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Q6NSU3

- GL8D1_MOUSE

UniProt

Q6NSU3 - GL8D1_MOUSE

Protein

Glycosyltransferase 8 domain-containing protein 1

Gene

Glt8d1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT8. Glycosyltransferase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 1 (EC:2.4.1.-)
    Gene namesi
    Name:Glt8d1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1923735. Glt8d1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Glycosyltransferase 8 domain-containing protein 1PRO_0000288529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6NSU3.
    PRIDEiQ6NSU3.

    PTM databases

    PhosphoSiteiQ6NSU3.

    Expressioni

    Gene expression databases

    BgeeiQ6NSU3.
    CleanExiMM_GLT8D1.
    GenevestigatoriQ6NSU3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NSU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 371343LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 8 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74598.
    GeneTreeiENSGT00390000016670.
    HOGENOMiHOG000112730.
    HOVERGENiHBG055240.
    InParanoidiQ6NSU3.
    OMAiPIDFVPN.
    OrthoDBiEOG7RBZ8R.
    PhylomeDBiQ6NSU3.
    TreeFamiTF332433.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR002495. Glyco_trans_8.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01501. Glyco_transf_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NSU3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFRKVNIII WVLAVVLFLL VLHHNFLSLS SLLKNDISDS GIVGLQPIDF    50
    VASAHQHPVS ERQEEIPVVI AASEDRLGGT IAAINSVHQN TRSNVMFYIV 100
    TFNSTADHLR SWLNSGSLKS IRYKIVNFDT KLLEGKVKQD PDQGESMKPL 150
    TFARFYLPIL VPSAKKAIYM DDDVIVQGDI LALYNTPLKP GHAAAFSEDC 200
    DSASTKVIIR GAGNQYNYIG YLDYKKERIR KLSMKASTCS FNPGVFVANL 250
    TEWKRQNVTN QLEKWMKLNV EEGLYSRTLA GSITTPPLLI VFYQQHSTID 300
    PMWNVRHLGS SAGKRYSPQF VKAAKLLHWN GHFKPWGRTA SYADVWEKWY 350
    IPDPTGKFSL IRRHMDTSNI K 371
    Length:371
    Mass (Da):41,990
    Last modified:July 5, 2004 - v1
    Checksum:i61E507E46C18185B
    GO
    Isoform 2 (identifier: Q6NSU3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-227: YNYIGYLDYKKE → VMTYCRSHSGKA
         228-371: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:227
    Mass (Da):25,041
    Checksum:i9FBA9E087BA9CC24
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921R → G in BAB26903. (PubMed:16141072)Curated
    Sequence conflicti185 – 1851N → K in BAB26903. (PubMed:16141072)Curated
    Sequence conflicti363 – 3631R → S in BAB26903. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei216 – 22712YNYIG…DYKKE → VMTYCRSHSGKA in isoform 2. 1 PublicationVSP_025707Add
    BLAST
    Alternative sequencei228 – 371144Missing in isoform 2. 1 PublicationVSP_025708Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010388 mRNA. Translation: BAB26903.1.
    AK160461 mRNA. Translation: BAE35802.1.
    BC069873 mRNA. Translation: AAH69873.1.
    CCDSiCCDS26904.1. [Q6NSU3-1]
    RefSeqiNP_001159402.1. NM_001165930.1. [Q6NSU3-1]
    NP_083902.2. NM_029626.2. [Q6NSU3-1]
    XP_006519735.1. XM_006519672.1. [Q6NSU3-1]
    XP_006519736.1. XM_006519673.1. [Q6NSU3-1]
    XP_006519737.1. XM_006519674.1. [Q6NSU3-1]
    UniGeneiMm.8766.

    Genome annotation databases

    EnsembliENSMUST00000022476; ENSMUSP00000022476; ENSMUSG00000021916. [Q6NSU3-1]
    ENSMUST00000168584; ENSMUSP00000129323; ENSMUSG00000021916. [Q6NSU3-1]
    GeneIDi76485.
    KEGGimmu:76485.
    UCSCiuc007swf.2. mouse. [Q6NSU3-1]
    uc007swg.2. mouse. [Q6NSU3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010388 mRNA. Translation: BAB26903.1 .
    AK160461 mRNA. Translation: BAE35802.1 .
    BC069873 mRNA. Translation: AAH69873.1 .
    CCDSi CCDS26904.1. [Q6NSU3-1 ]
    RefSeqi NP_001159402.1. NM_001165930.1. [Q6NSU3-1 ]
    NP_083902.2. NM_029626.2. [Q6NSU3-1 ]
    XP_006519735.1. XM_006519672.1. [Q6NSU3-1 ]
    XP_006519736.1. XM_006519673.1. [Q6NSU3-1 ]
    XP_006519737.1. XM_006519674.1. [Q6NSU3-1 ]
    UniGenei Mm.8766.

    3D structure databases

    ProteinModelPortali Q6NSU3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT8. Glycosyltransferase Family 8.

    PTM databases

    PhosphoSitei Q6NSU3.

    Proteomic databases

    PaxDbi Q6NSU3.
    PRIDEi Q6NSU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022476 ; ENSMUSP00000022476 ; ENSMUSG00000021916 . [Q6NSU3-1 ]
    ENSMUST00000168584 ; ENSMUSP00000129323 ; ENSMUSG00000021916 . [Q6NSU3-1 ]
    GeneIDi 76485.
    KEGGi mmu:76485.
    UCSCi uc007swf.2. mouse. [Q6NSU3-1 ]
    uc007swg.2. mouse. [Q6NSU3-2 ]

    Organism-specific databases

    CTDi 55830.
    MGIi MGI:1923735. Glt8d1.

    Phylogenomic databases

    eggNOGi NOG74598.
    GeneTreei ENSGT00390000016670.
    HOGENOMi HOG000112730.
    HOVERGENi HBG055240.
    InParanoidi Q6NSU3.
    OMAi PIDFVPN.
    OrthoDBi EOG7RBZ8R.
    PhylomeDBi Q6NSU3.
    TreeFami TF332433.

    Miscellaneous databases

    ChiTaRSi GLT8D1. mouse.
    NextBioi 345236.
    PROi Q6NSU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NSU3.
    CleanExi MM_GLT8D1.
    Genevestigatori Q6NSU3.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR002495. Glyco_trans_8.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01501. Glyco_transf_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiGL8D1_MOUSE
    AccessioniPrimary (citable) accession number: Q6NSU3
    Secondary accession number(s): Q3TV18, Q9CWT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3