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Protein

Uracil nucleotide/cysteinyl leukotriene receptor

Gene

Gpr17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of inflammatory response to antigenic stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391906. Leukotriene receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil nucleotide/cysteinyl leukotriene receptor
Short name:
UDP/CysLT receptor
Alternative name(s):
G-protein coupled receptor 17
Gene namesi
Name:Gpr17Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3584514. Gpr17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 647CytoplasmicSequence analysis
Transmembranei65 – 8521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini86 – 10520ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 14721CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 19527ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23216CytoplasmicSequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini254 – 28027ExtracellularSequence analysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini302 – 33938CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi88.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Uracil nucleotide/cysteinyl leukotriene receptorPRO_0000278171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6NS65.
PaxDbiQ6NS65.
PeptideAtlasiQ6NS65.
PRIDEiQ6NS65.

PTM databases

iPTMnetiQ6NS65.
PhosphoSiteiQ6NS65.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052229.
CleanExiMM_GPR17.
GenevisibleiQ6NS65. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-48915N.
STRINGi10090.ENSMUSP00000063670.

Structurei

3D structure databases

ProteinModelPortaliQ6NS65.
SMRiQ6NS65. Positions 32-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZC. Eukaryota.
ENOG41110RZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG102010.
InParanoidiQ6NS65.
KOiK08404.
OMAiFRDALCN.
OrthoDBiEOG091G0A8K.
PhylomeDBiQ6NS65.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NS65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGLEAALPS LTDNSSLAYS EQCGQETPLE NMLFACFYLL DFILAFVGNA
60 70 80 90 100
LALWLFIWDH KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG
110 120 130 140 150
EIPCRLTGFL FYLNMYASIY FLTCISADRF LAIVHPVKSL KLRRPLYAHL
160 170 180 190 200
ACAFLWIVVA VAMAPLLVSP QTVQTNHTVV CLQLYREKAS HHALASLAVA
210 220 230 240 250
FTFPFITTVT CYLLIIRSLR QGPRIEKHLK NKAVRMIAMV LAIFLICFVP
260 270 280 290 300
YHIHRSVYVL HYRGGGTSCA AQRALALGNR ITSCLTSLNG ALDPVMYFFV
310 320 330
AEKFRHALCN LLCSKRLTGP PPSFEGKTNE SSLSARSEL
Length:339
Mass (Da):37,839
Last modified:July 5, 2004 - v1
Checksum:i087248DC3294D0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070439 mRNA. Translation: AAH70439.1.
AY255543 mRNA. Translation: AAO85055.1.
CCDSiCCDS29114.1.
RefSeqiNP_001020552.1. NM_001025381.2.
UniGeneiMm.391108.

Genome annotation databases

EnsembliENSMUST00000064016; ENSMUSP00000063670; ENSMUSG00000052229.
GeneIDi574402.
KEGGimmu:574402.
UCSCiuc008eiw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070439 mRNA. Translation: AAH70439.1.
AY255543 mRNA. Translation: AAO85055.1.
CCDSiCCDS29114.1.
RefSeqiNP_001020552.1. NM_001025381.2.
UniGeneiMm.391108.

3D structure databases

ProteinModelPortaliQ6NS65.
SMRiQ6NS65. Positions 32-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48915N.
STRINGi10090.ENSMUSP00000063670.

Chemistry

GuidetoPHARMACOLOGYi88.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6NS65.
PhosphoSiteiQ6NS65.

Proteomic databases

MaxQBiQ6NS65.
PaxDbiQ6NS65.
PeptideAtlasiQ6NS65.
PRIDEiQ6NS65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064016; ENSMUSP00000063670; ENSMUSG00000052229.
GeneIDi574402.
KEGGimmu:574402.
UCSCiuc008eiw.2. mouse.

Organism-specific databases

CTDi2840.
MGIiMGI:3584514. Gpr17.

Phylogenomic databases

eggNOGiENOG410IGZC. Eukaryota.
ENOG41110RZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG102010.
InParanoidiQ6NS65.
KOiK08404.
OMAiFRDALCN.
OrthoDBiEOG091G0A8K.
PhylomeDBiQ6NS65.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-MMU-391906. Leukotriene receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ6NS65.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052229.
CleanExiMM_GPR17.
GenevisibleiQ6NS65. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR17_MOUSE
AccessioniPrimary (citable) accession number: Q6NS65
Secondary accession number(s): Q80UD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.