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Protein

Putative homeobox protein NANOGP8

Gene

NANOGP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi95 – 154HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative homeobox protein NANOGP8
Gene namesi
Name:NANOGP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23106. NANOGP8.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi388112.

Polymorphism and mutation databases

DMDMi74762336.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002614241 – 305Putative homeobox protein NANOGP8Add BLAST305

Proteomic databases

EPDiQ6NSW7.
PaxDbiQ6NSW7.
PRIDEiQ6NSW7.

Expressioni

Tissue specificityi

Expressed in osteosarcoma cancer cell line (at protein level), breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines.1 Publication

Interactioni

Protein-protein interaction databases

IntActiQ6NSW7. 1 interactor.
STRINGi9606.ENSP00000229307.

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi104 – 116Combined sources13
Helixi122 – 131Combined sources10
Helixi136 – 152Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RBOX-ray3.30A/D94-162[»]
ProteinModelPortaliQ6NSW7.
SMRiQ6NSW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati196 – 20015
Repeati201 – 20525
Repeati206 – 21035
Repeati216 – 22045
Repeati221 – 22555
Repeati226 – 23065
Repeati231 – 23575
Repeati236 – 24085

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 2408 X repeats starting with a Trp in each unitAdd BLAST45
Regioni196 – 240Sufficient for transactivation activityBy similarityAdd BLAST45
Regioni241 – 305Sufficient for strong transactivation activityBy similarityAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 236Trp-richAdd BLAST41

Sequence similaritiesi

Belongs to the Nanog homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0491. Eukaryota.
ENOG4111UAT. LUCA.
HOVERGENiHBG058783.
InParanoidiQ6NSW7.
PhylomeDBiQ6NSW7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET
60 70 80 90 100
VSPLPSSMDL LIQDSPDSST SPKGKQPTSA ENSVAKKEDK VPVKKQKTRT
110 120 130 140 150
VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS
160 170 180 190 200
KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT
210 220 230 240 250
WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS
260 270 280 290 300
CMHFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM

QPEDV
Length:305
Mass (Da):34,615
Last modified:July 5, 2004 - v1
Checksum:i005F78401BA3E7CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC069807 mRNA. No translation available.
BC098275 mRNA. No translation available.
BC099704 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC069807 mRNA. No translation available.
BC098275 mRNA. No translation available.
BC099704 mRNA. No translation available.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RBOX-ray3.30A/D94-162[»]
ProteinModelPortaliQ6NSW7.
SMRiQ6NSW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NSW7. 1 interactor.
STRINGi9606.ENSP00000229307.

Polymorphism and mutation databases

DMDMi74762336.

Proteomic databases

EPDiQ6NSW7.
PaxDbiQ6NSW7.
PRIDEiQ6NSW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi388112.
GeneCardsiNANOGP8.
HGNCiHGNC:23106. NANOGP8.
neXtProtiNX_Q6NSW7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0491. Eukaryota.
ENOG4111UAT. LUCA.
HOVERGENiHBG058783.
InParanoidiQ6NSW7.
PhylomeDBiQ6NSW7.

Enzyme and pathway databases

BioCyciZFISH:G66-30707-MONOMER.

Miscellaneous databases

PROiQ6NSW7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNANP8_HUMAN
AccessioniPrimary (citable) accession number: Q6NSW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Almost identical to NANOG. There is only one change in the inferred amino acid sequence from 'Gln-253' in NANOG to His-253 in NANOGP8.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.