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Q6NSI4

- CX057_HUMAN

UniProt

Q6NSI4 - CX057_HUMAN

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Protein

Uncharacterized protein CXorf57

Gene

CXorf57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein CXorf57
Gene namesi
Name:CXorf57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:25486. CXorf57.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 855855Uncharacterized protein CXorf57PRO_0000254127Add
BLAST

Proteomic databases

MaxQBiQ6NSI4.
PaxDbiQ6NSI4.
PRIDEiQ6NSI4.

PTM databases

PhosphoSiteiQ6NSI4.

Expressioni

Gene expression databases

BgeeiQ6NSI4.
CleanExiHS_CXorf57.
ExpressionAtlasiQ6NSI4. baseline and differential.
GenevestigatoriQ6NSI4.

Organism-specific databases

HPAiHPA000298.
HPA000896.
HPA001374.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCD3Q8IVD92EBI-8634209,EBI-744342

Protein-protein interaction databases

BioGridi120400. 7 interactions.
IntActiQ6NSI4. 5 interactions.
STRINGi9606.ENSP00000361628.

Structurei

3D structure databases

ProteinModelPortaliQ6NSI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG26588.
GeneTreeiENSGT00390000005094.
HOVERGENiHBG079874.
InParanoidiQ6NSI4.
OMAiRWESQLW.
OrthoDBiEOG7X3QQ9.
PhylomeDBiQ6NSI4.
TreeFamiTF331019.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 3 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NSI4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGESGQPEA GPSHAGLDWP NPERNRAGVP GGVIRRAGSQ GPRSWIQKVL
60 70 80 90 100
EQIMDSPRQC VTPSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS
110 120 130 140 150
DGVYQEKCYL DPSLNSLVYQ NILKVGIQMR ISRVSCLYNE KRIGQGILCI
160 170 180 190 200
DNVHCGETSD SISLETPFRN RAHQEKPERP LRGGKSHYLA LWNNEDPYGD
210 220 230 240 250
IWLTDKQPEE HNFSDTKIIS LSHLEMTWTN RRNFPALLVR ILHKSKLRYY
260 270 280 290 300
GKPDKKMIEP YQTFLEVADS SGTVSVIMWN ALCPEWYKSL RVGLVLLLQD
310 320 330 340 350
YSVKKSYPFR IQPVPVDPQI KLISTMEICL NLRDPPTNII IIPEKQVKPE
360 370 380 390 400
WRLPKLNHRF TTRSELDDMP ENCICDVIGL LVFVGRVQRS KKKENREDFW
410 420 430 440 450
SYRWIHIADG TSEQPFIVEL FSTSQPEIFE NIYPMAYFVC TQLKVVRNDN
460 470 480 490 500
QVPKLLYLTT TNESGVFITG HRGQPYTYDA KVKNFIQWIR TKSDSGEQKN
510 520 530 540 550
MVIGGYYPYP PVPETFSKYS SSIKVESLLT AISEVRKEIE DLQYREQKRI
560 570 580 590 600
AIQGIITAIK YIPHSSATES ASASETLRNA NRPSTSQAAR VEIQERNGKR
610 620 630 640 650
HQDDEPVNSQ YFQTTSTNLS LSNKIRILQG PHANPVAVPQ PGASVQTKGI
660 670 680 690 700
KPGMPSIFNR RANINANLQG KARKTISDRW ESQLWREKKF GLIDHLHYSR
710 720 730 740 750
VYPESIPRKF MFEHRKFLSD QYNSQPAKYV PPEGRPPKLD DFKSARSLGH
760 770 780 790 800
FEVTILGLNH EIAIDVAFLP MYCPEDIRTS QIDTLLTSMN YSCAYPQDTT
810 820 830 840 850
GNDRLPGPRA VAGDIIKAAT ELDRVHIVGI LDICNLGNNK VEVYLHKIYS

PENTS
Length:855
Mass (Da):97,554
Last modified:October 31, 2006 - v2
Checksum:i31EE2E17E7D9BF47
GO
Isoform 2 (identifier: Q6NSI4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     525-567: VESLLTAISE...AIKYIPHSSA → GTNVIASPSK...SDLKFSNIHR
     568-855: Missing.

Show »
Length:567
Mass (Da):65,383
Checksum:i5C7B0E4896EAFF4E
GO
Isoform 3 (identifier: Q6NSI4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.
     482-578: Missing.

Note: No experimental confirmation available.

Show »
Length:533
Mass (Da):61,268
Checksum:iBBC25B38E7C29DFE
GO
Isoform 4 (identifier: Q6NSI4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-578: Missing.

Note: No experimental confirmation available.

