Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein NANOGP8

Gene

NANOGP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi95 – 154HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein NANOGP8
Gene namesi
Name:NANOGP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000255192.5
HGNCiHGNC:23106 NANOGP8
neXtProtiNX_Q6NSW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi388112
OpenTargetsiENSG00000255192

Polymorphism and mutation databases

DMDMi74762336

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002614241 – 305Homeobox protein NANOGP8Add BLAST305

Proteomic databases

EPDiQ6NSW7
PeptideAtlasiQ6NSW7
PRIDEiQ6NSW7

Interactioni

Protein-protein interaction databases

IntActiQ6NSW7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6NSW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati196 – 20015
Repeati201 – 20525
Repeati206 – 21035
Repeati216 – 22045
Repeati221 – 22555
Repeati226 – 23065
Repeati231 – 23575
Repeati236 – 24085

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 2408 X repeats starting with a Trp in each unitAdd BLAST45
Regioni196 – 240Sufficient for transactivation activityBy similarityAdd BLAST45
Regioni241 – 305Sufficient for strong transactivation activityBy similarityAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 236Trp-richAdd BLAST41

Sequence similaritiesi

Belongs to the Nanog homeobox family.Curated

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0491 Eukaryota
ENOG4111UAT LUCA
GeneTreeiENSGT00670000098076
HOVERGENiHBG058783
InParanoidiQ6NSW7
OMAiPHMETIS
PhylomeDBiQ6NSW7

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDPACPQS LPCFEESDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET
60 70 80 90 100
VSPLPSSMDL LIQDSPDSST SPKGKQPTSA ENSVAKKEDK VPVKKQKTRT
110 120 130 140 150
VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS
160 170 180 190 200
KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT
210 220 230 240 250
WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS
260 270 280 290 300
CMHFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM

QPEDV
Length:305
Mass (Da):34,673
Last modified:March 28, 2018 - v2
Checksum:iC59ECF476A600EB0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08014213C → R1 Publication1
Natural variantiVAR_08014316E → A Common polymorphism; found in ethnically diverse individuals. 1 Publication1
Natural variantiVAR_08014437S → P1 Publication1
Natural variantiVAR_08014564D → Y1 Publication1
Natural variantiVAR_08014668S → Y1 Publication1
Natural variantiVAR_08014796Q → R1 Publication1
Natural variantiVAR_080148107L → P1 Publication1
Natural variantiVAR_080149127E → G1 Publication1
Natural variantiVAR_080150146Q → R1 Publication1
Natural variantiVAR_080151207S → G1 Publication1
Natural variantiVAR_080152208N → S1 Publication1
Natural variantiVAR_080153210T → I1 Publication1
Natural variantiVAR_080154218N → S1 Publication1
Natural variantiVAR_080155262D → G1 Publication1
Natural variantiVAR_080156301Q → R1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX104830 Genomic DNA Translation: AFP90859.1
JX104831 Genomic DNA Translation: AFP90860.1
JX104832 Genomic DNA Translation: AFP90861.1
JX104833 Genomic DNA Translation: AFP90862.1
JX104834 Genomic DNA Translation: AFP90863.1
JX104835 Genomic DNA Translation: AFP90864.1
JX104836 Genomic DNA Translation: AFP90865.1
JX104837 Genomic DNA Translation: AFP90866.1
JX104838 Genomic DNA Translation: AFP90867.1
JX104839 Genomic DNA Translation: AFP90868.1
JX104840 Genomic DNA Translation: AFP90869.1
JX104841 Genomic DNA Translation: AFP90870.1
JX104842 Genomic DNA Translation: AFP90871.1
JX104843 Genomic DNA Translation: AFP90872.1
JX104844 Genomic DNA Translation: AFP90873.1
JX104845 Genomic DNA Translation: AFP90874.1
JX104846 Genomic DNA Translation: AFP90875.1
JX104847 Genomic DNA Translation: AFP90876.1
JX104848 Genomic DNA Translation: AFP90877.1
AC021231 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92325.1
CH471125 Genomic DNA Translation: EAW92326.1
BC069807 mRNA No translation available.
BC098275 mRNA No translation available.
BC099704 mRNA No translation available.
UniGeneiHs.635882

Genome annotation databases

EnsembliENST00000528386; ENSP00000487073; ENSG00000255192
UCSCiuc032bzh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNANP8_HUMAN
AccessioniPrimary (citable) accession number: Q6NSW7
Secondary accession number(s): J7H3Y9
, J7H3Z5, J7H408, J7H412, J7H416, J7H738, J7H745, J7H749, J7H9S6, J7H9T4, J7HAW9, J7HAX1, J7HAX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health