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Protein

G antigen 2A

Gene

GAGE2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2A
Short name:
GAGE-2A
Gene namesi
Name:GAGE2A
Synonyms:GAGE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4099. GAGE2A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116G antigen 2APRO_0000395445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei114 – 1141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6NT46.
PaxDbiQ6NT46.
PRIDEiQ6NT46.

PTM databases

PhosphoSiteiQ6NT46.

Expressioni

Gene expression databases

BgeeiQ6NT46.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355421.

Structurei

3D structure databases

ProteinModelPortaliQ6NT46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG293879.
GeneTreeiENSGT00760000119480.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ6NT46.
OrthoDBiEOG7XM316.
PhylomeDBiQ6NT46.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NT46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGQD EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,785
Last modified:July 4, 2004 - v1
Checksum:iDD24495CB68EF19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA. No translation available.
BC069397 mRNA. Translation: AAH69397.1.
CCDSiCCDS48114.1.
RefSeqiNP_001120684.1. NM_001127212.1.
UniGeneiHs.460641.
Hs.722100.

Genome annotation databases

EnsembliENST00000362097; ENSP00000355421; ENSG00000189064.
GeneIDi729447.
KEGGihsa:729447.
UCSCiuc004dnr.4. human.

Polymorphism databases

DMDMi74736753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA. No translation available.
BC069397 mRNA. Translation: AAH69397.1.
CCDSiCCDS48114.1.
RefSeqiNP_001120684.1. NM_001127212.1.
UniGeneiHs.460641.
Hs.722100.

3D structure databases

ProteinModelPortaliQ6NT46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355421.

PTM databases

PhosphoSiteiQ6NT46.

Polymorphism databases

DMDMi74736753.

Proteomic databases

MaxQBiQ6NT46.
PaxDbiQ6NT46.
PRIDEiQ6NT46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362097; ENSP00000355421; ENSG00000189064.
GeneIDi729447.
KEGGihsa:729447.
UCSCiuc004dnr.4. human.

Organism-specific databases

CTDi729447.
GeneCardsiGC0XP049360.
HGNCiHGNC:4099. GAGE2A.
HPAiHPA043232.
MIMi300720. gene.
neXtProtiNX_Q6NT46.
PharmGKBiPA162389230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG293879.
GeneTreeiENSGT00760000119480.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ6NT46.
OrthoDBiEOG7XM316.
PhylomeDBiQ6NT46.
TreeFamiTF340669.

Miscellaneous databases

GenomeRNAii729447.
NextBioi130319.
PROiQ6NT46.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NT46.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
    De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
    Cancer Res. 59:3157-3165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
  4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGAG2A_HUMAN
AccessioniPrimary (citable) accession number: Q6NT46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 12, 2010
Last sequence update: July 4, 2004
Last modified: March 3, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.