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Protein

Uncharacterized family 31 glucosidase KIAA1161

Gene

KIAA1161

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative glucosidase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei463By similarity1
Active sitei466By similarity1
Active sitei528Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized family 31 glucosidase KIAA1161 (EC:3.2.1.-)
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:19918. KIAA1161.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Transmembranei57 – 77Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini78 – 714ExtracellularSequence analysisAdd BLAST637

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57462.
OpenTargetsiENSG00000164976.
PharmGKBiPA134929853.

Polymorphism and mutation databases

BioMutaiKIAA1161.
DMDMi158563982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957521 – 714Uncharacterized family 31 glucosidase KIAA1161Add BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Glycosylationi250N-linked (GlcNAc...)1 Publication1
Glycosylationi511N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6NSJ0.
MaxQBiQ6NSJ0.
PaxDbiQ6NSJ0.
PeptideAtlasiQ6NSJ0.
PRIDEiQ6NSJ0.

PTM databases

iPTMnetiQ6NSJ0.
PhosphoSitePlusiQ6NSJ0.

Expressioni

Gene expression databases

BgeeiENSG00000164976.
CleanExiHS_KIAA1161.
ExpressionAtlasiQ6NSJ0. baseline and differential.
GenevisibleiQ6NSJ0. HS.

Organism-specific databases

HPAiHPA049361.
HPA060533.

Interactioni

Protein-protein interaction databases

BioGridi121532. 15 interactors.
STRINGi9606.ENSP00000297625.

Structurei

3D structure databases

ProteinModelPortaliQ6NSJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1065. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
HOGENOMiHOG000046241.
HOVERGENiHBG108028.
InParanoidiQ6NSJ0.
OMAiTHPKARD.
OrthoDBiEOG091G04I6.
PhylomeDBiQ6NSJ0.
TreeFamiTF324266.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP
60 70 80 90 100
SKDLKPLLGS AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF
110 120 130 140 150
SIRNQKGEQV FRLAFRSGAL DLDSCSRDGA LLGCSLTADG LPLHFFIQTV
160 170 180 190 200
RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD AAAHWYGGAE MRTQHWPIRL
210 220 230 240 250
DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN DSVPFHLGWN
260 270 280 290 300
STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY
310 320 330 340 350
FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL
360 370 380 390 400
EIDDMYTPAY GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS
410 420 430 440 450
RFGEGVEREL FVREPTGRLP ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR
460 470 480 490 500
LRSRYSVASF KFDAGEVSYL PRDFSTYRPL PDPSVWSRRY TEMALPFFSL
510 520 530 540 550
AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT VSMLGYPFIL
560 570 580 590 600
PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV
610 620 630 640 650
VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI
660 670 680 690 700
DSQFLIGDTL LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY
710
PVDLDEIAYF TWAS
Length:714
Mass (Da):81,087
Last modified:July 24, 2007 - v2
Checksum:iD17E4A75A81DBB46
GO

Sequence cautioni

The sequence CAI15965 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15966 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0333594N → I.1 PublicationCorresponds to variant rs2297776dbSNPEnsembl.1
Natural variantiVAR_03336053D → E.2 PublicationsCorresponds to variant rs4879781dbSNPEnsembl.1
Natural variantiVAR_033361199R → S.Corresponds to variant rs12377dbSNPEnsembl.1
Natural variantiVAR_033362385F → Y.Corresponds to variant rs7852399dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
BC070098 mRNA. Translation: AAH70098.1.
BC110493 mRNA. Translation: AAI10494.1.
AB032987 mRNA. Translation: BAA86475.2.
CCDSiCCDS78391.1.
RefSeqiNP_065753.2. NM_020702.4.
XP_011516268.1. XM_011517966.2.
XP_016870419.1. XM_017014930.1.
UniGeneiHs.522083.
Hs.655456.

Genome annotation databases

EnsembliENST00000297625; ENSP00000297625; ENSG00000164976.
GeneIDi57462.
KEGGihsa:57462.
UCSCiuc033cpb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356494 Genomic DNA. Translation: CAI15965.1. Sequence problems.
AL356494 Genomic DNA. Translation: CAI15966.1. Sequence problems.
BC070098 mRNA. Translation: AAH70098.1.
BC110493 mRNA. Translation: AAI10494.1.
AB032987 mRNA. Translation: BAA86475.2.
CCDSiCCDS78391.1.
RefSeqiNP_065753.2. NM_020702.4.
XP_011516268.1. XM_011517966.2.
XP_016870419.1. XM_017014930.1.
UniGeneiHs.522083.
Hs.655456.

3D structure databases

ProteinModelPortaliQ6NSJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121532. 15 interactors.
STRINGi9606.ENSP00000297625.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

PTM databases

iPTMnetiQ6NSJ0.
PhosphoSitePlusiQ6NSJ0.

Polymorphism and mutation databases

BioMutaiKIAA1161.
DMDMi158563982.

Proteomic databases

EPDiQ6NSJ0.
MaxQBiQ6NSJ0.
PaxDbiQ6NSJ0.
PeptideAtlasiQ6NSJ0.
PRIDEiQ6NSJ0.

Protocols and materials databases

DNASUi57462.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297625; ENSP00000297625; ENSG00000164976.
GeneIDi57462.
KEGGihsa:57462.
UCSCiuc033cpb.2. human.

Organism-specific databases

CTDi57462.
DisGeNETi57462.
GeneCardsiKIAA1161.
HGNCiHGNC:19918. KIAA1161.
HPAiHPA049361.
HPA060533.
neXtProtiNX_Q6NSJ0.
OpenTargetsiENSG00000164976.
PharmGKBiPA134929853.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1065. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
HOGENOMiHOG000046241.
HOVERGENiHBG108028.
InParanoidiQ6NSJ0.
OMAiTHPKARD.
OrthoDBiEOG091G04I6.
PhylomeDBiQ6NSJ0.
TreeFamiTF324266.

Miscellaneous databases

ChiTaRSiKIAA1161. human.
GenomeRNAii57462.
PROiQ6NSJ0.

Gene expression databases

BgeeiENSG00000164976.
CleanExiHS_KIAA1161.
ExpressionAtlasiQ6NSJ0. baseline and differential.
GenevisibleiQ6NSJ0. HS.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiK1161_HUMAN
AccessioniPrimary (citable) accession number: Q6NSJ0
Secondary accession number(s): Q5T587, Q5T588, Q9ULQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.