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Q6NSI7

- Q6NSI7_HUMAN

UniProt

Q6NSI7 - Q6NSI7_HUMAN

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Protein
Submitted name:

Solute carrier family 12 (Potassium/chloride transporters), member 6

Gene

SLC12A6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. potassium:chloride symporter activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 (Potassium/chloride transporters), member 6Imported
Gene namesi
Name:SLC12A6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35808.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052852.
KOiK14427.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR018491. K/Cl_cotranspt_1/3.
IPR000076. KCL_cotranspt.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view]
PfamiPF00324. AA_permease. 2 hits.
PF03522. KCl_Cotrans_1. 1 hit.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSI7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSEMSGATTS LATVALDPPS DRTSHPQDVI EDLSQNSITG EHSQLLDDGH
60 70 80 90 100
KKARNAYLNN SNYEEGDEYF DKNLALFEEE MDTRPKVSSL LNRMANYTNL
110 120 130 140 150
TQGAKEHEEA ENITEGKKKP TKTPQMGTFM GVYPPCLQNI FGVILFLRLT
160 170 180 190 200
WVVGTAGVLQ AFAIVLICCC CTMLTAISMS AIATNGVVPA GGSYFMISRA
210 220 230 240 250
LGPEFGGAVG LCFYLGTTFA AAMYILGAIE IFLVYIVPRA AIFHSDDALK
260 270 280 290 300
ESAAMLNNMR VYGTAFLVLM VLVVFIGVRY VNKFASLFLA CVIVSILAIY
310 320 330 340 350
AGAIKSSFAP PHFPVCMLGN RTLSSRHIDV CSKTKEINNM TVPSKLWGFF
360 370 380 390 400
CNSSQFFNAT CDEYFVHNNV TSIQGIPGLA SGIITENLWS NYLPKGEIIE
410 420 430 440 450
KPSAKSSDVL GSLNHEYVLV DITTSFTLLV GIFFPSVTGI MAGSNRSGDL
460 470 480 490 500
KDAQKSIPIG TILAILTTSF VYLSNVVLFG ACIEGVVLRD KFGDAVKGNL
510 520 530 540 550
VVGTLSWPSP WVIVIGSFFS TCGAGLQSLT GAPRLLQAIA KDNIIPFLRV
560 570 580 590 600
FGHSKANGEP TWALLLTAAI AELGILIASL DLVAPILSMF FLMCYLFVNL
610 620 630 640 650
ACALQTLLRT PNWRPRFRYY HWALSFMGMS ICLALMFISS WYYAIVAMVI
660 670 680 690 700
AGMIYKYIEY QGAEKEWGDG IRGLSLSAAR FALLRLEEGP PHTKNWRPQL
710 720 730 740 750
LVLLKLDEDL HVKHPRLLTF ASQLKAGKGL TIVGSVIVGN FLENYGEALA
760 770 780 790 800
AEQTIKHLME AEKVKGFCQL VVAAKLREGI SHLIQSCGLG GMKHNTVVMG
810 820 830 840 850
WPNGWRQSED ARAWKTFIGT VRVTTAAHLA LLVAKNISFF PSNVEQFSEG
860 870 880 890 900
NIDVWWIVHD GGMLMLLPFL LKQHKVWRKC SIRIFTVAQL EDNSIQMKKD
910 920 930 940 950
LATFLYHLRI EAEVEVVEMH DSDISAYTYE RTLMMEQRSQ MLRHMRLSKT
960 970 980 990 1000
ERDREAQLVK DRNSMLRLTS IGSDEDEETE TYQEKVHMTW TKDKYMASRG
1010 1020 1030 1040 1050
QKAKSMEGFQ DLLNMRPDQS NVRRMHTAVK LNEVIVNKSH EAKLVLLNMP
1060 1070 1080 1090
GPPRNPEGDE NYMEFLEVLT EGLERVLLVR GGGSEVITIY S
Length:1,091
Mass (Da):121,109
Last modified:April 17, 2007 - v2
Checksum:iEC5F6EE6E9E6957B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070107 mRNA. Translation: AAH70107.2.
RefSeqiNP_001035960.1. NM_001042495.1.
UniGeneiHs.510939.

Genome annotation databases

GeneIDi9990.
KEGGihsa:9990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070107 mRNA. Translation: AAH70107.2 .
RefSeqi NP_001035960.1. NM_001042495.1.
UniGenei Hs.510939.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9990.
KEGGi hsa:9990.

Organism-specific databases

CTDi 9990.
PharmGKBi PA35808.

Phylogenomic databases

HOVERGENi HBG052852.
KOi K14427.

Miscellaneous databases

ChiTaRSi SLC12A6. human.
GenomeRNAii 9990.
NextBioi 37729.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
IPR018491. K/Cl_cotranspt_1/3.
IPR000076. KCL_cotranspt.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view ]
Pfami PF00324. AA_permease. 2 hits.
PF03522. KCl_Cotrans_1. 1 hit.
[Graphical view ]
PRINTSi PR01081. KCLTRNSPORT.
TIGRFAMsi TIGR00930. 2a30. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiQ6NSI7_HUMAN
AccessioniPrimary (citable) accession number: Q6NSI7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: April 17, 2007
Last modified: October 1, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.