Q6NSI4 (CX057_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein CXorf57

Gene names

Name:

CXorf57

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	855 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NSI4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NSI4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     525-567: VESLLTAISE...AIKYIPHSSA → GTNVIASPSK...SDLKFSNIHR
     568-855: Missing.

Isoform 3 (identifier: Q6NSI4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.
     482-578: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 855	855	Uncharacterized protein CXorf57		PRO_0000254127
Natural variations
	Alternative sequence	1 – 225	225	Missing in isoform 3.		VSP_044983
	Alternative sequence	482 – 578	97	Missing in isoform 3.		VSP_044984
	Alternative sequence	525 – 567	43	VESLL…PHSSA → GTNVIASPSKYVYILYVWLM LFQLVIFILFFYGSDLKFSN IHR in isoform 2.		VSP_021182
	Alternative sequence	568 – 855	288	Missing in isoform 2.		VSP_021183
	Natural variant	593	1	I → M. Ref.4 Corresponds to variant rs5962707 [ dbSNP | Ensembl ].		VAR_028816
Experimental info
	Sequence conflict	29	1	V → A in AK001040. Ref.1
	Sequence conflict	33	1	V → L in AAH70110. Ref.4
	Sequence conflict	89	1	K → E in AAH11483. Ref.4
	Sequence conflict	394	1	E → K in AAH54032. Ref.4
	Sequence conflict	674	1	K → N in BAB14859. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 31EE2E17E7D9BF47	FASTA	855	97,554
	10 20 30 40 50 60 MSGESGQPEA GPSHAGLDWP NPERNRAGVP GGVIRRAGSQ GPRSWIQKVL EQIMDSPRQC 70 80 90 100 110 120 VTPSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS DGVYQEKCYL DPSLNSLVYQ 130 140 150 160 170 180 NILKVGIQMR ISRVSCLYNE KRIGQGILCI DNVHCGETSD SISLETPFRN RAHQEKPERP 190 200 210 220 230 240 LRGGKSHYLA LWNNEDPYGD IWLTDKQPEE HNFSDTKIIS LSHLEMTWTN RRNFPALLVR 250 260 270 280 290 300 ILHKSKLRYY GKPDKKMIEP YQTFLEVADS SGTVSVIMWN ALCPEWYKSL RVGLVLLLQD 310 320 330 340 350 360 YSVKKSYPFR IQPVPVDPQI KLISTMEICL NLRDPPTNII IIPEKQVKPE WRLPKLNHRF 370 380 390 400 410 420 TTRSELDDMP ENCICDVIGL LVFVGRVQRS KKKENREDFW SYRWIHIADG TSEQPFIVEL 430 440 450 460 470 480 FSTSQPEIFE NIYPMAYFVC TQLKVVRNDN QVPKLLYLTT TNESGVFITG HRGQPYTYDA 490 500 510 520 530 540 KVKNFIQWIR TKSDSGEQKN MVIGGYYPYP PVPETFSKYS SSIKVESLLT AISEVRKEIE 550 560 570 580 590 600 DLQYREQKRI AIQGIITAIK YIPHSSATES ASASETLRNA NRPSTSQAAR VEIQERNGKR 610 620 630 640 650 660 HQDDEPVNSQ YFQTTSTNLS LSNKIRILQG PHANPVAVPQ PGASVQTKGI KPGMPSIFNR 670 680 690 700 710 720 RANINANLQG KARKTISDRW ESQLWREKKF GLIDHLHYSR VYPESIPRKF MFEHRKFLSD 730 740 750 760 770 780 QYNSQPAKYV PPEGRPPKLD DFKSARSLGH FEVTILGLNH EIAIDVAFLP MYCPEDIRTS 790 800 810 820 830 840 QIDTLLTSMN YSCAYPQDTT GNDRLPGPRA VAGDIIKAAT ELDRVHIVGI LDICNLGNNK 850 VEVYLHKIYS PENTS
	Isoform 2 [UniParc]. Checksum: 5C7B0E4896EAFF4E	FASTA	567	65,383
	10 20 30 40 50 60 MSGESGQPEA GPSHAGLDWP NPERNRAGVP GGVIRRAGSQ GPRSWIQKVL EQIMDSPRQC 70 80 90 100 110 120 VTPSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS DGVYQEKCYL DPSLNSLVYQ 130 140 150 160 170 180 NILKVGIQMR ISRVSCLYNE KRIGQGILCI DNVHCGETSD SISLETPFRN RAHQEKPERP 190 200 210 220 230 240 LRGGKSHYLA LWNNEDPYGD IWLTDKQPEE HNFSDTKIIS LSHLEMTWTN RRNFPALLVR 250 260 270 280 290 300 ILHKSKLRYY GKPDKKMIEP YQTFLEVADS SGTVSVIMWN ALCPEWYKSL RVGLVLLLQD 310 320 330 340 350 360 YSVKKSYPFR IQPVPVDPQI KLISTMEICL NLRDPPTNII IIPEKQVKPE WRLPKLNHRF 370 380 390 400 410 420 TTRSELDDMP ENCICDVIGL LVFVGRVQRS KKKENREDFW SYRWIHIADG TSEQPFIVEL 430 440 450 460 470 480 FSTSQPEIFE NIYPMAYFVC TQLKVVRNDN QVPKLLYLTT TNESGVFITG HRGQPYTYDA 490 500 510 520 530 540 KVKNFIQWIR TKSDSGEQKN MVIGGYYPYP PVPETFSKYS SSIKGTNVIA SPSKYVYILY 550 560 VWLMLFQLVI FILFFYGSDL KFSNIHR
