Q6NT32 (EST5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carboxylesterase 5A
EC=3.1.1.1

Alternative name(s):
Carboxylesterase-like urinary excreted protein homolog
Short name=Cauxin

Gene names

Name:	CES5A
Synonyms:	CES7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs By similarity.
Catalytic activity	A carboxylic ester + H2O = an alcohol + a carboxylate.
Subcellular location	Secreted By similarity.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.
Caution	Was termed (Ref.1) CES5.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carboxylesterase activity Inferred from Biological aspect of Ancestor. Source: RefGenome methyl indole-3-acetate esterase activity Inferred from electronic annotation. Source: EC methyl jasmonate esterase activity Inferred from electronic annotation. Source: EC methyl salicylate esterase activity Inferred from electronic annotation. Source: EC retinyl-palmitate esterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NT32-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NT32-2)

The sequence of this isoform differs from the canonical sequence as follows:
     425-474: Missing.

Isoform 3 (identifier: Q6NT32-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6NT32-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSGNWVHPGQILIWAIWVLAAPTK → MAVLVCPASC...DVLNYTSKDE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 575	555	Carboxylesterase 5A		PRO_0000308591
Sites
	Active site	226	1	Acyl-ester intermediate By similarity
	Active site	345	1	Charge relay system By similarity
	Active site	454	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	281	1	N-linked (GlcNAc...) Potential
	Glycosylation	363	1	N-linked (GlcNAc...) Potential
	Glycosylation	513	1	N-linked (GlcNAc...) Potential
	Glycosylation	524	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 121		By similarity
Natural variations
	Alternative sequence	1 – 106	106	Missing in isoform 3.		VSP_029005
	Alternative sequence	1 – 24	24	MSGNW…AAPTK → MAVLVCPASCHGLKEFRIRR GMWRLCLVYYFYPASSTLYV LRIDVLNYTSKDE in isoform 4.		VSP_043296
	Alternative sequence	425 – 474	50	Missing in isoform 2.		VSP_029006
	Natural variant	71	1	R → Q. Corresponds to variant rs2397965 [ dbSNP | Ensembl ].		VAR_036836
	Natural variant	261	1	E → K. Corresponds to variant rs11076126 [ dbSNP | Ensembl ].		VAR_036837
	Natural variant	344	1	H → Q. Corresponds to variant rs11860946 [ dbSNP | Ensembl ].		VAR_036838
	Natural variant	499	1	G → R. Corresponds to variant rs16955812 [ dbSNP | Ensembl ].		VAR_036839
	Natural variant	537	1	D → E. Ref.2 Corresponds to variant rs11860456 [ dbSNP | Ensembl ].		VAR_036840
Experimental info
	Sequence conflict	343	1	N → S in BAC03565. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6F5B735BDEFC9C09	FASTA	575	63,926
	10 20 30 40 50 60 MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV 70 80 90 100 110 120 PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV HYPKFGVSED 130 140 150 160 170 180 CLYLNIYAPA HADTGSKLPV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF 190 200 210 220 230 240 GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM 250 260 270 280 290 300 AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL 310 320 330 340 350 360 LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL PMKEAPEILS 370 380 390 400 410 420 GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA 430 440 450 460 470 480 RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV KADHADEVRF VFGGAFLKGD IVMFEGATEE 490 500 510 520 530 540 EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT 550 560 570 STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP
	Isoform 2 [UniParc]. Checksum: 7724878B8A22F215	FASTA	525	58,201
	10 20 30 40 50 60 MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV 70 80 90 100 110 120 PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV HYPKFGVSED 130 140 150 160 170 180 CLYLNIYAPA HADTGSKLPV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF 190 200 210 220 230 240 GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM 250 260 270 280 290 300 AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL 310 320 330 340 350 360 LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL PMKEAPEILS 370 380 390 400 410 420 GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA 430 440 450 460 470 480 RYHREGATEE EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR 490 500 510 520 LKEPRVDFWT STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP
