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Protein

Uncharacterized aarF domain-containing protein kinase 2

Gene

Adck2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei302ATPBy similarity1
Active sitei436Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 214ATPBy similarity9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 2 (EC:2.7.11.-)
Gene namesi
Name:Adck2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1889336. Adck2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717931 – 617Uncharacterized aarF domain-containing protein kinase 2Add BLAST617

Proteomic databases

MaxQBiQ6NSR3.
PaxDbiQ6NSR3.
PRIDEiQ6NSR3.

PTM databases

iPTMnetiQ6NSR3.
PhosphoSitePlusiQ6NSR3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046947.
CleanExiMM_ADCK2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123563.

Structurei

3D structure databases

ProteinModelPortaliQ6NSR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 609Protein kinaseAdd BLAST410

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi457 – 460Poly-Gln4

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1236. Eukaryota.
COG0661. LUCA.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ6NSR3.
KOiK08869.
TreeFamiTF315018.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6NSR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTPWRLSVR VCLSHLRCFE FRKELGHSRP LGCSRNARLC WFLLGTLPKL
60 70 80 90 100
ISAHGSVGEG APGSLCQRKT HWSDLAENGL VEKVAQEGPL ARVLLCLRLG
110 120 130 140 150
LRAGVLLAKF FPLLFLYPLT YLAPGLSTLW LHLLFKATET SGPTYIKLGQ
160 170 180 190 200
WASTRRDLFS EAFCTQFSKL HVQVTPHPWA RTEYLLQQAF GEDWGSLLFF
210 220 230 240 250
ETREPVGSGC VAQVYKAFAS ISLLEEDRIW RLGELSAPGT RAVVMQREPF
260 270 280 290 300
MKDRKPSENL ADEAFLEKLL LPKADLGGSE VGVSQAPWHL PKSDHLIPVA
310 320 330 340 350
VKVLHPGLLS QVSMDLLLMK IGSKALGLLP GVKWLSLPEI VEEFEKLMVQ
360 370 380 390 400
QTDLRYEAQN LEHFQHNFQD MASVKFPTPL RPLITRDILV ETYEESVPVS
410 420 430 440 450
SYQQAGIPTD LKRKIAQLGI NMLLKMIFVD NFVHGDLHPG NILVQGADGV
460 470 480 490 500
SPSLEMQQQQ VNVCDTLVAT IAPALCPLRL VLLDAGIVAK LQASDLRNFR
510 520 530 540 550
AVFQAVVMGQ GHRVAELMLH HAQANECRDV ERFKAEMATL VTQARKNIVT
560 570 580 590 600
LEKLHVSSLL SSVFKLLMTH KVKLESNFAS IVVAIMVLEG LGRSLDPTLD
610
ILEAAKPFLF KGPASFL
Length:617
Mass (Da):68,677
Last modified:July 5, 2004 - v1
Checksum:i3230111C7DB65CEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti342E → K in BAE36249 (PubMed:16141072).Curated1
Sequence conflicti528R → K in BAC26008 (PubMed:16141072).Curated1
Sequence conflicti528R → K in BAC26013 (PubMed:16141072).Curated1
Sequence conflicti528R → K in BAE36249 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028557 mRNA. Translation: BAC26008.1.
AK028568 mRNA. Translation: BAC26013.1.
AK161225 mRNA. Translation: BAE36249.1.
BC069944 mRNA. Translation: AAH69944.1.
CCDSiCCDS20024.1.
RefSeqiNP_849204.1. NM_178873.3.
UniGeneiMm.247957.

Genome annotation databases

GeneIDi57869.
KEGGimmu:57869.
UCSCiuc009bmb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028557 mRNA. Translation: BAC26008.1.
AK028568 mRNA. Translation: BAC26013.1.
AK161225 mRNA. Translation: BAE36249.1.
BC069944 mRNA. Translation: AAH69944.1.
CCDSiCCDS20024.1.
RefSeqiNP_849204.1. NM_178873.3.
UniGeneiMm.247957.

3D structure databases

ProteinModelPortaliQ6NSR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123563.

PTM databases

iPTMnetiQ6NSR3.
PhosphoSitePlusiQ6NSR3.

Proteomic databases

MaxQBiQ6NSR3.
PaxDbiQ6NSR3.
PRIDEiQ6NSR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi57869.
KEGGimmu:57869.
UCSCiuc009bmb.1. mouse.

Organism-specific databases

CTDi90956.
MGIiMGI:1889336. Adck2.

Phylogenomic databases

eggNOGiKOG1236. Eukaryota.
COG0661. LUCA.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ6NSR3.
KOiK08869.
TreeFamiTF315018.

Miscellaneous databases

PROiQ6NSR3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046947.
CleanExiMM_ADCK2.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiADCK2_MOUSE
AccessioniPrimary (citable) accession number: Q6NSR3
Secondary accession number(s): Q3TTS5, Q8BHC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.