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Q6NSN2

- AOF_DANRE

UniProt

Q6NSN2 - AOF_DANRE

Protein

Amine oxidase [flavin-containing]

Gene

mao

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).By similarity2 Publications

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.2 Publications

    Cofactori

    FAD.Curated

    Enzyme regulationi

    Inhibited by both clorgyline (selective MAOA inhibitor) and deprenyl (selective MAOB inhibitor).2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei157 – 1571Important for catalytic activityBy similarity
    Sitei366 – 3661Important for catalytic activityBy similarity
    Sitei383 – 3831Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. primary amine oxidase activity Source: UniProtKB

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. cellular biogenic amine catabolic process Source: UniProtKB
    3. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Catecholamine metabolism, Neurotransmitter degradation

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BRENDAi1.4.3.4. 1832.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase
    Short name:
    MAO
    Short name:
    Z-MAO
    Gene namesi
    Name:maoImported
    ORF Names:zgc:85761
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 9

    Organism-specific databases

    ZFINiZDB-GENE-040329-3. mao.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Amine oxidase [flavin-containing]PRO_0000283788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei398 – 3981S-8alpha-FAD cysteineBy similarity

    Proteomic databases

    PRIDEiQ6NSN2.

    Expressioni

    Tissue specificityi

    Strongest expression in brain and intestine, followed by liver, heart and gill. Little expression in spleen, eye or muscle. In brain, highest activity in noradrenergic and serotonergic cell groups and those of the habenulointerpeduncular pathway; moderate levels in dopaminergic cell clusters.1 Publication

    Gene expression databases

    BgeeiQ6NSN2.

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NSN2.
    SMRiQ6NSN2. Positions 6-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 492492CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini514 – 5229Mitochondrial intermembraneSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei493 – 51321Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    GeneTreeiENSGT00730000110903.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    InParanoidiQ6NSN2.
    KOiK00274.
    OMAiREVLCAM.
    OrthoDBiEOG7K6PTP.
    PhylomeDBiQ6NSN2.
    TreeFamiTF313314.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    Q6NSN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTANAYDVIV IGGGISGLSA AKLLVDSGLN PVVLEARSRV GGRTYTVQNK    50
    ETKWVDLGGA YIGPTQNRIL RIAKQYGVKT YKVNEEESLV HYVKGKSYPF 100
    KGPFPPMWNP FAYMDYNNLW RTMDKMGMEI PKEAPWRAPH AEEWDKMTMQ 150
    QLFDKICWTR SARRFATLFV NVNVTSEPHE VSALWFLWYV KQCGGTMRIF 200
    STTNGGQERK FAGGANQISE GMARELGDRV KLSRAVCSID QTGDLVEVRT 250
    VNEEVYKAKY VILAIPPGLN LKIHFNPELP PLRNQLIHRV PMGSVIKCMV 300
    YYKENFWRKK GYCGSMVIEE EDAPIGLTLD DTKPDGSVPA IMGFILARKS 350
    RKLANLTRDE RKRRICEIYA RVLGSEEALY PVHYEEKNWC EEEYSGGCYT 400
    AYFPPGIMTQ FGRVLREPVG RLYFAGTETA TEWSGYMEGA VQAGERASRE 450
    VMCAMGKLHA SQIWQSEPES MDVPARPFVT TFWERNLPSV GGFLKFMGVS 500
    SFLAAATAAG LVACKKGLLP RC 522
    Length:522
    Mass (Da):58,765
    Last modified:July 5, 2004 - v1
    Checksum:i8FC58B2A13BFE15C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2242AR → QK in AAO16681. (PubMed:15621520)Curated
    Sequence conflicti234 – 2341R → K in AAO16681. (PubMed:15621520)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY185211 mRNA. Translation: AAO16681.3.
    BC070013 mRNA. Translation: AAH70013.1.
    RefSeqiNP_997992.2. NM_212827.2.
    UniGeneiDr.77508.

    Genome annotation databases

    EnsembliENSDART00000028225; ENSDARP00000032834; ENSDARG00000023712.
    GeneIDi404730.
    KEGGidre:404730.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY185211 mRNA. Translation: AAO16681.3 .
    BC070013 mRNA. Translation: AAH70013.1 .
    RefSeqi NP_997992.2. NM_212827.2.
    UniGenei Dr.77508.

    3D structure databases

    ProteinModelPortali Q6NSN2.
    SMRi Q6NSN2. Positions 6-504.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q6NSN2.
    ChEMBLi CHEMBL1681610.

    Proteomic databases

    PRIDEi Q6NSN2.

    Protocols and materials databases

    DNASUi 404730.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000028225 ; ENSDARP00000032834 ; ENSDARG00000023712 .
    GeneIDi 404730.
    KEGGi dre:404730.

    Organism-specific databases

    CTDi 404730.
    ZFINi ZDB-GENE-040329-3. mao.

    Phylogenomic databases

    eggNOGi COG1231.
    GeneTreei ENSGT00730000110903.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    InParanoidi Q6NSN2.
    KOi K00274.
    OMAi REVLCAM.
    OrthoDBi EOG7K6PTP.
    PhylomeDBi Q6NSN2.
    TreeFami TF313314.

    Enzyme and pathway databases

    BRENDAi 1.4.3.4. 1832.

    Miscellaneous databases

    NextBioi 20817705.
    PROi Q6NSN2.

    Gene expression databases

    Bgeei Q6NSN2.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of monoamine oxidase in zebrafish (Danio rerio)."
      Setini A., Pierucci F., Senatori O., Nicotra A.
      Comp. Biochem. Physiol. 140B:153-161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, 3D-STRUCTURE MODELING.
      Tissue: LiverImported.
    2. "Distinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio)."
      Anichtchik O., Sallinen V., Peitsaro N., Panula P.
      J. Comp. Neurol. 498:593-610(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, TISSUE SPECIFICITY.
      Tissue: Brain1 Publication.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiAOF_DANRE
    AccessioniPrimary (citable) accession number: Q6NSN2
    Secondary accession number(s): Q804D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There appears to be only one form of this enzyme in zebrafish, whereas in mammals two forms (MAOA and MAOB) exist.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3