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Protein

Glycosyltransferase 8 domain-containing protein 1

Gene

Glt8d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyltransferase 8 domain-containing protein 1 (EC:2.4.1.-)
Gene namesi
Name:Glt8d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923735. Glt8d1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 371LumenalSequence analysisAdd BLAST343

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885291 – 371Glycosyltransferase 8 domain-containing protein 1Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NSU3.
PeptideAtlasiQ6NSU3.
PRIDEiQ6NSU3.

PTM databases

PhosphoSitePlusiQ6NSU3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021916.
CleanExiMM_GLT8D1.
GenevisibleiQ6NSU3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022476.

Structurei

3D structure databases

ProteinModelPortaliQ6NSU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEE5. Eukaryota.
ENOG41106K3. LUCA.
GeneTreeiENSGT00390000016670.
HOGENOMiHOG000112730.
HOVERGENiHBG055240.
InParanoidiQ6NSU3.
OMAiFWSEERF.
OrthoDBiEOG091G0CFQ.
PhylomeDBiQ6NSU3.
TreeFamiTF332433.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NSU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRKVNIII WVLAVVLFLL VLHHNFLSLS SLLKNDISDS GIVGLQPIDF
60 70 80 90 100
VASAHQHPVS ERQEEIPVVI AASEDRLGGT IAAINSVHQN TRSNVMFYIV
110 120 130 140 150
TFNSTADHLR SWLNSGSLKS IRYKIVNFDT KLLEGKVKQD PDQGESMKPL
160 170 180 190 200
TFARFYLPIL VPSAKKAIYM DDDVIVQGDI LALYNTPLKP GHAAAFSEDC
210 220 230 240 250
DSASTKVIIR GAGNQYNYIG YLDYKKERIR KLSMKASTCS FNPGVFVANL
260 270 280 290 300
TEWKRQNVTN QLEKWMKLNV EEGLYSRTLA GSITTPPLLI VFYQQHSTID
310 320 330 340 350
PMWNVRHLGS SAGKRYSPQF VKAAKLLHWN GHFKPWGRTA SYADVWEKWY
360 370
IPDPTGKFSL IRRHMDTSNI K
Length:371
Mass (Da):41,990
Last modified:July 5, 2004 - v1
Checksum:i61E507E46C18185B
GO
Isoform 2 (identifier: Q6NSU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-227: YNYIGYLDYKKE → VMTYCRSHSGKA
     228-371: Missing.

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):25,041
Checksum:i9FBA9E087BA9CC24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92R → G in BAB26903 (PubMed:16141072).Curated1
Sequence conflicti185N → K in BAB26903 (PubMed:16141072).Curated1
Sequence conflicti363R → S in BAB26903 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025707216 – 227YNYIG…DYKKE → VMTYCRSHSGKA in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_025708228 – 371Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010388 mRNA. Translation: BAB26903.1.
AK160461 mRNA. Translation: BAE35802.1.
BC069873 mRNA. Translation: AAH69873.1.
CCDSiCCDS26904.1. [Q6NSU3-1]
RefSeqiNP_001159402.1. NM_001165930.1. [Q6NSU3-1]
NP_083902.2. NM_029626.2. [Q6NSU3-1]
XP_006519732.2. XM_006519669.2. [Q6NSU3-1]
XP_006519735.1. XM_006519672.3. [Q6NSU3-1]
XP_006519736.1. XM_006519673.3. [Q6NSU3-1]
XP_006519737.1. XM_006519674.2. [Q6NSU3-1]
UniGeneiMm.8766.

Genome annotation databases

EnsembliENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916. [Q6NSU3-1]
ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916. [Q6NSU3-1]
GeneIDi76485.
KEGGimmu:76485.
UCSCiuc007swf.2. mouse. [Q6NSU3-1]
uc007swg.2. mouse. [Q6NSU3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010388 mRNA. Translation: BAB26903.1.
AK160461 mRNA. Translation: BAE35802.1.
BC069873 mRNA. Translation: AAH69873.1.
CCDSiCCDS26904.1. [Q6NSU3-1]
RefSeqiNP_001159402.1. NM_001165930.1. [Q6NSU3-1]
NP_083902.2. NM_029626.2. [Q6NSU3-1]
XP_006519732.2. XM_006519669.2. [Q6NSU3-1]
XP_006519735.1. XM_006519672.3. [Q6NSU3-1]
XP_006519736.1. XM_006519673.3. [Q6NSU3-1]
XP_006519737.1. XM_006519674.2. [Q6NSU3-1]
UniGeneiMm.8766.

3D structure databases

ProteinModelPortaliQ6NSU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022476.

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

PTM databases

PhosphoSitePlusiQ6NSU3.

Proteomic databases

PaxDbiQ6NSU3.
PeptideAtlasiQ6NSU3.
PRIDEiQ6NSU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916. [Q6NSU3-1]
ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916. [Q6NSU3-1]
GeneIDi76485.
KEGGimmu:76485.
UCSCiuc007swf.2. mouse. [Q6NSU3-1]
uc007swg.2. mouse. [Q6NSU3-2]

Organism-specific databases

CTDi55830.
MGIiMGI:1923735. Glt8d1.

Phylogenomic databases

eggNOGiENOG410IEE5. Eukaryota.
ENOG41106K3. LUCA.
GeneTreeiENSGT00390000016670.
HOGENOMiHOG000112730.
HOVERGENiHBG055240.
InParanoidiQ6NSU3.
OMAiFWSEERF.
OrthoDBiEOG091G0CFQ.
PhylomeDBiQ6NSU3.
TreeFamiTF332433.

Miscellaneous databases

ChiTaRSiGlt8d1. mouse.
PROiQ6NSU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021916.
CleanExiMM_GLT8D1.
GenevisibleiQ6NSU3. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGL8D1_MOUSE
AccessioniPrimary (citable) accession number: Q6NSU3
Secondary accession number(s): Q3TV18, Q9CWT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.