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Q6NSJ0 (K1161_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized family 31 glucosidase KIAA1161

EC=3.2.1.-
Gene names
Name:KIAA1161
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length714 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative glucosidase By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 31 family.

Sequence caution

The sequence CAI15965.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI15966.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 714714Uncharacterized family 31 glucosidase KIAA1161
PRO_0000295752

Regions

Topological domain1 – 5656Cytoplasmic Potential
Transmembrane57 – 7721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain78 – 714637Extracellular Potential

Sites

Active site4631 By similarity
Active site4661 By similarity
Active site5281Proton donor By similarity

Amino acid modifications

Glycosylation2401N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Ref.4

Natural variations

Natural variant41N → I. Ref.2
Corresponds to variant rs2297776 [ dbSNP | Ensembl ].
VAR_033359
Natural variant531D → E. Ref.2 Ref.3
Corresponds to variant rs4879781 [ dbSNP | Ensembl ].
VAR_033360
Natural variant1991R → S.
Corresponds to variant rs12377 [ dbSNP | Ensembl ].
VAR_033361
Natural variant3851F → Y.
Corresponds to variant rs7852399 [ dbSNP | Ensembl ].
VAR_033362

Sequences

Sequence LengthMass (Da)Tools
Q6NSJ0 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: D17E4A75A81DBB46

FASTA71481,087
        10         20         30         40         50         60 
MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP SKDLKPLLGS 

        70         80         90        100        110        120 
AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF SIRNQKGEQV FRLAFRSGAL 

       130        140        150        160        170        180 
DLDSCSRDGA LLGCSLTADG LPLHFFIQTV RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD 

       190        200        210        220        230        240 
AAAHWYGGAE MRTQHWPIRL DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN 

       250        260        270        280        290        300 
DSVPFHLGWN STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY 

       310        320        330        340        350        360 
FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL EIDDMYTPAY 

       370        380        390        400        410        420 
GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS RFGEGVEREL FVREPTGRLP 

       430        440        450        460        470        480 
ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR LRSRYSVASF KFDAGEVSYL PRDFSTYRPL 

       490        500        510        520        530        540 
PDPSVWSRRY TEMALPFFSL AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT 

       550        560        570        580        590        600 
VSMLGYPFIL PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV 

       610        620        630        640        650        660 
VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI DSQFLIGDTL 

       670        680        690        700        710 
LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY PVDLDEIAYF TWAS 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-4 AND GLU-53.
Tissue: Placenta.
[3]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-714, VARIANT GLU-53.
Tissue: Brain.
[4]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-250.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
BC070098 mRNA. Translation: AAH70098.1.
BC110493 mRNA. Translation: AAI10494.1.
AB032987 mRNA. Translation: BAA86475.2.
RefSeqNP_065753.2. NM_020702.4.
XP_006716871.1. XM_006716808.1.
UniGeneHs.522083.
Hs.655456.

3D structure databases

ProteinModelPortalQ6NSJ0.
SMRQ6NSJ0. Positions 294-707.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121532. 2 interactions.

Protein family/group databases

CAZyGH31. Glycoside Hydrolase Family 31.

PTM databases

PhosphoSiteQ6NSJ0.

Polymorphism databases

DMDM158563982.

Proteomic databases

MaxQBQ6NSJ0.
PaxDbQ6NSJ0.
PRIDEQ6NSJ0.

Protocols and materials databases

DNASU57462.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297625; ENSP00000297625; ENSG00000164976.
GeneID57462.
KEGGhsa:57462.
UCSCuc003zue.4. human.

Organism-specific databases

CTD57462.
GeneCardsGC09M034323.
HGNCHGNC:19918. KIAA1161.
HPAHPA049361.
HPA060533.
neXtProtNX_Q6NSJ0.
PharmGKBPA134929853.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1501.
HOGENOMHOG000046241.
HOVERGENHBG108028.
InParanoidQ6NSJ0.
OrthoDBEOG79KPDQ.
PhylomeDBQ6NSJ0.
TreeFamTF324266.

Gene expression databases

BgeeQ6NSJ0.
CleanExHS_KIAA1161.
GenevestigatorQ6NSJ0.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
InterProIPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi57462.
NextBio63662.

Entry information

Entry nameK1161_HUMAN
AccessionPrimary (citable) accession number: Q6NSJ0
Secondary accession number(s): Q5T587, Q5T588, Q9ULQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries