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Q6NSQ9

- G6PC3_MOUSE

UniProt

Q6NSQ9 - G6PC3_MOUSE

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Protein

Glucose-6-phosphatase 3

Gene

G6pc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.4 Publications

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateSequence Analysis
Active sitei114 – 1141Proton donorSequence Analysis
Binding sitei161 – 1611SubstrateSequence Analysis
Active sitei167 – 1671NucleophileBy similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: MGI

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. gluconeogenesis Source: UniProtKB-UniPathway
  3. glucose 6-phosphate metabolic process Source: Ensembl
  4. glucose-6-phosphate transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Alternative name(s):
Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
Gene namesi
Name:G6pc3
Synonyms:Ugrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1915651. G6pc3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display reduced glucose-6-phosphate hydrolytic activity in the brain. No phenotypic difference was noted at birth but 4 months old female mice display growth retardation. Mutant mice exhibit a decreased plasma cholesterol concentration and an increased plasma glucagon concentration but no difference in blood glucose concentration (PubMed:17023421). Mice display neutropenia and neutrophil dysfunctions.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Glucose-6-phosphatase 3PRO_0000334513Add
BLAST

Proteomic databases

MaxQBiQ6NSQ9.
PaxDbiQ6NSQ9.
PRIDEiQ6NSQ9.

PTM databases

PhosphoSiteiQ6NSQ9.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart, brain, kidney and testis and to a lower extent in lung, spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level).3 Publications

Gene expression databases

BgeeiQ6NSQ9.
GenevestigatoriQ6NSQ9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077995.

Structurei

3D structure databases

ProteinModelPortaliQ6NSQ9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424LumenalSequence AnalysisAdd
BLAST
Topological domaini46 – 5611CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini78 – 10831LumenalSequence AnalysisAdd
BLAST
Topological domaini130 – 1389CytoplasmicSequence Analysis
Topological domaini160 – 1678LumenalSequence Analysis
Topological domaini187 – 19711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini219 – 25436LumenalSequence AnalysisAdd
BLAST
Topological domaini274 – 28310CytoplasmicSequence Analysis
Topological domaini305 – 3073LumenalSequence Analysis
Topological domaini329 – 34618CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18619HelicalSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27319HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ6NSQ9.
KOiK01084.
OMAiKWFLFGD.
OrthoDBiEOG73NG4N.
PhylomeDBiQ6NSQ9.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESTLSAGII MAEALQNRLP GLENMWLWVT FLGDPKNLFQ FCFPAAYYAS
60 70 80 90 100
RRLGISVLWI TFIAEWLNLV FKWFLFGDRP FWWVHESGYS TQTPIQIHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPVMTAIS SQVASRSRSP WVRVIPGLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLGGLIVGA ALGWLMSPRV PMERELSFYG
210 220 230 240 250
LTALALMLGA SLMYWTLFTL GLDLSWSINL ASKWCERPEW VHMDSRPFAS
260 270 280 290 300
LSRDSGSALG LGIALHTPCY AQIRRAHLGN GQKIACFVLA MGLLVFLEWL
310 320 330 340
GYPPQISLFY IFNFLKYTLW PCLVLALVPW VVHTLSDQEA PPIRSS
Length:346
Mass (Da):38,782
Last modified:July 5, 2004 - v1
Checksum:i50CDA634BCABA014
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361R → Q in BAE38159. (PubMed:16141072)Curated
Sequence conflicti207 – 2071M → L in AAO39164. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY186239 mRNA. Translation: AAO39164.1.
AK165395 mRNA. Translation: BAE38159.1.
AL954730 Genomic DNA. Translation: CAM25070.1.
BC069959 mRNA. Translation: AAH69959.1.
CCDSiCCDS25491.1.
RefSeqiNP_787949.2. NM_175935.3.
UniGeneiMm.22385.

Genome annotation databases

EnsembliENSMUST00000070334; ENSMUSP00000064276; ENSMUSG00000034793.
ENSMUST00000078975; ENSMUSP00000077995; ENSMUSG00000034793.
GeneIDi68401.
KEGGimmu:68401.
UCSCiuc007lqt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY186239 mRNA. Translation: AAO39164.1 .
AK165395 mRNA. Translation: BAE38159.1 .
AL954730 Genomic DNA. Translation: CAM25070.1 .
BC069959 mRNA. Translation: AAH69959.1 .
CCDSi CCDS25491.1.
RefSeqi NP_787949.2. NM_175935.3.
UniGenei Mm.22385.

3D structure databases

ProteinModelPortali Q6NSQ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077995.

PTM databases

PhosphoSitei Q6NSQ9.

Proteomic databases

MaxQBi Q6NSQ9.
PaxDbi Q6NSQ9.
PRIDEi Q6NSQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070334 ; ENSMUSP00000064276 ; ENSMUSG00000034793 .
ENSMUST00000078975 ; ENSMUSP00000077995 ; ENSMUSG00000034793 .
GeneIDi 68401.
KEGGi mmu:68401.
UCSCi uc007lqt.2. mouse.

Organism-specific databases

CTDi 92579.
MGIi MGI:1915651. G6pc3.

Phylogenomic databases

eggNOGi NOG82628.
GeneTreei ENSGT00510000046465.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi Q6NSQ9.
KOi K01084.
OMAi KWFLFGD.
OrthoDBi EOG73NG4N.
PhylomeDBi Q6NSQ9.
TreeFami TF324388.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Miscellaneous databases

NextBioi 327124.
PROi Q6NSQ9.
SOURCEi Search...

Gene expression databases

Bgeei Q6NSQ9.
Genevestigatori Q6NSQ9.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a glucose-6-phosphatase catalytic subunit-related sequence expressed in rodent tissues."
    Middleditch C., Darakhshan F., Bonnefont J., Guionie O., Burchell A., Clottes E.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "A potential new role for muscle in blood glucose homeostasis."
    Shieh J.-J., Pan C.-J., Mansfield B.C., Chou J.Y.
    J. Biol. Chem. 279:26215-26219(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein."
    Boustead J.N., Martin C.C., Oeser J.K., Svitek C.A., Hunter S.I., Hutton J.C., O'Brien R.M.
    J. Mol. Endocrinol. 32:33-53(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  7. "Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production."
    Ghosh A., Cheung Y.Y., Mansfield B.C., Chou J.Y.
    J. Biol. Chem. 280:11114-11119(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. "Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon."
    Wang Y., Oeser J.K., Yang C., Sarkar S., Hackl S.I., Hasty A.H., McGuinness O.P., Paradee W., Hutton J.C., Powell D.R., O'Brien R.M.
    J. Biol. Chem. 281:39982-39989(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  9. "Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta."
    Cheung Y.Y., Kim S.Y., Yiu W.H., Pan C.-J., Jun H.-S., Ruef R.A., Lee E.J., Westphal H., Mansfield B.C., Chou J.Y.
    J. Clin. Invest. 117:784-793(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiG6PC3_MOUSE
AccessioniPrimary (citable) accession number: Q6NSQ9
Secondary accession number(s): Q3TND0, Q811R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3