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Protein

RPA-related protein RADX

Gene

RADX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi228 – 331OB1 PublicationAdd BLAST104

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RPA-related protein RADXCurated
Alternative name(s):
RPA-related and RAD51-antagonist, X-chromosome1 Publication
Gene namesi
Name:RADX1 Publication
Synonyms:CXorf57Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147231.13
HGNCiHGNC:25486 CXorf57
neXtProtiNX_Q6NSI4

Subcellular locationi

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi240R → E: Decreased binding to single-stranded DNA; when associated with E-248; 252-E--E-256; A-279; E-304; E-310 and A-327. 1 Publication1
Mutagenesisi248R → E: Decreased binding to single-stranded DNA; when associated with E-240; 252-E--E-256; A-279; E-304; E-310 and A-327. 1 Publication1
Mutagenesisi252 – 256KPDKK → EPDEE: Decreased binding to single-stranded DNA; when associated with E-240; E-248; A-279; E-304; E-310 and A-327. 1 Publication5
Mutagenesisi279W → A: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; E-304; E-310 and A-327. 1 Publication1
Mutagenesisi304K → E: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; A-279; E-310 and A-327. 1 Publication1
Mutagenesisi310R → E: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; A-279; E-304 and A-327. 1 Publication1
Mutagenesisi327E → A: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; A-279; E-304 and E-310. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000147231
PharmGKBiPA145149058

Polymorphism and mutation databases

BioMutaiCXorf57
DMDMi117949773

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541271 – 855RPA-related protein RADXAdd BLAST855

Proteomic databases

MaxQBiQ6NSI4
PaxDbiQ6NSI4
PeptideAtlasiQ6NSI4
PRIDEiQ6NSI4

PTM databases

iPTMnetiQ6NSI4
PhosphoSitePlusiQ6NSI4

Expressioni

Gene expression databases

BgeeiENSG00000147231
CleanExiHS_CXorf57
ExpressionAtlasiQ6NSI4 baseline and differential
GenevisibleiQ6NSI4 HS

Organism-specific databases

HPAiHPA000896
HPA001374

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120400, 11 interactors
IntActiQ6NSI4, 10 interactors
MINTiQ6NSI4
STRINGi9606.ENSP00000361628

Structurei

3D structure databases

ProteinModelPortaliQ6NSI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH30 Eukaryota
ENOG410XQP7 LUCA
GeneTreeiENSGT00390000005094
HOVERGENiHBG079874
InParanoidiQ6NSI4
OMAiSYRWIHI
OrthoDBiEOG091G01M0
PhylomeDBiQ6NSI4
TreeFamiTF331019

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
SUPFAMiSSF50249 SSF50249, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NSI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGESGQPEA GPSHAGLDWP NPERNRAGVP GGVIRRAGSQ GPRSWIQKVL
60 70 80 90 100
EQIMDSPRQC VTPSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS
110 120 130 140 150
DGVYQEKCYL DPSLNSLVYQ NILKVGIQMR ISRVSCLYNE KRIGQGILCI
160 170 180 190 200
DNVHCGETSD SISLETPFRN RAHQEKPERP LRGGKSHYLA LWNNEDPYGD
210 220 230 240 250
IWLTDKQPEE HNFSDTKIIS LSHLEMTWTN RRNFPALLVR ILHKSKLRYY
260 270 280 290 300
GKPDKKMIEP YQTFLEVADS SGTVSVIMWN ALCPEWYKSL RVGLVLLLQD
310 320 330 340 350
YSVKKSYPFR IQPVPVDPQI KLISTMEICL NLRDPPTNII IIPEKQVKPE
360 370 380 390 400
WRLPKLNHRF TTRSELDDMP ENCICDVIGL LVFVGRVQRS KKKENREDFW
410 420 430 440 450
SYRWIHIADG TSEQPFIVEL FSTSQPEIFE NIYPMAYFVC TQLKVVRNDN
460 470 480 490 500
QVPKLLYLTT TNESGVFITG HRGQPYTYDA KVKNFIQWIR TKSDSGEQKN
510 520 530 540 550
MVIGGYYPYP PVPETFSKYS SSIKVESLLT AISEVRKEIE DLQYREQKRI
560 570 580 590 600
AIQGIITAIK YIPHSSATES ASASETLRNA NRPSTSQAAR VEIQERNGKR
610 620 630 640 650
HQDDEPVNSQ YFQTTSTNLS LSNKIRILQG PHANPVAVPQ PGASVQTKGI
660 670 680 690 700
KPGMPSIFNR RANINANLQG KARKTISDRW ESQLWREKKF GLIDHLHYSR
710 720 730 740 750
VYPESIPRKF MFEHRKFLSD QYNSQPAKYV PPEGRPPKLD DFKSARSLGH
760 770 780 790 800
FEVTILGLNH EIAIDVAFLP MYCPEDIRTS QIDTLLTSMN YSCAYPQDTT
810 820 830 840 850
GNDRLPGPRA VAGDIIKAAT ELDRVHIVGI LDICNLGNNK VEVYLHKIYS

