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Protein

F-box only protein 41

Gene

Fbxo41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 41
Gene namesi
Name:Fbxo41
Synonyms:D6Ertd538e, Kiaa1940
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1261912. Fbxo41.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199411 – 873F-box only protein 41Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei358Omega-N-methylarginineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei477PhosphothreonineCombined sources1
Modified residuei760PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ6NS60.
PaxDbiQ6NS60.
PRIDEiQ6NS60.

PTM databases

iPTMnetiQ6NS60.
PhosphoSitePlusiQ6NS60.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047013.
CleanExiMM_FBXO41.
ExpressionAtlasiQ6NS60. baseline and differential.
GenevisibleiQ6NS60. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124524.

Structurei

3D structure databases

ProteinModelPortaliQ6NS60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini548 – 592F-boxAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 349Sequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 61Poly-AlaAdd BLAST11
Compositional biasi107 – 112Poly-His6
Compositional biasi357 – 362Poly-Gly6

Sequence similaritiesi

Contains 1 F-box domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IPN2. Eukaryota.
ENOG410YK32. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000112547.
HOVERGENiHBG051581.
InParanoidiQ6NS60.
KOiK10316.
OMAiWGLRKQA.
OrthoDBiEOG091G01PD.
PhylomeDBiQ6NS60.
TreeFamiTF329439.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NS60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG
60 70 80 90 100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQATGPSP
110 120 130 140 150
AGPHLLHHHH HHAPLAHFPA DLVPASLPCE ELAEPGLVPA ARYALREIEI
160 170 180 190 200
PLGELFARKS VASSACSTPP PGPGPGPCSG PSSASPASPS PADVAYEEGL
210 220 230 240 250
ARLKIRALEK LEVDRRLERL SEEVEQKIAG QVGRLQAELE RKAAELETAR
260 270 280 290 300
QESARLGREK EELEERASEL SRQVDVSVEL LASLKQDLVH KEQELSRKQQ
310 320 330 340 350
EVVQIDQFLK ETAAREASAK LRLQQFIEEL LERADRAERQ LQVISSSCGS
360 370 380 390 400
TPSASLGRGG GGSASGPGVR GPGRMREHHA GSAVPSTYAV SRHGSSPSTG
410 420 430 440 450
ASSRVPAASQ SSGCYDSDSL ELPRPEEGPS EDSGPGGLGS RAQATNGGSE
460 470 480 490 500
RSQAPRSSGL RRQAIQNWQR RPRRHSTEGE EGDVSDVGSR TTESEAEGPS
510 520 530 540 550
DVPRPGPAVA GPLNSCRLSA RPEGGSGRGR RVERGSPSRS NEVISPEILK
560 570 580 590 600
MRAALFCIFT YLDTRTLLHA AEVCRDWRFV ARHPAVWTRV LLENARVCSK
610 620 630 640 650
FLAMLAQWCT QAHSLTLQNL KPRQRGKKES KEEYARSTRG CLEAGLESLL
660 670 680 690 700
KAAGGNLLIL RISHCPNILT DRSLWLASCY CRALQAVTYR SATDPVGHEV
710 720 730 740 750
IWALGAGCRD IVSLQVAPLH PCQQPTRFSN RCLQMIGRCW PHLRALGVGG
760 770 780 790 800
AGCGVQGLAS LARNCMRLQV LELDHVSEIT QEVAAEVCRE GLKGLEMLVL
810 820 830 840 850
TATPVTPKAL LHFNSICRNL KSIVVQIGIA DYFKEPSSPE AQKLFEDMVT
860 870
KLQALRRRPG FSKILHIKVE GGC
Length:873
Mass (Da):94,331
Last modified:January 23, 2007 - v3
Checksum:i2B1BA501527F9700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061475 mRNA. Translation: AAH61475.1.
BC070445 mRNA. Translation: AAH70445.1.
AK129466 mRNA. Translation: BAC98276.1.
CCDSiCCDS20296.1.
RefSeqiNP_001001160.1. NM_001001160.3.
NP_001276603.1. NM_001289674.1.
NP_001276604.1. NM_001289675.1.
UniGeneiMm.38777.

Genome annotation databases

EnsembliENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013.
ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013.
ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013.
GeneIDi330369.
KEGGimmu:330369.
UCSCiuc009cpw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061475 mRNA. Translation: AAH61475.1.
BC070445 mRNA. Translation: AAH70445.1.
AK129466 mRNA. Translation: BAC98276.1.
CCDSiCCDS20296.1.
RefSeqiNP_001001160.1. NM_001001160.3.
NP_001276603.1. NM_001289674.1.
NP_001276604.1. NM_001289675.1.
UniGeneiMm.38777.

3D structure databases

ProteinModelPortaliQ6NS60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124524.

PTM databases

iPTMnetiQ6NS60.
PhosphoSitePlusiQ6NS60.

Proteomic databases

MaxQBiQ6NS60.
PaxDbiQ6NS60.
PRIDEiQ6NS60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013.
ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013.
ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013.
GeneIDi330369.
KEGGimmu:330369.
UCSCiuc009cpw.2. mouse.

Organism-specific databases

CTDi150726.
MGIiMGI:1261912. Fbxo41.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IPN2. Eukaryota.
ENOG410YK32. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000112547.
HOVERGENiHBG051581.
InParanoidiQ6NS60.
KOiK10316.
OMAiWGLRKQA.
OrthoDBiEOG091G01PD.
PhylomeDBiQ6NS60.
TreeFamiTF329439.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ6NS60.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047013.
CleanExiMM_FBXO41.
ExpressionAtlasiQ6NS60. baseline and differential.
GenevisibleiQ6NS60. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX41_MOUSE
AccessioniPrimary (citable) accession number: Q6NS60
Secondary accession number(s): Q6P7W4, Q6ZPG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.