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Protein

Probable aminopeptidase NPEPL1

Gene

Npepl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.By similarity

Cofactori

Zn2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi260Zinc 2By similarity1
Metal bindingi265Zinc 1By similarity1
Metal bindingi265Zinc 2By similarity1
Active sitei272Sequence analysis1
Metal bindingi283Zinc 2By similarity1
Metal bindingi342Zinc 1By similarity1
Metal bindingi344Zinc 1By similarity1
Metal bindingi344Zinc 2By similarity1
Active sitei346Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding, Zinc

Protein family/group databases

MEROPSiM17.006

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aminopeptidase NPEPL1 (EC:3.4.11.-)
Alternative name(s):
Aminopeptidase-like 1
Gene namesi
Name:Npepl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2448523 Npepl1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001658291 – 524Probable aminopeptidase NPEPL1Add BLAST524

Proteomic databases

EPDiQ6NSR8
MaxQBiQ6NSR8
PaxDbiQ6NSR8
PRIDEiQ6NSR8

PTM databases

iPTMnetiQ6NSR8
PhosphoSitePlusiQ6NSR8
SwissPalmiQ6NSR8

Expressioni

Gene expression databases

BgeeiENSMUSG00000039263
CleanExiMM_NPEPL1
ExpressionAtlasiQ6NSR8 baseline and differential
GenevisibleiQ6NSR8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042808

Structurei

3D structure databases

ProteinModelPortaliQ6NSR8
SMRiQ6NSR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

eggNOGiKOG2597 Eukaryota
COG0260 LUCA
GeneTreeiENSGT00530000063255
HOGENOMiHOG000243131
HOVERGENiHBG053563
InParanoidiQ6NSR8
KOiK09611
OMAiRNCGDLV
OrthoDBiEOG091G0A99
PhylomeDBiQ6NSR8
TreeFamiTF314954

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NSR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVGLQFQA SAGDADPQSR PLLLLGQLQH LHRVPWSHVR GKLQPRVTEE
60 70 80 90 100
LWQAALATLN PNPTDSCPLY LNCATVAALP SRVSRHNSPS AAHFITRLVR
110 120 130 140 150
TCLPPGTHRC ILMVCEQTEV FASACALARA FPLFTHRSGA SRRAEKRTVM
160 170 180 190 200
VEFFLVGQDN GPVEVSTLQC LTNATEGVRL AARIVDTPCN EMNTDIFLEE
210 220 230 240 250
IIQVGKELGI TPTIIRDEQL KTKGFGGIYG VGKAALHPPA LAILSHTPDG
260 270 280 290 300
ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAIKQ
310 320 330 340 350
GFKDNLHAVF CLAENAVGPN ATRPDDIHLL YSGKTVEINN TDAEGRLVLA
360 370 380 390 400
DGVSYACKDL GADIIVDMAT LTGAQGIATG KYHAAVLTNS AEWEAACVKA
410 420 430 440 450
GRKCGDLVHP LVYCPELHFS EFTSAVADMK NSVADRDNSP SSCAGLFIAS
460 470 480 490 500
HIGFDWPGVW VHLDIAAPVH AGERATGFGV ALLLALFGRA SEDPLLNLVS
510 520
PLDCEVDAQE GDNMGRDSKR RRLV
Length:524
Mass (Da):55,940
Last modified:July 5, 2004 - v1
Checksum:i4B45CD164D1F65CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669896 Genomic DNA No translation available.
BC069933 mRNA Translation: AAH69933.1
BC080707 mRNA Translation: AAH80707.1
CCDSiCCDS17148.1
RefSeqiNP_998898.1, NM_213733.2
UniGeneiMm.295629

Genome annotation databases

EnsembliENSMUST00000044415; ENSMUSP00000042808; ENSMUSG00000039263
GeneIDi228961
KEGGimmu:228961
UCSCiuc008oeo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPEPL1_MOUSE
AccessioniPrimary (citable) accession number: Q6NSR8
Secondary accession number(s): A2ACM6, Q66JY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health