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Protein

Probable aminopeptidase NPEPL1

Gene

Npepl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.By similarity

Cofactori

Zn2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi260Zinc 2By similarity1
Metal bindingi265Zinc 1By similarity1
Metal bindingi265Zinc 2By similarity1
Active sitei272Sequence analysis1
Metal bindingi283Zinc 2By similarity1
Metal bindingi342Zinc 1By similarity1
Metal bindingi344Zinc 1By similarity1
Metal bindingi344Zinc 2By similarity1
Active sitei346Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding, Zinc

Protein family/group databases

MEROPSiM17.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aminopeptidase NPEPL1 (EC:3.4.11.-)
Alternative name(s):
Aminopeptidase-like 1
Gene namesi
Name:Npepl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2448523. Npepl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001658291 – 524Probable aminopeptidase NPEPL1Add BLAST524

Proteomic databases

EPDiQ6NSR8.
MaxQBiQ6NSR8.
PaxDbiQ6NSR8.
PRIDEiQ6NSR8.

PTM databases

iPTMnetiQ6NSR8.
PhosphoSitePlusiQ6NSR8.
SwissPalmiQ6NSR8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039263.
CleanExiMM_NPEPL1.
ExpressionAtlasiQ6NSR8. baseline and differential.
GenevisibleiQ6NSR8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042808.

Structurei

3D structure databases

ProteinModelPortaliQ6NSR8.
SMRiQ6NSR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

eggNOGiKOG2597. Eukaryota.
COG0260. LUCA.
GeneTreeiENSGT00530000063255.
HOGENOMiHOG000243131.
HOVERGENiHBG053563.
InParanoidiQ6NSR8.
KOiK09611.
OMAiPGVWVHV.
OrthoDBiEOG091G0A99.
PhylomeDBiQ6NSR8.
TreeFamiTF314954.

Family and domain databases

CDDicd00433. Peptidase_M17. 1 hit.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
[Graphical view]
PANTHERiPTHR11963. PTHR11963. 1 hit.
PfamiPF00883. Peptidase_M17. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NSR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVGLQFQA SAGDADPQSR PLLLLGQLQH LHRVPWSHVR GKLQPRVTEE
60 70 80 90 100
LWQAALATLN PNPTDSCPLY LNCATVAALP SRVSRHNSPS AAHFITRLVR
110 120 130 140 150
TCLPPGTHRC ILMVCEQTEV FASACALARA FPLFTHRSGA SRRAEKRTVM
160 170 180 190 200
VEFFLVGQDN GPVEVSTLQC LTNATEGVRL AARIVDTPCN EMNTDIFLEE
210 220 230 240 250
IIQVGKELGI TPTIIRDEQL KTKGFGGIYG VGKAALHPPA LAILSHTPDG
260 270 280 290 300
ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAIKQ
310 320 330 340 350
GFKDNLHAVF CLAENAVGPN ATRPDDIHLL YSGKTVEINN TDAEGRLVLA
360 370 380 390 400
DGVSYACKDL GADIIVDMAT LTGAQGIATG KYHAAVLTNS AEWEAACVKA
410 420 430 440 450
GRKCGDLVHP LVYCPELHFS EFTSAVADMK NSVADRDNSP SSCAGLFIAS
460 470 480 490 500
HIGFDWPGVW VHLDIAAPVH AGERATGFGV ALLLALFGRA SEDPLLNLVS
510 520
PLDCEVDAQE GDNMGRDSKR RRLV
Length:524
Mass (Da):55,940
Last modified:July 5, 2004 - v1
Checksum:i4B45CD164D1F65CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669896 Genomic DNA. Translation: CAM25415.1.
BC069933 mRNA. Translation: AAH69933.1.
BC080707 mRNA. Translation: AAH80707.1.
CCDSiCCDS17148.1.
RefSeqiNP_998898.1. NM_213733.2.
UniGeneiMm.295629.

Genome annotation databases

EnsembliENSMUST00000044415; ENSMUSP00000042808; ENSMUSG00000039263.
GeneIDi228961.
KEGGimmu:228961.
UCSCiuc008oeo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669896 Genomic DNA. Translation: CAM25415.1.
BC069933 mRNA. Translation: AAH69933.1.
BC080707 mRNA. Translation: AAH80707.1.
CCDSiCCDS17148.1.
RefSeqiNP_998898.1. NM_213733.2.
UniGeneiMm.295629.

3D structure databases

ProteinModelPortaliQ6NSR8.
SMRiQ6NSR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042808.

Protein family/group databases

MEROPSiM17.006.

PTM databases

iPTMnetiQ6NSR8.
PhosphoSitePlusiQ6NSR8.
SwissPalmiQ6NSR8.

Proteomic databases

EPDiQ6NSR8.
MaxQBiQ6NSR8.
PaxDbiQ6NSR8.
PRIDEiQ6NSR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044415; ENSMUSP00000042808; ENSMUSG00000039263.
GeneIDi228961.
KEGGimmu:228961.
UCSCiuc008oeo.2. mouse.

Organism-specific databases

CTDi79716.
MGIiMGI:2448523. Npepl1.

Phylogenomic databases

eggNOGiKOG2597. Eukaryota.
COG0260. LUCA.
GeneTreeiENSGT00530000063255.
HOGENOMiHOG000243131.
HOVERGENiHBG053563.
InParanoidiQ6NSR8.
KOiK09611.
OMAiPGVWVHV.
OrthoDBiEOG091G0A99.
PhylomeDBiQ6NSR8.
TreeFamiTF314954.

Miscellaneous databases

PROiQ6NSR8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039263.
CleanExiMM_NPEPL1.
ExpressionAtlasiQ6NSR8. baseline and differential.
GenevisibleiQ6NSR8. MM.

Family and domain databases

CDDicd00433. Peptidase_M17. 1 hit.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
[Graphical view]
PANTHERiPTHR11963. PTHR11963. 1 hit.
PfamiPF00883. Peptidase_M17. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPL1_MOUSE
AccessioniPrimary (citable) accession number: Q6NSR8
Secondary accession number(s): A2ACM6, Q66JY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.