Show »
Length:758
Mass (Da):86,574
Checksum:iA656C673DD8844ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291V → A in AK001040. (PubMed:14702039)Curated
Sequence conflicti33 – 331V → L in AAH70110. (PubMed:15489334)Curated
Sequence conflicti89 – 891K → E in AAH11483. (PubMed:15489334)Curated
Sequence conflicti394 – 3941E → K in AAH54032. (PubMed:15489334)Curated
Sequence conflicti674 – 6741K → N in BAB14859. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti593 – 5931I → M.1 Publication
Corresponds to variant rs5962707 [ dbSNP | Ensembl ].
VAR_028816

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 225225Missing in isoform 3. 1 PublicationVSP_044983Add
BLAST
Alternative sequencei482 – 57897Missing in isoform 3 and isoform 4. 1 PublicationVSP_044984Add
BLAST
Alternative sequencei525 – 56743VESLL…PHSSA → GTNVIASPSKYVYILYVWLM LFQLVIFILFFYGSDLKFSN IHR in isoform 2. 1 PublicationVSP_021182Add
BLAST
Alternative sequencei568 – 855288Missing in isoform 2. 1 PublicationVSP_021183Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001040 mRNA. No translation available.
AK024253 mRNA. Translation: BAB14859.1.
AL606833, AL590808 Genomic DNA. Translation: CAI41230.1.
AL590808, AL606833 Genomic DNA. Translation: CAI41594.1.
CH471120 Genomic DNA. Translation: EAX02740.1.
BC011483 mRNA. Translation: AAH11483.1.
BC033709 mRNA. Translation: AAH33709.1.
BC054032 mRNA. Translation: AAH54032.1. Sequence problems.
BC070110 mRNA. Translation: AAH70110.1.
CCDSiCCDS14519.1. [Q6NSI4-1]
CCDS55470.1. [Q6NSI4-4]
RefSeqiNP_001171711.1. NM_001184782.1. [Q6NSI4-4]
NP_060485.4. NM_018015.5. [Q6NSI4-1]
UniGeneiHs.274267.

Genome annotation databases

EnsembliENST00000372544; ENSP00000361623; ENSG00000147231. [Q6NSI4-4]
ENST00000372548; ENSP00000361628; ENSG00000147231. [Q6NSI4-1]
ENST00000461251; ENSP00000432238; ENSG00000147231. [Q6NSI4-2]
GeneIDi55086.
KEGGihsa:55086.
UCSCiuc004emh.2. human. [Q6NSI4-2]
uc004emi.4. human. [Q6NSI4-1]
uc004emj.4. human.

Polymorphism databases

DMDMi117949773.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001040 mRNA. No translation available.
AK024253 mRNA. Translation: BAB14859.1 .
AL606833 , AL590808 Genomic DNA. Translation: CAI41230.1 .
AL590808 , AL606833 Genomic DNA. Translation: CAI41594.1 .
CH471120 Genomic DNA. Translation: EAX02740.1 .
BC011483 mRNA. Translation: AAH11483.1 .
BC033709 mRNA. Translation: AAH33709.1 .
BC054032 mRNA. Translation: AAH54032.1 . Sequence problems.
BC070110 mRNA. Translation: AAH70110.1 .
CCDSi CCDS14519.1. [Q6NSI4-1 ]
CCDS55470.1. [Q6NSI4-4 ]
RefSeqi NP_001171711.1. NM_001184782.1. [Q6NSI4-4 ]
NP_060485.4. NM_018015.5. [Q6NSI4-1 ]
UniGenei Hs.274267.

3D structure databases

ProteinModelPortali Q6NSI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120400. 7 interactions.
IntActi Q6NSI4. 5 interactions.
STRINGi 9606.ENSP00000361628.

PTM databases

PhosphoSitei Q6NSI4.

Polymorphism databases

DMDMi 117949773.

Proteomic databases

MaxQBi Q6NSI4.
PaxDbi Q6NSI4.
PRIDEi Q6NSI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372544 ; ENSP00000361623 ; ENSG00000147231 . [Q6NSI4-4 ]
ENST00000372548 ; ENSP00000361628 ; ENSG00000147231 . [Q6NSI4-1 ]
ENST00000461251 ; ENSP00000432238 ; ENSG00000147231 . [Q6NSI4-2 ]
GeneIDi 55086.
KEGGi hsa:55086.
UCSCi uc004emh.2. human. [Q6NSI4-2 ]
uc004emi.4. human. [Q6NSI4-1 ]
uc004emj.4. human.

Organism-specific databases

CTDi 55086.
GeneCardsi GC0XP105855.
H-InvDB HIX0203276.
HGNCi HGNC:25486. CXorf57.
HPAi HPA000298.
HPA000896.
HPA001374.
neXtProti NX_Q6NSI4.
PharmGKBi PA145149058.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26588.
GeneTreei ENSGT00390000005094.
HOVERGENi HBG079874.
InParanoidi Q6NSI4.
OMAi RWESQLW.
OrthoDBi EOG7X3QQ9.
PhylomeDBi Q6NSI4.
TreeFami TF331019.

Miscellaneous databases

GenomeRNAii 55086.
NextBioi 58653.

Gene expression databases

Bgeei Q6NSI4.
CleanExi HS_CXorf57.
ExpressionAtlasi Q6NSI4. baseline and differential.
Genevestigatori Q6NSI4.

Family and domain databases

InterProi IPR012340. NA-bd_OB-fold.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Embryo.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-593.
    Tissue: Brain, Choriocarcinoma and Leiomyosarcoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCX057_HUMAN
AccessioniPrimary (citable) accession number: Q6NSI4
Secondary accession number(s): H7BY89
, Q4G0L7, Q5JQS1, Q5JRF9, Q6PHY5, Q6PII9, Q6PJU8, Q9H7W5, Q9NWA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3