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Q6NT46

- GAG2A_HUMAN

UniProt

Q6NT46 - GAG2A_HUMAN

Protein

G antigen 2A

Gene

GAGE2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 2A
    Short name:
    GAGE-2A
    Gene namesi
    Name:GAGE2A
    Synonyms:GAGE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4099. GAGE2A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162389230.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116G antigen 2APRO_0000395445Add
    BLAST

    Proteomic databases

    PaxDbiQ6NT46.
    PRIDEiQ6NT46.

    PTM databases

    PhosphoSiteiQ6NT46.

    Expressioni

    Gene expression databases

    BgeeiQ6NT46.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355421.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NT46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    eggNOGiNOG293879.
    HOGENOMiHOG000237345.
    HOVERGENiHBG056227.
    OMAiTSMIVDT.
    OrthoDBiEOG7XM316.
    PhylomeDBiQ6NT46.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NT46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ    50
    DPAAAQEGQD EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN 100
    PEEVKTPEEG EKQSQC 116
    Length:116
    Mass (Da):12,785
    Last modified:July 5, 2004 - v1
    Checksum:iDD24495CB68EF19A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142497 Genomic DNA. No translation available.
    BC069397 mRNA. Translation: AAH69397.1.
    CCDSiCCDS48114.1.
    RefSeqiNP_001120684.1. NM_001127212.1.
    UniGeneiHs.460641.
    Hs.722100.

    Genome annotation databases

    EnsembliENST00000362097; ENSP00000355421; ENSG00000189064.
    GeneIDi729447.
    KEGGihsa:729447.
    UCSCiuc004dnr.4. human.

    Polymorphism databases

    DMDMi74736753.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142497 Genomic DNA. No translation available.
    BC069397 mRNA. Translation: AAH69397.1 .
    CCDSi CCDS48114.1.
    RefSeqi NP_001120684.1. NM_001127212.1.
    UniGenei Hs.460641.
    Hs.722100.

    3D structure databases

    ProteinModelPortali Q6NT46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355421.

    PTM databases

    PhosphoSitei Q6NT46.

    Polymorphism databases

    DMDMi 74736753.

    Proteomic databases

    PaxDbi Q6NT46.
    PRIDEi Q6NT46.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000362097 ; ENSP00000355421 ; ENSG00000189064 .
    GeneIDi 729447.
    KEGGi hsa:729447.
    UCSCi uc004dnr.4. human.

    Organism-specific databases

    CTDi 729447.
    GeneCardsi GC0XP049360.
    HGNCi HGNC:4099. GAGE2A.
    HPAi HPA043232.
    MIMi 300720. gene.
    neXtProti NX_Q6NT46.
    PharmGKBi PA162389230.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293879.
    HOGENOMi HOG000237345.
    HOVERGENi HBG056227.
    OMAi TSMIVDT.
    OrthoDBi EOG7XM316.
    PhylomeDBi Q6NT46.
    TreeFami TF340669.

    Miscellaneous databases

    GenomeRNAii 729447.
    NextBioi 130319.
    PROi Q6NT46.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NT46.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
      De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
      Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
    4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGAG2A_HUMAN
    AccessioniPrimary (citable) accession number: Q6NT46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3