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Q6NSI7

- Q6NSI7_HUMAN

UniProt

Q6NSI7 - Q6NSI7_HUMAN

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Protein
Submitted name:

Solute carrier family 12 (Potassium/chloride transporters), member 6

Gene
SLC12A6
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. potassium:chloride symporter activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 (Potassium/chloride transporters), member 6Imported
Gene namesi
Name:SLC12A6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35808.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052852.
KOiK14427.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR018491. K/Cl_cotranspt_1/3.
IPR000076. KCL_cotranspt.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view]
PfamiPF00324. AA_permease. 2 hits.
PF03522. KCl_Cotrans_1. 1 hit.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NSI7-1 [UniParc]FASTAAdd to Basket

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MSEMSGATTS LATVALDPPS DRTSHPQDVI EDLSQNSITG EHSQLLDDGH     50
KKARNAYLNN SNYEEGDEYF DKNLALFEEE MDTRPKVSSL LNRMANYTNL 100
TQGAKEHEEA ENITEGKKKP TKTPQMGTFM GVYPPCLQNI FGVILFLRLT 150
WVVGTAGVLQ AFAIVLICCC CTMLTAISMS AIATNGVVPA GGSYFMISRA 200
LGPEFGGAVG LCFYLGTTFA AAMYILGAIE IFLVYIVPRA AIFHSDDALK 250
ESAAMLNNMR VYGTAFLVLM VLVVFIGVRY VNKFASLFLA CVIVSILAIY 300
AGAIKSSFAP PHFPVCMLGN RTLSSRHIDV CSKTKEINNM TVPSKLWGFF 350
CNSSQFFNAT CDEYFVHNNV TSIQGIPGLA SGIITENLWS NYLPKGEIIE 400
KPSAKSSDVL GSLNHEYVLV DITTSFTLLV GIFFPSVTGI MAGSNRSGDL 450
KDAQKSIPIG TILAILTTSF VYLSNVVLFG ACIEGVVLRD KFGDAVKGNL 500
VVGTLSWPSP WVIVIGSFFS TCGAGLQSLT GAPRLLQAIA KDNIIPFLRV 550
FGHSKANGEP TWALLLTAAI AELGILIASL DLVAPILSMF FLMCYLFVNL 600
ACALQTLLRT PNWRPRFRYY HWALSFMGMS ICLALMFISS WYYAIVAMVI 650
AGMIYKYIEY QGAEKEWGDG IRGLSLSAAR FALLRLEEGP PHTKNWRPQL 700
LVLLKLDEDL HVKHPRLLTF ASQLKAGKGL TIVGSVIVGN FLENYGEALA 750
AEQTIKHLME AEKVKGFCQL VVAAKLREGI SHLIQSCGLG GMKHNTVVMG 800
WPNGWRQSED ARAWKTFIGT VRVTTAAHLA LLVAKNISFF PSNVEQFSEG 850
NIDVWWIVHD GGMLMLLPFL LKQHKVWRKC SIRIFTVAQL EDNSIQMKKD 900
LATFLYHLRI EAEVEVVEMH DSDISAYTYE RTLMMEQRSQ MLRHMRLSKT 950
ERDREAQLVK DRNSMLRLTS IGSDEDEETE TYQEKVHMTW TKDKYMASRG 1000
QKAKSMEGFQ DLLNMRPDQS NVRRMHTAVK LNEVIVNKSH EAKLVLLNMP 1050
GPPRNPEGDE NYMEFLEVLT EGLERVLLVR GGGSEVITIY S 1091
Length:1,091
Mass (Da):121,109
Last modified:April 17, 2007 - v2
Checksum:iEC5F6EE6E9E6957B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070107 mRNA. Translation: AAH70107.2.
RefSeqiNP_001035960.1. NM_001042495.1.
UniGeneiHs.510939.

Genome annotation databases

GeneIDi9990.
KEGGihsa:9990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070107 mRNA. Translation: AAH70107.2 .
RefSeqi NP_001035960.1. NM_001042495.1.
UniGenei Hs.510939.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9990.
KEGGi hsa:9990.

Organism-specific databases

CTDi 9990.
PharmGKBi PA35808.

Phylogenomic databases

HOVERGENi HBG052852.
KOi K14427.

Miscellaneous databases

ChiTaRSi SLC12A6. human.
GenomeRNAii 9990.
NextBioi 37729.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
IPR018491. K/Cl_cotranspt_1/3.
IPR000076. KCL_cotranspt.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view ]
Pfami PF00324. AA_permease. 2 hits.
PF03522. KCl_Cotrans_1. 1 hit.
[Graphical view ]
PRINTSi PR01081. KCLTRNSPORT.
TIGRFAMsi TIGR00930. 2a30. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiQ6NSI7_HUMAN
AccessioniPrimary (citable) accession number: Q6NSI7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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