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Q6NSJ0

- K1161_HUMAN

UniProt

Q6NSJ0 - K1161_HUMAN

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Protein
Uncharacterized family 31 glucosidase KIAA1161
Gene
KIAA1161
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Putative glucosidase By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei463 – 4631 By similarity
Active sitei466 – 4661 By similarity
Active sitei528 – 5281Proton donor By similarity

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  3. positive regulation of protein kinase B signaling Source: Ensembl
  4. skeletal muscle fiber development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized family 31 glucosidase KIAA1161 (EC:3.2.1.-)
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:19918. KIAA1161.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei57 – 7721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini78 – 714637Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Uncharacterized family 31 glucosidase KIAA1161
PRO_0000295752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6NSJ0.
PaxDbiQ6NSJ0.
PRIDEiQ6NSJ0.

PTM databases

PhosphoSiteiQ6NSJ0.

Expressioni

Gene expression databases

BgeeiQ6NSJ0.
CleanExiHS_KIAA1161.
GenevestigatoriQ6NSJ0.

Organism-specific databases

HPAiHPA049361.
HPA060533.

Interactioni

Protein-protein interaction databases

BioGridi121532. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6NSJ0.
SMRiQ6NSJ0. Positions 294-707.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000046241.
HOVERGENiHBG108028.
InParanoidiQ6NSJ0.
OrthoDBiEOG79KPDQ.
PhylomeDBiQ6NSJ0.
TreeFamiTF324266.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP    50
SKDLKPLLGS AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF 100
SIRNQKGEQV FRLAFRSGAL DLDSCSRDGA LLGCSLTADG LPLHFFIQTV 150
RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD AAAHWYGGAE MRTQHWPIRL 200
DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN DSVPFHLGWN 250
STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY 300
FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL 350
EIDDMYTPAY GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS 400
RFGEGVEREL FVREPTGRLP ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR 450
LRSRYSVASF KFDAGEVSYL PRDFSTYRPL PDPSVWSRRY TEMALPFFSL 500
AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT VSMLGYPFIL 550
PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV 600
VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI 650
DSQFLIGDTL LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY 700
PVDLDEIAYF TWAS 714
Length:714
Mass (Da):81,087
Last modified:July 24, 2007 - v2
Checksum:iD17E4A75A81DBB46
GO

Sequence cautioni

The sequence CAI15965.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI15966.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41N → I.1 Publication
Corresponds to variant rs2297776 [ dbSNP | Ensembl ].
VAR_033359
Natural varianti53 – 531D → E.2 Publications
Corresponds to variant rs4879781 [ dbSNP | Ensembl ].
VAR_033360
Natural varianti199 – 1991R → S.
Corresponds to variant rs12377 [ dbSNP | Ensembl ].
VAR_033361
Natural varianti385 – 3851F → Y.
Corresponds to variant rs7852399 [ dbSNP | Ensembl ].
VAR_033362

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
BC070098 mRNA. Translation: AAH70098.1.
BC110493 mRNA. Translation: AAI10494.1.
AB032987 mRNA. Translation: BAA86475.2.
RefSeqiNP_065753.2. NM_020702.4.
XP_006716871.1. XM_006716808.1.
UniGeneiHs.522083.
Hs.655456.

Genome annotation databases

EnsembliENST00000297625; ENSP00000297625; ENSG00000164976.
GeneIDi57462.
KEGGihsa:57462.
UCSCiuc003zue.4. human.

Polymorphism databases

DMDMi158563982.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356494 Genomic DNA. Translation: CAI15965.1 . Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1 . Sequence problems.
BC070098 mRNA. Translation: AAH70098.1 .
BC110493 mRNA. Translation: AAI10494.1 .
AB032987 mRNA. Translation: BAA86475.2 .
RefSeqi NP_065753.2. NM_020702.4.
XP_006716871.1. XM_006716808.1.
UniGenei Hs.522083.
Hs.655456.

3D structure databases

ProteinModelPortali Q6NSJ0.
SMRi Q6NSJ0. Positions 294-707.
ModBasei Search...

Protein-protein interaction databases

BioGridi 121532. 2 interactions.

Protein family/group databases

CAZyi GH31. Glycoside Hydrolase Family 31.

PTM databases

PhosphoSitei Q6NSJ0.

Polymorphism databases

DMDMi 158563982.

Proteomic databases

MaxQBi Q6NSJ0.
PaxDbi Q6NSJ0.
PRIDEi Q6NSJ0.

Protocols and materials databases

DNASUi 57462.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297625 ; ENSP00000297625 ; ENSG00000164976 .
GeneIDi 57462.
KEGGi hsa:57462.
UCSCi uc003zue.4. human.

Organism-specific databases

CTDi 57462.
GeneCardsi GC09M034323.
HGNCi HGNC:19918. KIAA1161.
HPAi HPA049361.
HPA060533.
neXtProti NX_Q6NSJ0.
PharmGKBi PA134929853.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1501.
HOGENOMi HOG000046241.
HOVERGENi HBG108028.
InParanoidi Q6NSJ0.
OrthoDBi EOG79KPDQ.
PhylomeDBi Q6NSJ0.
TreeFami TF324266.

Miscellaneous databases

GenomeRNAii 57462.
NextBioi 63662.

Gene expression databases

Bgeei Q6NSJ0.
CleanExi HS_KIAA1161.
Genevestigatori Q6NSJ0.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-4 AND GLU-53.
    Tissue: Placenta.
  3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-714, VARIANT GLU-53.
    Tissue: Brain.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-250.
    Tissue: Liver.

Entry informationi

Entry nameiK1161_HUMAN
AccessioniPrimary (citable) accession number: Q6NSJ0
Secondary accession number(s): Q5T587, Q5T588, Q9ULQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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