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Protein
Submitted name:

CSF2RB protein

Gene

CSF2RB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
CSF2RB proteinImported
Submitted name:
Cytokine receptor common subunit betaImported
Gene namesi
Name:CSF2RBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100368.13
HGNCiHGNC:2436 CSF2RB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei442 – 468HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100368
PharmGKBiPA26939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501431055423 – 889Sequence analysisAdd BLAST867

Proteomic databases

PRIDEiQ6NSJ8

Expressioni

Gene expression databases

BgeeiENSG00000100368
ExpressionAtlasiQ6NSJ8 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 240Fibronectin type-IIIInterPro annotationAdd BLAST108
Domaini339 – 436Fibronectin type-IIIInterPro annotationAdd BLAST98

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IGEX Eukaryota
ENOG4112BQP LUCA
GeneTreeiENSGT00510000048963
HOVERGENiHBG052113
KOiK04738

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR011365 IL3_rcpt_beta
IPR015373 Interferon/interleukin_rcp_dom
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
PF09294 Interfer-bind, 1 hit
PIRSFiPIRSF001956 IL3R_beta_c, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NSJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT
60 70 80 90 100
QDAQRLVNVT LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC
110 120 130 140 150
QSFVVTDVDY FSFQPDRPLG TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL
160 170 180 190 200
TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD SWEDAAILLS NTSQATLGPE
210 220 230 240 250
HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG DEAQPQNLEC
260 270 280 290 300
FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL
310 320 330 340 350
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD
360 370 380 390 400
GDSYSLRWET MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP
410 420 430 440 450
ALEPSTRYWA RVRVRTSRTG YNGIWSEWSE ARSWDTESVL PMWVLALIVI
460 470 480 490 500
FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN PSKSHLFQNG SAELWPPGSM
510 520 530 540 550
SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE DPKHVCDPPS
560 570 580 590 600
GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR
610 620 630 640 650
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ
660 670 680 690 700
AVEVERRPSQ GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG
710 720 730 740 750
DTEDPGVASG YVSSADLVFT PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS
760 770 780 790 800
GPPGAPGPVK SGFEGYVELP PIEGRSPRSP RNNPVPPEAK SPVLNPGERP
810 820 830 840 850
ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS SPGPGPEIKN
860 870 880
LDQAFQVKKP PGQAVPQVPV IQLFKALVVS VMSVGPPVP
Length:889
Mass (Da):96,173
Last modified:July 5, 2004 - v1
Checksum:i1BD57B91E8CC079F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008637 Genomic DNA No translation available.
AL133392 Genomic DNA No translation available.
BC070085 mRNA Translation: AAH70085.1
RefSeqiNP_000386.1, NM_000395.2
UniGeneiHs.592192

Genome annotation databases

EnsembliENST00000262825; ENSP00000262825; ENSG00000100368
GeneIDi1439
KEGGihsa:1439
UCSCiuc062dvk.1 human

Similar proteinsi

Entry informationi

Entry nameiQ6NSJ8_HUMAN
AccessioniPrimary (citable) accession number: Q6NSJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health