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Protein

Coiled-coil domain-containing protein 70

Gene

CCDC70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 70
Gene namesi
Name:CCDC70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25303. CCDC70.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485421.

Polymorphism and mutation databases

BioMutaiCCDC70.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 233201Coiled-coil domain-containing protein 70PRO_0000234432Add
BLAST

Proteomic databases

PaxDbiQ6NSX1.
PeptideAtlasiQ6NSX1.
PRIDEiQ6NSX1.

PTM databases

iPTMnetiQ6NSX1.
PhosphoSiteiQ6NSX1.

Expressioni

Gene expression databases

BgeeiENSG00000123171.
CleanExiHS_CCDC70.
GenevisibleiQ6NSX1. HS.

Organism-specific databases

HPAiHPA045405.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-6873045,EBI-10175124
FATE1Q969F03EBI-6873045,EBI-743099
GOLGA2Q083793EBI-6873045,EBI-618309

Protein-protein interaction databases

BioGridi123648. 4 interactions.
IntActiQ6NSX1. 4 interactions.
MINTiMINT-4724677.
STRINGi9606.ENSP00000242819.

Structurei

3D structure databases

ProteinModelPortaliQ6NSX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili140 – 16425Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IVG6. Eukaryota.
ENOG410YWSA. LUCA.
GeneTreeiENSGT00510000049032.
HOGENOMiHOG000230956.
HOVERGENiHBG080013.
InParanoidiQ6NSX1.
OMAiWKEDKAF.
OrthoDBiEOG091G0JWB.
PhylomeDBiQ6NSX1.
TreeFamiTF336984.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NSX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPPFRLIR KMFSFKVSRW MGLACFRSLA ASSPSIRQKK LMHKLQEEKA
60 70 80 90 100
FREEMKIFRE KIEDFREEMW TFRGKIHAFR GQILGFWEEE RPFWEEEKTF
110 120 130 140 150
WKEEKSFWEM EKSFREEEKT FWKKYRTFWK EDKAFWKEDN ALWERDRNLL
160 170 180 190 200
QEDKALWEEE KALWVEERAL LEGEKALWED KTSLWEEENA LWEEERAFWM
210 220 230
ENNGHIAGEQ MLEDGPHNAN RGQRLLAFSR GRA
Length:233
Mass (Da):28,767
Last modified:July 5, 2004 - v1
Checksum:iC692D2230C2BD090
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321R → G in BAC05391 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261R → C.
Corresponds to variant rs17076052 [ dbSNP | Ensembl ].
VAR_050763
Natural varianti206 – 2061I → V.3 Publications
Corresponds to variant rs1054515 [ dbSNP | Ensembl ].
VAR_026238

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136887 mRNA. Translation: CAB66821.1.
AK098719 mRNA. Translation: BAC05391.1.
AL162377 Genomic DNA. Translation: CAI13430.1.
BC069691 mRNA. Translation: AAH69691.1.
BC069748 mRNA. Translation: AAH69748.1.
BC069770 mRNA. Translation: AAH69770.1.
BC069806 mRNA. Translation: AAH69806.1.
CCDSiCCDS9431.1.
RefSeqiNP_112580.2. NM_031290.2.
UniGeneiHs.120573.

Genome annotation databases

EnsembliENST00000242819; ENSP00000242819; ENSG00000123171.
GeneIDi83446.
KEGGihsa:83446.
UCSCiuc001vfu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136887 mRNA. Translation: CAB66821.1.
AK098719 mRNA. Translation: BAC05391.1.
AL162377 Genomic DNA. Translation: CAI13430.1.
BC069691 mRNA. Translation: AAH69691.1.
BC069748 mRNA. Translation: AAH69748.1.
BC069770 mRNA. Translation: AAH69770.1.
BC069806 mRNA. Translation: AAH69806.1.
CCDSiCCDS9431.1.
RefSeqiNP_112580.2. NM_031290.2.
UniGeneiHs.120573.

3D structure databases

ProteinModelPortaliQ6NSX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123648. 4 interactions.
IntActiQ6NSX1. 4 interactions.
MINTiMINT-4724677.
STRINGi9606.ENSP00000242819.

PTM databases

iPTMnetiQ6NSX1.
PhosphoSiteiQ6NSX1.

Polymorphism and mutation databases

BioMutaiCCDC70.

Proteomic databases

PaxDbiQ6NSX1.
PeptideAtlasiQ6NSX1.
PRIDEiQ6NSX1.

Protocols and materials databases

DNASUi83446.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242819; ENSP00000242819; ENSG00000123171.
GeneIDi83446.
KEGGihsa:83446.
UCSCiuc001vfu.5. human.

Organism-specific databases

CTDi83446.
GeneCardsiCCDC70.
HGNCiHGNC:25303. CCDC70.
HPAiHPA045405.
neXtProtiNX_Q6NSX1.
PharmGKBiPA143485421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVG6. Eukaryota.
ENOG410YWSA. LUCA.
GeneTreeiENSGT00510000049032.
HOGENOMiHOG000230956.
HOVERGENiHBG080013.
InParanoidiQ6NSX1.
OMAiWKEDKAF.
OrthoDBiEOG091G0JWB.
PhylomeDBiQ6NSX1.
TreeFamiTF336984.

Miscellaneous databases

GeneWikiiCCDC70.
GenomeRNAii83446.
PROiQ6NSX1.

Gene expression databases

BgeeiENSG00000123171.
CleanExiHS_CCDC70.
GenevisibleiQ6NSX1. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD70_HUMAN
AccessioniPrimary (citable) accession number: Q6NSX1
Secondary accession number(s): Q8N7A8, Q9H097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.