SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6NT32

- EST5A_HUMAN

UniProt

Q6NT32 - EST5A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Carboxylesterase 5A
Gene
CES5A, CES7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs By similarity.

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Acyl-ester intermediate By similarity
Active sitei345 – 3451Charge relay system By similarity
Active sitei454 – 4541Charge relay system By similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Protein family/group databases

    MEROPSiS09.960.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxylesterase 5A (EC:3.1.1.1)
    Alternative name(s):
    Carboxylesterase-like urinary excreted protein homolog
    Short name:
    Cauxin
    Gene namesi
    Name:CES5A
    Synonyms:CES7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26459. CES5A.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672130.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020 Reviewed prediction
    Add
    BLAST
    Chaini21 – 575555Carboxylesterase 5A
    PRO_0000308591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi94 ↔ 121 By similarity
    Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi363 – 3631N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi524 – 5241N-linked (GlcNAc...) Reviewed prediction

    Post-translational modificationi

    N-glycosylated By similarity.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6NT32.
    PRIDEiQ6NT32.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NT32.
    BgeeiQ6NT32.
    CleanExiHS_CES7.
    GenevestigatoriQ6NT32.

    Organism-specific databases

    HPAiHPA047635.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000290567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NT32.
    SMRiQ6NT32. Positions 31-541.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2272.
    HOGENOMiHOG000091866.
    HOVERGENiHBG008839.
    InParanoidiQ6NT32.
    KOiK15743.
    OMAiLTEEYFR.
    OrthoDBiEOG75XGKD.
    PhylomeDBiQ6NT32.
    TreeFamiTF315470.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NT32-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS    50
    PVPVNVFLGV PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW 100
    LLLDQHMLKV HYPKFGVSED CLYLNIYAPA HADTGSKLPV LVWFPGGAFK 150
    TGSASIFDGS ALAAYEDVLV VVVQYRLGIF GFFTTWDQHA PGNWAFKDQV 200
    AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM AKGLFHKAIM 250
    ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL 300
    LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL 350
    PMKEAPEILS GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR 400
    DSLLDLLGDV FFVVPALITA RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV 450
    KADHADEVRF VFGGAFLKGD IVMFEGATEE EKLLSRKMMK YWATFARTGN 500
    PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT STIPLILSAS 550
    DMLHSPLSSL TFLSLLQPFF FFCAP 575
    Length:575
    Mass (Da):63,926
    Last modified:July 5, 2004 - v1
    Checksum:i6F5B735BDEFC9C09
    GO
    Isoform 2 (identifier: Q6NT32-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         425-474: Missing.

    Show »
    Length:525
    Mass (Da):58,201
    Checksum:i7724878B8A22F215
    GO
    Isoform 3 (identifier: Q6NT32-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:469
    Mass (Da):52,325
    Checksum:i62F180A83206A1E8
    GO
    Isoform 4 (identifier: Q6NT32-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MSGNWVHPGQILIWAIWVLAAPTK → MAVLVCPASC...DVLNYTSKDE

    Note: No experimental confirmation available.

    Show »
    Length:604
    Mass (Da):67,487
    Checksum:iCE123CDD0AF142FC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711R → Q.
    Corresponds to variant rs2397965 [ dbSNP | Ensembl ].
    VAR_036836
    Natural varianti261 – 2611E → K.
    Corresponds to variant rs11076126 [ dbSNP | Ensembl ].
    VAR_036837
    Natural varianti344 – 3441H → Q.
    Corresponds to variant rs11860946 [ dbSNP | Ensembl ].
    VAR_036838
    Natural varianti499 – 4991G → R.
    Corresponds to variant rs16955812 [ dbSNP | Ensembl ].
    VAR_036839
    Natural varianti537 – 5371D → E.1 Publication
    Corresponds to variant rs11860456 [ dbSNP | Ensembl ].
    VAR_036840

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 106106Missing in isoform 3.
    VSP_029005Add
    BLAST
    Alternative sequencei1 – 2424MSGNW…AAPTK → MAVLVCPASCHGLKEFRIRR GMWRLCLVYYFYPASSTLYV LRIDVLNYTSKDE in isoform 4.
    VSP_043296Add
    BLAST
    Alternative sequencei425 – 47450Missing in isoform 2.
    VSP_029006Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti343 – 3431N → S in BAC03565. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY907669 mRNA. Translation: AAX86044.1.
    AK056109 mRNA. Translation: BAB71094.1.
    AK090997 mRNA. Translation: BAC03565.1.
    AK294334 mRNA. Translation: BAH11738.1.
    AC007335 Genomic DNA. No translation available.
    AC147362 Genomic DNA. No translation available.
    BC069501 mRNA. Translation: AAH69501.1.
    BC069548 mRNA. Translation: AAH69548.1.
    BC117126 mRNA. Translation: AAI17127.1.
    BC143692 mRNA. Translation: AAI43693.1.
    CCDSiCCDS10755.1. [Q6NT32-2]
    CCDS45490.1. [Q6NT32-1]
    CCDS54012.1. [Q6NT32-4]
    RefSeqiNP_001137157.1. NM_001143685.1. [Q6NT32-1]
    NP_001177087.1. NM_001190158.1. [Q6NT32-4]
    NP_659461.1. NM_145024.2. [Q6NT32-2]
    UniGeneiHs.350800.

