true2007-04-032024-03-27131AOF_DANREMolecular characterization of monoamine oxidase in zebrafish (Danio rerio).Setini A.Pierucci F.Senatori O.Nicotra A.doi:10.1016/j.cbpc.2004.10.0022005Comp. Biochem. Physiol.140B153-161NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONCATALYTIC ACTIVITYACTIVITY REGULATION3D-STRUCTURE MODELINGLiverDistinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio).Anichtchik O.Sallinen V.Peitsaro N.Panula P.doi:10.1002/cne.210572006J. Comp. Neurol.498593-610NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONCATALYTIC ACTIVITYACTIVITY REGULATIONTISSUE SPECIFICITYBrainNIH - Zebrafish Gene Collection (ZGC) project2004-05EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]KidneymaoEukaryota928Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOBNorepinephrine Neurotransmitter Release CycleEnzymatic degradation of dopamine by COMTEnzymatic degradation of Dopamine by monoamine oxidaseDopamine clearance from the synaptic cleftMetabolism of serotoninExpressed in intestine and 52 other cell types or tissuesFAD/NAD(P)-binding domainGuanine Nucleotide Dissociation Inhibitor, domain 1Amino_oxidaseFAD/NAD-bd_sfFlavin_amine_oxidaseAMINE OXIDASEAMINE OXIDASE [FLAVIN-CONTAINING] BAmino_oxidaseAMINEOXDASEFFAD-linked reductases, C-terminal domainFAD/NAD(P)-binding domainAmine oxidase [flavin-containing]1.4.3.211.4.3.4Monoamine oxidaseMAOZ-MAOmaozgc:85761Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:15621520, PubMed:16917825). Preferentially oxidizes serotonin and tyramine (PubMed:15621520, PubMed:16917825). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).Inhibited by both clorgyline (selective MAOA inhibitor) and deprenyl (selective MAOB inhibitor).Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).Strongest expression in brain and intestine, followed by liver, heart and gill. Little expression in spleen, eye or muscle. In brain, highest activity in noradrenergic and serotonergic cell groups and those of the habenulointerpeduncular pathway; moderate levels in dopaminergic cell clusters.There appears to be only one form of this enzyme in zebrafish, whereas in mammals two forms (MAOA and MAOB) exist.Belongs to the flavin monoamine oxidase family.Amine oxidase [flavin-containing]587651522Cytoplasmic492Helical; Anchor for type IV membrane protein493513Mitochondrial intermembrane514Important for catalytic activity157Important for catalytic activity366Important for catalytic activity383S-8alpha-FAD cysteine398QK223224K2342004-07-051587653ac8f8e345c2b7fb684f462aadec1f62MTANAYDVIVIGGGISGLSAAKLLVDSGLNPVVLEARSRVGGRTYTVQNKETKWVDLGGAYIGPTQNRILRIAKQYGVKTYKVNEEESLVHYVKGKSYPFKGPFPPMWNPFAYMDYNNLWRTMDKMGMEIPKEAPWRAPHAEEWDKMTMQQLFDKICWTRSARRFATLFVNVNVTSEPHEVSALWFLWYVKQCGGTMRIFSTTNGGQERKFAGGANQISEGMARELGDRVKLSRAVCSIDQTGDLVEVRTVNEEVYKAKYVILAIPPGLNLKIHFNPELPPLRNQLIHRVPMGSVIKCMVYYKENFWRKKGYCGSMVIEEEDAPIGLTLDDTKPDGSVPAIMGFILARKSRKLANLTRDERKRRICEIYARVLGSEEALYPVHYEEKNWCEEEYSGGCYTAYFPPGIMTQFGRVLREPVGRLYFAGTETATEWSGYMEGAVQAGERASREVMCAMGKLHASQIWQSEPESMDVPARPFVTTFWERNLPSVGGFLKFMGVSSFLAAATAAGLVACKKGLLPRCtruetruetruetruetruetruetruetruetruetruetruetruetruetrue