Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphatase 3

Gene

G6pc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.4 Publications

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate.By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateSequence analysis1
Active sitei114Proton donorSequence analysis1
Binding sitei161SubstrateSequence analysis1
Active sitei167NucleophileBy similarity1

GO - Molecular functioni

  • glucose-6-phosphatase activity Source: MGI

GO - Biological processi

  • gluconeogenesis Source: GO_Central
  • glucose 6-phosphate metabolic process Source: GO_Central
  • glucose-6-phosphate transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

ReactomeiR-MMU-70153. Glucose transport.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Alternative name(s):
Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
Gene namesi
Name:G6pc3
Synonyms:Ugrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915651. G6pc3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 56CytoplasmicSequence analysisAdd BLAST11
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 108LumenalSequence analysisAdd BLAST31
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 138CytoplasmicSequence analysis9
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 167LumenalSequence analysis8
Transmembranei168 – 186HelicalSequence analysisAdd BLAST19
Topological domaini187 – 197CytoplasmicSequence analysisAdd BLAST11
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 254LumenalSequence analysisAdd BLAST36
Transmembranei255 – 273HelicalSequence analysisAdd BLAST19
Topological domaini274 – 283CytoplasmicSequence analysis10
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 307LumenalSequence analysis3
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 346CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display reduced glucose-6-phosphate hydrolytic activity in the brain. No phenotypic difference was noted at birth but 4 months old female mice display growth retardation. Mutant mice exhibit a decreased plasma cholesterol concentration and an increased plasma glucagon concentration but no difference in blood glucose concentration (PubMed:17023421). Mice display neutropenia and neutrophil dysfunctions.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345131 – 346Glucose-6-phosphatase 3Add BLAST346

Proteomic databases

EPDiQ6NSQ9.
MaxQBiQ6NSQ9.
PaxDbiQ6NSQ9.
PeptideAtlasiQ6NSQ9.
PRIDEiQ6NSQ9.

PTM databases

iPTMnetiQ6NSQ9.
PhosphoSitePlusiQ6NSQ9.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart, brain, kidney and testis and to a lower extent in lung, spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000034793.
GenevisibleiQ6NSQ9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064276.

Structurei

3D structure databases

ProteinModelPortaliQ6NSQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXG. Eukaryota.
ENOG4110AJ7. LUCA.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ6NSQ9.
KOiK01084.
OMAiHMFSAQE.
OrthoDBiEOG091G0AXF.
PhylomeDBiQ6NSQ9.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTLSAGII MAEALQNRLP GLENMWLWVT FLGDPKNLFQ FCFPAAYYAS
60 70 80 90 100
RRLGISVLWI TFIAEWLNLV FKWFLFGDRP FWWVHESGYS TQTPIQIHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPVMTAIS SQVASRSRSP WVRVIPGLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLGGLIVGA ALGWLMSPRV PMERELSFYG
210 220 230 240 250
LTALALMLGA SLMYWTLFTL GLDLSWSINL ASKWCERPEW VHMDSRPFAS
260 270 280 290 300
LSRDSGSALG LGIALHTPCY AQIRRAHLGN GQKIACFVLA MGLLVFLEWL
310 320 330 340
GYPPQISLFY IFNFLKYTLW PCLVLALVPW VVHTLSDQEA PPIRSS
Length:346
Mass (Da):38,782
Last modified:July 5, 2004 - v1
Checksum:i50CDA634BCABA014
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136R → Q in BAE38159 (PubMed:16141072).Curated1
Sequence conflicti207M → L in AAO39164 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186239 mRNA. Translation: AAO39164.1.
AK165395 mRNA. Translation: BAE38159.1.
AL954730 Genomic DNA. Translation: CAM25070.1.
BC069959 mRNA. Translation: AAH69959.1.
CCDSiCCDS25491.1.
RefSeqiNP_787949.2. NM_175935.3.
UniGeneiMm.22385.

Genome annotation databases

EnsembliENSMUST00000070334; ENSMUSP00000064276; ENSMUSG00000034793.
ENSMUST00000078975; ENSMUSP00000077995; ENSMUSG00000034793.
GeneIDi68401.
KEGGimmu:68401.
UCSCiuc007lqt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186239 mRNA. Translation: AAO39164.1.
AK165395 mRNA. Translation: BAE38159.1.
AL954730 Genomic DNA. Translation: CAM25070.1.
BC069959 mRNA. Translation: AAH69959.1.
CCDSiCCDS25491.1.
RefSeqiNP_787949.2. NM_175935.3.
UniGeneiMm.22385.

3D structure databases

ProteinModelPortaliQ6NSQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064276.

PTM databases

iPTMnetiQ6NSQ9.
PhosphoSitePlusiQ6NSQ9.

Proteomic databases

EPDiQ6NSQ9.
MaxQBiQ6NSQ9.
PaxDbiQ6NSQ9.
PeptideAtlasiQ6NSQ9.
PRIDEiQ6NSQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070334; ENSMUSP00000064276; ENSMUSG00000034793.
ENSMUST00000078975; ENSMUSP00000077995; ENSMUSG00000034793.
GeneIDi68401.
KEGGimmu:68401.
UCSCiuc007lqt.2. mouse.

Organism-specific databases

CTDi92579.
MGIiMGI:1915651. G6pc3.

Phylogenomic databases

eggNOGiENOG410IDXG. Eukaryota.
ENOG4110AJ7. LUCA.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ6NSQ9.
KOiK01084.
OMAiHMFSAQE.
OrthoDBiEOG091G0AXF.
PhylomeDBiQ6NSQ9.
TreeFamiTF324388.

Enzyme and pathway databases

UniPathwayiUPA00138.
ReactomeiR-MMU-70153. Glucose transport.

Miscellaneous databases

PROiQ6NSQ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034793.
GenevisibleiQ6NSQ9. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG6PC3_MOUSE
AccessioniPrimary (citable) accession number: Q6NSQ9
Secondary accession number(s): Q3TND0, Q811R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.