiQ6NT46.
TopDownProteomicsiQ6NT46.

PTM databases

iPTMnetiQ6NT46.
PhosphoSitePlusiQ6NT46.

Expressioni

Gene expression databases

BgeeiENSG00000189064.
GenevisibleiQ6NT46. HS.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355421.

Structurei

3D structure databases

ProteinModelPortaliQ6NT46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
GeneTreeiENSGT00900000141202.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ6NT46.
OMAiNSREILW.
OrthoDBiEOG091G0UGV.
PhylomeDBiQ6NT46.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NT46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGQD EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,785
Last modified:July 5, 2004 - v1
Checksum:iDD24495CB68EF19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA. No translation available.
BC069397 mRNA. Translation: AAH69397.1.
CCDSiCCDS48114.1.
RefSeqiNP_001120684.1. NM_001127212.1.
UniGeneiHs.460641.
Hs.722100.

Genome annotation databases

EnsembliENST00000362097; ENSP00000355421; ENSG00000189064.
GeneIDi729447.
KEGGihsa:729447.
UCSCiuc004doi.6. human.

Similar proteinsi

Entry informationi

Entry nameiGAG2A_HUMAN
AccessioniPrimary (citable) accession number: Q6NT46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families