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Q6NSU3

- GL8D1_MOUSE

UniProt

Q6NSU3 - GL8D1_MOUSE

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Protein
Glycosyltransferase 8 domain-containing protein 1
Gene
Glt8d1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyltransferase 8 domain-containing protein 1 (EC:2.4.1.-)
Gene namesi
Name:Glt8d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1923735. Glt8d1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini29 – 371343Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Glycosyltransferase 8 domain-containing protein 1
PRO_0000288529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi257 – 2571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NSU3.
PRIDEiQ6NSU3.

PTM databases

PhosphoSiteiQ6NSU3.

Expressioni

Gene expression databases

BgeeiQ6NSU3.
CleanExiMM_GLT8D1.
GenevestigatoriQ6NSU3.

Structurei

3D structure databases

ProteinModelPortaliQ6NSU3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74598.
GeneTreeiENSGT00390000016670.
HOGENOMiHOG000112730.
HOVERGENiHBG055240.
InParanoidiQ6NSU3.
OMAiPIDFVPN.
OrthoDBiEOG7RBZ8R.
PhylomeDBiQ6NSU3.
TreeFamiTF332433.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NSU3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSFRKVNIII WVLAVVLFLL VLHHNFLSLS SLLKNDISDS GIVGLQPIDF    50
VASAHQHPVS ERQEEIPVVI AASEDRLGGT IAAINSVHQN TRSNVMFYIV 100
TFNSTADHLR SWLNSGSLKS IRYKIVNFDT KLLEGKVKQD PDQGESMKPL 150
TFARFYLPIL VPSAKKAIYM DDDVIVQGDI LALYNTPLKP GHAAAFSEDC 200
DSASTKVIIR GAGNQYNYIG YLDYKKERIR KLSMKASTCS FNPGVFVANL 250
TEWKRQNVTN QLEKWMKLNV EEGLYSRTLA GSITTPPLLI VFYQQHSTID 300
PMWNVRHLGS SAGKRYSPQF VKAAKLLHWN GHFKPWGRTA SYADVWEKWY 350
IPDPTGKFSL IRRHMDTSNI K 371
Length:371
Mass (Da):41,990
Last modified:July 5, 2004 - v1
Checksum:i61E507E46C18185B
GO
Isoform 2 (identifier: Q6NSU3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-227: YNYIGYLDYKKE → VMTYCRSHSGKA
     228-371: Missing.

Note: No experimental confirmation available.

Show »
Length:227
Mass (Da):25,041
Checksum:i9FBA9E087BA9CC24
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 22712YNYIG…DYKKE → VMTYCRSHSGKA in isoform 2.
VSP_025707Add
BLAST
Alternative sequencei228 – 371144Missing in isoform 2.
VSP_025708Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921R → G in BAB26903. 1 Publication
Sequence conflicti185 – 1851N → K in BAB26903. 1 Publication
Sequence conflicti363 – 3631R → S in BAB26903. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010388 mRNA. Translation: BAB26903.1.
AK160461 mRNA. Translation: BAE35802.1.
BC069873 mRNA. Translation: AAH69873.1.
CCDSiCCDS26904.1. [Q6NSU3-1]
RefSeqiNP_001159402.1. NM_001165930.1. [Q6NSU3-1]
NP_083902.2. NM_029626.2. [Q6NSU3-1]
XP_006519735.1. XM_006519672.1. [Q6NSU3-1]
XP_006519736.1. XM_006519673.1. [Q6NSU3-1]
XP_006519737.1. XM_006519674.1. [Q6NSU3-1]
UniGeneiMm.8766.

Genome annotation databases

EnsembliENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916. [Q6NSU3-1]
ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916. [Q6NSU3-1]
GeneIDi76485.
KEGGimmu:76485.
UCSCiuc007swf.2. mouse. [Q6NSU3-1]
uc007swg.2. mouse. [Q6NSU3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010388 mRNA. Translation: BAB26903.1 .
AK160461 mRNA. Translation: BAE35802.1 .
BC069873 mRNA. Translation: AAH69873.1 .
CCDSi CCDS26904.1. [Q6NSU3-1 ]
RefSeqi NP_001159402.1. NM_001165930.1. [Q6NSU3-1 ]
NP_083902.2. NM_029626.2. [Q6NSU3-1 ]
XP_006519735.1. XM_006519672.1. [Q6NSU3-1 ]
XP_006519736.1. XM_006519673.1. [Q6NSU3-1 ]
XP_006519737.1. XM_006519674.1. [Q6NSU3-1 ]
UniGenei Mm.8766.

3D structure databases

ProteinModelPortali Q6NSU3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT8. Glycosyltransferase Family 8.

PTM databases

PhosphoSitei Q6NSU3.

Proteomic databases

PaxDbi Q6NSU3.
PRIDEi Q6NSU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022476 ; ENSMUSP00000022476 ; ENSMUSG00000021916 . [Q6NSU3-1 ]
ENSMUST00000168584 ; ENSMUSP00000129323 ; ENSMUSG00000021916 . [Q6NSU3-1 ]
GeneIDi 76485.
KEGGi mmu:76485.
UCSCi uc007swf.2. mouse. [Q6NSU3-1 ]
uc007swg.2. mouse. [Q6NSU3-2 ]

Organism-specific databases

CTDi 55830.
MGIi MGI:1923735. Glt8d1.

Phylogenomic databases

eggNOGi NOG74598.
GeneTreei ENSGT00390000016670.
HOGENOMi HOG000112730.
HOVERGENi HBG055240.
InParanoidi Q6NSU3.
OMAi PIDFVPN.
OrthoDBi EOG7RBZ8R.
PhylomeDBi Q6NSU3.
TreeFami TF332433.

Miscellaneous databases

ChiTaRSi GLT8D1. mouse.
NextBioi 345236.
PROi Q6NSU3.
SOURCEi Search...

Gene expression databases

Bgeei Q6NSU3.
CleanExi MM_GLT8D1.
Genevestigatori Q6NSU3.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01501. Glyco_transf_8. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiGL8D1_MOUSE
AccessioniPrimary (citable) accession number: Q6NSU3
Secondary accession number(s): Q3TV18, Q9CWT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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