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Q6NSI4

- CX057_HUMAN

UniProt

Q6NSI4 - CX057_HUMAN

Protein

Uncharacterized protein CXorf57

Gene

CXorf57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein CXorf57
    Gene namesi
    Name:CXorf57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25486. CXorf57.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145149058.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 855855Uncharacterized protein CXorf57PRO_0000254127Add
    BLAST

    Proteomic databases

    MaxQBiQ6NSI4.
    PaxDbiQ6NSI4.
    PRIDEiQ6NSI4.

    PTM databases

    PhosphoSiteiQ6NSI4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NSI4.
    BgeeiQ6NSI4.
    CleanExiHS_CXorf57.
    GenevestigatoriQ6NSI4.

    Organism-specific databases

    HPAiHPA000298.
    HPA000896.
    HPA001374.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NUDCD3Q8IVD92EBI-8634209,EBI-744342

    Protein-protein interaction databases

    BioGridi120400. 4 interactions.
    IntActiQ6NSI4. 5 interactions.
    STRINGi9606.ENSP00000361628.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NSI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG26588.
    HOVERGENiHBG079874.
    InParanoidiQ6NSI4.
    OMAiRWESQLW.
    OrthoDBiEOG7X3QQ9.
    PhylomeDBiQ6NSI4.
    TreeFamiTF331019.

    Family and domain databases

    InterProiIPR012340. NA-bd_OB-fold.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 3 hits.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NSI4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGESGQPEA GPSHAGLDWP NPERNRAGVP GGVIRRAGSQ GPRSWIQKVL    50
    EQIMDSPRQC VTPSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS 100
    DGVYQEKCYL DPSLNSLVYQ NILKVGIQMR ISRVSCLYNE KRIGQGILCI 150
    DNVHCGETSD SISLETPFRN RAHQEKPERP LRGGKSHYLA LWNNEDPYGD 200
    IWLTDKQPEE HNFSDTKIIS LSHLEMTWTN RRNFPALLVR ILHKSKLRYY 250
    GKPDKKMIEP YQTFLEVADS SGTVSVIMWN ALCPEWYKSL RVGLVLLLQD 300
    YSVKKSYPFR IQPVPVDPQI KLISTMEICL NLRDPPTNII IIPEKQVKPE 350
    WRLPKLNHRF TTRSELDDMP ENCICDVIGL LVFVGRVQRS KKKENREDFW 400
    SYRWIHIADG TSEQPFIVEL FSTSQPEIFE NIYPMAYFVC TQLKVVRNDN 450
    QVPKLLYLTT TNESGVFITG HRGQPYTYDA KVKNFIQWIR TKSDSGEQKN 500
    MVIGGYYPYP PVPETFSKYS SSIKVESLLT AISEVRKEIE DLQYREQKRI 550
    AIQGIITAIK YIPHSSATES ASASETLRNA NRPSTSQAAR VEIQERNGKR 600
    HQDDEPVNSQ YFQTTSTNLS LSNKIRILQG PHANPVAVPQ PGASVQTKGI 650
    KPGMPSIFNR RANINANLQG KARKTISDRW ESQLWREKKF GLIDHLHYSR 700
    VYPESIPRKF MFEHRKFLSD QYNSQPAKYV PPEGRPPKLD DFKSARSLGH 750
    FEVTILGLNH EIAIDVAFLP MYCPEDIRTS QIDTLLTSMN YSCAYPQDTT 800
    GNDRLPGPRA VAGDIIKAAT ELDRVHIVGI LDICNLGNNK VEVYLHKIYS 850
    PENTS 855
    Length:855
    Mass (Da):97,554
    Last modified:October 31, 2006 - v2
    Checksum:i31EE2E17E7D9BF47
    GO
    Isoform 2 (identifier: Q6NSI4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         525-567: VESLLTAISE...AIKYIPHSSA → GTNVIASPSK...SDLKFSNIHR
         568-855: Missing.

    Show »
    Length:567
    Mass (Da):65,383
    Checksum:i5C7B0E4896EAFF4E
    GO
    Isoform 3 (identifier: Q6NSI4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-225: Missing.
         482-578: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:533
    Mass (Da):61,268
    Checksum:iBBC25B38E7C29DFE
    GO
    Isoform 4 (identifier: Q6NSI4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         482-578: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:758
    Mass (Da):86,574
    Checksum:iA656C673DD8844ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291V → A in AK001040. (PubMed:14702039)Curated
    Sequence conflicti33 – 331V → L in AAH70110. (PubMed:15489334)Curated
    Sequence conflicti89 – 891K → E in AAH11483. (PubMed:15489334)Curated
    Sequence conflicti394 – 3941E → K in AAH54032. (PubMed:15489334)Curated
    Sequence conflicti674 – 6741K → N in BAB14859. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti593 – 5931I → M.1 Publication
    Corresponds to variant rs5962707 [ dbSNP | Ensembl ].
    VAR_028816

