Q6NSW7 (NANP8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative homeobox protein NANOGP8

Gene names

Name:

NANOGP8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	May act as a transcription regulator By similarity. When overexpressed, promotes entry of cells into S phase and cell proliferation. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Expressed in osteosarcoma cancer cell line (at protein level) Probable. Expressed in tumor uterine cervix, breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines. Ref.1
Miscellaneous	Almost identical to NANOG. There is only one change in the inferred amino acid sequence from 'Gln-253' in NANOG to His-253 in NANOGP8.
Sequence similarities	Belongs to the Nanog homeobox family. Contains 1 homeobox DNA-binding domain.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox Repeat
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Putative homeobox protein NANOGP8		PRO_0000261424
Regions
	Repeat	196 – 200	5	1
	Repeat	201 – 205	5	2
	Repeat	206 – 210	5	3
	Repeat	216 – 220	5	4
	Repeat	221 – 225	5	5
	Repeat	226 – 230	5	6
	Repeat	231 – 235	5	7
	Repeat	236 – 240	5	8
	DNA binding	95 – 154	60	Homeobox
	Region	196 – 240	45	8 X repeats starting with a Trp in each unit
	Region	196 – 240	45	Sufficient for transactivation activity By similarity
	Region	241 – 305	65	Sufficient for strong transactivation activity By similarity
	Compositional bias	196 – 236	41	Trp-rich By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6NSW7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 005F78401BA3E7CE	FASTA	305	34,615
	10 20 30 40 50 60 MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL 70 80 90 100 110 120 LIQDSPDSST SPKGKQPTSA ENSVAKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL 130 140 150 160 170 180 SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS 190 200 210 220 230 240 YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF 250 260 270 280 290 300 YNCGEESLQS CMHFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM QPEDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NANOGP8 is a retrogene expressed in cancers." Zhang J., Wang X., Li M., Han J., Chen B., Wang B., Dai J. FEBS J. 273:1723-1730(2006) [PubMed: 16623708] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Urinary bladder carcinoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Eleven daughters of NANOG." Booth H.A., Holland P.W. Genomics 84:229-238(2004) [PubMed: 15233988] [Abstract] Cited for: GENE FAMILY.
[4]	"Evolution of the NANOG pseudogene family in the human and chimpanzee genomes." Fairbanks D.J., Maughan P.J. BMC Evol. Biol. 6:12-12(2006) [PubMed: 16469101] [Abstract] Cited for: GENE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC069807 mRNA. No translation available. BC098275 mRNA. No translation available. BC099704 mRNA. No translation available.
IPI	IPI00552676.
3D structure databases
ProteinModelPortal	Q6NSW7.
SMR	Q6NSW7. Positions 75-157.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6NSW7.
Polymorphism databases
DMDM	74762336.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229307; ENSP00000229307; ENSG00000111704.
Organism-specific databases
GeneCards	GC15M035375.
H-InvDB	HIX0038147.
HGNC	HGNC:23106. NANOGP8.
HPA	CAB019380.
neXtProt	NX_Q6NSW7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07287.
HOVERGEN	HBG058783.
InParanoid	Q6NSW7.
Gene expression databases
ArrayExpress	Q6NSW7.
Bgee	Q6NSW7.
Genevestigator	Q6NSW7.
GermOnline	ENSG00000179437. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NANP8_HUMAN

Accession

Primary (citable) accession number: Q6NSW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.