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Q6NSU3 (GL8D1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycosyltransferase 8 domain-containing protein 1
EC=2.4.1.-
Gene names
Name:Glt8d1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 8 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from electronic annotation. Source: Compara

   Molecular_functiontransferase activity, transferring glycosyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NSU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NSU3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     216-227: YNYIGYLDYKKE → VMTYCRSHSGKA
     228-371: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Glycosyltransferase 8 domain-containing protein 1
PRO_0000288529

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain29 – 371343Lumenal Potential

Amino acid modifications

Glycosylation2571N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence216 – 22712YNYIG…DYKKE → VMTYCRSHSGKA in isoform 2.
VSP_025707
Alternative sequence228 – 371144Missing in isoform 2.
VSP_025708

Experimental info

Sequence conflict921R → G in BAB26903. Ref.1
Sequence conflict1851N → K in BAB26903. Ref.1
Sequence conflict3631R → S in BAB26903. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 61E507E46C18185B

FASTA37141,990
        10         20         30         40         50         60 
MSFRKVNIII WVLAVVLFLL VLHHNFLSLS SLLKNDISDS GIVGLQPIDF VASAHQHPVS 

        70         80         90        100        110        120 
ERQEEIPVVI AASEDRLGGT IAAINSVHQN TRSNVMFYIV TFNSTADHLR SWLNSGSLKS 

       130        140        150        160        170        180 
IRYKIVNFDT KLLEGKVKQD PDQGESMKPL TFARFYLPIL VPSAKKAIYM DDDVIVQGDI 

       190        200        210        220        230        240 
LALYNTPLKP GHAAAFSEDC DSASTKVIIR GAGNQYNYIG YLDYKKERIR KLSMKASTCS 

       250        260        270        280        290        300 
FNPGVFVANL TEWKRQNVTN QLEKWMKLNV EEGLYSRTLA GSITTPPLLI VFYQQHSTID 

       310        320        330        340        350        360 
PMWNVRHLGS SAGKRYSPQF VKAAKLLHWN GHFKPWGRTA SYADVWEKWY IPDPTGKFSL 

       370 
IRRHMDTSNI K

« Hide

Isoform 2 [UniParc].

Checksum: 9FBA9E087BA9CC24
Show »

FASTA22725,041

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK010388 mRNA. Translation: BAB26903.1.
AK160461 mRNA. Translation: BAE35802.1.
BC069873 mRNA. Translation: AAH69873.1.
IPIIPI00467883.
IPI00845594.
RefSeqNP_001159402.1. NM_001165930.1.
NP_083902.2. NM_029626.2.
UniGeneMm.8766.

3D structure databases

ProteinModelPortalQ6NSU3.
ModBaseSearch...

Protein family/group databases

CAZyGT8. Glycosyltransferase Family 8.

PTM databases

PhosphoSiteQ6NSU3.

Proteomic databases

PaxDbQ6NSU3.
PRIDEQ6NSU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916.
ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916.
GeneID76485.
KEGGmmu:76485.
UCSCuc007swf.2. mouse.
uc007swg.2. mouse.

Organism-specific databases

CTD55830.
MGIMGI:1923735. Glt8d1.

Phylogenomic databases

eggNOGNOG74598.
GeneTreeENSGT00390000016670.
HOGENOMHOG000112730.
HOVERGENHBG055240.
InParanoidQ6NSU3.
OMAMSFRKVN.
OrthoDBEOG46MBJS.

Gene expression databases

BgeeQ6NSU3.
CleanExMM_GLT8D1.
GenevestigatorQ6NSU3.

Family and domain databases

InterProIPR002495. Glyco_trans_8.
[Graphical view]
PfamPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGLT8D1. mouse.
NextBio345236.
SOURCESearch...

Entry information

Entry nameGL8D1_MOUSE
AccessionPrimary (citable) accession number: Q6NSU3
Secondary accession number(s): Q3TV18, Q9CWT8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: March 6, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents