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Protein

Glycosyltransferase 8 domain-containing protein 1

Gene

Glt8d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyltransferase 8 domain-containing protein 1 (EC:2.4.1.-)
Gene namesi
Name:Glt8d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923735. Glt8d1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini29 – 371343LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Glycosyltransferase 8 domain-containing protein 1PRO_0000288529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6NSU3.
PaxDbiQ6NSU3.
PRIDEiQ6NSU3.

PTM databases

PhosphoSiteiQ6NSU3.

Expressioni

Gene expression databases

BgeeiQ6NSU3.
CleanExiMM_GLT8D1.
GenevisibleiQ6NSU3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022476.

Structurei

3D structure databases

ProteinModelPortaliQ6NSU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74598.
GeneTreeiENSGT00390000016670.
HOGENOMiHOG000112730.
HOVERGENiHBG055240.
InParanoidiQ6NSU3.
OMAiVKEDPGQ.
OrthoDBiEOG7RBZ8R.
PhylomeDBiQ6NSU3.
TreeFamiTF332433.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NSU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRKVNIII WVLAVVLFLL VLHHNFLSLS SLLKNDISDS GIVGLQPIDF
60 70 80 90 100
VASAHQHPVS ERQEEIPVVI AASEDRLGGT IAAINSVHQN TRSNVMFYIV
110 120 130 140 150
TFNSTADHLR SWLNSGSLKS IRYKIVNFDT KLLEGKVKQD PDQGESMKPL
160 170 180 190 200
TFARFYLPIL VPSAKKAIYM DDDVIVQGDI LALYNTPLKP GHAAAFSEDC
210 220 230 240 250
DSASTKVIIR GAGNQYNYIG YLDYKKERIR KLSMKASTCS FNPGVFVANL
260 270 280 290 300
TEWKRQNVTN QLEKWMKLNV EEGLYSRTLA GSITTPPLLI VFYQQHSTID
310 320 330 340 350
PMWNVRHLGS SAGKRYSPQF VKAAKLLHWN GHFKPWGRTA SYADVWEKWY
360 370
IPDPTGKFSL IRRHMDTSNI K
Length:371
Mass (Da):41,990
Last modified:July 5, 2004 - v1
Checksum:i61E507E46C18185B
GO
Isoform 2 (identifier: Q6NSU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-227: YNYIGYLDYKKE → VMTYCRSHSGKA
     228-371: Missing.

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):25,041
Checksum:i9FBA9E087BA9CC24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921R → G in BAB26903 (PubMed:16141072).Curated
Sequence conflicti185 – 1851N → K in BAB26903 (PubMed:16141072).Curated
Sequence conflicti363 – 3631R → S in BAB26903 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 22712YNYIG…DYKKE → VMTYCRSHSGKA in isoform 2. 1 PublicationVSP_025707Add
BLAST
Alternative sequencei228 – 371144Missing in isoform 2. 1 PublicationVSP_025708Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010388 mRNA. Translation: BAB26903.1.
AK160461 mRNA. Translation: BAE35802.1.
BC069873 mRNA. Translation: AAH69873.1.
CCDSiCCDS26904.1. [Q6NSU3-1]
RefSeqiNP_001159402.1. NM_001165930.1. [Q6NSU3-1]
NP_083902.2. NM_029626.2. [Q6NSU3-1]
XP_006519732.2. XM_006519669.2. [Q6NSU3-1]
XP_006519735.1. XM_006519672.2. [Q6NSU3-1]
XP_006519736.1. XM_006519673.2. [Q6NSU3-1]
XP_006519737.1. XM_006519674.1. [Q6NSU3-1]
UniGeneiMm.8766.

Genome annotation databases

EnsembliENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916. [Q6NSU3-1]
ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916. [Q6NSU3-1]
GeneIDi76485.
KEGGimmu:76485.
UCSCiuc007swf.2. mouse. [Q6NSU3-1]
uc007swg.2. mouse. [Q6NSU3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010388 mRNA. Translation: BAB26903.1.
AK160461 mRNA. Translation: BAE35802.1.
BC069873 mRNA. Translation: AAH69873.1.
CCDSiCCDS26904.1. [Q6NSU3-1]
RefSeqiNP_001159402.1. NM_001165930.1. [Q6NSU3-1]
NP_083902.2. NM_029626.2. [Q6NSU3-1]
XP_006519732.2. XM_006519669.2. [Q6NSU3-1]
XP_006519735.1. XM_006519672.2. [Q6NSU3-1]
XP_006519736.1. XM_006519673.2. [Q6NSU3-1]
XP_006519737.1. XM_006519674.1. [Q6NSU3-1]
UniGeneiMm.8766.

3D structure databases

ProteinModelPortaliQ6NSU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022476.

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

PTM databases

PhosphoSiteiQ6NSU3.

Proteomic databases

MaxQBiQ6NSU3.
PaxDbiQ6NSU3.
PRIDEiQ6NSU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916. [Q6NSU3-1]
ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916. [Q6NSU3-1]
GeneIDi76485.
KEGGimmu:76485.
UCSCiuc007swf.2. mouse. [Q6NSU3-1]
uc007swg.2. mouse. [Q6NSU3-2]

Organism-specific databases

CTDi55830.
MGIiMGI:1923735. Glt8d1.

Phylogenomic databases

eggNOGiNOG74598.
GeneTreeiENSGT00390000016670.
HOGENOMiHOG000112730.
HOVERGENiHBG055240.
InParanoidiQ6NSU3.
OMAiVKEDPGQ.
OrthoDBiEOG7RBZ8R.
PhylomeDBiQ6NSU3.
TreeFamiTF332433.

Miscellaneous databases

ChiTaRSiGlt8d1. mouse.
NextBioi345236.
PROiQ6NSU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NSU3.
CleanExiMM_GLT8D1.
GenevisibleiQ6NSU3. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiGL8D1_MOUSE
AccessioniPrimary (citable) accession number: Q6NSU3
Secondary accession number(s): Q3TV18, Q9CWT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.