    Genome annotation databases

    EnsembliENST00000290567; ENSP00000290567; ENSG00000159398. [Q6NT32-1]
    ENST00000319165; ENSP00000324271; ENSG00000159398. [Q6NT32-2]
    ENST00000518005; ENSP00000428571; ENSG00000159398. [Q6NT32-3]
    ENST00000521992; ENSP00000428864; ENSG00000159398. [Q6NT32-4]
    GeneIDi221223.
    KEGGihsa:221223.
    UCSCiuc002eio.2. human. [Q6NT32-2]
    uc002eip.2. human. [Q6NT32-1]
    uc021tir.1. human. [Q6NT32-4]

    Polymorphism databases

    DMDMi74758113.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY907669 mRNA. Translation: AAX86044.1 .
    AK056109 mRNA. Translation: BAB71094.1 .
    AK090997 mRNA. Translation: BAC03565.1 .
    AK294334 mRNA. Translation: BAH11738.1 .
    AC007335 Genomic DNA. No translation available.
    AC147362 Genomic DNA. No translation available.
    BC069501 mRNA. Translation: AAH69501.1 .
    BC069548 mRNA. Translation: AAH69548.1 .
    BC117126 mRNA. Translation: AAI17127.1 .
    BC143692 mRNA. Translation: AAI43693.1 .
    CCDSi CCDS10755.1. [Q6NT32-2 ]
    CCDS45490.1. [Q6NT32-1 ]
    CCDS54012.1. [Q6NT32-4 ]
    RefSeqi NP_001137157.1. NM_001143685.1. [Q6NT32-1 ]
    NP_001177087.1. NM_001190158.1. [Q6NT32-4 ]
    NP_659461.1. NM_145024.2. [Q6NT32-2 ]
    UniGenei Hs.350800.

    3D structure databases

    ProteinModelPortali Q6NT32.
    SMRi Q6NT32. Positions 31-541.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000290567.

    Protein family/group databases

    MEROPSi S09.960.

    Polymorphism databases

    DMDMi 74758113.

    Proteomic databases

    PaxDbi Q6NT32.
    PRIDEi Q6NT32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290567 ; ENSP00000290567 ; ENSG00000159398 . [Q6NT32-1 ]
    ENST00000319165 ; ENSP00000324271 ; ENSG00000159398 . [Q6NT32-2 ]
    ENST00000518005 ; ENSP00000428571 ; ENSG00000159398 . [Q6NT32-3 ]
    ENST00000521992 ; ENSP00000428864 ; ENSG00000159398 . [Q6NT32-4 ]
    GeneIDi 221223.
    KEGGi hsa:221223.
    UCSCi uc002eio.2. human. [Q6NT32-2 ]
    uc002eip.2. human. [Q6NT32-1 ]
    uc021tir.1. human. [Q6NT32-4 ]

    Organism-specific databases

    CTDi 221223.
    GeneCardsi GC16M055881.
    HGNCi HGNC:26459. CES5A.
    HPAi HPA047635.
    neXtProti NX_Q6NT32.
    PharmGKBi PA142672130.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2272.
    HOGENOMi HOG000091866.
    HOVERGENi HBG008839.
    InParanoidi Q6NT32.
    KOi K15743.
    OMAi LTEEYFR.
    OrthoDBi EOG75XGKD.
    PhylomeDBi Q6NT32.
    TreeFami TF315470.

    Miscellaneous databases

    GenomeRNAii 221223.
    NextBioi 91242.
    PROi Q6NT32.

    Gene expression databases

    ArrayExpressi Q6NT32.
    Bgeei Q6NT32.
    CleanExi HS_CES7.
    Genevestigatori Q6NT32.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Liu Q., Hamil K.G., French F.S., Hall S.H., Zhang Y.-L.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT GLU-537.
      Tissue: Amygdala and Brain.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiEST5A_HUMAN
    AccessioniPrimary (citable) accession number: Q6NT32
    Secondary accession number(s): B7Z252
    , B7ZLB6, Q8NBC8, Q96DN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: July 9, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi