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Protein

Zinc finger and SCAN domain-containing protein 25

Gene

ZSCAN25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri348 – 370C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 480C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri486 – 508C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 25
Alternative name(s):
Zinc finger protein 498
Gene namesi
Name:ZSCAN25
Synonyms:ZNF498
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197037.10
HGNCiHGNC:21961 ZSCAN25
neXtProtiNX_Q6NSZ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197037
PharmGKBiPA134962723

Polymorphism and mutation databases

BioMutaiZSCAN25
DMDMi160359044

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093321 – 544Zinc finger and SCAN domain-containing protein 25Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6NSZ9
MaxQBiQ6NSZ9
PaxDbiQ6NSZ9
PeptideAtlasiQ6NSZ9
PRIDEiQ6NSZ9

PTM databases

iPTMnetiQ6NSZ9
PhosphoSitePlusiQ6NSZ9

Expressioni

Gene expression databases

BgeeiENSG00000197037
CleanExiHS_ZNF498
ExpressionAtlasiQ6NSZ9 baseline and differential
GenevisibleiQ6NSZ9 HS

Organism-specific databases

HPAiHPA055127
HPA057173

Interactioni

Protein-protein interaction databases

BioGridi128753, 25 interactors
IntActiQ6NSZ9, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6NSZ9
SMRiQ6NSZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri348 – 370C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 480C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri486 – 508C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
ENOG41112SP LUCA
GeneTreeiENSGT00910000144000
HOVERGENiHBG018163
InParanoidiQ6NSZ9
KOiK09229
OMAiHQKTQHR
OrthoDBiEOG091G02KC
PhylomeDBiQ6NSZ9
TreeFamiTF350842

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NSZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKEHPEMAE APQQQLGIPV VKLEKELPWG RGREDPSPET FRLRFRQFRY
60 70 80 90 100
QEAAGPQEAL RELQELCRRW LRPELHTKEQ ILELLVLEQF LTILPREFYA
110 120 130 140 150
WIREHGPESG KALAAMVEDL TERALEAKAV PCHRQGEQEE TALCRGAWEP
160 170 180 190 200
GIQLGPVEVK PEWGMPPGEG VQGPDPGTEE QLSQDPGDET RAFQEQALPV
210 220 230 240 250
LQAGPGLPAV NPRDQEMAAG FFTAGSQGLG PFKDMALAFP EEEWRHVTPA
260 270 280 290 300
QIDCFGEYVE PQDCRVSPGG GSKEKEAKPP QEDLKGALVA LTSERFGEAS
310 320 330 340 350
LQGPGLGRVC EQEPGGPAGS APGLPPPQHG AIPLPDEVKT HSSFWKPFQC
360 370 380 390 400
PECGKGFSRS SNLVRHQRTH EEKSYGCVEC GKGFTLREYL MKHQRTHLGK
410 420 430 440 450
RPYVCSECWK TFSQRHHLEV HQRSHTGEKP YKCGDCWKSF SRRQHLQVHR
460 470 480 490 500
RTHTGEKPYT CECGKSFSRN ANLAVHRRAH TGEKPYGCQV CGKRFSKGER
510 520 530 540
LVRHQRIHTG EKPYHCPACG RSFNQRSILN RHQKTQHRQE PLVQ
Length:544
Mass (Da):61,474
Last modified:November 13, 2007 - v3
Checksum:iE63AA7ACDA7E7E8B
GO
Isoform 2 (identifier: Q6NSZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-268: Missing.

Show »
Length:472
Mass (Da):53,733
Checksum:i3B5396BD57BD8B29
GO
Isoform 3 (identifier: Q6NSZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Show »
Length:328
Mass (Da):37,004
Checksum:i54ADCCF0A8BFF578
GO
Isoform 4 (identifier: Q6NSZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-544: VPCHRQGEQE...TQHRQEPLVQ → VGSMPQAGRAGGNSTLQRRLGARHPAGASGGQA

Show »
Length:162
Mass (Da):18,342
Checksum:i2DBAF62F0025F67A
GO

Sequence cautioni

The sequence AAI14574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI14942 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAD18712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL23869 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036931325P → A. Corresponds to variant dbSNP:rs10239632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0291451 – 216Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_029146130 – 544VPCHR…EPLVQ → VGSMPQAGRAGGNSTLQRRL GARHPAGASGGQA in isoform 4. 2 PublicationsAdd BLAST415
Alternative sequenceiVSP_029147197 – 268Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160369 mRNA Translation: BAD18712.1 Different initiation.
BX640720 mRNA Translation: CAE45839.1
CH236956 Genomic DNA Translation: EAL23869.1 Sequence problems.
CH471091 Genomic DNA Translation: EAW76643.1
CH471091 Genomic DNA Translation: EAW76646.1
CH471091 Genomic DNA Translation: EAW76647.1
BC069644 mRNA Translation: AAH69644.2
BC074902 mRNA Translation: AAH74902.3
BC074903 mRNA Translation: AAH74903.3
BC089402 mRNA Translation: AAH89402.1
BC114573 mRNA Translation: AAI14574.1 Different initiation.
BC114941 mRNA Translation: AAI14942.1 Sequence problems.
CCDSiCCDS5671.2 [Q6NSZ9-1]
RefSeqiNP_660090.2, NM_145115.2 [Q6NSZ9-1]
XP_005250251.1, XM_005250194.2
XP_011514207.1, XM_011515905.2 [Q6NSZ9-1]
XP_011514208.1, XM_011515906.2
XP_011514209.1, XM_011515907.2 [Q6NSZ9-1]
XP_011514210.1, XM_011515908.2
XP_016867313.1, XM_017011824.1 [Q6NSZ9-1]
XP_016867314.1, XM_017011825.1
XP_016867315.1, XM_017011826.1
UniGeneiHs.446297

Genome annotation databases

EnsembliENST00000334715; ENSP00000334800; ENSG00000197037 [Q6NSZ9-1]
ENST00000394150; ENSP00000377706; ENSG00000197037 [Q6NSZ9-4]
ENST00000394152; ENSP00000377708; ENSG00000197037 [Q6NSZ9-1]
GeneIDi221785
KEGGihsa:221785
UCSCiuc003url.1 human [Q6NSZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZSC25_HUMAN
AccessioniPrimary (citable) accession number: Q6NSZ9
Secondary accession number(s): A4D290
, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6ZML3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health