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 225225Missing in isoform 3. 1 PublicationVSP_044983Add
    BLAST
    Alternative sequencei482 – 57897Missing in isoform 3 and isoform 4. 1 PublicationVSP_044984Add
    BLAST
    Alternative sequencei525 – 56743VESLL…PHSSA → GTNVIASPSKYVYILYVWLM LFQLVIFILFFYGSDLKFSN IHR in isoform 2. 1 PublicationVSP_021182Add
    BLAST
    Alternative sequencei568 – 855288Missing in isoform 2. 1 PublicationVSP_021183Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001040 mRNA. No translation available.
    AK024253 mRNA. Translation: BAB14859.1.
    AL606833, AL590808 Genomic DNA. Translation: CAI41230.1.
    AL590808, AL606833 Genomic DNA. Translation: CAI41594.1.
    CH471120 Genomic DNA. Translation: EAX02740.1.
    BC011483 mRNA. Translation: AAH11483.1.
    BC033709 mRNA. Translation: AAH33709.1.
    BC054032 mRNA. Translation: AAH54032.1. Sequence problems.
    BC070110 mRNA. Translation: AAH70110.1.
    CCDSiCCDS14519.1. [Q6NSI4-1]
    CCDS55470.1. [Q6NSI4-4]
    RefSeqiNP_001171711.1. NM_001184782.1. [Q6NSI4-4]
    NP_060485.4. NM_018015.5. [Q6NSI4-1]
    UniGeneiHs.274267.

    Genome annotation databases

    EnsembliENST00000372544; ENSP00000361623; ENSG00000147231. [Q6NSI4-4]
    ENST00000372548; ENSP00000361628; ENSG00000147231. [Q6NSI4-1]
    ENST00000461251; ENSP00000432238; ENSG00000147231. [Q6NSI4-2]
    GeneIDi55086.
    KEGGihsa:55086.
    UCSCiuc004emh.2. human. [Q6NSI4-2]
    uc004emi.4. human. [Q6NSI4-1]
    uc004emj.4. human.

    Polymorphism databases

    DMDMi117949773.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001040 mRNA. No translation available.
    AK024253 mRNA. Translation: BAB14859.1 .
    AL606833 , AL590808 Genomic DNA. Translation: CAI41230.1 .
    AL590808 , AL606833 Genomic DNA. Translation: CAI41594.1 .
    CH471120 Genomic DNA. Translation: EAX02740.1 .
    BC011483 mRNA. Translation: AAH11483.1 .
    BC033709 mRNA. Translation: AAH33709.1 .
    BC054032 mRNA. Translation: AAH54032.1 . Sequence problems.
    BC070110 mRNA. Translation: AAH70110.1 .
    CCDSi CCDS14519.1. [Q6NSI4-1 ]
    CCDS55470.1. [Q6NSI4-4 ]
    RefSeqi NP_001171711.1. NM_001184782.1. [Q6NSI4-4 ]
    NP_060485.4. NM_018015.5. [Q6NSI4-1 ]
    UniGenei Hs.274267.

    3D structure databases

    ProteinModelPortali Q6NSI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120400. 4 interactions.
    IntActi Q6NSI4. 5 interactions.
    STRINGi 9606.ENSP00000361628.

    PTM databases

    PhosphoSitei Q6NSI4.

    Polymorphism databases

    DMDMi 117949773.

    Proteomic databases

    MaxQBi Q6NSI4.
    PaxDbi Q6NSI4.
    PRIDEi Q6NSI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372544 ; ENSP00000361623 ; ENSG00000147231 . [Q6NSI4-4 ]
    ENST00000372548 ; ENSP00000361628 ; ENSG00000147231 . [Q6NSI4-1 ]
    ENST00000461251 ; ENSP00000432238 ; ENSG00000147231 . [Q6NSI4-2 ]
    GeneIDi 55086.
    KEGGi hsa:55086.
    UCSCi uc004emh.2. human. [Q6NSI4-2 ]
    uc004emi.4. human. [Q6NSI4-1 ]
    uc004emj.4. human.

    Organism-specific databases

    CTDi 55086.
    GeneCardsi GC0XP105855.
    H-InvDB HIX0203276.
    HGNCi HGNC:25486. CXorf57.
    HPAi HPA000298.
    HPA000896.
    HPA001374.
    neXtProti NX_Q6NSI4.
    PharmGKBi PA145149058.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26588.
    HOVERGENi HBG079874.
    InParanoidi Q6NSI4.
    OMAi RWESQLW.
    OrthoDBi EOG7X3QQ9.
    PhylomeDBi Q6NSI4.
    TreeFami TF331019.

    Miscellaneous databases

    GenomeRNAii 55086.
    NextBioi 58653.

    Gene expression databases

    ArrayExpressi Q6NSI4.
    Bgeei Q6NSI4.
    CleanExi HS_CXorf57.
    Genevestigatori Q6NSI4.

    Family and domain databases

    InterProi IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Embryo.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-593.
      Tissue: Brain, Choriocarcinoma and Leiomyosarcoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCX057_HUMAN
    AccessioniPrimary (citable) accession number: Q6NSI4
    Secondary accession number(s): H7BY89
    , Q4G0L7, Q5JQS1, Q5JRF9, Q6PHY5, Q6PII9, Q6PJU8, Q9H7W5, Q9NWA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3