ID   Q6NSA1_HUMAN            Unreviewed;       273 AA.
AC   Q6NSA1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=TRA@ protein {ECO:0000313|EMBL:AAH70343.1};
GN   Name=TRA@ {ECO:0000313|EMBL:AAH70343.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH70343.1};
RN   [1] {ECO:0000313|EMBL:AAH70343.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0007829|PDB:6FR4}
RP   X-RAY CRYSTALLOGRAPHY (1.28 ANGSTROMS) OF 21-223, AND DISULFIDE BONDS.
RX   PubMed=29696015; DOI=10.3389/fimmu.2018.00674;
RA   Holland C.J., MacLachlan B.J., Bianchi V., Hesketh S.J., Morgan R.,
RA   Vickery O., Bulek A.M., Fuller A., Godkin A., Sewell A.K., Rizkallah P.J.,
RA   Wells S., Cole D.K.;
RT   "<i>In Silico</i> and Structural Analyses Demonstrate That Intrinsic
RT   Protein Motions Guide T Cell Receptor Complementarity Determining Region
RT   Loop Flexibility.";
RL   Front. Immunol. 9:674-674(2018).
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DR   EMBL; BC070343; AAH70343.1; -; mRNA.
DR   PDB; 6FR4; X-ray; 1.28 A; A=21-223.
DR   AlphaFoldDB; Q6NSA1; -.
DR   SMR; Q6NSA1; -.
DR   PeptideAtlas; Q6NSA1; -.
DR   ChiTaRS; TRA; human.
DR   CDD; cd07688; IgC_TCR_alpha; 1.
DR   CDD; cd04983; IgV_TCR_alpha; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR015370; TCR_alpha_C.
DR   PANTHER; PTHR19343; T CELL RECEPTOR ALPHA VARIABLE 1-2; 1.
DR   PANTHER; PTHR19343:SF12; T CELL RECEPTOR ALPHA VARIABLE 12-3; 1.
DR   Pfam; PF09291; DUF1968; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:6FR4};
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00043266};
KW   Immunity {ECO:0000256|ARBA:ARBA00043266}; Signal {ECO:0000256|SAM:SignalP};
KW   T cell receptor {ECO:0000256|ARBA:ARBA00043266}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..273
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004277824"
FT   DOMAIN          23..129
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DISULFID        44..110
FT                   /evidence="ECO:0007829|PDB:6FR4"
FT   DISULFID        155..205
FT                   /evidence="ECO:0007829|PDB:6FR4"
SQ   SEQUENCE   273 AA;  30867 MW;  ED69F23D7785C220 CRC64;
     MKSLRVLLVI LWLQLSWVWS QQKEVEQDPG PLSVPEGAIV SLNCTYSNSA FQYFMWYRQY
     SRKGPELLMY TYSSGNKEDG RFTAQVDKSS KYISLFIRDS QPSDSATYLC AMSARTGNQF
     YFGTGTSLTV IPNIQNPDPA VYQLRDSKSS DKSVCLFTDF DSQTNVSQSK DSDVYITDKT
     VLDMRSMDFK SNSAVAWSNK SDFACANAFN NSIIPEDTFF PSPESSCDVK LVEKSFETDT
     NLNFQNLSVI GFRILLLKVA GFNLLMTLRL WSS
//