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Protein

Zinc finger protein 366

Gene

Znf366

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 272C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 366Imported
Alternative name(s):
Dendritic cell-specific transcript protein1 Publication
Short name:
DC-SCRIPT1 Publication
Gene namesi
Name:Znf366By similarity
Synonyms:Zfp366Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2178429. Zfp366.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004398561 – 746Zinc finger protein 366Add BLAST746

Proteomic databases

MaxQBiQ6NS86.

Expressioni

Tissue specificityi

Expressed in immature and mature dendritic cells (DCs).1 Publication

Gene expression databases

BgeeiENSMUSG00000050919.

Interactioni

Subunit structurei

Interacts with ESR1 and NRIP1. Interacts (via PXDLS motif) with CTBP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060040.

Structurei

3D structure databases

SMRiQ6NS86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni452 – 746Interaction with NRIP1By similarityAdd BLAST295

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi587 – 591PXDLSBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 216Pro-richPROSITE-ProRule annotationAdd BLAST71

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 272C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117653.
HOGENOMiHOG000138030.
HOVERGENiHBG055962.
OMAiHMMQHSE.
OrthoDBiEOG091G02N1.
TreeFamiTF331510.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q6NS86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKAMKMVKD EDGPLNAAAK SIPSFPHCLQ PEASRGKAPQ RHPFPEALRG
60 70 80 90 100
PFSQFRYEPS PGDLDGFPEV FEGGGSRKRK SMPTKVPYTH PAEEASIAQE
110 120 130 140 150
SKSLGPPNLT LLFPQPQRPK CDSQMIDLCN VGLQFYRTLE HLGGKPVKQE
160 170 180 190 200
PVKPSAMWPQ PTPPAFLPAP YPYYPKVHPG LMFPFFVPSS SPFPFSRHTF
210 220 230 240 250
LPKQPPEPVL PRKVEPLESE ETKQKVERVD VNVQIDDSYY VDVGGAQKRW
260 270 280 290 300
QCPTCEKSYT SKYNLVTHIL GHSGIKPHAC SRCGKLFKQL SHLHTHMLTH
310 320 330 340 350
QGTRPHKCQV CHKAFTQTSH LKRHMMQHSE VKPHNCRVCS RGFAYPSELK
360 370 380 390 400
AHEAKHASGR ENICVECGLD FPTLAQLKRH LTTHRGPIQY NCSECDKTFQ
410 420 430 440 450
YPSQLQNHMM KHKDIRPYIC SECGMEFVQP HHLKQHSLTH KGVKEHKCGI
460 470 480 490 500
CGREFTLLAN MKRHVLIHTN IRAYQCHLCY KSFVQKQTLK AHMIVHSDVK
510 520 530 540 550
PFKCKLCGKE FNRMHNLMGH LHLHSDSKPF KCLYCPSKFT LKGNLTRHMK
560 570 580 590 600
VKHGVMERGL HSQGLGRGRL VLVQSAGVLR NLEQEEPFDL SQKRSANGPM
610 620 630 640 650
FQSDVDSTQD CLCQEEEEEA GEEDNCYEVE PYSPSLAPES QQLCAPEDLS
660 670 680 690 700
TKQEQTLQDP GEGCRDQDAP EEQQEDRSED HEGSDIDCEG KDIDCAIREE
710 720 730 740
RLSSRLLQSG GQGPSFSDYL YFKHRDEGLK ELLERKMEKQ AVLLGI
Length:746
Mass (Da):84,826
Last modified:July 5, 2004 - v1
Checksum:i428CD35E52054AEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128670 Genomic DNA. No translation available.
BC070399 mRNA. Translation: AAH70399.1.
CCDSiCCDS26720.1.
RefSeqiNP_001004149.1. NM_001004149.1.
UniGeneiMm.343207.

Genome annotation databases

EnsembliENSMUST00000056558; ENSMUSP00000060040; ENSMUSG00000050919.
GeneIDi238803.
KEGGimmu:238803.
UCSCiuc007rpl.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN366_MOUSE
AccessioniPrimary (citable) accession number: Q6NS86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot