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Protein

MFS-type transporter SLC18B1

Gene

SLC18B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.2.57. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
MFS-type transporter SLC18B1
Alternative name(s):
Solute carrier family 18 member B1
Gene namesi
Name:SLC18B1
Synonyms:C6orf192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21573. SLC18B1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 7016ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 1009CytoplasmicSequence analysis
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 1276ExtracellularSequence analysis
Transmembranei128 – 14821HelicalSequence analysisAdd
BLAST
Topological domaini149 – 16113CytoplasmicSequence analysisAdd
BLAST
Transmembranei162 – 18423HelicalSequence analysisAdd
BLAST
Topological domaini185 – 19511ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 23014CytoplasmicSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Topological domaini252 – 27221ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Topological domaini294 – 30411CytoplasmicSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 3316ExtracellularSequence analysis
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 37725CytoplasmicSequence analysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence analysisAdd
BLAST
Topological domaini399 – 4079ExtracellularSequence analysis
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST
Topological domaini429 – 45628CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992727.

Polymorphism and mutation databases

BioMutaiSLC18B1.
DMDMi74748975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456MFS-type transporter SLC18B1PRO_0000294450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei438 – 4381PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NT16.
MaxQBiQ6NT16.
PaxDbiQ6NT16.
PeptideAtlasiQ6NT16.
PRIDEiQ6NT16.

PTM databases

iPTMnetiQ6NT16.
PhosphoSiteiQ6NT16.

Expressioni

Gene expression databases

BgeeiENSG00000146409.
CleanExiHS_C6orf192.
ExpressionAtlasiQ6NT16. baseline and differential.
GenevisibleiQ6NT16. HS.

Organism-specific databases

HPAiHPA029747.
HPA049659.

Interactioni

Protein-protein interaction databases

BioGridi125536. 1 interaction.
STRINGi9606.ENSP00000275227.

Structurei

3D structure databases

ProteinModelPortaliQ6NT16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INZN. Eukaryota.
ENOG410XYVZ. LUCA.
GeneTreeiENSGT00390000003851.
HOGENOMiHOG000007824.
HOVERGENiHBG054469.
InParanoidiQ6NT16.
OMAiRIGAKFM.
OrthoDBiEOG091G07C8.
PhylomeDBiQ6NT16.
TreeFamiTF313494.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NT16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALGDLEGP RAPGGDDPAG SAGETPGWLS REQVFVLISA ASVNLGSMMC
60 70 80 90 100
YSILGPFFPK EAEKKGASNT IIGMIFGCFA LFELLASLVF GNYLVHIGAK
110 120 130 140 150
FMFVAGMFVS GGVTILFGVL DRVPDGPVFI AMCFLVRVMD AVSFAAAMTA
160 170 180 190 200
SSSILAKAFP NNVATVLGSL ETFSGLGLIL GPPVGGFLYQ SFGYEVPFIV
210 220 230 240 250
LGCVVLLMVP LNMYILPNYE SDPGEHSFWK LIALPKVGLI AFVINSLSSC
260 270 280 290 300
FGFLDPTLSL FVLEKFNLPA GYVGLVFLGM ALSYAISSPL FGLLSDKRPP
310 320 330 340 350
LRKWLLVFGN LITAGCYMLL GPVPILHIKS QLWLLVLILV VSGLSAGMSI
360 370 380 390 400
IPTFPEILSC AHENGFEEGL STLGLVSGLF SAMWSIGAFM GPTLGGFLYE
410 420 430 440 450
KIGFEWAAAI QGLWALISGL AMGLFYLLEY SRRKRSKSQN ILSTEEERTT

LLPNET
Length:456
Mass (Da):48,869
Last modified:July 5, 2004 - v1
Checksum:iFB4F89B9C15C0EA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061G → R in BAG54039 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111R → L.
Corresponds to variant rs59989552 [ dbSNP | Ensembl ].
VAR_061382
Natural varianti30 – 301S → P.
Corresponds to variant rs41286192 [ dbSNP | Ensembl ].
VAR_063260
Natural varianti204 – 2041V → I.
Corresponds to variant rs6926101 [ dbSNP | Ensembl ].
VAR_033185

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289918 mRNA. Translation: BAF82607.1.
AK124442 mRNA. Translation: BAG54039.1.
AL137783, AL032821 Genomic DNA. Translation: CAI19370.1.
AL032821, AL137783 Genomic DNA. Translation: CAI95705.1.
CH471051 Genomic DNA. Translation: EAW48013.1.
BC069567 mRNA. Translation: AAH69567.1.
BC069570 mRNA. Translation: AAH69570.1.
CCDSiCCDS5163.1.
RefSeqiNP_439896.1. NM_052831.2.
UniGeneiHs.347144.

Genome annotation databases

EnsembliENST00000275227; ENSP00000275227; ENSG00000146409.
GeneIDi116843.
KEGGihsa:116843.
UCSCiuc003qdw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289918 mRNA. Translation: BAF82607.1.
AK124442 mRNA. Translation: BAG54039.1.
AL137783, AL032821 Genomic DNA. Translation: CAI19370.1.
AL032821, AL137783 Genomic DNA. Translation: CAI95705.1.
CH471051 Genomic DNA. Translation: EAW48013.1.
BC069567 mRNA. Translation: AAH69567.1.
BC069570 mRNA. Translation: AAH69570.1.
CCDSiCCDS5163.1.
RefSeqiNP_439896.1. NM_052831.2.
UniGeneiHs.347144.

3D structure databases

ProteinModelPortaliQ6NT16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125536. 1 interaction.
STRINGi9606.ENSP00000275227.

Protein family/group databases

TCDBi2.A.1.2.57. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ6NT16.
PhosphoSiteiQ6NT16.

Polymorphism and mutation databases

BioMutaiSLC18B1.
DMDMi74748975.

Proteomic databases

EPDiQ6NT16.
MaxQBiQ6NT16.
PaxDbiQ6NT16.
PeptideAtlasiQ6NT16.
PRIDEiQ6NT16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275227; ENSP00000275227; ENSG00000146409.
GeneIDi116843.
KEGGihsa:116843.
UCSCiuc003qdw.2. human.

Organism-specific databases

CTDi116843.
GeneCardsiSLC18B1.
HGNCiHGNC:21573. SLC18B1.
HPAiHPA029747.
HPA049659.
MIMi613361. gene.
neXtProtiNX_Q6NT16.
PharmGKBiPA134992727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INZN. Eukaryota.
ENOG410XYVZ. LUCA.
GeneTreeiENSGT00390000003851.
HOGENOMiHOG000007824.
HOVERGENiHBG054469.
InParanoidiQ6NT16.
OMAiRIGAKFM.
OrthoDBiEOG091G07C8.
PhylomeDBiQ6NT16.
TreeFamiTF313494.

Miscellaneous databases

GenomeRNAii116843.
PROiQ6NT16.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146409.
CleanExiHS_C6orf192.
ExpressionAtlasiQ6NT16. baseline and differential.
GenevisibleiQ6NT16. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS18B1_HUMAN
AccessioniPrimary (citable) accession number: Q6NT16
Secondary accession number(s): A8K1K3, B3KW77, Q6ISF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.