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Protein

Ferritin

Gene

FTH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIron storageUniRule annotationSAAS annotation
LigandIron, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
FerritinUniRule annotation
Gene namesi
Name:FTH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6NS36
PRIDEiQ6NS36

Structurei

3D structure databases

ProteinModelPortaliQ6NS36
SMRiQ6NS36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 209Ferritin-like diironInterPro annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOGENOMiHOG000223383
HOVERGENiHBG000410
PhylomeDBiQ6NS36

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Fragment.

Q6NS36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGFPASTVLG RNPALVPHPG RPPIASPPSP LHRTLGLPQG PRRLSLVAAM
60 70 80 90 100
TTASTSQVRQ NYHQDSEAAI NRQINLELYA SYVYLSMSYY FDRDDVALKN
110 120 130 140 150
FAKYFLHQSH EEREHAEKLM KLQNQRGGRI FLQDIKKPDC DDWESGLNAM
160 170 180 190 200
ECALHLEKNV NQSLLELHKL ATDKNDPHLC DFIETHYLNE QVKAIKELGD
210 220 230
HVTNLRKMGA PESGLAEYLF DKHTLGDSDN ES
Length:232
Mass (Da):26,219
Last modified:July 5, 2004 - v1
Checksum:i6C17564616345A85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070494 mRNA Translation: AAH70494.1
UniGeneiHs.524910
Hs.645560

Similar proteinsi

Entry informationi

Entry nameiQ6NS36_HUMAN
AccessioniPrimary (citable) accession number: Q6NS36
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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