	Isoform 3 [UniParc]. Checksum: 62F180A83206A1E8	FASTA	469	52,325
	10 20 30 40 50 60 MLKVHYPKFG VSEDCLYLNI YAPAHADTGS KLPVLVWFPG GAFKTGSASI FDGSALAAYE 70 80 90 100 110 120 DVLVVVVQYR LGIFGFFTTW DQHAPGNWAF KDQVAALSWV QKNIEFFGGD PSSVTIFGES 130 140 150 160 170 180 AGAISVSSLI LSPMAKGLFH KAIMESGVAI IPYLEAHDYE KSEDLQVVAH FCGNNASDSE 190 200 210 220 230 240 ALLRCLRTKP SKELLTLSQK TKSFTRVVDG AFFPNEPLDL LSQKAFKAIP SIIGVNNHEC 250 260 270 280 290 300 GFLLPMKEAP EILSGSNKSL ALHLIQNILH IPPQYLHLVA NEYFHDKHSL TEIRDSLLDL 310 320 330 340 350 360 LGDVFFVVPA LITARYHRDA GAPVYFYEFR HRPQCFEDTK PAFVKADHAD EVRFVFGGAF 370 380 390 400 410 420 LKGDIVMFEG ATEEEKLLSR KMMKYWATFA RTGNPNGNDL SLWPAYNLTE QYLQLDLNMS 430 440 450 460 LGQRLKEPRV DFWTSTIPLI LSASDMLHSP LSSLTFLSLL QPFFFFCAP
	Isoform 4 [UniParc]. Checksum: CE123CDD0AF142FC	FASTA	604	67,487
	10 20 30 40 50 60 MAVLVCPASC HGLKEFRIRR GMWRLCLVYY FYPASSTLYV LRIDVLNYTS KDEGPSAEGP 70 80 90 100 110 120 QRNTRLGWIQ GKQVTVLGSP VPVNVFLGVP FAAPPLGSLR FTNPQPASPW DNLREATSYP 130 140 150 160 170 180 NLCLQNSEWL LLDQHMLKVH YPKFGVSEDC LYLNIYAPAH ADTGSKLPVL VWFPGGAFKT 190 200 210 220 230 240 GSASIFDGSA LAAYEDVLVV VVQYRLGIFG FFTTWDQHAP GNWAFKDQVA ALSWVQKNIE 250 260 270 280 290 300 FFGGDPSSVT IFGESAGAIS VSSLILSPMA KGLFHKAIME SGVAIIPYLE AHDYEKSEDL 310 320 330 340 350 360 QVVAHFCGNN ASDSEALLRC LRTKPSKELL TLSQKTKSFT RVVDGAFFPN EPLDLLSQKA 370 380 390 400 410 420 FKAIPSIIGV NNHECGFLLP MKEAPEILSG SNKSLALHLI QNILHIPPQY LHLVANEYFH 430 440 450 460 470 480 DKHSLTEIRD SLLDLLGDVF FVVPALITAR YHRDAGAPVY FYEFRHRPQC FEDTKPAFVK 490 500 510 520 530 540 ADHADEVRFV FGGAFLKGDI VMFEGATEEE KLLSRKMMKY WATFARTGNP NGNDLSLWPA 550 560 570 580 590 600 YNLTEQYLQL DLNMSLGQRL KEPRVDFWTS TIPLILSASD MLHSPLSSLT FLSLLQPFFF FCAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Liu Q., Hamil K.G., French F.S., Hall S.H., Zhang Y.-L. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT GLU-537. Tissue: Amygdala and Brain.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY907669 mRNA. Translation: AAX86044.1. AK056109 mRNA. Translation: BAB71094.1. AK090997 mRNA. Translation: BAC03565.1. AK294334 mRNA. Translation: BAH11738.1. AC007335 Genomic DNA. No translation available. AC147362 Genomic DNA. No translation available. BC069501 mRNA. Translation: AAH69501.1. BC069548 mRNA. Translation: AAH69548.1. BC117126 mRNA. Translation: AAI17127.1. BC143692 mRNA. Translation: AAI43693.1.
IPI	IPI00061013. IPI00431768. IPI00790315. IPI01013312.
RefSeq	NP_001137157.1. NM_001143685.1. NP_001177087.1. NM_001190158.1. NP_659461.1. NM_145024.2.
UniGene	Hs.350800.
3D structure databases
HSSP	HSSP built from PDB template 1K4Y based on UniProtKB P12337.
ProteinModelPortal	Q6NT32.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000290567.
Protein family/group databases
MEROPS	S09.960.
Polymorphism databases
DMDM	74758113.
Proteomic databases
PaxDb	Q6NT32.
PRIDE	Q6NT32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290567; ENSP00000290567; ENSG00000159398. ENST00000319165; ENSP00000324271; ENSG00000159398. ENST00000518005; ENSP00000428571; ENSG00000159398. ENST00000521992; ENSP00000428864; ENSG00000159398.
GeneID	221223.
KEGG	hsa:221223.
UCSC	uc002eio.2. human. uc002eip.2. human.
Organism-specific databases
CTD	221223.
GeneCards	GC16M055881.
HGNC	HGNC:26459. CES5A.
HPA	HPA047635.
neXtProt	NX_Q6NT32.
PharmGKB	PA142672130.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2272.
HOGENOM	HOG000091866.
HOVERGEN	HBG008839.
InParanoid	Q6NT32.
KO	K15743.
OMA	GPQRNTR.
OrthoDB	EOG466VM9.
Gene expression databases
ArrayExpress	Q6NT32.
Bgee	Q6NT32.
CleanEx	HS_CES7.
Genevestigator	Q6NT32.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR019819. Carboxylesterase_B_CS. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	221223.
NextBio	91242.

Entry information

Entry name

EST5A_HUMAN

Accession

Primary (citable) accession number: Q6NT32
Secondary accession number(s): B7Z252 , B7ZLB6, Q8NBC8, Q96DN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.