	Isoform 3 [UniParc]. Checksum: BBC25B38E7C29DFE	FASTA	533	61,268
	10 20 30 40 50 60 MTWTNRRNFP ALLVRILHKS KLRYYGKPDK KMIEPYQTFL EVADSSGTVS VIMWNALCPE 70 80 90 100 110 120 WYKSLRVGLV LLLQDYSVKK SYPFRIQPVP VDPQIKLIST MEICLNLRDP PTNIIIIPEK 130 140 150 160 170 180 QVKPEWRLPK LNHRFTTRSE LDDMPENCIC DVIGLLVFVG RVQRSKKKEN REDFWSYRWI 190 200 210 220 230 240 HIADGTSEQP FIVELFSTSQ PEIFENIYPM AYFVCTQLKV VRNDNQVPKL LYLTTTNESG 250 260 270 280 290 300 VFITGHRGQP YTYDAKNANR PSTSQAARVE IQERNGKRHQ DDEPVNSQYF QTTSTNLSLS 310 320 330 340 350 360 NKIRILQGPH ANPVAVPQPG ASVQTKGIKP GMPSIFNRRA NINANLQGKA RKTISDRWES 370 380 390 400 410 420 QLWREKKFGL IDHLHYSRVY PESIPRKFMF EHRKFLSDQY NSQPAKYVPP EGRPPKLDDF 430 440 450 460 470 480 KSARSLGHFE VTILGLNHEI AIDVAFLPMY CPEDIRTSQI DTLLTSMNYS CAYPQDTTGN 490 500 510 520 530 DRLPGPRAVA GDIIKAATEL DRVHIVGILD ICNLGNNKVE VYLHKIYSPE NTS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Embryo.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-593. Tissue: Brain, Choriocarcinoma and Leiomyosarcoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001040 mRNA. No translation available. AK024253 mRNA. Translation: BAB14859.1. AL606833, AL590808 Genomic DNA. Translation: CAI41230.1. AL590808, AL606833 Genomic DNA. Translation: CAI41594.1. CH471120 Genomic DNA. Translation: EAX02740.1. BC011483 mRNA. Translation: AAH11483.1. BC033709 mRNA. Translation: AAH33709.1. BC054032 mRNA. Translation: AAH54032.1. Sequence problems. BC070110 mRNA. Translation: AAH70110.1.
IPI	IPI00301517. IPI00477042. IPI00640891.
RefSeq	NP_001171711.1. NM_001184782.1. NP_060485.4. NM_018015.5.
UniGene	Hs.274267.
3D structure databases
ProteinModelPortal	Q6NSI4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361628.
PTM databases
PhosphoSite	Q6NSI4.
Polymorphism databases
DMDM	117949773.
Proteomic databases
PaxDb	Q6NSI4.
PRIDE	Q6NSI4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372544; ENSP00000361623; ENSG00000147231. ENST00000372548; ENSP00000361628; ENSG00000147231. ENST00000461251; ENSP00000432238; ENSG00000147231.
GeneID	55086.
KEGG	hsa:55086.
UCSC	uc004emh.2. human. uc004emi.4. human.
Organism-specific databases
CTD	55086.
GeneCards	GC0XP105855.
H-InvDB	HIX0203276.
HGNC	HGNC:25486. CXorf57.
HPA	HPA000896. HPA001374.
neXtProt	NX_Q6NSI4.
PharmGKB	PA145149058.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26588.
HOVERGEN	HBG079874.
InParanoid	Q6NSI4.
OMA	ENREDFW.
OrthoDB	EOG4JM7PD.
PhylomeDB	Q6NSI4.
Gene expression databases
ArrayExpress	Q6NSI4.
Bgee	Q6NSI4.
CleanEx	HS_CXorf57.
Genevestigator	Q6NSI4.
GermOnline	ENSG00000147231. Homo sapiens.
Family and domain databases
InterPro	IPR012340. NA-bd_OB-fold. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 2 hits.
ProtoNet	Search...
Other
GenomeRNAi	55086.
NextBio	58653.

Entry information

Entry name

CX057_HUMAN

Accession

Primary (citable) accession number: Q6NSI4
Secondary accession number(s): H7BY89 , Q4G0L7, Q5JQS1, Q5JRF9, Q6PHY5, Q6PII9, Q6PJU8, Q9H7W5, Q9NWA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	April 3, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.