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Protein

Protein FAM53A

Gene

FAM53A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in neural development; the dorsomedial roof of the third ventricle.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM53A
Alternative name(s):
Dorsal neural-tube nuclear protein
Gene namesi
Name:FAM53A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:31860. FAM53A.

Subcellular locationi

  • Nucleus By similarity

  • Note: Subnuclear distribution.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671887.

Polymorphism and mutation databases

BioMutaiFAM53A.
DMDMi74736712.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Protein FAM53APRO_0000261628Add
BLAST

Proteomic databases

PaxDbiQ6NSI3.
PRIDEiQ6NSI3.

PTM databases

PhosphoSiteiQ6NSI3.

Expressioni

Gene expression databases

BgeeiQ6NSI3.
CleanExiHS_FAM53A.
ExpressionAtlasiQ6NSI3. baseline and differential.
GenevisibleiQ6NSI3. HS.

Organism-specific databases

HPAiHPA036452.

Interactioni

Protein-protein interaction databases

BioGridi127470. 1 interaction.
STRINGi9606.ENSP00000310057.

Structurei

3D structure databases

ProteinModelPortaliQ6NSI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi268 – 2769Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the FAM53 family.Curated

Phylogenomic databases

eggNOGiENOG410II6P. Eukaryota.
ENOG410ZSMG. LUCA.
GeneTreeiENSGT00530000063371.
HOGENOMiHOG000059662.
HOVERGENiHBG051537.
InParanoidiQ6NSI3.
OMAiCNSHGSA.
PhylomeDBiQ6NSI3.
TreeFamiTF332095.

Family and domain databases

InterProiIPR029356. FAM53.
[Graphical view]
PfamiPF15242. FAM53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NSI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLITEKLQ SQSLDDLTCK AEAGPLQYSA ETLNKSGRLF PLELNDQSPW
60 70 80 90 100
KVFSGGPPVR SQAATGPDFS FLPGLSAAAH TMGLQWQPQS PRPGAGLGAA
110 120 130 140 150
STVDPSESTG SSTAPPTKRH CRSLSEPEEL VRCRSPWRPG SSKVWTPVSK
160 170 180 190 200
RRCDSGGSAT RQGSPGAVLP RSAVWSTGPT SPATPRPSSA SGGFVDSSEG
210 220 230 240 250
SAGSGPLWCS AESCLPSTRR RPSLSQERLA GAGTPLPWAS SSPTSTPALG
260 270 280 290 300
GRRGLLRCRS QPCVLSGKRS RRKRRREEDA RWTRPSLDFL KMTQTLKNSK
310 320 330 340 350
SLCSLNYEDD DEDDTPVKTV LSSPCDSRGL PGITMPGCSQ RGLRTSPVHP
360 370 380 390
NLWASRESVT SDGSRRSSGD PRDGDSVGEE GVFPRARWEL DLEQIENN
Length:398
Mass (Da):42,585
Last modified:July 5, 2004 - v1
Checksum:i045E6F7C1969CD00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951A → V in BAC86205 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125566 mRNA. Translation: BAC86205.1.
BC070112 mRNA. Translation: AAH70112.1.
CCDSiCCDS33939.1.
RefSeqiNP_001013644.1. NM_001013622.3.
NP_001167541.1. NM_001174070.2.
NP_001284364.1. NM_001297435.1.
XP_005248005.1. XM_005247948.2.
XP_011511704.1. XM_011513402.1.
UniGeneiHs.143314.
Hs.192784.

Genome annotation databases

EnsembliENST00000308132; ENSP00000310057; ENSG00000174137.
ENST00000461064; ENSP00000418243; ENSG00000174137.
ENST00000472884; ENSP00000426260; ENSG00000174137.
GeneIDi152877.
KEGGihsa:152877.
UCSCiuc021xkk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125566 mRNA. Translation: BAC86205.1.
BC070112 mRNA. Translation: AAH70112.1.
CCDSiCCDS33939.1.
RefSeqiNP_001013644.1. NM_001013622.3.
NP_001167541.1. NM_001174070.2.
NP_001284364.1. NM_001297435.1.
XP_005248005.1. XM_005247948.2.
XP_011511704.1. XM_011513402.1.
UniGeneiHs.143314.
Hs.192784.

3D structure databases

ProteinModelPortaliQ6NSI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127470. 1 interaction.
STRINGi9606.ENSP00000310057.

PTM databases

PhosphoSiteiQ6NSI3.

Polymorphism and mutation databases

BioMutaiFAM53A.
DMDMi74736712.

Proteomic databases

PaxDbiQ6NSI3.
PRIDEiQ6NSI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308132; ENSP00000310057; ENSG00000174137.
ENST00000461064; ENSP00000418243; ENSG00000174137.
ENST00000472884; ENSP00000426260; ENSG00000174137.
GeneIDi152877.
KEGGihsa:152877.
UCSCiuc021xkk.2. human.

Organism-specific databases

CTDi152877.
GeneCardsiFAM53A.
HGNCiHGNC:31860. FAM53A.
HPAiHPA036452.
neXtProtiNX_Q6NSI3.
PharmGKBiPA142671887.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II6P. Eukaryota.
ENOG410ZSMG. LUCA.
GeneTreeiENSGT00530000063371.
HOGENOMiHOG000059662.
HOVERGENiHBG051537.
InParanoidiQ6NSI3.
OMAiCNSHGSA.
PhylomeDBiQ6NSI3.
TreeFamiTF332095.

Miscellaneous databases

GenomeRNAii152877.
NextBioi87050.
PROiQ6NSI3.

Gene expression databases

BgeeiQ6NSI3.
CleanExiHS_FAM53A.
ExpressionAtlasiQ6NSI3. baseline and differential.
GenevisibleiQ6NSI3. HS.

Family and domain databases

InterProiIPR029356. FAM53.
[Graphical view]
PfamiPF15242. FAM53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFA53A_HUMAN
AccessioniPrimary (citable) accession number: Q6NSI3
Secondary accession number(s): Q6ZUL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.