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Q6NSI7

- Q6NSI7_HUMAN

UniProt

Q6NSI7 - Q6NSI7_HUMAN

Protein
Submitted name:

Solute carrier family 12 (Potassium/chloride transporters), member 6

Gene

SLC12A6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. potassium:chloride symporter activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Solute carrier family 12 (Potassium/chloride transporters), member 6Imported
    Gene namesi
    Name:SLC12A6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35808.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG052852.
    KOiK14427.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    IPR018491. K/Cl_cotranspt_1/3.
    IPR000076. KCL_cotranspt.
    IPR004842. Na/K/Cl_cotransptS.
    [Graphical view]
    PfamiPF00324. AA_permease. 2 hits.
    PF03522. KCl_Cotrans_1. 1 hit.
    [Graphical view]
    PRINTSiPR01081. KCLTRNSPORT.
    TIGRFAMsiTIGR00930. 2a30. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6NSI7-1 [UniParc]FASTAAdd to Basket

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    MSEMSGATTS LATVALDPPS DRTSHPQDVI EDLSQNSITG EHSQLLDDGH     50
    KKARNAYLNN SNYEEGDEYF DKNLALFEEE MDTRPKVSSL LNRMANYTNL 100
    TQGAKEHEEA ENITEGKKKP TKTPQMGTFM GVYPPCLQNI FGVILFLRLT 150
    WVVGTAGVLQ AFAIVLICCC CTMLTAISMS AIATNGVVPA GGSYFMISRA 200
    LGPEFGGAVG LCFYLGTTFA AAMYILGAIE IFLVYIVPRA AIFHSDDALK 250
    ESAAMLNNMR VYGTAFLVLM VLVVFIGVRY VNKFASLFLA CVIVSILAIY 300
    AGAIKSSFAP PHFPVCMLGN RTLSSRHIDV CSKTKEINNM TVPSKLWGFF 350
    CNSSQFFNAT CDEYFVHNNV TSIQGIPGLA SGIITENLWS NYLPKGEIIE 400
    KPSAKSSDVL GSLNHEYVLV DITTSFTLLV GIFFPSVTGI MAGSNRSGDL 450
    KDAQKSIPIG TILAILTTSF VYLSNVVLFG ACIEGVVLRD KFGDAVKGNL 500
    VVGTLSWPSP WVIVIGSFFS TCGAGLQSLT GAPRLLQAIA KDNIIPFLRV 550
    FGHSKANGEP TWALLLTAAI AELGILIASL DLVAPILSMF FLMCYLFVNL 600
    ACALQTLLRT PNWRPRFRYY HWALSFMGMS ICLALMFISS WYYAIVAMVI 650
    AGMIYKYIEY QGAEKEWGDG IRGLSLSAAR FALLRLEEGP PHTKNWRPQL 700
    LVLLKLDEDL HVKHPRLLTF ASQLKAGKGL TIVGSVIVGN FLENYGEALA 750
    AEQTIKHLME AEKVKGFCQL VVAAKLREGI SHLIQSCGLG GMKHNTVVMG 800
    WPNGWRQSED ARAWKTFIGT VRVTTAAHLA LLVAKNISFF PSNVEQFSEG 850
    NIDVWWIVHD GGMLMLLPFL LKQHKVWRKC SIRIFTVAQL EDNSIQMKKD 900
    LATFLYHLRI EAEVEVVEMH DSDISAYTYE RTLMMEQRSQ MLRHMRLSKT 950
    ERDREAQLVK DRNSMLRLTS IGSDEDEETE TYQEKVHMTW TKDKYMASRG 1000
    QKAKSMEGFQ DLLNMRPDQS NVRRMHTAVK LNEVIVNKSH EAKLVLLNMP 1050
    GPPRNPEGDE NYMEFLEVLT EGLERVLLVR GGGSEVITIY S 1091
    Length:1,091
    Mass (Da):121,109
    Last modified:April 17, 2007 - v2
    Checksum:iEC5F6EE6E9E6957B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070107 mRNA. Translation: AAH70107.2.
    RefSeqiNP_001035960.1. NM_001042495.1.
    UniGeneiHs.510939.

    Genome annotation databases

    GeneIDi9990.
    KEGGihsa:9990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070107 mRNA. Translation: AAH70107.2 .
    RefSeqi NP_001035960.1. NM_001042495.1.
    UniGenei Hs.510939.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9990.
    KEGGi hsa:9990.

    Organism-specific databases

    CTDi 9990.
    PharmGKBi PA35808.

    Phylogenomic databases

    HOVERGENi HBG052852.
    KOi K14427.

    Miscellaneous databases

    ChiTaRSi SLC12A6. human.
    GenomeRNAii 9990.
    NextBioi 37729.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    IPR018491. K/Cl_cotranspt_1/3.
    IPR000076. KCL_cotranspt.
    IPR004842. Na/K/Cl_cotransptS.
    [Graphical view ]
    Pfami PF00324. AA_permease. 2 hits.
    PF03522. KCl_Cotrans_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01081. KCLTRNSPORT.
    TIGRFAMsi TIGR00930. 2a30. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiQ6NSI7_HUMAN
    AccessioniPrimary (citable) accession number: Q6NSI7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.