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Q6NSJ0

- K1161_HUMAN

UniProt

Q6NSJ0 - K1161_HUMAN

Protein

Uncharacterized family 31 glucosidase KIAA1161

Gene

KIAA1161

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Putative glucosidase.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei463 – 4631By similarity
    Active sitei466 – 4661By similarity
    Active sitei528 – 5281Proton donorBy similarity

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of protein kinase B signaling Source: Ensembl
    4. skeletal muscle fiber development Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH31. Glycoside Hydrolase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized family 31 glucosidase KIAA1161 (EC:3.2.1.-)
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:19918. KIAA1161.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nuclear membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134929853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 714714Uncharacterized family 31 glucosidase KIAA1161PRO_0000295752Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)1 Publication
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6NSJ0.
    PaxDbiQ6NSJ0.
    PRIDEiQ6NSJ0.

    PTM databases

    PhosphoSiteiQ6NSJ0.

    Expressioni

    Gene expression databases

    BgeeiQ6NSJ0.
    CleanExiHS_KIAA1161.
    GenevestigatoriQ6NSJ0.

    Organism-specific databases

    HPAiHPA049361.
    HPA060533.

    Interactioni

    Protein-protein interaction databases

    BioGridi121532. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NSJ0.
    SMRiQ6NSJ0. Positions 294-707.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini78 – 714637ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1501.
    HOGENOMiHOG000046241.
    HOVERGENiHBG108028.
    InParanoidiQ6NSJ0.
    OrthoDBiEOG79KPDQ.
    PhylomeDBiQ6NSJ0.
    TreeFamiTF324266.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR000322. Glyco_hydro_31.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF01055. Glyco_hydro_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6NSJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP    50
    SKDLKPLLGS AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF 100
    SIRNQKGEQV FRLAFRSGAL DLDSCSRDGA LLGCSLTADG LPLHFFIQTV 150
    RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD AAAHWYGGAE MRTQHWPIRL 200
    DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN DSVPFHLGWN 250
    STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY 300
    FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL 350
    EIDDMYTPAY GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS 400
    RFGEGVEREL FVREPTGRLP ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR 450
    LRSRYSVASF KFDAGEVSYL PRDFSTYRPL PDPSVWSRRY TEMALPFFSL 500
    AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT VSMLGYPFIL 550
    PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV 600
    VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI 650
    DSQFLIGDTL LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY 700
    PVDLDEIAYF TWAS 714
    Length:714
    Mass (Da):81,087
    Last modified:July 24, 2007 - v2
    Checksum:iD17E4A75A81DBB46
    GO

    Sequence cautioni

    The sequence CAI15965.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI15966.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41N → I.1 Publication
    Corresponds to variant rs2297776 [ dbSNP | Ensembl ].
    VAR_033359
    Natural varianti53 – 531D → E.2 Publications
    Corresponds to variant rs4879781 [ dbSNP | Ensembl ].
    VAR_033360
    Natural varianti199 – 1991R → S.
    Corresponds to variant rs12377 [ dbSNP | Ensembl ].
    VAR_033361
    Natural varianti385 – 3851F → Y.
    Corresponds to variant rs7852399 [ dbSNP | Ensembl ].
    VAR_033362

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
    AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
    BC070098 mRNA. Translation: AAH70098.1.
    BC110493 mRNA. Translation: AAI10494.1.
    AB032987 mRNA. Translation: BAA86475.2.
    RefSeqiNP_065753.2. NM_020702.4.
    XP_006716871.1. XM_006716808.1.
    UniGeneiHs.522083.
    Hs.655456.

    Genome annotation databases

    EnsembliENST00000297625; ENSP00000297625; ENSG00000164976.
    GeneIDi57462.
    KEGGihsa:57462.
    UCSCiuc003zue.4. human.

    Polymorphism databases

    DMDMi158563982.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356494 Genomic DNA. Translation: CAI15965.1 . Sequence problems.
    AL356494 Genomic DNA. Translation: CAI15966.1 . Sequence problems.
    BC070098 mRNA. Translation: AAH70098.1 .
    BC110493 mRNA. Translation: AAI10494.1 .
    AB032987 mRNA. Translation: BAA86475.2 .
    RefSeqi NP_065753.2. NM_020702.4.
    XP_006716871.1. XM_006716808.1.
    UniGenei Hs.522083.
    Hs.655456.

    3D structure databases

    ProteinModelPortali Q6NSJ0.
    SMRi Q6NSJ0. Positions 294-707.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121532. 2 interactions.

    Protein family/group databases

    CAZyi GH31. Glycoside Hydrolase Family 31.

    PTM databases

    PhosphoSitei Q6NSJ0.

    Polymorphism databases

    DMDMi 158563982.

    Proteomic databases

    MaxQBi Q6NSJ0.
    PaxDbi Q6NSJ0.
    PRIDEi Q6NSJ0.

    Protocols and materials databases

    DNASUi 57462.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297625 ; ENSP00000297625 ; ENSG00000164976 .
    GeneIDi 57462.
    KEGGi hsa:57462.
    UCSCi uc003zue.4. human.

    Organism-specific databases

    CTDi 57462.
    GeneCardsi GC09M034323.
    HGNCi HGNC:19918. KIAA1161.
    HPAi HPA049361.
    HPA060533.
    neXtProti NX_Q6NSJ0.
    PharmGKBi PA134929853.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1501.
    HOGENOMi HOG000046241.
    HOVERGENi HBG108028.
    InParanoidi Q6NSJ0.
    OrthoDBi EOG79KPDQ.
    PhylomeDBi Q6NSJ0.
    TreeFami TF324266.

    Miscellaneous databases

    GenomeRNAii 57462.
    NextBioi 63662.

    Gene expression databases

    Bgeei Q6NSJ0.
    CleanExi HS_KIAA1161.
    Genevestigatori Q6NSJ0.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR000322. Glyco_hydro_31.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF01055. Glyco_hydro_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-4 AND GLU-53.
      Tissue: Placenta.
    3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-714, VARIANT GLU-53.
      Tissue: Brain.
    4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-250.
      Tissue: Liver.

    Entry informationi

    Entry nameiK1161_HUMAN
    AccessioniPrimary (citable) accession number: Q6NSJ0
    Secondary accession number(s): Q5T587, Q5T588, Q9ULQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3