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Protein

Carboxylesterase 5A

Gene

CES5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei345 – 3451Charge relay systemBy similarity
Active sitei454 – 4541Charge relay systemBy similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: GO_Central

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylesterase 5A (EC:3.1.1.1)
Alternative name(s):
Carboxylesterase-like urinary excreted protein homolog
Short name:
Cauxin
Gene namesi
Name:CES5A
Synonyms:CES7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26459. CES5A.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672130.

Polymorphism and mutation databases

BioMutaiCES5A.
DMDMi74758113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 575555Carboxylesterase 5APRO_0000308591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 121By similarity
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6NT32.
PRIDEiQ6NT32.

Expressioni

Gene expression databases

BgeeiQ6NT32.
CleanExiHS_CES7.
ExpressionAtlasiQ6NT32. baseline.
GenevestigatoriQ6NT32.

Organism-specific databases

HPAiHPA047635.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000290567.

Structurei

3D structure databases

ProteinModelPortaliQ6NT32.
SMRiQ6NT32. Positions 31-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2272.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
InParanoidiQ6NT32.
KOiK15743.
OMAiVANEYFY.
OrthoDBiEOG75XGKD.
PhylomeDBiQ6NT32.
TreeFamiTF315470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NT32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS
60 70 80 90 100
PVPVNVFLGV PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW
110 120 130 140 150
LLLDQHMLKV HYPKFGVSED CLYLNIYAPA HADTGSKLPV LVWFPGGAFK
160 170 180 190 200
TGSASIFDGS ALAAYEDVLV VVVQYRLGIF GFFTTWDQHA PGNWAFKDQV
210 220 230 240 250
AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM AKGLFHKAIM
260 270 280 290 300
ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL
310 320 330 340 350
LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL
360 370 380 390 400
PMKEAPEILS GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR
410 420 430 440 450
DSLLDLLGDV FFVVPALITA RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV
460 470 480 490 500
KADHADEVRF VFGGAFLKGD IVMFEGATEE EKLLSRKMMK YWATFARTGN
510 520 530 540 550
PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT STIPLILSAS
560 570
DMLHSPLSSL TFLSLLQPFF FFCAP
Length:575
Mass (Da):63,926
Last modified:July 5, 2004 - v1
Checksum:i6F5B735BDEFC9C09
GO
Isoform 2 (identifier: Q6NT32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     425-474: Missing.

Show »
Length:525
Mass (Da):58,201
Checksum:i7724878B8A22F215
GO
Isoform 3 (identifier: Q6NT32-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):52,325
Checksum:i62F180A83206A1E8
GO
Isoform 4 (identifier: Q6NT32-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSGNWVHPGQILIWAIWVLAAPTK → MAVLVCPASC...DVLNYTSKDE

Note: No experimental confirmation available.

Show »
Length:604
Mass (Da):67,487
Checksum:iCE123CDD0AF142FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431N → S in BAC03565 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711R → Q.
Corresponds to variant rs2397965 [ dbSNP | Ensembl ].
VAR_036836
Natural varianti261 – 2611E → K.
Corresponds to variant rs11076126 [ dbSNP | Ensembl ].
VAR_036837
Natural varianti344 – 3441H → Q.
Corresponds to variant rs11860946 [ dbSNP | Ensembl ].
VAR_036838
Natural varianti499 – 4991G → R.
Corresponds to variant rs16955812 [ dbSNP | Ensembl ].
VAR_036839
Natural varianti537 – 5371D → E.1 Publication
Corresponds to variant rs11860456 [ dbSNP | Ensembl ].
VAR_036840

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 3. 1 PublicationVSP_029005Add
BLAST
Alternative sequencei1 – 2424MSGNW…AAPTK → MAVLVCPASCHGLKEFRIRR GMWRLCLVYYFYPASSTLYV LRIDVLNYTSKDE in isoform 4. 1 PublicationVSP_043296Add
BLAST
Alternative sequencei425 – 47450Missing in isoform 2. 2 PublicationsVSP_029006Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY907669 mRNA. Translation: AAX86044.1.
AK056109 mRNA. Translation: BAB71094.1.
AK090997 mRNA. Translation: BAC03565.1.
AK294334 mRNA. Translation: BAH11738.1.
AC007335 Genomic DNA. No translation available.
AC147362 Genomic DNA. No translation available.
BC069501 mRNA. Translation: AAH69501.1.
BC069548 mRNA. Translation: AAH69548.1.
BC117126 mRNA. Translation: AAI17127.1.
BC143692 mRNA. Translation: AAI43693.1.
CCDSiCCDS10755.1. [Q6NT32-2]
CCDS45490.1. [Q6NT32-1]
CCDS54012.1. [Q6NT32-4]
RefSeqiNP_001137157.1. NM_001143685.1. [Q6NT32-1]
NP_001177087.1. NM_001190158.1. [Q6NT32-4]
NP_659461.1. NM_145024.2. [Q6NT32-2]
UniGeneiHs.350800.

Genome annotation databases

EnsembliENST00000290567; ENSP00000290567; ENSG00000159398. [Q6NT32-1]
ENST00000319165; ENSP00000324271; ENSG00000159398. [Q6NT32-2]
ENST00000518005; ENSP00000428571; ENSG00000159398. [Q6NT32-3]
ENST00000521992; ENSP00000428864; ENSG00000159398. [Q6NT32-4]
GeneIDi221223.
KEGGihsa:221223.
UCSCiuc002eio.2. human. [Q6NT32-2]
uc002eip.2. human. [Q6NT32-1]
uc021tir.1. human. [Q6NT32-4]

Polymorphism and mutation databases

BioMutaiCES5A.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY907669 mRNA. Translation: AAX86044.1.
AK056109 mRNA. Translation: BAB71094.1.
AK090997 mRNA. Translation: BAC03565.1.
AK294334 mRNA. Translation: BAH11738.1.
AC007335 Genomic DNA. No translation available.
AC147362 Genomic DNA. No translation available.
BC069501 mRNA. Translation: AAH69501.1.
BC069548 mRNA. Translation: AAH69548.1.
BC117126 mRNA. Translation: AAI17127.1.
BC143692 mRNA. Translation: AAI43693.1.
CCDSiCCDS10755.1. [Q6NT32-2]
CCDS45490.1. [Q6NT32-1]
CCDS54012.1. [Q6NT32-4]
RefSeqiNP_001137157.1. NM_001143685.1. [Q6NT32-1]
NP_001177087.1. NM_001190158.1. [Q6NT32-4]
NP_659461.1. NM_145024.2. [Q6NT32-2]
UniGeneiHs.350800.

3D structure databases

ProteinModelPortaliQ6NT32.
SMRiQ6NT32. Positions 31-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000290567.

Polymorphism and mutation databases

BioMutaiCES5A.
DMDMi74758113.

Proteomic databases

PaxDbiQ6NT32.
PRIDEiQ6NT32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290567; ENSP00000290567; ENSG00000159398. [Q6NT32-1]
ENST00000319165; ENSP00000324271; ENSG00000159398. [Q6NT32-2]
ENST00000518005; ENSP00000428571; ENSG00000159398. [Q6NT32-3]
ENST00000521992; ENSP00000428864; ENSG00000159398. [Q6NT32-4]
GeneIDi221223.
KEGGihsa:221223.
UCSCiuc002eio.2. human. [Q6NT32-2]
uc002eip.2. human. [Q6NT32-1]
uc021tir.1. human. [Q6NT32-4]

Organism-specific databases

CTDi221223.
GeneCardsiGC16M055881.
HGNCiHGNC:26459. CES5A.
HPAiHPA047635.
neXtProtiNX_Q6NT32.
PharmGKBiPA142672130.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2272.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
InParanoidiQ6NT32.
KOiK15743.
OMAiVANEYFY.
OrthoDBiEOG75XGKD.
PhylomeDBiQ6NT32.
TreeFamiTF315470.

Miscellaneous databases

GenomeRNAii221223.
NextBioi91242.
PROiQ6NT32.

Gene expression databases

BgeeiQ6NT32.
CleanExiHS_CES7.
ExpressionAtlasiQ6NT32. baseline.
GenevestigatoriQ6NT32.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Liu Q., Hamil K.G., French F.S., Hall S.H., Zhang Y.-L.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT GLU-537.
    Tissue: Amygdala and Brain.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiEST5A_HUMAN
AccessioniPrimary (citable) accession number: Q6NT32
Secondary accession number(s): B7Z252
, B7ZLB6, Q8NBC8, Q96DN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (Ref. 1) CES5.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.