Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized family 31 glucosidase KIAA1161

Gene

KIAA1161

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative glucosidase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei463 – 4631By similarity
Active sitei466 – 4661By similarity
Active sitei528 – 5281Proton donorBy similarity

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  3. positive regulation of protein kinase B signaling Source: Ensembl
  4. skeletal muscle fiber development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized family 31 glucosidase KIAA1161 (EC:3.2.1.-)
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:19918. KIAA1161.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini78 – 714637ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Uncharacterized family 31 glucosidase KIAA1161PRO_0000295752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi250 – 2501N-linked (GlcNAc...)1 Publication
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6NSJ0.
PaxDbiQ6NSJ0.
PRIDEiQ6NSJ0.

PTM databases

PhosphoSiteiQ6NSJ0.

Expressioni

Gene expression databases

BgeeiQ6NSJ0.
CleanExiHS_KIAA1161.
ExpressionAtlasiQ6NSJ0. baseline and differential.
GenevestigatoriQ6NSJ0.

Organism-specific databases

HPAiHPA049361.
HPA060533.

Interactioni

Protein-protein interaction databases

BioGridi121532. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6NSJ0.
SMRiQ6NSJ0. Positions 294-707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1501.
GeneTreeiENSGT00510000047561.
HOGENOMiHOG000046241.
HOVERGENiHBG108028.
InParanoidiQ6NSJ0.
OrthoDBiEOG79KPDQ.
PhylomeDBiQ6NSJ0.
TreeFamiTF324266.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP
60 70 80 90 100
SKDLKPLLGS AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF
110 120 130 140 150
SIRNQKGEQV FRLAFRSGAL DLDSCSRDGA LLGCSLTADG LPLHFFIQTV
160 170 180 190 200
RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD AAAHWYGGAE MRTQHWPIRL
210 220 230 240 250
DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN DSVPFHLGWN
260 270 280 290 300
STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY
310 320 330 340 350
FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL
360 370 380 390 400
EIDDMYTPAY GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS
410 420 430 440 450
RFGEGVEREL FVREPTGRLP ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR
460 470 480 490 500
LRSRYSVASF KFDAGEVSYL PRDFSTYRPL PDPSVWSRRY TEMALPFFSL
510 520 530 540 550
AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT VSMLGYPFIL
560 570 580 590 600
PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV
610 620 630 640 650
VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI
660 670 680 690 700
DSQFLIGDTL LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY
710
PVDLDEIAYF TWAS
Length:714
Mass (Da):81,087
Last modified:July 24, 2007 - v2
Checksum:iD17E4A75A81DBB46
GO

Sequence cautioni

The sequence CAI15965.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI15966.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41N → I.1 Publication
Corresponds to variant rs2297776 [ dbSNP | Ensembl ].
VAR_033359
Natural varianti53 – 531D → E.2 Publications
Corresponds to variant rs4879781 [ dbSNP | Ensembl ].
VAR_033360
Natural varianti199 – 1991R → S.
Corresponds to variant rs12377 [ dbSNP | Ensembl ].
VAR_033361
Natural varianti385 – 3851F → Y.
Corresponds to variant rs7852399 [ dbSNP | Ensembl ].
VAR_033362

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
BC070098 mRNA. Translation: AAH70098.1.
BC110493 mRNA. Translation: AAI10494.1.
AB032987 mRNA. Translation: BAA86475.2.
RefSeqiNP_065753.2. NM_020702.4.
XP_006716871.1. XM_006716808.1.
UniGeneiHs.522083.
Hs.655456.

Genome annotation databases

EnsembliENST00000297625; ENSP00000297625; ENSG00000164976.
GeneIDi57462.
KEGGihsa:57462.
UCSCiuc003zue.4. human.

Polymorphism databases

DMDMi158563982.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
BC070098 mRNA. Translation: AAH70098.1.
BC110493 mRNA. Translation: AAI10494.1.
AB032987 mRNA. Translation: BAA86475.2.
RefSeqiNP_065753.2. NM_020702.4.
XP_006716871.1. XM_006716808.1.
UniGeneiHs.522083.
Hs.655456.

3D structure databases

ProteinModelPortaliQ6NSJ0.
SMRiQ6NSJ0. Positions 294-707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121532. 7 interactions.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

PTM databases

PhosphoSiteiQ6NSJ0.

Polymorphism databases

DMDMi158563982.

Proteomic databases

MaxQBiQ6NSJ0.
PaxDbiQ6NSJ0.
PRIDEiQ6NSJ0.

Protocols and materials databases

DNASUi57462.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297625; ENSP00000297625; ENSG00000164976.
GeneIDi57462.
KEGGihsa:57462.
UCSCiuc003zue.4. human.

Organism-specific databases

CTDi57462.
GeneCardsiGC09M034323.
HGNCiHGNC:19918. KIAA1161.
HPAiHPA049361.
HPA060533.
neXtProtiNX_Q6NSJ0.
PharmGKBiPA134929853.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1501.
GeneTreeiENSGT00510000047561.
HOGENOMiHOG000046241.
HOVERGENiHBG108028.
InParanoidiQ6NSJ0.
OrthoDBiEOG79KPDQ.
PhylomeDBiQ6NSJ0.
TreeFamiTF324266.

Miscellaneous databases

ChiTaRSiKIAA1161. human.
GenomeRNAii57462.
NextBioi63662.

Gene expression databases

BgeeiQ6NSJ0.
CleanExiHS_KIAA1161.
ExpressionAtlasiQ6NSJ0. baseline and differential.
GenevestigatoriQ6NSJ0.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-4 AND GLU-53.
    Tissue: Placenta.
  3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-714, VARIANT GLU-53.
    Tissue: Brain.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-250.
    Tissue: Liver.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiK1161_HUMAN
AccessioniPrimary (citable) accession number: Q6NSJ0
Secondary accession number(s): Q5T587, Q5T588, Q9ULQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 4, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.