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Q6NSQ9

- G6PC3_MOUSE

UniProt

Q6NSQ9 - G6PC3_MOUSE

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Protein
Glucose-6-phosphatase 3
Gene
G6pc3, Ugrp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.4 Publications

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate Reviewed prediction
Active sitei114 – 1141Proton donor Reviewed prediction
Binding sitei161 – 1611Substrate Reviewed prediction
Active sitei167 – 1671Nucleophile By similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: MGI

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. gluconeogenesis Source: UniProtKB-UniPathway
  3. glucose 6-phosphate metabolic process Source: Ensembl
  4. glucose-6-phosphate transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Alternative name(s):
Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
Gene namesi
Name:G6pc3
Synonyms:Ugrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1915651. G6pc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Lumenal Reviewed prediction
Add
BLAST
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Topological domaini46 – 5611Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei57 – 7721Helical; Reviewed prediction
Add
BLAST
Topological domaini78 – 10831Lumenal Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Topological domaini130 – 1389Cytoplasmic Reviewed prediction
Transmembranei139 – 15921Helical; Reviewed prediction
Add
BLAST
Topological domaini160 – 1678Lumenal Reviewed prediction
Transmembranei168 – 18619Helical; Reviewed prediction
Add
BLAST
Topological domaini187 – 19711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Topological domaini219 – 25436Lumenal Reviewed prediction
Add
BLAST
Transmembranei255 – 27319Helical; Reviewed prediction
Add
BLAST
Topological domaini274 – 28310Cytoplasmic Reviewed prediction
Transmembranei284 – 30421Helical; Reviewed prediction
Add
BLAST
Topological domaini305 – 3073Lumenal Reviewed prediction
Transmembranei308 – 32821Helical; Reviewed prediction
Add
BLAST
Topological domaini329 – 34618Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display reduced glucose-6-phosphate hydrolytic activity in the brain. No phenotypic difference was noted at birth but 4 months old female mice display growth retardation. Mutant mice exhibit a decreased plasma cholesterol concentration and an increased plasma glucagon concentration but no difference in blood glucose concentration (1 Publication). Mice display neutropenia and neutrophil dysfunctions.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Glucose-6-phosphatase 3
PRO_0000334513Add
BLAST

Proteomic databases

PaxDbiQ6NSQ9.
PRIDEiQ6NSQ9.

PTM databases

PhosphoSiteiQ6NSQ9.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart, brain, kidney and testis and to a lower extent in lung, spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level).3 Publications

Gene expression databases

BgeeiQ6NSQ9.
GenevestigatoriQ6NSQ9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077995.

Structurei

3D structure databases

ProteinModelPortaliQ6NSQ9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ6NSQ9.
KOiK01084.
OMAiKWFLFGD.
OrthoDBiEOG73NG4N.
PhylomeDBiQ6NSQ9.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSQ9-1 [UniParc]FASTAAdd to Basket

« Hide

MESTLSAGII MAEALQNRLP GLENMWLWVT FLGDPKNLFQ FCFPAAYYAS    50
RRLGISVLWI TFIAEWLNLV FKWFLFGDRP FWWVHESGYS TQTPIQIHQF 100
PSSCETGPGS PSGHCMITGA ALWPVMTAIS SQVASRSRSP WVRVIPGLAY 150
CTFLLAVGLS RVFLLAHFPH QVLGGLIVGA ALGWLMSPRV PMERELSFYG 200
LTALALMLGA SLMYWTLFTL GLDLSWSINL ASKWCERPEW VHMDSRPFAS 250
LSRDSGSALG LGIALHTPCY AQIRRAHLGN GQKIACFVLA MGLLVFLEWL 300
GYPPQISLFY IFNFLKYTLW PCLVLALVPW VVHTLSDQEA PPIRSS 346
Length:346
Mass (Da):38,782
Last modified:July 5, 2004 - v1
Checksum:i50CDA634BCABA014
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361R → Q in BAE38159. 1 Publication
Sequence conflicti207 – 2071M → L in AAO39164. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY186239 mRNA. Translation: AAO39164.1.
AK165395 mRNA. Translation: BAE38159.1.
AL954730 Genomic DNA. Translation: CAM25070.1.
BC069959 mRNA. Translation: AAH69959.1.
CCDSiCCDS25491.1.
RefSeqiNP_787949.2. NM_175935.3.
UniGeneiMm.22385.

Genome annotation databases

EnsembliENSMUST00000070334; ENSMUSP00000064276; ENSMUSG00000034793.
ENSMUST00000078975; ENSMUSP00000077995; ENSMUSG00000034793.
GeneIDi68401.
KEGGimmu:68401.
UCSCiuc007lqt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY186239 mRNA. Translation: AAO39164.1 .
AK165395 mRNA. Translation: BAE38159.1 .
AL954730 Genomic DNA. Translation: CAM25070.1 .
BC069959 mRNA. Translation: AAH69959.1 .
CCDSi CCDS25491.1.
RefSeqi NP_787949.2. NM_175935.3.
UniGenei Mm.22385.

3D structure databases

ProteinModelPortali Q6NSQ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077995.

PTM databases

PhosphoSitei Q6NSQ9.

Proteomic databases

PaxDbi Q6NSQ9.
PRIDEi Q6NSQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070334 ; ENSMUSP00000064276 ; ENSMUSG00000034793 .
ENSMUST00000078975 ; ENSMUSP00000077995 ; ENSMUSG00000034793 .
GeneIDi 68401.
KEGGi mmu:68401.
UCSCi uc007lqt.2. mouse.

Organism-specific databases

CTDi 92579.
MGIi MGI:1915651. G6pc3.

Phylogenomic databases

eggNOGi NOG82628.
GeneTreei ENSGT00510000046465.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi Q6NSQ9.
KOi K01084.
OMAi KWFLFGD.
OrthoDBi EOG73NG4N.
PhylomeDBi Q6NSQ9.
TreeFami TF324388.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Miscellaneous databases

NextBioi 327124.
PROi Q6NSQ9.
SOURCEi Search...

Gene expression databases

Bgeei Q6NSQ9.
Genevestigatori Q6NSQ9.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a glucose-6-phosphatase catalytic subunit-related sequence expressed in rodent tissues."
    Middleditch C., Darakhshan F., Bonnefont J., Guionie O., Burchell A., Clottes E.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "A potential new role for muscle in blood glucose homeostasis."
    Shieh J.-J., Pan C.-J., Mansfield B.C., Chou J.Y.
    J. Biol. Chem. 279:26215-26219(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein."
    Boustead J.N., Martin C.C., Oeser J.K., Svitek C.A., Hunter S.I., Hutton J.C., O'Brien R.M.
    J. Mol. Endocrinol. 32:33-53(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  7. "Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production."
    Ghosh A., Cheung Y.Y., Mansfield B.C., Chou J.Y.
    J. Biol. Chem. 280:11114-11119(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. "Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon."
    Wang Y., Oeser J.K., Yang C., Sarkar S., Hackl S.I., Hasty A.H., McGuinness O.P., Paradee W., Hutton J.C., Powell D.R., O'Brien R.M.
    J. Biol. Chem. 281:39982-39989(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  9. "Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta."
    Cheung Y.Y., Kim S.Y., Yiu W.H., Pan C.-J., Jun H.-S., Ruef R.A., Lee E.J., Westphal H., Mansfield B.C., Chou J.Y.
    J. Clin. Invest. 117:784-793(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiG6PC3_MOUSE
AccessioniPrimary (citable) accession number: Q6NSQ9
Secondary accession number(s): Q3TND0, Q811R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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