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Q6NT32 (EST5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxylesterase 5A

EC=3.1.1.1
Alternative name(s):
Carboxylesterase-like urinary excreted protein homolog
Short name=Cauxin
Gene names
Name:CES5A
Synonyms:CES7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs By similarity.

Catalytic activity

A carboxylic ester + H2O = an alcohol + a carboxylate.

Subcellular location

Secreted By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Caution

Was termed (Ref.1) CES5.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHydrolase
Serine esterase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarboxylic ester hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NT32-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NT32-2)

The sequence of this isoform differs from the canonical sequence as follows:
     425-474: Missing.
Isoform 3 (identifier: Q6NT32-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6NT32-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSGNWVHPGQILIWAIWVLAAPTK → MAVLVCPASC...DVLNYTSKDE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 575555Carboxylesterase 5A
PRO_0000308591

Sites

Active site2261Acyl-ester intermediate By similarity
Active site3451Charge relay system By similarity
Active site4541Charge relay system By similarity

Amino acid modifications

Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation3631N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 121 By similarity

Natural variations

Alternative sequence1 – 106106Missing in isoform 3.
VSP_029005
Alternative sequence1 – 2424MSGNW…AAPTK → MAVLVCPASCHGLKEFRIRR GMWRLCLVYYFYPASSTLYV LRIDVLNYTSKDE in isoform 4.
VSP_043296
Alternative sequence425 – 47450Missing in isoform 2.
VSP_029006
Natural variant711R → Q.
Corresponds to variant rs2397965 [ dbSNP | Ensembl ].
VAR_036836
Natural variant2611E → K.
Corresponds to variant rs11076126 [ dbSNP | Ensembl ].
VAR_036837
Natural variant3441H → Q.
Corresponds to variant rs11860946 [ dbSNP | Ensembl ].
VAR_036838
Natural variant4991G → R.
Corresponds to variant rs16955812 [ dbSNP | Ensembl ].
VAR_036839
Natural variant5371D → E. Ref.2
Corresponds to variant rs11860456 [ dbSNP | Ensembl ].
VAR_036840

Experimental info

Sequence conflict3431N → S in BAC03565. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6F5B735BDEFC9C09

FASTA57563,926
        10         20         30         40         50         60 
MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV 

        70         80         90        100        110        120 
PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV HYPKFGVSED 

       130        140        150        160        170        180 
CLYLNIYAPA HADTGSKLPV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF 

       190        200        210        220        230        240 
GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM 

       250        260        270        280        290        300 
AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL 

       310        320        330        340        350        360 
LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL PMKEAPEILS 

       370        380        390        400        410        420 
GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA 

       430        440        450        460        470        480 
RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV KADHADEVRF VFGGAFLKGD IVMFEGATEE 

       490        500        510        520        530        540 
EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT 

       550        560        570 
STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP 

« Hide

Isoform 2 [UniParc].

Checksum: 7724878B8A22F215
Show »

FASTA52558,201
Isoform 3 [UniParc].

Checksum: 62F180A83206A1E8
Show »

FASTA46952,325
Isoform 4 [UniParc].

Checksum: CE123CDD0AF142FC
Show »

FASTA60467,487

References

« Hide 'large scale' references
[1]Liu Q., Hamil K.G., French F.S., Hall S.H., Zhang Y.-L.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT GLU-537.
Tissue: Amygdala and Brain.
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY907669 mRNA. Translation: AAX86044.1.
AK056109 mRNA. Translation: BAB71094.1.
AK090997 mRNA. Translation: BAC03565.1.
AK294334 mRNA. Translation: BAH11738.1.
AC007335 Genomic DNA. No translation available.
AC147362 Genomic DNA. No translation available.
BC069501 mRNA. Translation: AAH69501.1.
BC069548 mRNA. Translation: AAH69548.1.
BC117126 mRNA. Translation: AAI17127.1.
BC143692 mRNA. Translation: AAI43693.1.
RefSeqNP_001137157.1. NM_001143685.1.
NP_001177087.1. NM_001190158.1.
NP_659461.1. NM_145024.2.
UniGeneHs.350800.

3D structure databases

ProteinModelPortalQ6NT32.
SMRQ6NT32. Positions 31-541.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000290567.

Protein family/group databases

MEROPSS09.960.

Polymorphism databases

DMDM74758113.

Proteomic databases

PaxDbQ6NT32.
PRIDEQ6NT32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290567; ENSP00000290567; ENSG00000159398. [Q6NT32-1]
ENST00000319165; ENSP00000324271; ENSG00000159398. [Q6NT32-2]
ENST00000518005; ENSP00000428571; ENSG00000159398. [Q6NT32-3]
ENST00000521992; ENSP00000428864; ENSG00000159398. [Q6NT32-4]
GeneID221223.
KEGGhsa:221223.
UCSCuc002eio.2. human. [Q6NT32-2]
uc002eip.2. human. [Q6NT32-1]
uc021tir.1. human. [Q6NT32-4]

Organism-specific databases

CTD221223.
GeneCardsGC16M055881.
HGNCHGNC:26459. CES5A.
HPAHPA047635.
neXtProtNX_Q6NT32.
PharmGKBPA142672130.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2272.
HOGENOMHOG000091866.
HOVERGENHBG008839.
InParanoidQ6NT32.
KOK15743.
OMALTEEYFR.
OrthoDBEOG75XGKD.
PhylomeDBQ6NT32.
TreeFamTF315470.

Gene expression databases

ArrayExpressQ6NT32.
BgeeQ6NT32.
CleanExHS_CES7.
GenevestigatorQ6NT32.

Family and domain databases

InterProIPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi221223.
NextBio91242.
PROQ6NT32.

Entry information

Entry nameEST5A_HUMAN
AccessionPrimary (citable) accession number: Q6NT32
Secondary accession number(s): B7Z252 expand/collapse secondary AC list , B7ZLB6, Q8NBC8, Q96DN9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM