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Protein

Zinc finger and SCAN domain-containing protein 25

Gene

ZSCAN25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri348 – 370C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 480C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri486 – 508C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 25
Alternative name(s):
Zinc finger protein 498
Gene namesi
Name:ZSCAN25
Synonyms:ZNF498
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21961. ZSCAN25.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197037.
PharmGKBiPA134962723.

Polymorphism and mutation databases

BioMutaiZSCAN25.
DMDMi160359044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093321 – 544Zinc finger and SCAN domain-containing protein 25Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6NSZ9.
MaxQBiQ6NSZ9.
PaxDbiQ6NSZ9.
PeptideAtlasiQ6NSZ9.
PRIDEiQ6NSZ9.

PTM databases

iPTMnetiQ6NSZ9.
PhosphoSitePlusiQ6NSZ9.

Expressioni

Gene expression databases

BgeeiENSG00000197037.
CleanExiHS_ZNF498.
ExpressionAtlasiQ6NSZ9. baseline and differential.
GenevisibleiQ6NSZ9. HS.

Organism-specific databases

HPAiHPA055127.
HPA057173.

Interactioni

Protein-protein interaction databases

BioGridi128753. 21 interactors.
IntActiQ6NSZ9. 3 interactors.
STRINGi9606.ENSP00000334800.

Structurei

3D structure databases

ProteinModelPortaliQ6NSZ9.
SMRiQ6NSZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri348 – 370C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 480C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri486 – 508C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
ENOG41112SP. LUCA.
GeneTreeiENSGT00760000118881.
HOVERGENiHBG018163.
InParanoidiQ6NSZ9.
KOiK09229.
OMAiHQKTQHR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6NSZ9.
TreeFamiTF350842.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NSZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKEHPEMAE APQQQLGIPV VKLEKELPWG RGREDPSPET FRLRFRQFRY
60 70 80 90 100
QEAAGPQEAL RELQELCRRW LRPELHTKEQ ILELLVLEQF LTILPREFYA
110 120 130 140 150
WIREHGPESG KALAAMVEDL TERALEAKAV PCHRQGEQEE TALCRGAWEP
160 170 180 190 200
GIQLGPVEVK PEWGMPPGEG VQGPDPGTEE QLSQDPGDET RAFQEQALPV
210 220 230 240 250
LQAGPGLPAV NPRDQEMAAG FFTAGSQGLG PFKDMALAFP EEEWRHVTPA
260 270 280 290 300
QIDCFGEYVE PQDCRVSPGG GSKEKEAKPP QEDLKGALVA LTSERFGEAS
310 320 330 340 350
LQGPGLGRVC EQEPGGPAGS APGLPPPQHG AIPLPDEVKT HSSFWKPFQC
360 370 380 390 400
PECGKGFSRS SNLVRHQRTH EEKSYGCVEC GKGFTLREYL MKHQRTHLGK
410 420 430 440 450
RPYVCSECWK TFSQRHHLEV HQRSHTGEKP YKCGDCWKSF SRRQHLQVHR
460 470 480 490 500
RTHTGEKPYT CECGKSFSRN ANLAVHRRAH TGEKPYGCQV CGKRFSKGER
510 520 530 540
LVRHQRIHTG EKPYHCPACG RSFNQRSILN RHQKTQHRQE PLVQ
Length:544
Mass (Da):61,474
Last modified:November 13, 2007 - v3
Checksum:iE63AA7ACDA7E7E8B
GO
Isoform 2 (identifier: Q6NSZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-268: Missing.

Show »
Length:472
Mass (Da):53,733
Checksum:i3B5396BD57BD8B29
GO
Isoform 3 (identifier: Q6NSZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Show »
Length:328
Mass (Da):37,004
Checksum:i54ADCCF0A8BFF578
GO
Isoform 4 (identifier: Q6NSZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-544: VPCHRQGEQE...TQHRQEPLVQ → VGSMPQAGRAGGNSTLQRRLGARHPAGASGGQA

Show »
Length:162
Mass (Da):18,342
Checksum:i2DBAF62F0025F67A
GO

Sequence cautioni

The sequence AAI14574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI14942 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAD18712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL23869 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036931325P → A.Corresponds to variant rs10239632dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0291451 – 216Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_029146130 – 544VPCHR…EPLVQ → VGSMPQAGRAGGNSTLQRRL GARHPAGASGGQA in isoform 4. 2 PublicationsAdd BLAST415
Alternative sequenceiVSP_029147197 – 268Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160369 mRNA. Translation: BAD18712.1. Different initiation.
BX640720 mRNA. Translation: CAE45839.1.
CH236956 Genomic DNA. Translation: EAL23869.1. Sequence problems.
CH471091 Genomic DNA. Translation: EAW76643.1.
CH471091 Genomic DNA. Translation: EAW76646.1.
CH471091 Genomic DNA. Translation: EAW76647.1.
BC069644 mRNA. Translation: AAH69644.2.
BC074902 mRNA. Translation: AAH74902.3.
BC074903 mRNA. Translation: AAH74903.3.
BC089402 mRNA. Translation: AAH89402.1.
BC114573 mRNA. Translation: AAI14574.1. Different initiation.
BC114941 mRNA. Translation: AAI14942.1. Sequence problems.
CCDSiCCDS5671.2. [Q6NSZ9-1]
RefSeqiNP_660090.2. NM_145115.2. [Q6NSZ9-1]
XP_005250251.1. XM_005250194.2. [Q6NSZ9-1]
XP_011514207.1. XM_011515905.2. [Q6NSZ9-1]
XP_011514208.1. XM_011515906.2. [Q6NSZ9-1]
XP_011514209.1. XM_011515907.2. [Q6NSZ9-1]
XP_011514210.1. XM_011515908.2.
XP_016867313.1. XM_017011824.1. [Q6NSZ9-1]
XP_016867314.1. XM_017011825.1.
XP_016867315.1. XM_017011826.1.
UniGeneiHs.446297.

Genome annotation databases

EnsembliENST00000334715; ENSP00000334800; ENSG00000197037. [Q6NSZ9-1]
ENST00000394150; ENSP00000377706; ENSG00000197037. [Q6NSZ9-4]
ENST00000394152; ENSP00000377708; ENSG00000197037. [Q6NSZ9-1]
GeneIDi221785.
KEGGihsa:221785.
UCSCiuc003url.1. human. [Q6NSZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160369 mRNA. Translation: BAD18712.1. Different initiation.
BX640720 mRNA. Translation: CAE45839.1.
CH236956 Genomic DNA. Translation: EAL23869.1. Sequence problems.
CH471091 Genomic DNA. Translation: EAW76643.1.
CH471091 Genomic DNA. Translation: EAW76646.1.
CH471091 Genomic DNA. Translation: EAW76647.1.
BC069644 mRNA. Translation: AAH69644.2.
BC074902 mRNA. Translation: AAH74902.3.
BC074903 mRNA. Translation: AAH74903.3.
BC089402 mRNA. Translation: AAH89402.1.
BC114573 mRNA. Translation: AAI14574.1. Different initiation.
BC114941 mRNA. Translation: AAI14942.1. Sequence problems.
CCDSiCCDS5671.2. [Q6NSZ9-1]
RefSeqiNP_660090.2. NM_145115.2. [Q6NSZ9-1]
XP_005250251.1. XM_005250194.2. [Q6NSZ9-1]
XP_011514207.1. XM_011515905.2. [Q6NSZ9-1]
XP_011514208.1. XM_011515906.2. [Q6NSZ9-1]
XP_011514209.1. XM_011515907.2. [Q6NSZ9-1]
XP_011514210.1. XM_011515908.2.
XP_016867313.1. XM_017011824.1. [Q6NSZ9-1]
XP_016867314.1. XM_017011825.1.
XP_016867315.1. XM_017011826.1.
UniGeneiHs.446297.

3D structure databases

ProteinModelPortaliQ6NSZ9.
SMRiQ6NSZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128753. 21 interactors.
IntActiQ6NSZ9. 3 interactors.
STRINGi9606.ENSP00000334800.

PTM databases

iPTMnetiQ6NSZ9.
PhosphoSitePlusiQ6NSZ9.

Polymorphism and mutation databases

BioMutaiZSCAN25.
DMDMi160359044.

Proteomic databases

EPDiQ6NSZ9.
MaxQBiQ6NSZ9.
PaxDbiQ6NSZ9.
PeptideAtlasiQ6NSZ9.
PRIDEiQ6NSZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334715; ENSP00000334800; ENSG00000197037. [Q6NSZ9-1]
ENST00000394150; ENSP00000377706; ENSG00000197037. [Q6NSZ9-4]
ENST00000394152; ENSP00000377708; ENSG00000197037. [Q6NSZ9-1]
GeneIDi221785.
KEGGihsa:221785.
UCSCiuc003url.1. human. [Q6NSZ9-1]

Organism-specific databases

CTDi221785.
GeneCardsiZSCAN25.
HGNCiHGNC:21961. ZSCAN25.
HPAiHPA055127.
HPA057173.
neXtProtiNX_Q6NSZ9.
OpenTargetsiENSG00000197037.
PharmGKBiPA134962723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
ENOG41112SP. LUCA.
GeneTreeiENSGT00760000118881.
HOVERGENiHBG018163.
InParanoidiQ6NSZ9.
KOiK09229.
OMAiHQKTQHR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6NSZ9.
TreeFamiTF350842.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii221785.
PROiQ6NSZ9.

Gene expression databases

BgeeiENSG00000197037.
CleanExiHS_ZNF498.
ExpressionAtlasiQ6NSZ9. baseline and differential.
GenevisibleiQ6NSZ9. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSC25_HUMAN
AccessioniPrimary (citable) accession number: Q6NSZ9
Secondary accession number(s): A4D290
, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6ZML3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.