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Protein

Protein FAM53A

Gene

FAM53A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in neural development; the dorsomedial roof of the third ventricle.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM53ACurated
Alternative name(s):
Dorsal neural-tube nuclear proteinBy similarity
Gene namesi
Name:FAM53AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000174137.12
HGNCiHGNC:31860 FAM53A
neXtProtiNX_Q6NSI3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174137
PharmGKBiPA142671887

Polymorphism and mutation databases

BioMutaiFAM53A
DMDMi74736712

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002616281 – 398Protein FAM53AAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineCombined sources1
Modified residuei301PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6NSI3
PeptideAtlasiQ6NSI3
PRIDEiQ6NSI3
ProteomicsDBi66629

PTM databases

iPTMnetiQ6NSI3
PhosphoSitePlusiQ6NSI3

Expressioni

Gene expression databases

BgeeiENSG00000174137
CleanExiHS_FAM53A
ExpressionAtlasiQ6NSI3 baseline and differential
GenevisibleiQ6NSI3 HS

Organism-specific databases

HPAiHPA036452
HPA058138

Interactioni

Protein-protein interaction databases

BioGridi127470, 1 interactor
STRINGi9606.ENSP00000310057

Structurei

3D structure databases

ProteinModelPortaliQ6NSI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi268 – 276Nuclear localization signalSequence analysis9

Sequence similaritiesi

Belongs to the FAM53 family.Curated

Phylogenomic databases

eggNOGiENOG410II6P Eukaryota
ENOG410ZSMG LUCA
GeneTreeiENSGT00530000063371
HOGENOMiHOG000059662
HOVERGENiHBG051537
InParanoidiQ6NSI3
OMAiVSKRRCN
OrthoDBiEOG091G091O
PhylomeDBiQ6NSI3
TreeFamiTF332095

Family and domain databases

InterProiView protein in InterPro
IPR029356 FAM53
PANTHERiPTHR28567 PTHR28567, 1 hit
PfamiView protein in Pfam
PF15242 FAM53, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NSI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLITEKLQ SQSLDDLTCK AEAGPLQYSA ETLNKSGRLF PLELNDQSPW
60 70 80 90 100
KVFSGGPPVR SQAATGPDFS FLPGLSAAAH TMGLQWQPQS PRPGAGLGAA
110 120 130 140 150
STVDPSESTG SSTAPPTKRH CRSLSEPEEL VRCRSPWRPG SSKVWTPVSK
160 170 180 190 200
RRCDSGGSAT RQGSPGAVLP RSAVWSTGPT SPATPRPSSA SGGFVDSSEG
210 220 230 240 250
SAGSGPLWCS AESCLPSTRR RPSLSQERLA GAGTPLPWAS SSPTSTPALG
260 270 280 290 300
GRRGLLRCRS QPCVLSGKRS RRKRRREEDA RWTRPSLDFL KMTQTLKNSK
310 320 330 340 350
SLCSLNYEDD DEDDTPVKTV LSSPCDSRGL PGITMPGCSQ RGLRTSPVHP
360 370 380 390
NLWASRESVT SDGSRRSSGD PRDGDSVGEE GVFPRARWEL DLEQIENN
Length:398
Mass (Da):42,585
Last modified:July 5, 2004 - v1
Checksum:i045E6F7C1969CD00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95A → V in BAC86205 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125566 mRNA Translation: BAC86205.1
BC070112 mRNA Translation: AAH70112.1
CCDSiCCDS33939.1
RefSeqiNP_001013644.1, NM_001013622.3
NP_001167541.1, NM_001174070.2
NP_001284364.1, NM_001297435.1
XP_005248005.1, XM_005247948.3
XP_011511704.1, XM_011513402.2
UniGeneiHs.143314
Hs.192784

Genome annotation databases

EnsembliENST00000308132; ENSP00000310057; ENSG00000174137
ENST00000461064; ENSP00000418243; ENSG00000174137
ENST00000472884; ENSP00000426260; ENSG00000174137
GeneIDi152877
KEGGihsa:152877
UCSCiuc021xkk.2 human

Similar proteinsi

Entry informationi

Entry nameiFA53A_HUMAN
AccessioniPrimary (citable) accession number: Q6NSI3
Secondary accession number(s): Q6ZUL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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