PENTS
Length:855
Mass (Da):97,554
Last modified:October 31, 2006 - v2
Checksum:i31EE2E17E7D9BF47
GO
Isoform 2 (identifier: Q6NSI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     525-567: VESLLTAISE...AIKYIPHSSA → GTNVIASPSK...SDLKFSNIHR
     568-855: Missing.

Show »
Length:567
Mass (Da):65,383
Checksum:i5C7B0E4896EAFF4E
GO
Isoform 3 (identifier: Q6NSI4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.
     482-578: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):61,268
Checksum:iBBC25B38E7C29DFE
GO
Isoform 4 (identifier: Q6NSI4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-578: Missing.

Note: No experimental confirmation available.
Show »
Length:758
Mass (Da):86,574
Checksum:iA656C673DD8844ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29V → A in AK001040 (PubMed:14702039).Curated1
Sequence conflicti33V → L in AAH70110 (PubMed:15489334).Curated1
Sequence conflicti89K → E in AAH11483 (PubMed:15489334).Curated1
Sequence conflicti394E → K in AAH54032 (PubMed:15489334).Curated1
Sequence conflicti674K → N in BAB14859 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028816593I → M1 PublicationCorresponds to variant dbSNP:rs5962707Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449831 – 225Missing in isoform 3. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_044984482 – 578Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_021182525 – 567VESLL…PHSSA → GTNVIASPSKYVYILYVWLM LFQLVIFILFFYGSDLKFSN IHR in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_021183568 – 855Missing in isoform 2. 1 PublicationAdd BLAST288

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001040 mRNA No translation available.
AK024253 mRNA Translation: BAB14859.1
AL590808 Genomic DNA No translation available.
AL606833 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02740.1
BC011483 mRNA Translation: AAH11483.1
BC033709 mRNA Translation: AAH33709.1
BC054032 mRNA Translation: AAH54032.1 Sequence problems.
BC070110 mRNA Translation: AAH70110.1
CCDSiCCDS14519.1 [Q6NSI4-1]
CCDS55470.1 [Q6NSI4-4]
RefSeqiNP_001171711.1, NM_001184782.1 [Q6NSI4-4]
NP_060485.4, NM_018015.5 [Q6NSI4-1]
UniGeneiHs.274267

Genome annotation databases

EnsembliENST00000372544; ENSP00000361623; ENSG00000147231 [Q6NSI4-4]
ENST00000372548; ENSP00000361628; ENSG00000147231 [Q6NSI4-1]
ENST00000461251; ENSP00000432238; ENSG00000147231 [Q6NSI4-2]
GeneIDi55086
KEGGihsa:55086
UCSCiuc004emi.5 human [Q6NSI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRADX_HUMAN
AccessioniPrimary (citable) accession number: Q6NSI4
Secondary accession number(s): H7BY89
, Q4G0L7, Q5JQS1, Q5JRF9, Q6PHY5, Q6PII9, Q6PJU8, Q9H7W5, Q9NWA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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